IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-05-17

AUTHORS

Justin Harper, Nicolas Huot, Luca Micci, Gregory Tharp, Colin King, Philippe Rascle, Neeta Shenvi, Hong Wang, Cristin Galardi, Amit A. Upadhyay, Francois Villinger, Jeffrey Lifson, Guido Silvestri, Kirk Easley, Beatrice Jacquelin, Steven Bosinger, Michaela Müller-Trutwin, Mirko Paiardini

ABSTRACT

Unlike HIV infection, which progresses to AIDS absent suppressive anti-retroviral therapy, nonpathogenic infections in natural hosts, such African green monkeys, are characterized by a lack of gut microbial translocation and robust secondary lymphoid natural killer cell responses resulting in an absence of chronic inflammation and limited SIV dissemination in lymph node B-cell follicles. Here we report, using the pathogenic model of antiretroviral therapy-treated, SIV-infected rhesus macaques that sequential interleukin-21 and interferon alpha therapy generate terminally differentiated blood natural killer cells (NKG2a/clowCD16+) with potent human leukocyte antigen-E-restricted activity in response to SIV envelope peptides. This is in contrast to control macaques, where less differentiated, interferon gamma-producing natural killer cells predominate. The frequency and activity of terminally differentiated NKG2a/clowCD16+ natural killer cells correlates with a reduction of replication-competent SIV in lymph node during antiretroviral therapy and time to viral rebound following analytical treatment interruption. These data demonstrate that African green monkey-like natural killer cell differentiation profiles can be rescued in rhesus macaques to promote viral clearance in tissues. More... »

PAGES

2866

References to SciGraph publications

  • 2017-10-16. Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys in NATURE MEDICINE
  • 2008-01. Fcγ receptors as regulators of immune responses in NATURE REVIEWS IMMUNOLOGY
  • 2000-11. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function in NATURE
  • 2006-04-16. T cell– and B cell–independent adaptive immunity mediated by natural killer cells in NATURE IMMUNOLOGY
  • 2017-06-21. Addendum: Immune clearance of highly pathogenic SIV infection in NATURE
  • 2014-10-14. A new rhesus macaque assembly and annotation for next-generation sequencing analyses in BIOLOGY DIRECT
  • 1998-02. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C in NATURE
  • 2020-03-16. CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption in NATURE MEDICINE
  • 2015-07-20. Antigen-specific NK cell memory in rhesus macaques in NATURE IMMUNOLOGY
  • 1985-03. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids in IMMUNOGENETICS
  • 2017-06-06. IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours in NATURE COMMUNICATIONS
  • 2005-08. Licensing of natural killer cells by host major histocompatibility complex class I molecules in NATURE
  • 2021-02-24. SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity in NATURE COMMUNICATIONS
  • 2020-02-17. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells in NATURE IMMUNOLOGY
  • 2014-12-05. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2010-10-24. Critical role for CXCR6 in NK cell-mediated antigen-specific memory to haptens and viruses in NATURE IMMUNOLOGY
  • 2020-01-22. Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells in NATURE
  • 2009-11-09. Functional Analysis of Human NK Cells by Flow Cytometry in NATURAL KILLER CELL PROTOCOLS
  • 2015-01-19. A B cell follicle sanctuary permits persistent productive SIV infection in elite controllers in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-021-23189-7

    DOI

    http://dx.doi.org/10.1038/s41467-021-23189-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1138108396

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34001890


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Retroviral Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antiviral Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD4-Positive T-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon-gamma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Killer Cells, Natural", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphocyte Activation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Macaca mulatta", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Simian Acquired Immunodeficiency Syndrome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Simian Immunodeficiency Virus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Viral Load", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Viremia", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harper", 
            "givenName": "Justin", 
            "id": "sg:person.0675507233.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675507233.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur, Unit\u00e9 HIV, Inflammation et Persistance, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.428999.7", 
              "name": [
                "Institut Pasteur, Unit\u00e9 HIV, Inflammation et Persistance, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huot", 
            "givenName": "Nicolas", 
            "id": "sg:person.0666740273.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666740273.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Micci", 
            "givenName": "Luca", 
