Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-05-10

AUTHORS

Smriti Prasad, Erkan Kalafat, Helena Blakeway, Rosemary Townsend, Pat O’Brien, Edward Morris, Tim Draycott, Shakila Thangaratinam, Kirsty Le Doare, Shamez Ladhani, Peter von Dadelszen, Laura A. Magee, Paul Heath, Asma Khalil

ABSTRACT

Safety and effectiveness of COVID-19 vaccines during pregnancy is a particular concern affecting vaccination uptake by this vulnerable group. Here we evaluated evidence from 23 studies including 117,552 COVID-19 vaccinated pregnant people, almost exclusively with mRNA vaccines. We show that the effectiveness of mRNA vaccination against RT-PCR confirmed SARS-CoV-2 infection 7 days after second dose was 89·5% (95% CI 69·0-96·4%, 18,828 vaccinated pregnant people, I2 = 73·9%). The risk of stillbirth was significantly lower in the vaccinated cohort by 15% (pooled OR 0·85; 95% CI 0·73–0·99, 66,067 vaccinated vs. 424,624 unvaccinated, I2 = 93·9%). There was no evidence of a higher risk of adverse outcomes including miscarriage, earlier gestation at birth, placental abruption, pulmonary embolism, postpartum haemorrhage, maternal death, intensive care unit admission, lower birthweight Z-score, or neonatal intensive care unit admission (p > 0.05 for all). COVID-19 mRNA vaccination in pregnancy appears to be safe and is associated with a reduction in stillbirth. More... »

PAGES

2414

Journal

TITLE

Nature Communications

ISSUE

1

VOLUME

13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-022-30052-w

DOI

http://dx.doi.org/10.1038/s41467-022-30052-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1147764134

