Acetate reprograms gut microbiota during alcohol consumption View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-08-08

AUTHORS

Cameron Martino, Livia S. Zaramela, Bei Gao, Mallory Embree, Janna Tarasova, Seth J. Parker, Yanhan Wang, Huikuan Chu, Peng Chen, Kuei-Chuan Lee, Daniela Domingos Galzerani, Jivani M. Gengatharan, Asama Lekbua, Maxwell Neal, Rob Knight, Hidekazu Tsukamoto, Christian M. Metallo, Bernd Schnabl, Karsten Zengler

ABSTRACT

Liver damage due to chronic alcohol use is among the most prevalent liver diseases. Alcohol consumption frequency is a strong factor of microbiota variance. Here we use isotope labeled [1-13C] ethanol, metagenomics, and metatranscriptomics in ethanol-feeding and intragastric mouse models to investigate the metabolic impacts of alcohol consumption on the gut microbiota. First, we show that although stable isotope labeled [1-13C] ethanol contributes to fatty acid pools in the liver, plasma, and cecum contents of mice, there is no evidence of ethanol metabolism by gut microbiota ex vivo under anaerobic conditions. Next, we observe through metatranscriptomics that the gut microbiota responds to ethanol-feeding by activating acetate dissimilation, not by metabolizing ethanol directly. We demonstrate that blood acetate concentrations are elevated during ethanol consumption. Finally, by increasing systemic acetate levels with glyceryl triacetate supplementation, we do not observe any impact on liver disease, but do induce similar gut microbiota alterations as chronic ethanol-feeding in mice. Our results show that ethanol is not directly metabolized by the gut microbiota, and changes in the gut microbiota linked to ethanol are a side effect of elevated acetate levels. De-trending for these acetate effects may be critical for understanding gut microbiota changes that cause alcohol-related liver disease. More... »

PAGES

4630

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-022-31973-2

DOI

http://dx.doi.org/10.1038/s41467-022-31973-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1150064536

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35941112


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358 Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA
359 Department of Bioengineering, University of California, San Diego, CA, USA
360 Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA
361 Department of Medicine, University of California San Diego, La Jolla, CA, USA
362 Department of Pediatrics, University of California San Diego, La Jolla, CA, USA
363 rdf:type schema:Organization
364 grid-institutes:grid.410371.0 schema:alternateName Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA
365 schema:name Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA
366 Department of Medicine, University of California San Diego, La Jolla, CA, USA
367 Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA
368 rdf:type schema:Organization
369 grid-institutes:grid.417119.b schema:alternateName Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
370 schema:name Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
371 Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, La Jolla, CA, USA
372 rdf:type schema:Organization
 




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