            "id": "sg:person.0751256324.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751256324.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nonhuman Primate Genomics Core, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Nonhuman Primate Genomics Core, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tharp", 
            "givenName": "Gregory", 
            "id": "sg:person.01011654251.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011654251.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "King", 
            "givenName": "Colin", 
            "id": "sg:person.016442265573.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016442265573.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.508487.6", 
              "name": [
                "Institut Pasteur, Unit\u00e9 HIV, Inflammation et Persistance, Paris, France", 
                "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rascle", 
            "givenName": "Philippe", 
            "id": "sg:person.014763503205.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014763503205.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shenvi", 
            "givenName": "Neeta", 
            "id": "sg:person.0726767165.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726767165.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Hong", 
            "id": "sg:person.01207367672.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207367672.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "HIV Discovery, ViiV Healthcare, Research Triangle Park, NC USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC USA", 
                "HIV Discovery, ViiV Healthcare, Research Triangle Park, NC USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Galardi", 
            "givenName": "Cristin", 
            "id": "sg:person.01113365165.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113365165.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nonhuman Primate Genomics Core, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Nonhuman Primate Genomics Core, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Upadhyay", 
            "givenName": "Amit A.", 
            "id": "sg:person.0662044551.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662044551.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology, New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA USA", 
              "id": "http://www.grid.ac/institutes/grid.266621.7", 
              "name": [
                "Department of Biology, New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Villinger", 
            "givenName": "Francois", 
            "id": "sg:person.01025200260.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025200260.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD USA", 
              "id": "http://www.grid.ac/institutes/grid.418021.e", 
              "name": [
                "AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lifson", 
            "givenName": "Jeffrey", 
            "id": "sg:person.011472222277.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011472222277.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA", 
                "Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Silvestri", 
            "givenName": "Guido", 
            "id": "sg:person.01351320203.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351320203.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Easley", 
            "givenName": "Kirk", 
            "id": "sg:person.0746040046.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746040046.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur, Unit\u00e9 HIV, Inflammation et Persistance, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.428999.7", 
              "name": [
                "Institut Pasteur, Unit\u00e9 HIV, Inflammation et Persistance, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jacquelin", 
            "givenName": "Beatrice", 
            "id": "sg:person.01063733063.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063733063.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA", 
                "Nonhuman Primate Genomics Core, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA", 
                "Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bosinger", 
            "givenName": "Steven", 
            "id": "sg:person.0655703651.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655703651.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur, Unit\u00e9 HIV, Inflammation et Persistance, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.428999.7", 
              "name": [
                "Institut Pasteur, Unit\u00e9 HIV, Inflammation et Persistance, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00fcller-Trutwin", 
            "givenName": "Michaela", 
            "id": "sg:person.0637117163.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637117163.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA", 
                "Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paiardini", 
            "givenName": "Mirko", 
            "id": "sg:person.0603442137.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603442137.42"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41586-020-1946-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1124223637", 
              "https://doi.org/10.1038/s41586-020-1946-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-021-21402-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1135663026", 
              "https://doi.org/10.1038/s41467-021-21402-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00375376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003287356", 