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35538060


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "COVID-19", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "COVID-19 Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intensive Care Units, Neonatal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Placenta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Premature Birth", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SARS-CoV-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stillbirth", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccination", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fetal Medicine Unit, St George\u2019s Hospital, St George\u2019s University of London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.264200.2", 
          "name": [
            "Fetal Medicine Unit, St George\u2019s Hospital, St George\u2019s University of London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prasad", 
        "givenName": "Smriti", 
        "id": "sg:person.016173010624.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016173010624.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Obstetrics and Gynaecology, School of Medicine, Koc University, Istanbul, Turkey", 
          "id": "http://www.grid.ac/institutes/grid.15876.3d", 
          "name": [
            "Department of Statistics, Faculty of Arts and Sciences, Middle East Technical University, Ankara, Turkey", 
            "Department of Obstetrics and Gynaecology, School of Medicine, Koc University, Istanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kalafat", 
        "givenName": "Erkan", 
        "id": "sg:person.0722003224.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722003224.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fetal Medicine Unit, St George\u2019s Hospital, St George\u2019s University of London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.264200.2", 
          "name": [
            "Fetal Medicine Unit, St George\u2019s Hospital, St George\u2019s University of London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blakeway", 
        "givenName": "Helena", 
        "id": "sg:person.011511427344.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011511427344.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George\u2019s University of London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.264200.2", 
          "name": [
            "Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK", 
            "Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George\u2019s University of London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Townsend", 
        "givenName": "Rosemary", 
        "id": "sg:person.0724462461.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724462461.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London Hospitals NHS Foundation Trust, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.52996.31", 
          "name": [
            "The Royal College of Obstetricians and Gynaecologists, London, UK", 
            "University College London Hospitals NHS Foundation Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Brien", 
        "givenName": "Pat", 
        "id": "sg:person.0650420167.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650420167.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, Norfolk, UK", 
          "id": "http://www.grid.ac/institutes/grid.240367.4", 
          "name": [
            "The Royal College of Obstetricians and Gynaecologists, London, UK", 
            "Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, Norfolk, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morris", 
        "givenName": "Edward", 
        "id": "sg:person.0714400302.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714400302.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "North Bristol NHS Trust Department of Women\u2019s Health, Westbury-on-Trym, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.418484.5", 
          "name": [
            "The Royal College of Obstetricians and Gynaecologists, London, UK", 
            "North Bristol NHS Trust Department of Women\u2019s Health, Westbury-on-Trym, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Draycott", 
        "givenName": "Tim", 
        "id": "sg:person.01364741575.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364741575.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Metabolism and Systems Research, WHO Collaborating Centre for Women\u2019s Health, University of Birmingham, Birmingham, UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Institute of Metabolism and Systems Research, WHO Collaborating Centre for Women\u2019s Health, University of Birmingham, Birmingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thangaratinam", 
        "givenName": "Shakila", 
        "id": "sg:person.0642623651.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642623651.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George\u2019s University of London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.264200.2", 
          "name": [
            "Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George\u2019s University of London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Le Doare", 
        "givenName": "Kirsty", 
        "id": "sg:person.0670216322.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670216322.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "British Paediatric Surveillance Unit, Royal College of Paediatrics and Child Health, England, UK", 
          "id": "http://www.grid.ac/institutes/grid.451235.4", 
          "name": [
            "Immunisation and Countermeasures Division, Public Health England, England, UK", 
            "British Paediatric Surveillance Unit, Royal College of Paediatrics and Child Health, England, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ladhani", 
