Systematic and quantitative view of the antiviral arsenal of prokaryotes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-05-10

AUTHORS

Florian Tesson, Alexandre Hervé, Ernest Mordret, Marie Touchon, Camille d’Humières, Jean Cury, Aude Bernheim

ABSTRACT

Bacteria and archaea have developed multiple antiviral mechanisms, and genomic evidence indicates that several of these antiviral systems co-occur in the same strain. Here, we introduce DefenseFinder, a tool that automatically detects known antiviral systems in prokaryotic genomes. We use DefenseFinder to analyse 21000 fully sequenced prokaryotic genomes, and find that antiviral strategies vary drastically between phyla, species and strains. Variations in composition of antiviral systems correlate with genome size, viral threat, and lifestyle traits. DefenseFinder will facilitate large-scale genomic analysis of antiviral defense systems and the study of host-virus interactions in prokaryotes. More... »

PAGES

2561

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-022-30269-9

    DOI

    http://dx.doi.org/10.1038/s41467-022-30269-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1147760017

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35538097


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