              "https://doi.org/10.1007/bf00375376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-60761-362-6_23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039378710", 
              "https://doi.org/10.1007/978-1-60761-362-6_23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41590-020-0593-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1124910767", 
              "https://doi.org/10.1038/s41590-020-0593-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086112423", 
              "https://doi.org/10.1038/nature22984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1745-6150-9-20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010087480", 
              "https://doi.org/10.1186/1745-6150-9-20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043990278", 
              "https://doi.org/10.1038/ni1332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092234623", 
              "https://doi.org/10.1038/nm.4421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms15776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085878858", 
              "https://doi.org/10.1038/ncomms15776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040169664", 
              "https://doi.org/10.1038/nm.3781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35040504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027439653", 
              "https://doi.org/10.1038/35040504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-020-0782-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1125678159", 
              "https://doi.org/10.1038/s41591-020-0782-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026463684", 
              "https://doi.org/10.1038/35869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.3227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031940708", 
              "https://doi.org/10.1038/ni.3227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029654969", 
              "https://doi.org/10.1038/nature03847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1953", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023711204", 
              "https://doi.org/10.1038/ni.1953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005072972", 
              "https://doi.org/10.1038/nri2206"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-05-17", 
        "datePublishedReg": "2021-05-17", 
        "description": "Unlike HIV infection, which progresses to AIDS absent suppressive anti-retroviral therapy, nonpathogenic infections in natural hosts, such African green monkeys, are characterized by a lack of gut microbial translocation and robust secondary lymphoid natural killer cell responses resulting in an absence of chronic inflammation and limited SIV dissemination in lymph node B-cell\u00a0follicles. Here we report, using the pathogenic model of antiretroviral therapy-treated, SIV-infected rhesus macaques that sequential interleukin-21 and interferon alpha therapy generate terminally\u00a0differentiated blood natural killer cells (NKG2a/clowCD16+) with potent human leukocyte antigen-E-restricted activity in response to SIV envelope peptides. This is in contrast to control macaques, where less differentiated, interferon gamma-producing natural killer cells predominate. The frequency and activity of terminally\u00a0differentiated NKG2a/clowCD16+ natural killer cells correlates with a reduction of replication-competent SIV in lymph node during antiretroviral therapy and time to viral rebound following analytical treatment interruption. These data demonstrate that African green monkey-like natural killer cell differentiation profiles can be rescued in rhesus macaques to promote viral clearance in tissues.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41467-021-23189-7", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2343593", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3867512", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7908901", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2622155", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2441129", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "keywords": [
          "natural killer cells", 
          "killer cells", 
          "African green monkeys", 
          "suppressive anti-retroviral therapy", 
          "blood natural killer cells", 
          "natural killer cell responses", 
          "rhesus macaques", 
          "green monkeys", 
          "gut microbial translocation", 
          "NKG2A/C", 
          "replication-competent SIV", 
          "analytical treatment interruption", 
          "anti-retroviral therapy", 
          "killer cell responses", 
          "human leukocyte antigen", 
          "SIV reservoirs", 
          "microbial translocation", 
          "viral rebound", 
          "antiretroviral therapy", 
          "treatment interruption", 
          "HIV infection", 
          "IL-21", 
          "NK cells", 
          "lymph nodes", 
          "viral clearance", 
          "chronic inflammation", 
          "interleukin-21", 
          "leukocyte antigen", 
          "nonpathogenic infection", 
          "envelope peptides", 
          "cell responses", 
          "pathogenic model", 
          "cell differentiation profiles", 
          "macaques", 
          "therapy", 
          "infection", 
          "SIV", 
          "differentiation profile", 