        "givenName": "Shamez", 
        "id": "sg:person.01325272575.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325272575.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Institute of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "von Dadelszen", 
        "givenName": "Peter", 
        "id": "sg:person.0707426565.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707426565.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Institute of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magee", 
        "givenName": "Laura A.", 
        "id": "sg:person.01105005516.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105005516.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George\u2019s University of London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.264200.2", 
          "name": [
            "Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George\u2019s University of London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heath", 
        "givenName": "Paul", 
        "id": "sg:person.01117742447.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117742447.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George\u2019s University of London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.264200.2", 
          "name": [
            "Fetal Medicine Unit, St George\u2019s Hospital, St George\u2019s University of London, London, UK", 
            "Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George\u2019s University of London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khalil", 
        "givenName": "Asma", 
        "id": "sg:person.01335002157.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335002157.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/s41467-021-23938-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1138891596", 
          "https://doi.org/10.1038/s41467-021-23938-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41591-021-01490-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1140937911", 
          "https://doi.org/10.1038/s41591-021-01490-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00404-021-06297-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1142179233", 
          "https://doi.org/10.1007/s00404-021-06297-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41591-021-01666-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1144621030", 
          "https://doi.org/10.1038/s41591-021-01666-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-05-10", 
    "datePublishedReg": "2022-05-10", 
    "description": "Safety and effectiveness of COVID-19 vaccines during pregnancy is a particular concern affecting vaccination uptake by this vulnerable group. Here we evaluated evidence from 23 studies including 117,552 COVID-19 vaccinated pregnant people, almost exclusively with mRNA vaccines. We show that the effectiveness of mRNA vaccination against RT-PCR confirmed SARS-CoV-2 infection 7 days after second dose was 89\u00b75% (95% CI 69\u00b70-96\u00b74%, 18,828 vaccinated pregnant people, I2\u2009=\u200973\u00b79%). The risk of stillbirth was significantly lower in the vaccinated cohort by 15% (pooled OR 0\u00b785; 95% CI 0\u00b773\u20130\u00b799, 66,067 vaccinated vs. 424,624 unvaccinated, I2\u2009=\u200993\u00b79%). There was no evidence of a higher risk of adverse outcomes including miscarriage, earlier gestation at birth, placental abruption, pulmonary embolism, postpartum haemorrhage, maternal death, intensive care unit admission, lower birthweight Z-score, or neonatal intensive care unit admission (p\u2009>\u20090.05 for all). COVID-19 mRNA vaccination in pregnancy appears to be safe and is associated with a reduction in stillbirth.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41467-022-30052-w", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "intensive care unit admission", 
      "care unit admission", 
      "unit admission", 
      "mRNA vaccination", 
      "neonatal intensive care unit admission", 
      "COVID-19 mRNA vaccination", 
      "risk of stillbirth", 
      "birthweight z-score", 
      "COVID-19 vaccination", 
      "COVID-19 vaccine", 
      "vaccinated cohort", 
      "placental abruption", 
      "perinatal outcomes", 
      "vaccination uptake", 
      "pulmonary embolism", 
      "maternal deaths", 
      "second dose", 
      "postpartum hemorrhage", 
      "adverse outcomes", 
      "mRNA vaccines", 
      "early gestation", 
      "high risk", 
      "systematic review", 
      "pregnant people", 
      "z-score", 
      "pregnancy", 
      "vaccination", 
      "RT-PCR", 
      "COVID-19", 
      "stillbirth", 
      "admission", 
      "vaccine", 
      "vulnerable groups", 
      "outcomes", 
      "risk", 
      "abruption", 
      "embolism", 
      "hemorrhage", 
      "gestation", 
      "miscarriage", 
      "cohort", 
      "dose", 
      "particular concern", 
      "evidence", 
      "death", 
      "birth", 
      "days", 
      "safety", 
      "review", 
      "group", 
      "uptake", 
      "effectiveness", 
      "study", 
      "reduction", 
      "people", 
      "concern"
    ], 
    "name": "Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy", 
    "pagination": "2414", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1147764134"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-022-30052-w"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35538060"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-022-30052-w", 
      "https://app.dimensions.ai/details/publication/pub.1147764134"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_935.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41467-022-30052-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-022-30052-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-022-30052-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-022-30052-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-022-30052-w'


