Genome editing in plants by engineered CRISPR–Cas9 recognizing NG PAM View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12-10

AUTHORS

Masaki Endo, Masafumi Mikami, Akira Endo, Hidetaka Kaya, Takeshi Itoh, Hiroshi Nishimasu, Osamu Nureki, Seiichi Toki

ABSTRACT

Streptococcus pyogenes Cas9 (SpCas9) is widely used for genome editing and requires NGG as a protospacer adjacent motif (PAM). Here, we show that the engineered SpCas9 (SpCas9-NGv1) can efficiently mutagenize endogenous target sites with NG PAMs in the rice and Arabidopsis genomes. Furthermore, we demonstrate that the SpCas9-NGv1 nickase fused to cytidine deaminase mediates C-to-T substitutions near the 5' end of the target sequence. More... »

PAGES

1-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41477-018-0321-8

DOI

http://dx.doi.org/10.1038/s41477-018-0321-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110204846

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30531939


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