          "natural host", 
          "monkeys", 
          "cells", 
          "CD16", 
          "lymph", 
          "inflammation", 
          "antigen", 
          "follicles", 
          "response", 
          "clearance", 
          "activity", 
          "tissue", 
          "peptides", 
          "dissemination", 
          "rebound", 
          "interruption", 
          "translocation", 
          "rescue", 
          "absence", 
          "contrast", 
          "lack", 
          "reduction", 
          "profile", 
          "host", 
          "sup", 
          "frequency", 
          "data", 
          "time", 
          "nodes", 
          "model", 
          "reservoir", 
          "generate", 
          "AIDS absent suppressive anti-retroviral therapy", 
          "absent suppressive anti-retroviral therapy", 
          "such African green monkeys", 
          "robust secondary lymphoid natural killer cell responses", 
          "secondary lymphoid natural killer cell responses", 
          "lymphoid natural killer cell responses", 
          "limited SIV dissemination", 
          "SIV dissemination", 
          "sequential interleukin-21", 
          "interferon alpha therapy generate", 
          "alpha therapy generate", 
          "therapy generate", 
          "potent human leukocyte antigen", 
          "gamma-producing natural killer cells", 
          "natural killer cell differentiation profiles", 
          "killer cell differentiation profiles", 
          "IFN\u03b1 therapy rescues", 
          "therapy rescues", 
          "limits SIV reservoir", 
          "ART-treated macaques"
        ], 
        "name": "IL-21 and IFN\u03b1 therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques", 
        "pagination": "2866", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1138108396"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-021-23189-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34001890"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-021-23189-7", 
          "https://app.dimensions.ai/details/publication/pub.1138108396"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T19:02", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_891.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41467-021-23189-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-021-23189-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-021-23189-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-021-23189-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-021-23189-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    435 TRIPLES      22 PREDICATES      149 URIs      122 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-021-23189-7 schema:about N12f65febfb3e4b69904ee024c6ea577f
    2 N1dfb9be8a85043dab386f0fa2d42daf8
    3 N2b9fa6a9e873435887cd2b4937b7e55e
    4 N389946c05ab840ecb0172bd2703a20df
    5 N396e816dcc1c4dc7bf144fd9ecebbc8f
    6 N610485f7f26d42f0bea051ef50a6d7a9
    7 N8790720ce78f491896fd6bf4c6c3bd58
    8 N897c41c6047346fe872cfb682ea796e9
    9 N984450c57159435ea08baa4b1cf76c0e
    10 Nb3c6dc517ac74c9780fd4ca7da628582
    11 Nb82c247ed01d4be48ace68c16575528c
    12 Nbb24871741b44bccade586ee83bf1012
    13 Ncdd3c6790e5747eda174fe2f7dd0a19f
    14 Need03b1593f249fab0f681f530eb4768
    15 anzsrc-for:11
    16 anzsrc-for:1107
    17 schema:author Nbd088d6fcb5f435890cbe0b39ab82e92
    18 schema:citation sg:pub.10.1007/978-1-60761-362-6_23
    19 sg:pub.10.1007/bf00375376
    20 sg:pub.10.1038/35040504
    21 sg:pub.10.1038/35869
    22 sg:pub.10.1038/nature03847
    23 sg:pub.10.1038/nature22984
    24 sg:pub.10.1038/ncomms15776
    25 sg:pub.10.1038/ni.1953
    26 sg:pub.10.1038/ni.3227
    27 sg:pub.10.1038/ni1332
    28 sg:pub.10.1038/nm.3781
    29 sg:pub.10.1038/nm.4421
    30 sg:pub.10.1038/nri2206
    31 sg:pub.10.1038/s41467-021-21402-1
    32 sg:pub.10.1038/s41586-020-1946-0
    33 sg:pub.10.1038/s41590-020-0593-9
    34 sg:pub.10.1038/s41591-020-0782-y
    35 sg:pub.10.1186/1745-6150-9-20
    36 sg:pub.10.1186/s13059-014-0550-8
    37 schema:datePublished 2021-05-17
    38 schema:datePublishedReg 2021-05-17
    39 schema:description Unlike HIV infection, which progresses to AIDS absent suppressive anti-retroviral therapy, nonpathogenic infections in natural hosts, such African green monkeys, are characterized by a lack of gut microbial translocation and robust secondary lymphoid natural killer cell responses resulting in an absence of chronic inflammation and limited SIV dissemination in lymph node B-cell follicles. Here we report, using the pathogenic model of antiretroviral therapy-treated, SIV-infected rhesus macaques that sequential interleukin-21 and interferon alpha therapy generate terminally differentiated blood natural killer cells (NKG2a/c<sup>low</sup>CD16<sup>+</sup>) with potent human leukocyte antigen-E-restricted activity in response to SIV envelope peptides. This is in contrast to control macaques, where less differentiated, interferon gamma-producing natural killer cells predominate. The frequency and activity of terminally differentiated NKG2a/c<sup>low</sup>CD16<sup>+</sup> natural killer cells correlates with a reduction of replication-competent SIV in lymph node during antiretroviral therapy and time to viral rebound following analytical treatment interruption. These data demonstrate that African green monkey-like natural killer cell differentiation profiles can be rescued in rhesus macaques to promote viral clearance in tissues.