 

This table displays all metadata directly associated to this object as RDF triples.

311 TRIPLES      22 PREDICATES      100 URIs      87 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-022-30052-w schema:about N0d5aca3455144815a9393020b44aeb62
2 N2fdab9efb31b4ae780fedcb814f81d9c
3 N41ac73e0992c4effbad36047b45818e4
4 N4839084a1f694709897992b0cb0ee304
5 N486d3123bec84cb98868a2ba3385b9fe
6 N4eea72ac81494790a4750008ce48fe66
7 N74bc1fc4c1fc47788ea41d99af5da2f4
8 N83b6bf5c6c8f4506966e5566d366d523
9 Nb23cf98d80ad484fa2efa857c32359e6
10 Nbbd22f94fe2748e4adb5aa658e5543da
11 Nc5c18b0ded564d9fb8671dcd826e2381
12 Ndf417c79294449769f63c67f71a58caa
13 Nf8e03285f2cf43d08c05bc85521f6711
14 anzsrc-for:11
15 anzsrc-for:1114
16 anzsrc-for:1117
17 schema:author Nd7159d8d9bc74c798874be3718ce24c3
18 schema:citation sg:pub.10.1007/s00404-021-06297-z
19 sg:pub.10.1038/s41467-021-23938-8
20 sg:pub.10.1038/s41591-021-01490-8
21 sg:pub.10.1038/s41591-021-01666-2
22 schema:datePublished 2022-05-10
23 schema:datePublishedReg 2022-05-10
24 schema:description Safety and effectiveness of COVID-19 vaccines during pregnancy is a particular concern affecting vaccination uptake by this vulnerable group. Here we evaluated evidence from 23 studies including 117,552 COVID-19 vaccinated pregnant people, almost exclusively with mRNA vaccines. We show that the effectiveness of mRNA vaccination against RT-PCR confirmed SARS-CoV-2 infection 7 days after second dose was 89·5% (95% CI 69·0-96·4%, 18,828 vaccinated pregnant people, I2 = 73·9%). The risk of stillbirth was significantly lower in the vaccinated cohort by 15% (pooled OR 0·85; 95% CI 0·73–0·99, 66,067 vaccinated vs. 424,624 unvaccinated, I2 = 93·9%). There was no evidence of a higher risk of adverse outcomes including miscarriage, earlier gestation at birth, placental abruption, pulmonary embolism, postpartum haemorrhage, maternal death, intensive care unit admission, lower birthweight Z-score, or neonatal intensive care unit admission (p > 0.05 for all). COVID-19 mRNA vaccination in pregnancy appears to be safe and is associated with a reduction in stillbirth.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf Nb464ff1ba1334132bd5b5a7c9be65ac6
29 Nf839884effb145c6b936d316b776464c
30 sg:journal.1043282
31 schema:keywords COVID-19
32 COVID-19 mRNA vaccination
33 COVID-19 vaccination
34 COVID-19 vaccine
35 RT-PCR
36 abruption
37 admission
38 adverse outcomes
39 birth
40 birthweight z-score
41 care unit admission
42 cohort
43 concern
44 days
45 death
46 dose
47 early gestation
48 effectiveness
49 embolism
50 evidence
51 gestation
52 group
53 hemorrhage
54 high risk
55 intensive care unit admission
56 mRNA vaccination
57 mRNA vaccines
58 maternal deaths
59 miscarriage
60 neonatal intensive care unit admission
61 outcomes
62 particular concern
63 people
64 perinatal outcomes
65 placental abruption
66 postpartum hemorrhage
67 pregnancy
68 pregnant people
69 pulmonary embolism
70 reduction
71 review
72 risk
73 risk of stillbirth
74 safety
75 second dose
76 stillbirth
77 study
78 systematic review
79 unit admission
80 uptake
81 vaccinated cohort
82 vaccination
83 vaccination uptake
84 vaccine
85 vulnerable groups
86 z-score
87 schema:name Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy
88 schema:pagination 2414
89 schema:productId N495ee91b19084a62ba86b7f5f2b8cbe4
90 N59b82b97827e4536be40b1f535bd8a69
91 N84e2040902c14bf9b81af6633f4a43db
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1147764134
93 https://doi.org/10.1038/s41467-022-30052-w
94 schema:sdDatePublished 2022-06-01T22:25
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher Nfefff0cb74fb4333a2b835f4ff57ade2
97 schema:url https://doi.org/10.1038/s41467-022-30052-w
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N0190114a841c40f19324b16650ddda9f rdf:first sg:person.011511427344.23
102 rdf:rest N66612087b0e5403e90948d40130a8c5a
103 N05772a637fbf4dc588b12d58854be484 rdf:first sg:person.01335002157.75
104 rdf:rest rdf:nil
105 N0d5aca3455144815a9393020b44aeb62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name COVID-19 Vaccines
107 rdf:type schema:DefinedTerm
108 N263e381dd1144a4ba6a5ed64d73a99f5 rdf:first sg:person.0642623651.76
109 rdf:rest Nae99b3d66fd6433f9c869a106616cc3e
110 N2fdab9efb31b4ae780fedcb814f81d9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name RNA, Messenger
112 rdf:type schema:DefinedTerm
113 N41ac73e0992c4effbad36047b45818e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Humans
115 rdf:type schema:DefinedTerm
116 N4839084a1f694709897992b0cb0ee304 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name COVID-19
118 rdf:type schema:DefinedTerm
119 N486d3123bec84cb98868a2ba3385b9fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Placenta
121 rdf:type schema:DefinedTerm
122 N495ee91b19084a62ba86b7f5f2b8cbe4 schema:name pubmed_id
123 schema:value 35538060
124 rdf:type schema:PropertyValue
125 N4eea72ac81494790a4750008ce48fe66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Pregnancy
127 rdf:type schema:DefinedTerm
128 N59b82b97827e4536be40b1f535bd8a69 schema:name dimensions_id
129 schema:value pub.1147764134
130 rdf:type schema:PropertyValue
