Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-10-30

AUTHORS

Igor Kondrychyn, Douglas J. Kelly, Núria Taberner Carretero, Akane Nomori, Kagayaki Kato, Jeronica Chong, Hiroyuki Nakajima, Satoru Okuda, Naoki Mochizuki, Li-Kun Phng

ABSTRACT

The formation of vascular tubes is driven by extensive changes in endothelial cell (EC) shape. Here, we have identified a role of the actin-binding protein, Marcksl1, in modulating the mechanical properties of EC cortex to regulate cell shape and vessel structure during angiogenesis. Increasing and depleting Marcksl1 expression level in vivo results in an increase and decrease, respectively, in EC size and the diameter of microvessels. Furthermore, endothelial overexpression of Marcksl1 induces ectopic blebbing on both apical and basal membranes, during and after lumen formation, that is suppressed by reduced blood flow. High resolution imaging reveals that Marcksl1 promotes the formation of linear actin bundles and decreases actin density at the EC cortex. Our findings demonstrate that a balanced network of linear and branched actin at the EC cortex is essential in conferring cortical integrity to resist the deforming forces of blood flow to regulate vessel structure. More... »

PAGES

5476

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-020-19308-5

DOI

http://dx.doi.org/10.1038/s41467-020-19308-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132148523

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33127887


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Actins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Actomyosin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Vessels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calmodulin-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Developmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microfilament Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zebrafish", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.508743.d", 
          "name": [
            "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kondrychyn", 
        "givenName": "Igor", 
        "id": "sg:person.0615620174.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615620174.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.508743.d", 
          "name": [
            "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kelly", 
        "givenName": "Douglas J.", 
        "id": "sg:person.013407273047.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013407273047.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.508743.d", 
          "name": [
            "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carretero", 
        "givenName": "N\u00faria Taberner", 
        "id": "sg:person.012343265742.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012343265742.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.508743.d", 
          "name": [
            "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nomori", 
        "givenName": "Akane", 
        "id": "sg:person.0730713622.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730713622.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Biological Diversity, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419396.0", 
          "name": [
            "Bioimage Informatics Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan", 
            "Laboratory of Biological Diversity, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Kagayaki", 
        "id": "sg:person.0624217516.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624217516.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.508743.d", 
          "name": [
            "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chong", 
        "givenName": "Jeronica", 
        "id": "sg:person.010107155771.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010107155771.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cell Biology and AMED-CREST, National Cerebral and Cardiovascular Center, Research Institute, 565-8565, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Cell Biology and AMED-CREST, National Cerebral and Cardiovascular Center, Research Institute, 565-8565, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakajima", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.07672123647.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07672123647.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "WPI Nano Life Science Institute, Kanazawa University, 920-1192, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "WPI Nano Life Science Institute, Kanazawa University, 920-1192, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okuda", 
        "givenName": "Satoru", 
        "id": "sg:person.010467504247.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010467504247.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cell Biology and AMED-CREST, National Cerebral and Cardiovascular Center, Research Institute, 565-8565, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Cell Biology and AMED-CREST, National Cerebral and Cardiovascular Center, Research Institute, 565-8565, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mochizuki", 
        "givenName": "Naoki", 
        "id": "sg:person.0715762471.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715762471.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.508743.d", 
          "name": [
            "Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phng", 
        "givenName": "Li-Kun", 
        "id": "sg:person.01365250605.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365250605.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncb3528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085462291", 
          "https://doi.org/10.1038/ncb3528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052648190", 
          "https://doi.org/10.1038/nprot.2007.514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.4096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101885942", 
          "https://doi.org/10.1038/nbt.4096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046251645", 
          "https://doi.org/10.1038/ng.321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017222272", 
          "https://doi.org/10.1038/nm.2022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12929-018-0445-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104089330", 
          "https://doi.org/10.1186/s12929-018-0445-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6750-8-77", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028939436", 
          "https://doi.org/10.1186/1472-6750-8-77"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb3320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017492426", 
          "https://doi.org/10.1038/ncb3320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/348728a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049560900", 
          "https://doi.org/10.1038/348728a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature16974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053579355", 
          "https://doi.org/10.1038/nature16974"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-10-30", 
    "datePublishedReg": "2020-10-30", 
    "description": "The formation of vascular tubes is driven by extensive changes in endothelial cell (EC) shape. Here, we have identified a role of the actin-binding protein, Marcksl1, in modulating the mechanical properties of EC cortex to regulate cell shape and vessel structure during angiogenesis. Increasing and depleting Marcksl1 expression level in vivo results in an increase and decrease, respectively, in EC size and the diameter of microvessels. Furthermore, endothelial overexpression of Marcksl1 induces ectopic blebbing on both apical and basal membranes, during and after lumen formation, that is suppressed by reduced blood flow. High resolution imaging reveals that Marcksl1 promotes the formation of linear actin bundles and decreases actin density at the EC cortex. Our findings demonstrate that a balanced network of linear and branched actin at the EC cortex is essential in conferring cortical integrity to resist the deforming forces of blood flow to regulate vessel structure.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41467-020-19308-5", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8437046", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7533102", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8426096", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "blood flow", 
      "reduced blood flow", 
      "EC cortex", 
      "diameter of microvessels", 
      "endothelial overexpression", 
      "EC size", 
      "cortical integrity", 
      "haemodynamic forces", 
      "expression levels", 
      "vivo results", 
      "basal membrane", 
      "cortex", 
      "linear actin bundles", 
      "vessel structure", 
      "endothelial cell shape", 
      "vascular tubes", 
      "cell mechanoresponse", 
      "microvessels", 
      "angiogenesis", 
      "lumen formation", 
      "extensive changes", 
      "overexpression", 
      "actin density", 
      "actin-binding proteins", 
      "imaging reveals", 
      "findings", 
      "actin", 
      "blood vessel shape", 
      "levels", 
      "decrease", 
      "protein", 
      "role", 
      "increase", 
      "cell shape", 
      "changes", 
      "balanced network", 
      "bundles", 
      "membrane", 
      "integrity", 
      "formation", 
      "size", 
      "tube", 
      "high-resolution imaging reveal", 
      "diameter", 
      "EC", 
      "vessel shape", 
      "results", 
      "actin bundles", 
      "mechanoresponse", 
      "flow", 
      "reveals", 
      "force", 
      "density", 
      "shape", 
      "structure", 
      "properties", 
      "network", 
      "linear", 
      "mechanical properties"
    ], 
    "name": "Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size", 
    "pagination": "5476", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1132148523"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-020-19308-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33127887"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-020-19308-5", 
      "https://app.dimensions.ai/details/publication/pub.1132148523"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_832.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41467-020-19308-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-19308-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-19308-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-19308-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-19308-5'