    40 schema:genre article
    41 schema:inLanguage en
    42 schema:isAccessibleForFree true
    43 schema:isPartOf N1a6f10b3dbb54b51bee271d9d2ce713d
    44 N96b034d6796b455ead64cb9440024712
    45 sg:journal.1043282
    46 schema:keywords AIDS absent suppressive anti-retroviral therapy
    47 ART-treated macaques
    48 African green monkeys
    49 CD16
    50 HIV infection
    51 IFNα therapy rescues
    52 IL-21
    53 NK cells
    54 NKG2A/C
    55 SIV
    56 SIV dissemination
    57 SIV reservoirs
    58 absence
    59 absent suppressive anti-retroviral therapy
    60 activity
    61 alpha therapy generate
    62 analytical treatment interruption
    63 anti-retroviral therapy
    64 antigen
    65 antiretroviral therapy
    66 blood natural killer cells
    67 cell differentiation profiles
    68 cell responses
    69 cells
    70 chronic inflammation
    71 clearance
    72 contrast
    73 data
    74 differentiation profile
    75 dissemination
    76 envelope peptides
    77 follicles
    78 frequency
    79 gamma-producing natural killer cells
    80 generate
    81 green monkeys
    82 gut microbial translocation
    83 host
    84 human leukocyte antigen
    85 infection
    86 inflammation
    87 interferon alpha therapy generate
    88 interleukin-21
    89 interruption
    90 killer cell differentiation profiles
    91 killer cell responses
    92 killer cells
    93 lack
    94 leukocyte antigen
    95 limited SIV dissemination
    96 limits SIV reservoir
    97 lymph
    98 lymph nodes
    99 lymphoid natural killer cell responses
    100 macaques
    101 microbial translocation
    102 model
    103 monkeys
    104 natural host
    105 natural killer cell differentiation profiles
    106 natural killer cell responses
    107 natural killer cells
    108 nodes
    109 nonpathogenic infection
    110 pathogenic model
    111 peptides
    112 potent human leukocyte antigen
    113 profile
    114 rebound
    115 reduction
    116 replication-competent SIV
    117 rescue
    118 reservoir
    119 response
    120 rhesus macaques
    121 robust secondary lymphoid natural killer cell responses
    122 secondary lymphoid natural killer cell responses
    123 sequential interleukin-21
    124 such African green monkeys
    125 sup
    126 suppressive anti-retroviral therapy
    127 therapy
    128 therapy generate
    129 therapy rescues
    130 time
    131 tissue
    132 translocation
    133 treatment interruption
    134 viral clearance
    135 viral rebound
    136 schema:name IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques
    137 schema:pagination 2866
    138 schema:productId N20ca8f6db09f49bcba37d811b049b065
    139 N686f3e67556c427b92a8cc0d4d9eb0a6
    140 Nfe22bc321e44484e984f8a8e8a8947e5
    141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1138108396
    142 https://doi.org/10.1038/s41467-021-23189-7
    143 schema:sdDatePublished 2022-01-01T19:02
    144 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    145 schema:sdPublisher N9fe6693a3e5f4b14b51d30b7cd19e227
    146 schema:url https://doi.org/10.1038/s41467-021-23189-7
    147 sgo:license sg:explorer/license/
    148 sgo:sdDataset articles
    149 rdf:type schema:ScholarlyArticle
    150 N12f65febfb3e4b69904ee024c6ea577f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Simian Acquired Immunodeficiency Syndrome
    152 rdf:type schema:DefinedTerm
    153 N1a6f10b3dbb54b51bee271d9d2ce713d schema:volumeNumber 12
    154 rdf:type schema:PublicationVolume
    155 N1dfb9be8a85043dab386f0fa2d42daf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Viremia
    157 rdf:type schema:DefinedTerm
    158 N20ca8f6db09f49bcba37d811b049b065 schema:name dimensions_id
    159 schema:value pub.1138108396
    160 rdf:type schema:PropertyValue
    161 N23a4a60aaf3e421c8dda1b775dde1254 rdf:first sg:person.0726767165.63
    162 rdf:rest N8b0f26bd717949198cb51199a91250b7
    163 N2b9fa6a9e873435887cd2b4937b7e55e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Lymphocyte Activation
    165 rdf:type schema:DefinedTerm
    166 N324cc13a7ec64c86b37877512e88519c rdf:first sg:person.0637117163.23
    167 rdf:rest N3e1ae197ee9c423fb445736e22aea027
