A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-12-04

AUTHORS

Arturo Hernández-Cervantes, Sadri Znaidi, Lasse van Wijlick, Iryna Denega, Virginia Basso, Jeanne Ropars, Natacha Sertour, Derek Sullivan, Gary Moran, Louise Basmaciyan, Fabienne Bon, Frédéric Dalle, Marie-Elisabeth Bougnoux, Teun Boekhout, Ying Yang, Zongwei Li, Sophie Bachellier-Bassi, Christophe d’Enfert

ABSTRACT

Transcription factor Rme1 is conserved among ascomycetes and regulates meiosis and pseudohyphal growth in Saccharomyces cerevisiae. The genome of the meiosis-defective pathogen Candida albicans encodes an Rme1 homolog that is part of a transcriptional circuitry controlling hyphal growth. Here, we use chromatin immunoprecipitation and genome-wide expression analyses to study a possible role of Rme1 in C. albicans morphogenesis. We find that Rme1 binds upstream and activates the expression of genes that are upregulated during chlamydosporulation, an asexual process leading to formation of large, spherical, thick-walled cells during nutrient starvation. RME1 deletion abolishes chlamydosporulation in three Candida species, whereas its overexpression bypasses the requirement for chlamydosporulation cues and regulators. RME1 expression levels correlate with chlamydosporulation efficiency across clinical isolates. Interestingly, RME1 displays a biphasic pattern of expression, with a first phase independent of Rme1 function and dependent on chlamydospore-inducing cues, and a second phase dependent on Rme1 function and independent of chlamydospore-inducing cues. Our results indicate that Rme1 plays a central role in chlamydospore development in Candida species. More... »

PAGES

6224

Journal

TITLE

Nature Communications

ISSUE

1

VOLUME

11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-020-20010-9

DOI

http://dx.doi.org/10.1038/s41467-020-20010-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1133092857

