Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer View Full Text


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Article Info

DATE

2022-05-10

AUTHORS

Liyuan Zhou, Qiongzi Qiu, Qing Zhou, Jianwei Li, Mengqian Yu, Kezhen Li, Lingling Xu, Xiaohui Ke, Haiming Xu, Bingjian Lu, Hui Wang, Weiguo Lu, Pengyuan Liu, Yan Lu

ABSTRACT

Integration of human papillomavirus (HPV) DNA into the human genome is considered as a key event in cervical carcinogenesis. Here, we perform comprehensive characterization of large-range virus-human integration events in 16 HPV16-positive cervical tumors using the Nanopore long-read sequencing technology. Four distinct integration types characterized by the integrated HPV DNA segments are identified with Type B being particularly notable as lacking E6/E7 genes. We further demonstrate that multiple clonal integration events are involved in the use of shared breakpoints, the induction of inter-chromosomal translocations and the formation of extrachromosomal circular virus-human hybrid structures. Combined with the corresponding RNA-seq data, we highlight LINC00290, LINC02500 and LENG9 as potential driver genes in cervical cancer. Finally, we reveal the spatial relationship of HPV integration and its various structural variations as well as their functional consequences in cervical cancer. These findings provide insight into HPV integration and its oncogenic progression in cervical cancer. More... »

PAGES

2563

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-022-30190-1

    DOI

    http://dx.doi.org/10.1038/s41467-022-30190-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1147764269

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35538075


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    342 Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
    343 Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
    344 rdf:type schema:Organization
    345 grid-institutes:grid.33199.31 schema:alternateName Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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    347 rdf:type schema:Organization
    348 grid-institutes:grid.415999.9 schema:alternateName Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
    349 schema:name Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
    350 rdf:type schema:Organization
    351 grid-institutes:grid.507993.1 schema:alternateName Department of Obstetrics and Gynecology, Wenzhou Central Hospital, 325000, Wenzhou, Zhejiang, China
    352 schema:name Department of Obstetrics and Gynecology, Wenzhou Central Hospital, 325000, Wenzhou, Zhejiang, China
    353 rdf:type schema:Organization
     




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