    168 N389946c05ab840ecb0172bd2703a20df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Simian Immunodeficiency Virus
    170 rdf:type schema:DefinedTerm
    171 N396e816dcc1c4dc7bf144fd9ecebbc8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Killer Cells, Natural
    173 rdf:type schema:DefinedTerm
    174 N3e1ae197ee9c423fb445736e22aea027 rdf:first sg:person.0603442137.42
    175 rdf:rest rdf:nil
    176 N4aef2dfce296417ca1541d38a624c175 rdf:first sg:person.011472222277.74
    177 rdf:rest N7cd54e8deb224e18945f6e6717678972
    178 N5fbf1997a7c745fabfdfb734cbcc2309 rdf:first sg:person.01025200260.11
    179 rdf:rest N4aef2dfce296417ca1541d38a624c175
    180 N610485f7f26d42f0bea051ef50a6d7a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Interleukins
    182 rdf:type schema:DefinedTerm
    183 N622b68972cae47eaba20659a84925c45 rdf:first sg:person.0655703651.37
    184 rdf:rest N324cc13a7ec64c86b37877512e88519c
    185 N686f3e67556c427b92a8cc0d4d9eb0a6 schema:name pubmed_id
    186 schema:value 34001890
    187 rdf:type schema:PropertyValue
    188 N6ff7e093641841b49dda2029988b1ac2 rdf:first sg:person.01063733063.03
    189 rdf:rest N622b68972cae47eaba20659a84925c45
    190 N7cd54e8deb224e18945f6e6717678972 rdf:first sg:person.01351320203.19
    191 rdf:rest N8bc833c188664cdfbd6a69a5afe31fc5
    192 N7fd31cb1ec50414abbda6c8a4e54b172 rdf:first sg:person.0662044551.10
    193 rdf:rest N5fbf1997a7c745fabfdfb734cbcc2309
    194 N8790720ce78f491896fd6bf4c6c3bd58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Viral Load
    196 rdf:type schema:DefinedTerm
    197 N897c41c6047346fe872cfb682ea796e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Animals
    199 rdf:type schema:DefinedTerm
    200 N8b0f26bd717949198cb51199a91250b7 rdf:first sg:person.01207367672.58
    201 rdf:rest Nc903ae81f0d64aa187c33202d00f8941
    202 N8b2a659ee04d4236b65a8973e6eda722 rdf:first sg:person.016442265573.15
    203 rdf:rest Nf847fa7005b1410899baf70716b3b9d8
    204 N8bc833c188664cdfbd6a69a5afe31fc5 rdf:first sg:person.0746040046.41
    205 rdf:rest N6ff7e093641841b49dda2029988b1ac2
    206 N96b034d6796b455ead64cb9440024712 schema:issueNumber 1
    207 rdf:type schema:PublicationIssue
    208 N984450c57159435ea08baa4b1cf76c0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Female
    210 rdf:type schema:DefinedTerm
    211 N9fe6693a3e5f4b14b51d30b7cd19e227 schema:name Springer Nature - SN SciGraph project
    212 rdf:type schema:Organization
    213 Nb3c6dc517ac74c9780fd4ca7da628582 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Anti-Retroviral Agents
    215 rdf:type schema:DefinedTerm
    216 Nb5169e383f304a3c96319722c45aeaae rdf:first sg:person.01011654251.52
    217 rdf:rest N8b2a659ee04d4236b65a8973e6eda722
    218 Nb82c247ed01d4be48ace68c16575528c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Interferon-gamma
    220 rdf:type schema:DefinedTerm
    221 Nbb24871741b44bccade586ee83bf1012 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Macaca mulatta
    223 rdf:type schema:DefinedTerm
    224 Nbd088d6fcb5f435890cbe0b39ab82e92 rdf:first sg:person.0675507233.38
    225 rdf:rest Nc547c1edc1ff4436b7863bc7e087cc18
    226 Nc547c1edc1ff4436b7863bc7e087cc18 rdf:first sg:person.0666740273.39
    227 rdf:rest Nf9f841adac0b42da87b06627d389c9cd
    228 Nc903ae81f0d64aa187c33202d00f8941 rdf:first sg:person.01113365165.50
    229 rdf:rest N7fd31cb1ec50414abbda6c8a4e54b172
    230 Ncdd3c6790e5747eda174fe2f7dd0a19f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Antiviral Agents
    232 rdf:type schema:DefinedTerm
    233 Need03b1593f249fab0f681f530eb4768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name CD4-Positive T-Lymphocytes
    235 rdf:type schema:DefinedTerm
    236 Nf847fa7005b1410899baf70716b3b9d8 rdf:first sg:person.014763503205.80
    237 rdf:rest N23a4a60aaf3e421c8dda1b775dde1254
    238 Nf9f841adac0b42da87b06627d389c9cd rdf:first sg:person.0751256324.13
    239 rdf:rest Nb5169e383f304a3c96319722c45aeaae
    240 Nfe22bc321e44484e984f8a8e8a8947e5 schema:name doi
    241 schema:value 10.1038/s41467-021-23189-7
    242 rdf:type schema:PropertyValue