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33277479


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Candida albicans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Candidemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fungal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spores, Fungal", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 de Paris / Inserm, 1 Avenue Claude Vellefaux, F-75010, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France", 
            "Universit\u00e9 de Paris / Inserm, 1 Avenue Claude Vellefaux, F-75010, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hern\u00e1ndez-Cervantes", 
        "givenName": "Arturo", 
        "id": "sg:person.01013553233.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013553233.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tunis-El Manar, 1036, Tunis, Tunisia", 
          "id": "http://www.grid.ac/institutes/grid.12574.35", 
          "name": [
            "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France", 
            "Institut Pasteur de Tunis, Laboratoire de Microbiologie Mol\u00e9culaire, Vaccinologie et D\u00e9veloppement Biotechnologique, B\u00e2timent Etienne Burnet, 13 Place Pasteur, B.P.74, 1002, Tunis-Belv\u00e9d\u00e8re, Tunisia", 
            "University of Tunis-El Manar, 1036, Tunis, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Znaidi", 
        "givenName": "Sadri", 
        "id": "sg:person.01136761734.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136761734.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Wijlick", 
        "givenName": "Lasse", 
        "id": "sg:person.01027022216.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027022216.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 de Paris, Sorbonne Paris Cit\u00e9, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France", 
            "Universit\u00e9 de Paris, Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Denega", 
        "givenName": "Iryna", 
        "id": "sg:person.012556162524.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012556162524.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Laboratory Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France", 
            "Universit\u00e9 de Paris, Sorbonne Paris Cit\u00e9, Paris, France", 
            "Department of Pathology and Laboratory Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Basso", 
        "givenName": "Virginia", 
        "id": "sg:person.012364000137.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012364000137.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Paris-Saclay, CNRS, AgroParisTech, \u00c9cologie, Syst\u00e9matique, \u00c9volution, F-91405, Orsay, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France", 
            "Universit\u00e9 Paris-Saclay, CNRS, AgroParisTech, \u00c9cologie, Syst\u00e9matique, \u00c9volution, F-91405, Orsay, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ropars", 
        "givenName": "Jeanne", 
        "id": "sg:person.01367471406.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367471406.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sertour", 
        "givenName": "Natacha", 
        "id": "sg:person.01042247474.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042247474.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dublin Dental University Hospital and School of Dental Science, Trinity College Dublin, 2, Dublin, Ireland", 
          "id": "http://www.grid.ac/institutes/grid.8217.c", 
          "name": [
            "Dublin Dental University Hospital and School of Dental Science, Trinity College Dublin, 2, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sullivan", 
        "givenName": "Derek", 
        "id": "sg:person.01252276150.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252276150.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dublin Dental University Hospital and School of Dental Science, Trinity College Dublin, 2, Dublin, Ireland", 
          "id": "http://www.grid.ac/institutes/grid.8217.c", 
          "name": [
            "Dublin Dental University Hospital and School of Dental Science, Trinity College Dublin, 2, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moran", 
        "givenName": "Gary", 
        "id": "sg:person.0760000606.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760000606.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire Fran\u00e7ois Mitterand, Service de Parasitologie Mycologie, Dijon, France", 
          "id": "http://www.grid.ac/institutes/grid.31151.37", 
          "name": [
            "UMR PAM, Universit\u00e9 de Bourgogne Franche-Comt\u00e9, AgroSup Dijon \u2013 Equipe VAIMiS, Dijon, France", 
            "Centre Hospitalier Universitaire Fran\u00e7ois Mitterand, Service de Parasitologie Mycologie, Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Basmaciyan", 
        "givenName": "Louise", 
        "id": "sg:person.01224423415.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224423415.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UMR PAM, Universit\u00e9 de Bourgogne Franche-Comt\u00e9, AgroSup Dijon \u2013 Equipe VAIMiS, Dijon, France", 
          "id": "http://www.grid.ac/institutes/grid.5613.1", 
          "name": [
            "UMR PAM, Universit\u00e9 de Bourgogne Franche-Comt\u00e9, AgroSup Dijon \u2013 Equipe VAIMiS, Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bon", 
        "givenName": "Fabienne", 
        "id": "sg:person.01371577661.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371577661.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire Fran\u00e7ois Mitterand, Service de Parasitologie Mycologie, Dijon, France", 
          "id": "http://www.grid.ac/institutes/grid.31151.37", 
          "name": [
            "UMR PAM, Universit\u00e9 de Bourgogne Franche-Comt\u00e9, AgroSup Dijon \u2013 Equipe VAIMiS, Dijon, France", 
            "Centre Hospitalier Universitaire Fran\u00e7ois Mitterand, Service de Parasitologie Mycologie, Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dalle", 
        "givenName": "Fr\u00e9d\u00e9ric", 
        "id": "sg:person.01325662006.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325662006.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie clinique, H\u00f4pital Necker-Enfants-Malades, Assistance Publique des H\u00f4pitaux de Paris (APHP), Universit\u00e9 de Paris, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.412134.1", 