131 N607069ceb37146c8a58412f36e527e8b rdf:first sg:person.0714400302.88
132 rdf:rest N9c77b98889a94c20b3837d1c647213bf
133 N66612087b0e5403e90948d40130a8c5a rdf:first sg:person.0724462461.46
134 rdf:rest Nfb32c01143014d9a881b45016c2d9f4c
135 N7349729c941e4df09b732a6e63797d7a rdf:first sg:person.0707426565.93
136 rdf:rest Nbc65ca80cf7a4c7f999f36ec3c9f21d3
137 N74bc1fc4c1fc47788ea41d99af5da2f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name SARS-CoV-2
139 rdf:type schema:DefinedTerm
140 N8188f79156e5453abb8a53cb181b79e0 rdf:first sg:person.0722003224.21
141 rdf:rest N0190114a841c40f19324b16650ddda9f
142 N83b6bf5c6c8f4506966e5566d366d523 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Infant, Newborn
144 rdf:type schema:DefinedTerm
145 N84e2040902c14bf9b81af6633f4a43db schema:name doi
146 schema:value 10.1038/s41467-022-30052-w
147 rdf:type schema:PropertyValue
148 N945fb7b447584ee6ba059a03469c6a8d rdf:first sg:person.01117742447.91
149 rdf:rest N05772a637fbf4dc588b12d58854be484
150 N9c77b98889a94c20b3837d1c647213bf rdf:first sg:person.01364741575.25
151 rdf:rest N263e381dd1144a4ba6a5ed64d73a99f5
152 Nae99b3d66fd6433f9c869a106616cc3e rdf:first sg:person.0670216322.16
153 rdf:rest Nc507ae4deebc415c8fa1bfae8c375d8c
154 Nb23cf98d80ad484fa2efa857c32359e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Vaccination
156 rdf:type schema:DefinedTerm
157 Nb464ff1ba1334132bd5b5a7c9be65ac6 schema:volumeNumber 13
158 rdf:type schema:PublicationVolume
159 Nbbd22f94fe2748e4adb5aa658e5543da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Stillbirth
161 rdf:type schema:DefinedTerm
162 Nbc65ca80cf7a4c7f999f36ec3c9f21d3 rdf:first sg:person.01105005516.93
163 rdf:rest N945fb7b447584ee6ba059a03469c6a8d
164 Nc507ae4deebc415c8fa1bfae8c375d8c rdf:first sg:person.01325272575.23
165 rdf:rest N7349729c941e4df09b732a6e63797d7a
166 Nc5c18b0ded564d9fb8671dcd826e2381 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Premature Birth
168 rdf:type schema:DefinedTerm
169 Nd7159d8d9bc74c798874be3718ce24c3 rdf:first sg:person.016173010624.43
170 rdf:rest N8188f79156e5453abb8a53cb181b79e0
171 Ndf417c79294449769f63c67f71a58caa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Intensive Care Units, Neonatal
173 rdf:type schema:DefinedTerm
174 Nf839884effb145c6b936d316b776464c schema:issueNumber 1
175 rdf:type schema:PublicationIssue
176 Nf8e03285f2cf43d08c05bc85521f6711 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Female
178 rdf:type schema:DefinedTerm
179 Nfb32c01143014d9a881b45016c2d9f4c rdf:first sg:person.0650420167.91
180 rdf:rest N607069ceb37146c8a58412f36e527e8b
181 Nfefff0cb74fb4333a2b835f4ff57ade2 schema:name Springer Nature - SN SciGraph project
182 rdf:type schema:Organization
183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
184 schema:name Medical and Health Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
187 schema:name Paediatrics and Reproductive Medicine
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
190 schema:name Public Health and Health Services
191 rdf:type schema:DefinedTerm
192 sg:journal.1043282 schema:issn 2041-1723
193 schema:name Nature Communications
194 schema:publisher Springer Nature
195 rdf:type schema:Periodical
196 sg:person.01105005516.93 schema:affiliation grid-institutes:grid.13097.3c
197 schema:familyName Magee
198 schema:givenName Laura A.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105005516.93
200 rdf:type schema:Person
201 sg:person.01117742447.91 schema:affiliation grid-institutes:grid.264200.2
202 schema:familyName Heath
203 schema:givenName Paul
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117742447.91
205 rdf:type schema:Person
206 sg:person.011511427344.23 schema:affiliation grid-institutes:grid.264200.2
207 schema:familyName Blakeway
208 schema:givenName Helena
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011511427344.23
210 rdf:type schema:Person
211 sg:person.01325272575.23 schema:affiliation grid-institutes:grid.451235.4
212 schema:familyName Ladhani
213 schema:givenName Shamez
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325272575.23
215 rdf:type schema:Person
216 sg:person.01335002157.75 schema:affiliation grid-institutes:grid.264200.2
217 schema:familyName Khalil
218 schema:givenName Asma
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335002157.75
220 rdf:type schema:Person
221 sg:person.01364741575.25 schema:affiliation grid-institutes:grid.418484.5
222 schema:familyName Draycott
223 schema:givenName Tim
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364741575.25
225 rdf:type schema:Person
226 sg:person.016173010624.43 schema:affiliation grid-institutes:grid.264200.2
227 schema:familyName Prasad
228 schema:givenName Smriti
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016173010624.43
230 rdf:type schema:Person
231 sg:person.0642623651.76 schema:affiliation grid-institutes:grid.6572.6
232 schema:familyName Thangaratinam
233 schema:givenName Shakila
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642623651.76
235 rdf:type schema:Person
236 sg:person.0650420167.91 schema:affiliation grid-institutes:grid.52996.31
237 schema:familyName O’Brien