    243 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    244 schema:name Medical and Health Sciences
    245 rdf:type schema:DefinedTerm
    246 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    247 schema:name Immunology
    248 rdf:type schema:DefinedTerm
    249 sg:grant.2343593 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-021-23189-7
    250 rdf:type schema:MonetaryGrant
    251 sg:grant.2441129 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-021-23189-7
    252 rdf:type schema:MonetaryGrant
    253 sg:grant.2622155 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-021-23189-7
    254 rdf:type schema:MonetaryGrant
    255 sg:grant.3867512 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-021-23189-7
    256 rdf:type schema:MonetaryGrant
    257 sg:grant.7908901 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-021-23189-7
    258 rdf:type schema:MonetaryGrant
    259 sg:journal.1043282 schema:issn 2041-1723
    260 schema:name Nature Communications
    261 schema:publisher Springer Nature
    262 rdf:type schema:Periodical
    263 sg:person.01011654251.52 schema:affiliation grid-institutes:grid.189967.8
    264 schema:familyName Tharp
    265 schema:givenName Gregory
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011654251.52
    267 rdf:type schema:Person
    268 sg:person.01025200260.11 schema:affiliation grid-institutes:grid.266621.7
    269 schema:familyName Villinger
    270 schema:givenName Francois
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025200260.11
    272 rdf:type schema:Person
    273 sg:person.01063733063.03 schema:affiliation grid-institutes:grid.428999.7
    274 schema:familyName Jacquelin
    275 schema:givenName Beatrice
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063733063.03
    277 rdf:type schema:Person
    278 sg:person.01113365165.50 schema:affiliation grid-institutes:None
    279 schema:familyName Galardi
    280 schema:givenName Cristin
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113365165.50
    282 rdf:type schema:Person
    283 sg:person.011472222277.74 schema:affiliation grid-institutes:grid.418021.e
    284 schema:familyName Lifson
    285 schema:givenName Jeffrey
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011472222277.74
    287 rdf:type schema:Person
    288 sg:person.01207367672.58 schema:affiliation grid-institutes:grid.189967.8
    289 schema:familyName Wang
    290 schema:givenName Hong
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207367672.58
    292 rdf:type schema:Person
    293 sg:person.01351320203.19 schema:affiliation grid-institutes:grid.189967.8
    294 schema:familyName Silvestri
    295 schema:givenName Guido
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351320203.19
    297 rdf:type schema:Person
    298 sg:person.014763503205.80 schema:affiliation grid-institutes:grid.508487.6
    299 schema:familyName Rascle
    300 schema:givenName Philippe
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014763503205.80
    302 rdf:type schema:Person
    303 sg:person.016442265573.15 schema:affiliation grid-institutes:grid.189967.8
    304 schema:familyName King
    305 schema:givenName Colin
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016442265573.15
    307 rdf:type schema:Person
    308 sg:person.0603442137.42 schema:affiliation grid-institutes:grid.189967.8
    309 schema:familyName Paiardini
    310 schema:givenName Mirko
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603442137.42
    312 rdf:type schema:Person
    313 sg:person.0637117163.23 schema:affiliation grid-institutes:grid.428999.7
    314 schema:familyName Müller-Trutwin
    315 schema:givenName Michaela
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637117163.23
    317 rdf:type schema:Person
    318 sg:person.0655703651.37 schema:affiliation grid-institutes:grid.189967.8
    319 schema:familyName Bosinger
    320 schema:givenName Steven
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655703651.37
    322 rdf:type schema:Person
    323 sg:person.0662044551.10 schema:affiliation grid-institutes:grid.189967.8
    324 schema:familyName Upadhyay
    325 schema:givenName Amit A.