          "name": [
            "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France", 
            "Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie clinique, H\u00f4pital Necker-Enfants-Malades, Assistance Publique des H\u00f4pitaux de Paris (APHP), Universit\u00e9 de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bougnoux", 
        "givenName": "Marie-Elisabeth", 
        "id": "sg:person.01173731273.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173731273.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands", 
            "Institute of Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boekhout", 
        "givenName": "Teun", 
        "id": "sg:person.01145115305.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145115305.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beijing Institute of Radiation Medicine, 100850, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.506261.6", 
          "name": [
            "Beijing Institute of Radiation Medicine, 100850, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Ying", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Hospital Infection Control, Institute for Disease Control & Prevention, 100071, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Center for Hospital Infection Control, Institute for Disease Control & Prevention, 100071, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Zongwei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bachellier-Bassi", 
        "givenName": "Sophie", 
        "id": "sg:person.0744545351.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744545351.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "d\u2019Enfert", 
        "givenName": "Christophe", 
        "id": "sg:person.0760564474.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760564474.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrmicro.2016.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045459868", 
          "https://doi.org/10.1038/nrmicro.2016.157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051483764", 
          "https://doi.org/10.1038/nbt.1505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00294-002-0349-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032828190", 
          "https://doi.org/10.1007/s00294-002-0349-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028200562", 
          "https://doi.org/10.1038/nature09560"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-12-04", 
    "datePublishedReg": "2020-12-04", 
    "description": "Transcription factor Rme1 is conserved among ascomycetes and regulates meiosis and pseudohyphal growth in Saccharomyces cerevisiae. The genome of the meiosis-defective pathogen Candida albicans encodes an Rme1 homolog that is part of a transcriptional circuitry controlling hyphal growth. Here, we use chromatin immunoprecipitation and genome-wide expression analyses to study a possible role of Rme1 in C. albicans morphogenesis. We find that Rme1 binds upstream and activates the expression of genes that are upregulated during chlamydosporulation, an asexual process leading to formation of large, spherical, thick-walled cells during nutrient starvation. RME1 deletion abolishes chlamydosporulation in three Candida species, whereas its overexpression bypasses the requirement for chlamydosporulation cues and regulators. RME1 expression levels correlate with chlamydosporulation efficiency across clinical isolates. Interestingly, RME1 displays a biphasic pattern of expression, with a first phase independent of Rme1 function and dependent on chlamydospore-inducing cues, and a second phase dependent on Rme1 function and independent of chlamydospore-inducing cues. Our results indicate that Rme1 plays a central role in chlamydospore development in Candida species.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41467-020-20010-9", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.9664194", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4057127", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "pathogen Candida albicans", 
      "genome-wide expression analysis", 
      "fungal pathogen Candida albicans", 
      "C. albicans morphogenesis", 
      "expression of genes", 
      "pseudohyphal growth", 
      "transcriptional circuitry", 
      "asexual process", 
      "thick-walled cells", 
      "asexual sporulation", 
      "nutrient starvation", 
      "chlamydospore development", 
      "chromatin immunoprecipitation", 
      "RME1", 
      "hyphal growth", 
      "expression analysis", 
      "Candida albicans", 
      "expression levels", 
      "regulator", 
      "species", 
      "central role", 
      "Candida species", 
      "chlamydosporulation", 
      "possible role", 
      "expression", 
      "genome", 
      "homolog", 
      "ascomycetes", 
      "meiosis", 
      "Saccharomyces", 
      "morphogenesis", 
      "cues", 
      "sporulation", 
      "immunoprecipitation", 
      "genes", 
      "albicans", 
      "starvation", 
      "growth", 
      "overexpression", 
      "binds", 
      "deletion", 
      "role", 
      "clinical isolates", 
      "cells", 
      "isolates", 
      "function", 
      "biphasic pattern", 
      "patterns", 
      "formation", 
      "development", 
      "levels", 
      "analysis", 
      "process", 
      "part", 
      "circuitry", 
      "results", 
      "phase", 
      "first phase", 
      "requirements", 
      "efficiency", 
      "second phase"
    ], 
    "name": "A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans", 
    "pagination": "6224", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1133092857"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-020-20010-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33277479"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-020-20010-9", 
      "https://app.dimensions.ai/details/publication/pub.1133092857"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_839.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41467-020-20010-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-20010-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-20010-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-20010-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-20010-9'


