Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-02-23

AUTHORS

Farshad Farshidfar, Kahn Rhrissorrakrai, Chaya Levovitz, Cong Peng, James Knight, Antonella Bacchiocchi, Juan Su, Mingzhu Yin, Mario Sznol, Stephan Ariyan, James Clune, Kelly Olino, Laxmi Parida, Joerg Nikolaus, Meiling Zhang, Shuang Zhao, Yan Wang, Gang Huang, Miaojian Wan, Xianan Li, Jian Cao, Qin Yan, Xiang Chen, Aaron M. Newman, Ruth Halaban

ABSTRACT

Acral melanoma, the most common melanoma subtype among non-White individuals, is associated with poor prognosis. However, its key molecular drivers remain obscure. Here, we perform integrative genomic and clinical profiling of acral melanomas from 104 patients treated in North America (n = 37) or China (n = 67). We find that recurrent, late-arising focal amplifications of cytoband 22q11.21 are a leading determinant of inferior survival, strongly associated with metastasis, and linked to downregulation of immunomodulatory genes associated with response to immune checkpoint blockade. Unexpectedly, LZTR1 – a known tumor suppressor in other cancers – is a key candidate oncogene in this cytoband. Silencing of LZTR1 in melanoma cell lines causes apoptotic cell death independent of major hotspot mutations or melanoma subtypes. Conversely, overexpression of LZTR1 in normal human melanocytes initiates processes associated with metastasis, including anchorage-independent growth, formation of spheroids, and an increase in MAPK and SRC activities. Our results provide insights into the etiology of acral melanoma and implicate LZTR1 as a key tumor promoter and therapeutic target. More... »

PAGES

898

References to SciGraph publications

  • 2000. Modeling Survival Data: Extending the Cox Model in NONE
  • 2018-10-27. Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1–PPP1CB complexes in HUMAN GENETICS
  • 2013-10-24. Genome engineering using the CRISPR-Cas9 system in NATURE PROTOCOLS
  • 2016-06-06. The Ensembl Variant Effect Predictor in GENOME BIOLOGY
  • 2020-01-08. Copy number gains of the putative CRKL oncogene in laryngeal squamous cell carcinoma result in strong nuclear expression of the protein and influence cell proliferation and migration in SCIENTIFIC REPORTS
  • 2012-07-29. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma in NATURE GENETICS
  • 2016-08-30. Racial differences in six major subtypes of melanoma: descriptive epidemiology in BMC CANCER
  • 2011-04-28. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers in GENOME BIOLOGY
  • 2013-08-05. The integrated landscape of driver genomic alterations in glioblastoma in NATURE GENETICS
  • 2008-01. Identification of cells initiating human melanomas in NATURE
  • 2016-08-17. Analysis of protein-coding genetic variation in 60,706 humans in NATURE
  • 2019-06-17. Phenotype plasticity as enabler of melanoma progression and therapy resistance in NATURE REVIEWS CANCER
  • 2013-05-15. Update on the Kelch-like (KLHL) gene family in HUMAN GENOMICS
  • 2020-10-16. Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity in NATURE COMMUNICATIONS
  • 2017-06-01. Single-cell entropy for accurate estimation of differentiation potency from a cell’s transcriptome in NATURE COMMUNICATIONS
  • 2017-03-06. Salmon provides fast and bias-aware quantification of transcript expression in NATURE METHODS
  • 2019-02-11. Metabolic signatures of cancer cells and stem cells in NATURE METABOLISM
  • 2018-10-06. The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers in NATURE REVIEWS CANCER
  • 1998-05-14. Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1 in ONCOGENE
  • 2012-04-29. Absolute quantification of somatic DNA alterations in human cancer in NATURE BIOTECHNOLOGY
  • 2008-08-24. Regulatory networks define phenotypic classes of human stem cell lines in NATURE
  • 2015-03-30. Robust enumeration of cell subsets from tissue expression profiles in NATURE METHODS
  • 2017-01-23. Single-cell mRNA quantification and differential analysis with Census in NATURE METHODS
  • 2015-03-09. HISAT: a fast spliced aligner with low memory requirements in NATURE METHODS
  • 2020-01-03. Cullin 3 and Its Role in Tumorigenesis in CULLIN-RING LIGASES AND PROTEIN NEDDYLATION
  • 2015-07-27. Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas in NATURE GENETICS
  • 2009-07-23. Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt in NATURE PROTOCOLS
  • 2017-05-12. Caspases and their substrates in CELL DEATH & DIFFERENTIATION
  • 1987-07. Normal murine melanocytes in culture in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY
  • 2017-05-03. Whole-genome landscapes of major melanoma subtypes in NATURE
  • 2016-06-28. Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo in BRITISH JOURNAL OF CANCER
  • 2020-08-26. Effects of extracellular matrix viscoelasticity on cellular behaviour in NATURE
  • 2016-08-22. Acral Melanoma in Chinese: A Clinicopathological and Prognostic Study of 142 cases in SCIENTIFIC REPORTS
  • 2009-12-07. Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer in ONCOGENE
  • 2007-01-29. Genomic profiling of malignant melanoma using tiling-resolution arrayCGH in ONCOGENE
  • 2013-06-16. Mutational heterogeneity in cancer and the search for new cancer-associated genes in NATURE
  • 2019-07-23. LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases in CELL DEATH & DIFFERENTIATION
  • 2019-05-06. Determining cell type abundance and expression from bulk tissues with digital cytometry in NATURE BIOTECHNOLOGY
  • 2017-07-17. A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress in SCIENTIFIC REPORTS
  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    13

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-022-28566-4

    DOI

    http://dx.doi.org/10.1038/s41467-022-28566-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1145780637

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35197475


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