Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations View Full Text


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Article Info

DATE

2021-08-11

AUTHORS

Martin Stražar, Godfrey S. Temba, Hera Vlamakis, Vesla I. Kullaya, Furaha Lyamuya, Blandina T. Mmbaga, Leo A. B. Joosten, Andre J. A. M. van der Ven, Mihai G. Netea, Quirijn de Mast, Ramnik J. Xavier

ABSTRACT

The human gut microbiota is increasingly recognized as an important factor in modulating innate and adaptive immunity through release of ligands and metabolites that translocate into circulation. Urbanizing African populations harbor large intestinal diversity due to a range of lifestyles, providing the necessary variation to gauge immunomodulatory factors. Here, we uncover a gradient of intestinal microbial compositions from rural through urban Tanzanian, towards European samples, manifested both in relative abundance and genomic variation observed in stool metagenomics. The rural population shows increased Bacteroidetes, led by Prevotella copri, but also presence of fungi. Measured ex vivo cytokine responses were significantly associated with 34 immunomodulatory microbes, which have a larger impact on circulating metabolites than non-significant microbes. Pathway effects on cytokines, notably TNF-α and IFN-γ, differential metabolome analysis and enzyme copy number enrichment converge on histidine and arginine metabolism as potential immunomodulatory pathways mediated by Bifidobacterium longum and Akkermansia muciniphila. More... »

PAGES

4845

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-021-25213-2

    DOI

    http://dx.doi.org/10.1038/s41467-021-25213-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1140346415

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34381036


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