 

This table displays all metadata directly associated to this object as RDF triples.

342 TRIPLES      21 PREDICATES      100 URIs      87 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-020-20010-9 schema:about N1d65e022f5af4fb18c6bbd2ac4014485
2 N41b00380ef4847e29eeb37c9237bb304
3 N4b45caeebaea4fab982c9db769828d97
4 N582b99910b134e2394cf653cf5e60bc4
5 N600c78e9fb0143c88ed97aa862c688c6
6 N63d1847b54f04551aae0c9c4576a434b
7 N8e75dd2624dd4c7b855607f97ef480a9
8 N913f6351343c4dd1b896fa6d26483388
9 N9bce644a1bbc4d2292014036c98298d0
10 anzsrc-for:06
11 anzsrc-for:0601
12 anzsrc-for:0604
13 schema:author N3df63c8cadc74f4c98a0be7e92a04630
14 schema:citation sg:pub.10.1007/s00294-002-0349-0
15 sg:pub.10.1038/nature09560
16 sg:pub.10.1038/nbt.1505
17 sg:pub.10.1038/nrmicro.2016.157
18 schema:datePublished 2020-12-04
19 schema:datePublishedReg 2020-12-04
20 schema:description Transcription factor Rme1 is conserved among ascomycetes and regulates meiosis and pseudohyphal growth in Saccharomyces cerevisiae. The genome of the meiosis-defective pathogen Candida albicans encodes an Rme1 homolog that is part of a transcriptional circuitry controlling hyphal growth. Here, we use chromatin immunoprecipitation and genome-wide expression analyses to study a possible role of Rme1 in C. albicans morphogenesis. We find that Rme1 binds upstream and activates the expression of genes that are upregulated during chlamydosporulation, an asexual process leading to formation of large, spherical, thick-walled cells during nutrient starvation. RME1 deletion abolishes chlamydosporulation in three Candida species, whereas its overexpression bypasses the requirement for chlamydosporulation cues and regulators. RME1 expression levels correlate with chlamydosporulation efficiency across clinical isolates. Interestingly, RME1 displays a biphasic pattern of expression, with a first phase independent of Rme1 function and dependent on chlamydospore-inducing cues, and a second phase dependent on Rme1 function and independent of chlamydospore-inducing cues. Our results indicate that Rme1 plays a central role in chlamydospore development in Candida species.
21 schema:genre article
22 schema:isAccessibleForFree true
23 schema:isPartOf N5751e0a9c1844f3c90c1d56e1e20d0a3
24 Na0fdc3b2f41342c5893ff324bc0c739f
25 sg:journal.1043282
26 schema:keywords C. albicans morphogenesis
27 Candida albicans
28 Candida species
29 RME1
30 Saccharomyces
31 albicans
32 analysis
33 ascomycetes
34 asexual process
35 asexual sporulation
36 binds
37 biphasic pattern
38 cells
39 central role
40 chlamydospore development
41 chlamydosporulation
42 chromatin immunoprecipitation
43 circuitry
44 clinical isolates
45 cues
46 deletion
47 development
48 efficiency
49 expression
50 expression analysis
51 expression levels
52 expression of genes
53 first phase
54 formation
55 function
56 fungal pathogen Candida albicans
57 genes
58 genome
59 genome-wide expression analysis
60 growth
61 homolog
62 hyphal growth
63 immunoprecipitation
64 isolates
65 levels
66 meiosis
67 morphogenesis
68 nutrient starvation
69 overexpression
70 part
71 pathogen Candida albicans
72 patterns
73 phase
74 possible role
75 process
76 pseudohyphal growth
77 regulator
78 requirements
79 results
80 role
81 second phase
82 species
83 sporulation
84 starvation
85 thick-walled cells
86 transcriptional circuitry
87 schema:name A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans
88 schema:pagination 6224
89 schema:productId N8592975fdfb04a5c876c5b2275d1c051
90 Nc3d6d71c9d634b4e91a209fe4c5bc59d
91 Nf17b4d25335544a3b8216ca6c4026c44
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1133092857
93 https://doi.org/10.1038/s41467-020-20010-9
94 schema:sdDatePublished 2022-10-01T06:46
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N159ffea34c0241e980d31d31183882f1
97 schema:url https://doi.org/10.1038/s41467-020-20010-9
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N159ffea34c0241e980d31d31183882f1 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N1d65e022f5af4fb18c6bbd2ac4014485 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Animals
105 rdf:type schema:DefinedTerm
106 N3cf1e24e11d24ba69624b6a5fb7cb3f8 rdf:first sg:person.0760564474.73
107 rdf:rest rdf:nil
108 N3df63c8cadc74f4c98a0be7e92a04630 rdf:first sg:person.01013553233.65
109 rdf:rest Nc2fa1877468048788620feb5f401bde2
110 N41b00380ef4847e29eeb37c9237bb304 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Candida albicans
