Ratiometric afterglow luminescent nanoplatform enables reliable quantification and molecular imaging View Full Text


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Article Info

DATE

2022-04-25

AUTHORS

Yongchao Liu, Lili Teng, Yifan Lyu, Guosheng Song, Xiao-Bing Zhang, Weihong Tan

ABSTRACT

Afterglow luminescence is an internal luminescence pathway that occurs after photo-excitation, holds great promise for non-background molecular imaging in vivo, but suffer from poor quantitative ability owing to luminescent attenuation over time. Moreover, the inert structure and insufficient reactive sites of current afterglow materials make it hard to design activatable afterglow probes for specific detection. Here, we report a ratiometric afterglow luminescent nanoplatform to customize various activatable afterglow probes for reliable quantification and molecular imaging of specific analytes, such as NO, ONOO− or pH. Notably, these afterglow probes can not only address the attenuation of afterglow intensity and eliminate the interference of factors (e.g., laser power, irradiation time, and exposure time), but also significantly improve the imaging reliability in vivo and signal-to-background ratios (~1200-fold), both of which enable more reliable quantitative analysis in biological systems. Moreover, as a proof-of-concept, we successfully design an NO-responsive ratiometric afterglow nanoprobe, RAN1. This nanoprobe can monitor the fluctuations of intratumoral NO, as a biomarker of macrophage polarization, making it possible to real-time dynamically evaluate the degree cancer immunotherapy, which provides a reliable parameter to predict the immunotherapeutic effect. More... »

PAGES

2216

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    33 schema:description Afterglow luminescence is an internal luminescence pathway that occurs after photo-excitation, holds great promise for non-background molecular imaging in vivo, but suffer from poor quantitative ability owing to luminescent attenuation over time. Moreover, the inert structure and insufficient reactive sites of current afterglow materials make it hard to design activatable afterglow probes for specific detection. Here, we report a ratiometric afterglow luminescent nanoplatform to customize various activatable afterglow probes for reliable quantification and molecular imaging of specific analytes, such as NO, ONOO− or pH. Notably, these afterglow probes can not only address the attenuation of afterglow intensity and eliminate the interference of factors (e.g., laser power, irradiation time, and exposure time), but also significantly improve the imaging reliability in vivo and signal-to-background ratios (~1200-fold), both of which enable more reliable quantitative analysis in biological systems. Moreover, as a proof-of-concept, we successfully design an NO-responsive ratiometric afterglow nanoprobe, RAN1. This nanoprobe can monitor the fluctuations of intratumoral NO, as a biomarker of macrophage polarization, making it possible to real-time dynamically evaluate the degree cancer immunotherapy, which provides a reliable parameter to predict the immunotherapeutic effect.
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    42 afterglow intensity
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    48 background ratio
    49 biological systems
    50 biomarkers
    51 cancer immunotherapy
    52 concept
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    54 effect
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    56 fluctuations
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    58 imaging
    59 immunotherapeutic effects
    60 immunotherapy
    61 inert structure
    62 intensity
    63 interference
    64 interference of factors
    65 luminescence
    66 luminescence pathways
    67 macrophage polarization
    68 materials
    69 molecular imaging
    70 nanoplatform
    71 nanoprobe
    72 parameters
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    74 polarization
    75 probe
    76 promise
    77 proof
    78 quantification
    79 quantitative ability
    80 quantitative analysis
    81 ratio
    82 reactive sites
    83 reliability
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