238 schema:givenName Pat
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650420167.91
240 rdf:type schema:Person
241 sg:person.0670216322.16 schema:affiliation grid-institutes:grid.264200.2
242 schema:familyName Le Doare
243 schema:givenName Kirsty
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670216322.16
245 rdf:type schema:Person
246 sg:person.0707426565.93 schema:affiliation grid-institutes:grid.13097.3c
247 schema:familyName von Dadelszen
248 schema:givenName Peter
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707426565.93
250 rdf:type schema:Person
251 sg:person.0714400302.88 schema:affiliation grid-institutes:grid.240367.4
252 schema:familyName Morris
253 schema:givenName Edward
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714400302.88
255 rdf:type schema:Person
256 sg:person.0722003224.21 schema:affiliation grid-institutes:grid.15876.3d
257 schema:familyName Kalafat
258 schema:givenName Erkan
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722003224.21
260 rdf:type schema:Person
261 sg:person.0724462461.46 schema:affiliation grid-institutes:grid.264200.2
262 schema:familyName Townsend
263 schema:givenName Rosemary
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724462461.46
265 rdf:type schema:Person
266 sg:pub.10.1007/s00404-021-06297-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1142179233
267 https://doi.org/10.1007/s00404-021-06297-z
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/s41467-021-23938-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1138891596
270 https://doi.org/10.1038/s41467-021-23938-8
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/s41591-021-01490-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1140937911
273 https://doi.org/10.1038/s41591-021-01490-8
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/s41591-021-01666-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1144621030
276 https://doi.org/10.1038/s41591-021-01666-2
277 rdf:type schema:CreativeWork
278 grid-institutes:grid.13097.3c schema:alternateName Institute of Women and Children’s Health, School of Life Course Sciences, King’s College London, London, UK
279 schema:name Institute of Women and Children’s Health, School of Life Course Sciences, King’s College London, London, UK
280 rdf:type schema:Organization
281 grid-institutes:grid.15876.3d schema:alternateName Department of Obstetrics and Gynaecology, School of Medicine, Koc University, Istanbul, Turkey
282 schema:name Department of Obstetrics and Gynaecology, School of Medicine, Koc University, Istanbul, Turkey
283 Department of Statistics, Faculty of Arts and Sciences, Middle East Technical University, Ankara, Turkey
284 rdf:type schema:Organization
285 grid-institutes:grid.240367.4 schema:alternateName Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, Norfolk, UK
286 schema:name Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, Norfolk, UK
287 The Royal College of Obstetricians and Gynaecologists, London, UK
288 rdf:type schema:Organization
289 grid-institutes:grid.264200.2 schema:alternateName Fetal Medicine Unit, St George’s Hospital, St George’s University of London, London, UK
290 Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George’s University of London, London, UK
291 Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George’s University of London, London, UK
292 schema:name Fetal Medicine Unit, St George’s Hospital, St George’s University of London, London, UK
293 Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George’s University of London, London, UK
294 Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
295 Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George’s University of London, London, UK
296 rdf:type schema:Organization
297 grid-institutes:grid.418484.5 schema:alternateName North Bristol NHS Trust Department of Women’s Health, Westbury-on-Trym, Bristol, UK
298 schema:name North Bristol NHS Trust Department of Women’s Health, Westbury-on-Trym, Bristol, UK
299 The Royal College of Obstetricians and Gynaecologists, London, UK
300 rdf:type schema:Organization
301 grid-institutes:grid.451235.4 schema:alternateName British Paediatric Surveillance Unit, Royal College of Paediatrics and Child Health, England, UK
302 schema:name British Paediatric Surveillance Unit, Royal College of Paediatrics and Child Health, England, UK
303 Immunisation and Countermeasures Division, Public Health England, England, UK
304 rdf:type schema:Organization
305 grid-institutes:grid.52996.31 schema:alternateName University College London Hospitals NHS Foundation Trust, London, UK
306 schema:name The Royal College of Obstetricians and Gynaecologists, London, UK
307 University College London Hospitals NHS Foundation Trust, London, UK
308 rdf:type schema:Organization
309 grid-institutes:grid.6572.6 schema:alternateName Institute of Metabolism and Systems Research, WHO Collaborating Centre for Women’s Health, University of Birmingham, Birmingham, UK
310 schema:name Institute of Metabolism and Systems Research, WHO Collaborating Centre for Women’s Health, University of Birmingham, Birmingham, UK
311 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...