112 rdf:type schema:DefinedTerm
113 N49891336e6ca461abdcc58eadc5546f9 rdf:first sg:person.01325662006.56
114 rdf:rest N946210b4c73b413f94e70fbdd5412afe
115 N4b45caeebaea4fab982c9db769828d97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Gene Expression Profiling
117 rdf:type schema:DefinedTerm
118 N5751e0a9c1844f3c90c1d56e1e20d0a3 schema:volumeNumber 11
119 rdf:type schema:PublicationVolume
120 N582b99910b134e2394cf653cf5e60bc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Gene Expression Regulation, Fungal
122 rdf:type schema:DefinedTerm
123 N5daee4ecf83f44339ff00cb4dfd7d053 rdf:first sg:person.01224423415.29
124 rdf:rest Na8dbc6533b9846719b1e95e49220b769
125 N5de860b6d27c4b3cb3d89ec42f21012f rdf:first sg:person.01252276150.53
126 rdf:rest Nd0eb57b835e04ed38535f5fdd4d9c2dc
127 N600c78e9fb0143c88ed97aa862c688c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Female
129 rdf:type schema:DefinedTerm
130 N62890b7e87054cadb4ec622dc3b71f37 rdf:first sg:person.01367471406.14
131 rdf:rest Na7b1ee43f1dc4dd7bd662a5ec1564bb3
132 N63d1847b54f04551aae0c9c4576a434b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Fungal Proteins
134 rdf:type schema:DefinedTerm
135 N7319a490bca6496dbbca571b6402d5a1 rdf:first sg:person.012364000137.22
136 rdf:rest N62890b7e87054cadb4ec622dc3b71f37
137 N7cbed5e748764da985a82cc16296ff82 rdf:first sg:person.01027022216.75
138 rdf:rest N8834947c64434fa9bc328b6c4c3c633a
139 N8592975fdfb04a5c876c5b2275d1c051 schema:name dimensions_id
140 schema:value pub.1133092857
141 rdf:type schema:PropertyValue
142 N8834947c64434fa9bc328b6c4c3c633a rdf:first sg:person.012556162524.30
143 rdf:rest N7319a490bca6496dbbca571b6402d5a1
144 N8e75dd2624dd4c7b855607f97ef480a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Spores, Fungal
146 rdf:type schema:DefinedTerm
147 N8e8b4167902847549dbdb0ab7a8c0e74 rdf:first N9fa052073839493c9dc9d0b8af5fae73
148 rdf:rest N94f4cbc4ff3c40848bd438d7e7a6ddf9
149 N913f6351343c4dd1b896fa6d26483388 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Mice, Inbred BALB C
151 rdf:type schema:DefinedTerm
152 N946210b4c73b413f94e70fbdd5412afe rdf:first sg:person.01173731273.36
153 rdf:rest Ncef575e10d5747fcbf5e7f113207f14a
154 N94f4cbc4ff3c40848bd438d7e7a6ddf9 rdf:first sg:person.0744545351.55
155 rdf:rest N3cf1e24e11d24ba69624b6a5fb7cb3f8
156 N9bce644a1bbc4d2292014036c98298d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Candidemia
158 rdf:type schema:DefinedTerm
159 N9fa052073839493c9dc9d0b8af5fae73 schema:affiliation grid-institutes:None
160 schema:familyName Li
161 schema:givenName Zongwei
162 rdf:type schema:Person
163 Na0fdc3b2f41342c5893ff324bc0c739f schema:issueNumber 1
164 rdf:type schema:PublicationIssue
165 Na1075e14e41542afa8b1f0bd1e51d2a4 schema:affiliation grid-institutes:grid.506261.6
166 schema:familyName Yang
167 schema:givenName Ying
168 rdf:type schema:Person
169 Na7b1ee43f1dc4dd7bd662a5ec1564bb3 rdf:first sg:person.01042247474.20
170 rdf:rest N5de860b6d27c4b3cb3d89ec42f21012f
171 Na8dbc6533b9846719b1e95e49220b769 rdf:first sg:person.01371577661.71
172 rdf:rest N49891336e6ca461abdcc58eadc5546f9
173 Nc2fa1877468048788620feb5f401bde2 rdf:first sg:person.01136761734.27
174 rdf:rest N7cbed5e748764da985a82cc16296ff82
175 Nc3d6d71c9d634b4e91a209fe4c5bc59d schema:name doi
176 schema:value 10.1038/s41467-020-20010-9
177 rdf:type schema:PropertyValue
178 Ncef575e10d5747fcbf5e7f113207f14a rdf:first sg:person.01145115305.44
179 rdf:rest Nfb7d5899d8354ed09264ac5aefa5f38a
180 Nd0eb57b835e04ed38535f5fdd4d9c2dc rdf:first sg:person.0760000606.28
181 rdf:rest N5daee4ecf83f44339ff00cb4dfd7d053
182 Nf17b4d25335544a3b8216ca6c4026c44 schema:name pubmed_id
183 schema:value 33277479
184 rdf:type schema:PropertyValue
185 Nfb7d5899d8354ed09264ac5aefa5f38a rdf:first Na1075e14e41542afa8b1f0bd1e51d2a4
186 rdf:rest N8e8b4167902847549dbdb0ab7a8c0e74
187 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
188 schema:name Biological Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
191 schema:name Biochemistry and Cell Biology
192 rdf:type schema:DefinedTerm
193 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
194 schema:name Genetics
195 rdf:type schema:DefinedTerm
196 sg:grant.4057127 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-020-20010-9
197 rdf:type schema:MonetaryGrant
198 sg:grant.9664194 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-020-20010-9
199 rdf:type schema:MonetaryGrant
