Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-10-30

AUTHORS

Igor Kondrychyn, Douglas J. Kelly, Núria Taberner Carretero, Akane Nomori, Kagayaki Kato, Jeronica Chong, Hiroyuki Nakajima, Satoru Okuda, Naoki Mochizuki, Li-Kun Phng

ABSTRACT

The formation of vascular tubes is driven by extensive changes in endothelial cell (EC) shape. Here, we have identified a role of the actin-binding protein, Marcksl1, in modulating the mechanical properties of EC cortex to regulate cell shape and vessel structure during angiogenesis. Increasing and depleting Marcksl1 expression level in vivo results in an increase and decrease, respectively, in EC size and the diameter of microvessels. Furthermore, endothelial overexpression of Marcksl1 induces ectopic blebbing on both apical and basal membranes, during and after lumen formation, that is suppressed by reduced blood flow. High resolution imaging reveals that Marcksl1 promotes the formation of linear actin bundles and decreases actin density at the EC cortex. Our findings demonstrate that a balanced network of linear and branched actin at the EC cortex is essential in conferring cortical integrity to resist the deforming forces of blood flow to regulate vessel structure. More... »

PAGES

5476

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-020-19308-5

DOI

http://dx.doi.org/10.1038/s41467-020-19308-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132148523

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33127887


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