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662044551.10
    327 rdf:type schema:Person
    328 sg:person.0666740273.39 schema:affiliation grid-institutes:grid.428999.7
    329 schema:familyName Huot
    330 schema:givenName Nicolas
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666740273.39
    332 rdf:type schema:Person
    333 sg:person.0675507233.38 schema:affiliation grid-institutes:grid.189967.8
    334 schema:familyName Harper
    335 schema:givenName Justin
    336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675507233.38
    337 rdf:type schema:Person
    338 sg:person.0726767165.63 schema:affiliation grid-institutes:grid.189967.8
    339 schema:familyName Shenvi
    340 schema:givenName Neeta
    341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726767165.63
    342 rdf:type schema:Person
    343 sg:person.0746040046.41 schema:affiliation grid-institutes:grid.189967.8
    344 schema:familyName Easley
    345 schema:givenName Kirk
    346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746040046.41
    347 rdf:type schema:Person
    348 sg:person.0751256324.13 schema:affiliation grid-institutes:grid.189967.8
    349 schema:familyName Micci
    350 schema:givenName Luca
    351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751256324.13
    352 rdf:type schema:Person
    353 sg:pub.10.1007/978-1-60761-362-6_23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039378710
    354 https://doi.org/10.1007/978-1-60761-362-6_23
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1007/bf00375376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003287356
    357 https://doi.org/10.1007/bf00375376
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/35040504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027439653
    360 https://doi.org/10.1038/35040504
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/35869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026463684
    363 https://doi.org/10.1038/35869
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nature03847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029654969
    366 https://doi.org/10.1038/nature03847
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/nature22984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086112423
    369 https://doi.org/10.1038/nature22984
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/ncomms15776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085878858
    372 https://doi.org/10.1038/ncomms15776
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/ni.1953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023711204
    375 https://doi.org/10.1038/ni.1953
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/ni.3227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031940708
    378 https://doi.org/10.1038/ni.3227
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/ni1332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043990278
    381 https://doi.org/10.1038/ni1332
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/nm.3781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040169664
    384 https://doi.org/10.1038/nm.3781
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/nm.4421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092234623
    387 https://doi.org/10.1038/nm.4421
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/nri2206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005072972
    390 https://doi.org/10.1038/nri2206
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/s41467-021-21402-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1135663026
    393 https://doi.org/10.1038/s41467-021-21402-1
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/s41586-020-1946-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124223637
    396 https://doi.org/10.1038/s41586-020-1946-0
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/s41590-020-0593-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124910767
    399 https://doi.org/10.1038/s41590-020-0593-9
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/s41591-020-0782-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1125678159
    402 https://doi.org/10.1038/s41591-020-0782-y
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1186/1745-6150-9-20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010087480
    405 https://doi.org/10.1186/1745-6150-9-20
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
    408 https://doi.org/10.1186/s13059-014-0550-8
    409 rdf:type schema:CreativeWork
    410 grid-institutes:None schema:alternateName HIV Discovery, ViiV Healthcare, Research Triangle Park, NC USA
    411 schema:name HIV Discovery, ViiV Healthcare, Research Triangle Park, NC USA
    412 UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC USA
    413 rdf:type schema:Organization
    414 grid-institutes:grid.189967.8 schema:alternateName Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA USA
    415 Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA USA
    416 Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA
    417 Nonhuman Primate Genomics Core, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA
    418 schema:name Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA USA
    419 Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA USA
    420 Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA
    421 Nonhuman Primate Genomics Core, Yerkes National Primate Research Center, Emory University, Atlanta, GA USA
    422 rdf:type schema:Organization
    423 grid-institutes:grid.266621.7 schema:alternateName Department of Biology, New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA USA
    424 schema:name Department of Biology, New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA USA
    425 rdf:type schema:Organization
    426 grid-institutes:grid.418021.e schema:alternateName AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD USA
    427 schema:name AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD USA
    428 rdf:type schema:Organization
    429 grid-institutes:grid.428999.7 schema:alternateName Institut Pasteur, Unité HIV, Inflammation et Persistance, Paris, France
    430 schema:name Institut Pasteur, Unité HIV, Inflammation et Persistance, Paris, France
    431 rdf:type schema:Organization
    432 grid-institutes:grid.508487.6 schema:alternateName Université Paris Diderot, Sorbonne Paris Cité, Paris, France
    433 schema:name Institut Pasteur, Unité HIV, Inflammation et Persistance, Paris, France
    434 Université Paris Diderot, Sorbonne Paris Cité, Paris, France
    435 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...