200 sg:journal.1043282 schema:issn 2041-1723
201 schema:name Nature Communications
202 schema:publisher Springer Nature
203 rdf:type schema:Periodical
204 sg:person.01013553233.65 schema:affiliation grid-institutes:grid.508487.6
205 schema:familyName Hernández-Cervantes
206 schema:givenName Arturo
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013553233.65
208 rdf:type schema:Person
209 sg:person.01027022216.75 schema:affiliation grid-institutes:grid.428999.7
210 schema:familyName van Wijlick
211 schema:givenName Lasse
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027022216.75
213 rdf:type schema:Person
214 sg:person.01042247474.20 schema:affiliation grid-institutes:grid.428999.7
215 schema:familyName Sertour
216 schema:givenName Natacha
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042247474.20
218 rdf:type schema:Person
219 sg:person.01136761734.27 schema:affiliation grid-institutes:grid.12574.35
220 schema:familyName Znaidi
221 schema:givenName Sadri
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136761734.27
223 rdf:type schema:Person
224 sg:person.01145115305.44 schema:affiliation grid-institutes:grid.7177.6
225 schema:familyName Boekhout
226 schema:givenName Teun
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145115305.44
228 rdf:type schema:Person
229 sg:person.01173731273.36 schema:affiliation grid-institutes:grid.412134.1
230 schema:familyName Bougnoux
231 schema:givenName Marie-Elisabeth
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173731273.36
233 rdf:type schema:Person
234 sg:person.01224423415.29 schema:affiliation grid-institutes:grid.31151.37
235 schema:familyName Basmaciyan
236 schema:givenName Louise
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224423415.29
238 rdf:type schema:Person
239 sg:person.012364000137.22 schema:affiliation grid-institutes:grid.42505.36
240 schema:familyName Basso
241 schema:givenName Virginia
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012364000137.22
243 rdf:type schema:Person
244 sg:person.01252276150.53 schema:affiliation grid-institutes:grid.8217.c
245 schema:familyName Sullivan
246 schema:givenName Derek
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252276150.53
248 rdf:type schema:Person
249 sg:person.012556162524.30 schema:affiliation grid-institutes:grid.508487.6
250 schema:familyName Denega
251 schema:givenName Iryna
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012556162524.30
253 rdf:type schema:Person
254 sg:person.01325662006.56 schema:affiliation grid-institutes:grid.31151.37
255 schema:familyName Dalle
256 schema:givenName Frédéric
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325662006.56
258 rdf:type schema:Person
259 sg:person.01367471406.14 schema:affiliation grid-institutes:grid.4444.0
260 schema:familyName Ropars
261 schema:givenName Jeanne
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367471406.14
263 rdf:type schema:Person
264 sg:person.01371577661.71 schema:affiliation grid-institutes:grid.5613.1
265 schema:familyName Bon
266 schema:givenName Fabienne
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371577661.71
268 rdf:type schema:Person
269 sg:person.0744545351.55 schema:affiliation grid-institutes:grid.428999.7
270 schema:familyName Bachellier-Bassi
271 schema:givenName Sophie
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744545351.55
273 rdf:type schema:Person
274 sg:person.0760000606.28 schema:affiliation grid-institutes:grid.8217.c
275 schema:familyName Moran
276 schema:givenName Gary
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760000606.28
278 rdf:type schema:Person
279 sg:person.0760564474.73 schema:affiliation grid-institutes:grid.428999.7
280 schema:familyName d’Enfert
281 schema:givenName Christophe
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760564474.73
283 rdf:type schema:Person
284 sg:pub.10.1007/s00294-002-0349-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032828190
285 https://doi.org/10.1007/s00294-002-0349-0
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/nature09560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028200562
288 https://doi.org/10.1038/nature09560
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nbt.1505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051483764
291 https://doi.org/10.1038/nbt.1505
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/nrmicro.2016.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045459868
294 https://doi.org/10.1038/nrmicro.2016.157
