SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity View Full Text


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Article Info

DATE

2021-02-24

AUTHORS

Nicolas Huot, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stürzel, Eduard Baquero, Justin L. Harper, Caroline Passaes, Rachel Legendre, Hugo Varet, Yoann Madec, Ulrike Sauermann, Christiane Stahl-Hennig, Jacob Nattermann, Asier Saez-Cirion, Roger Le Grand, R. Keith Reeves, Mirko Paiardini, Frank Kirchhoff, Beatrice Jacquelin, Michaela Müller-Trutwin

ABSTRACT

Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues. We demonstrate that SIVagm infection induces the expansion of terminally differentiated NKG2alow NK cells in secondary lymphoid organs displaying an adaptive transcriptional profile and increased MHC-E-restricted cytotoxicity in response to SIV Env peptides while expressing little IFN-γ. Such NK cell differentiation was lacking in SIVmac-infected macaques. Adaptive NK cells displayed no increased NKG2C expression. This study reveals a previously unknown profile of NK cell adaptation to a viral infection, thus accelerating strategies toward NK-cell directed therapies and viral control in tissues. More... »

PAGES

1282

References to SciGraph publications

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  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    12

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-021-21402-1

    DOI

    http://dx.doi.org/10.1038/s41467-021-21402-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1135663026

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33627642


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