Dominant subtype switch in avian influenza viruses during 2016–2019 in China View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-20

AUTHORS

Yuhai Bi, Juan Li, Shanqin Li, Guanghua Fu, Tao Jin, Cheng Zhang, Yongchun Yang, Zhenghai Ma, Wenxia Tian, Jida Li, Shuqi Xiao, Liqiang Li, Renfu Yin, Yi Zhang, Lixin Wang, Yantao Qin, Zhongzi Yao, Fanyu Meng, Dongfang Hu, Delong Li, Gary Wong, Fei Liu, Na Lv, Liang Wang, Lifeng Fu, Yang Yang, Yun Peng, Jinmin Ma, Kirill Sharshov, Alexander Shestopalov, Marina Gulyaeva, George F. Gao, Jianjun Chen, Yi Shi, William J. Liu, Dong Chu, Yu Huang, Yingxia Liu, Lei Liu, Wenjun Liu, Quanjiao Chen, Weifeng Shi

ABSTRACT

We have surveyed avian influenza virus (AIV) genomes from live poultry markets within China since 2014. Here we present a total of 16,091 samples that were collected from May 2016 to February 2019 in 23 provinces and municipalities in China. We identify 2048 AIV-positive samples and perform next generation sequencing. AIV-positive rates (12.73%) from samples had decreased substantially since 2016, compared to that during 2014–2016 (26.90%). Additionally, H9N2 has replaced H5N6 and H7N9 as the dominant AIV subtype in both chickens and ducks. Notably, novel reassortants and variants continually emerged and disseminated in avian populations, including H7N3, H9N9, H9N6 and H5N6 variants. Importantly, almost all of the H9 AIVs and many H7N9 and H6N2 strains prefer human-type receptors, posing an increased risk for human infections. In summary, our nation-wide surveillance highlights substantial changes in the circulation of AIVs since 2016, which greatly impacts the prevention and control of AIVs in China and worldwide. More... »

PAGES

5909

Journal

TITLE

Nature Communications

ISSUE

1

VOLUME

11

Author Affiliations

  • Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People’s Hospital, 518112, Shenzhen, China
  • Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, 271016, Taian, China
  • University of Chinese Academy of Sciences, 101408, Beijing, China
  • Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, 350013, Fuzhou, China
  • China National Genebank-Shenzhen, BGI-Shenzhen, 518083, Shenzhen, China
  • College of Life Science and Technology, Xinjiang University, 830046, Urumchi, China
  • Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, 311300, Hangzhou, China
  • College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, 030801, Taigu, China
  • Institute of Zoonosis, College of Public Hygiene, Zunyi Medical University, 563003, Zunyi, China
  • College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China
  • Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, 130062, Jilin, China
  • School of Basic Medicine and Life Science, Hainan Medical University, 571101, Haikou, China
  • Diqing Tibetan Autonomous Prefecture Centers for Disease Control and Prevention, 674400, Shangri-la, China
  • CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, CASCIRE, Chinese Academy of Sciences, 430071, Wuhan, China
  • College of Animal Science and Technology, Henan Institute of Science and Technology, 453003, Xinxiang, China
  • College of Animal Science, Southwest University, 402460, Chongqing, China
  • Département de microbiologie-infectiologie et d’immunologie, Université Laval, G1V 0A6, Québec City, Canada
  • CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID, Chinese Academy of Sciences, 100101, Beijing, China
  • Federal Research Center of Fundamental and Translational Medicine, Federal State Budget Scientific Institution, Siberian Branch of Russian Academy of Sciences, Novosibirsk State University, 630090, Novosibirsk, Russia
  • National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), 102206, Beijing, China
  • General Station for Surveillance of Wildlife-borne Infectious Diseases, State Forestry and Grassland Administration, 110034, Shenyang, Liaoning Province, PR China
  • School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 271000, Taian, China
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-020-19671-3

    DOI

    http://dx.doi.org/10.1038/s41467-020-19671-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1132769808

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33219213


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    61 market
    62 municipalities
    63 nation-wide surveillance
    64 next-generation sequencing
    65 novel reassortant
    66 population
    67 poultry markets
    68 prevention
    69 rate
    70 reassortants
    71 receptors
    72 risk
    73 samples
    74 sequencing
    75 substantial changes
    76 subtype switch
    77 subtypes
    78 summary
    79 surveillance
    80 switch
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