295 rdf:type schema:CreativeWork
296 grid-institutes:None schema:alternateName Center for Hospital Infection Control, Institute for Disease Control & Prevention, 100071, Beijing, China
297 schema:name Center for Hospital Infection Control, Institute for Disease Control & Prevention, 100071, Beijing, China
298 rdf:type schema:Organization
299 grid-institutes:grid.12574.35 schema:alternateName University of Tunis-El Manar, 1036, Tunis, Tunisia
300 schema:name Institut Pasteur de Tunis, Laboratoire de Microbiologie Moléculaire, Vaccinologie et Développement Biotechnologique, Bâtiment Etienne Burnet, 13 Place Pasteur, B.P.74, 1002, Tunis-Belvédère, Tunisia
301 Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France
302 University of Tunis-El Manar, 1036, Tunis, Tunisia
303 rdf:type schema:Organization
304 grid-institutes:grid.31151.37 schema:alternateName Centre Hospitalier Universitaire François Mitterand, Service de Parasitologie Mycologie, Dijon, France
305 schema:name Centre Hospitalier Universitaire François Mitterand, Service de Parasitologie Mycologie, Dijon, France
306 UMR PAM, Université de Bourgogne Franche-Comté, AgroSup Dijon – Equipe VAIMiS, Dijon, France
307 rdf:type schema:Organization
308 grid-institutes:grid.412134.1 schema:alternateName Unité de Parasitologie-Mycologie, Service de Microbiologie clinique, Hôpital Necker-Enfants-Malades, Assistance Publique des Hôpitaux de Paris (APHP), Université de Paris, Paris, France
309 schema:name Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France
310 Unité de Parasitologie-Mycologie, Service de Microbiologie clinique, Hôpital Necker-Enfants-Malades, Assistance Publique des Hôpitaux de Paris (APHP), Université de Paris, Paris, France
311 rdf:type schema:Organization
312 grid-institutes:grid.42505.36 schema:alternateName Department of Pathology and Laboratory Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
313 schema:name Department of Pathology and Laboratory Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
314 Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France
315 Université de Paris, Sorbonne Paris Cité, Paris, France
316 rdf:type schema:Organization
317 grid-institutes:grid.428999.7 schema:alternateName Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France
318 schema:name Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France
319 rdf:type schema:Organization
320 grid-institutes:grid.4444.0 schema:alternateName Université Paris-Saclay, CNRS, AgroParisTech, Écologie, Systématique, Évolution, F-91405, Orsay, France
321 schema:name Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France
322 Université Paris-Saclay, CNRS, AgroParisTech, Écologie, Systématique, Évolution, F-91405, Orsay, France
323 rdf:type schema:Organization
324 grid-institutes:grid.506261.6 schema:alternateName Beijing Institute of Radiation Medicine, 100850, Beijing, China
325 schema:name Beijing Institute of Radiation Medicine, 100850, Beijing, China
326 rdf:type schema:Organization
327 grid-institutes:grid.508487.6 schema:alternateName Université de Paris / Inserm, 1 Avenue Claude Vellefaux, F-75010, Paris, France
328 Université de Paris, Sorbonne Paris Cité, Paris, France
329 schema:name Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, USC, 2019 INRA, Paris, France
330 Université de Paris / Inserm, 1 Avenue Claude Vellefaux, F-75010, Paris, France
331 Université de Paris, Sorbonne Paris Cité, Paris, France
332 rdf:type schema:Organization
333 grid-institutes:grid.5613.1 schema:alternateName UMR PAM, Université de Bourgogne Franche-Comté, AgroSup Dijon – Equipe VAIMiS, Dijon, France
334 schema:name UMR PAM, Université de Bourgogne Franche-Comté, AgroSup Dijon – Equipe VAIMiS, Dijon, France
335 rdf:type schema:Organization
336 grid-institutes:grid.7177.6 schema:alternateName Institute of Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam, Amsterdam, The Netherlands
337 schema:name Institute of Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam, Amsterdam, The Netherlands
338 Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands
339 rdf:type schema:Organization
340 grid-institutes:grid.8217.c schema:alternateName Dublin Dental University Hospital and School of Dental Science, Trinity College Dublin, 2, Dublin, Ireland
341 schema:name Dublin Dental University Hospital and School of Dental Science, Trinity College Dublin, 2, Dublin, Ireland
342 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...