Caveolin-1 as a pathophysiological factor and target in psoriasis View Full Text


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Article Info

DATE

2019-12

AUTHORS

Ilja L. Kruglikov, Philipp E. Scherer

ABSTRACT

Low expression of caveolin-1 (Cav-1) is typical in psoriatic lesions and overexpression of Cav-1 leads to a reduction of inflammation and suppression of epidermal hyperproliferation, thus ameliorating these two well-known hallmarks of psoriasis. At the same time, the interfacial layers of the white adipose tissue (WAT) adjacent to psoriatic lesions demonstrate much higher stiffness, which also points to a modification of Cav-1 expression in this tissue. These processes are connected with each other and regulated via exosomal exchange. Here we discuss the role of Cav-1 expression in inflammatory and hyperproliferative processes and analyze the ways to provide spatially different modulation of Cav-1 expression in the skin and WAT. Such modulation can be induced by different pharmacological and physical factors. These include application of mechanical stress and supra-physiological temperatures. Cav-1 should therefore be considered as an important target in treatment of psoriasis. More... »

PAGES

4

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41514-019-0034-x

    DOI

    http://dx.doi.org/10.1038/s41514-019-0034-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111912267

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30729030


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