 

This table displays all metadata directly associated to this object as RDF triples.

290 TRIPLES      21 PREDICATES      107 URIs      89 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-020-19308-5 schema:about N1937c8a2f8b24f02b530770af34bb2c5
2 N1981ac415766415c95285b6d771e4072
3 N1b2d7495728a4af380f91e3dd3f44f27
4 N31a597ea39144969aa47252b4fb8f128
5 N632aa7c2011a44acbe45c970991ee132
6 Nad2753cab6814c238424bfe26cb3b955
7 Nc1fe46de41be4ee2b41e2f5abee2e479
8 Nc4eb566e80714192a15a23f4ac67d654
9 Nc854bba948be4e549f4b9e093f4970b7
10 Ncdf9efca3d824622bcb6c391e4c778cd
11 Ne513c6e6d5c740e6a710add66a05cbde
12 Ne7e2ae0176104120b712a0e9a135033a
13 Nf31775f1f80d466b9666c58374f8f825
14 anzsrc-for:11
15 anzsrc-for:1102
16 schema:author N89e1c459913c416186bf8f987ba5b327
17 schema:citation sg:pub.10.1038/348728a0
18 sg:pub.10.1038/nature16974
19 sg:pub.10.1038/nbt.4096
20 sg:pub.10.1038/ncb3320
21 sg:pub.10.1038/ncb3528
22 sg:pub.10.1038/ng.321
23 sg:pub.10.1038/nm.2022
24 sg:pub.10.1038/nprot.2007.514
25 sg:pub.10.1186/1472-6750-8-77
26 sg:pub.10.1186/s12929-018-0445-1
27 schema:datePublished 2020-10-30
28 schema:datePublishedReg 2020-10-30
29 schema:description The formation of vascular tubes is driven by extensive changes in endothelial cell (EC) shape. Here, we have identified a role of the actin-binding protein, Marcksl1, in modulating the mechanical properties of EC cortex to regulate cell shape and vessel structure during angiogenesis. Increasing and depleting Marcksl1 expression level in vivo results in an increase and decrease, respectively, in EC size and the diameter of microvessels. Furthermore, endothelial overexpression of Marcksl1 induces ectopic blebbing on both apical and basal membranes, during and after lumen formation, that is suppressed by reduced blood flow. High resolution imaging reveals that Marcksl1 promotes the formation of linear actin bundles and decreases actin density at the EC cortex. Our findings demonstrate that a balanced network of linear and branched actin at the EC cortex is essential in conferring cortical integrity to resist the deforming forces of blood flow to regulate vessel structure.
30 schema:genre article
31 schema:isAccessibleForFree true
32 schema:isPartOf N3a240be1d7e74a6bb9dede1b025ef219
33 Ne55ac03eb820424494c859d71509f8c4
34 sg:journal.1043282
35 schema:keywords EC
36 EC cortex
37 EC size
38 actin
39 actin bundles
40 actin density
41 actin-binding proteins
42 angiogenesis
43 balanced network
44 basal membrane
45 blood flow
46 blood vessel shape
47 bundles
48 cell mechanoresponse
49 cell shape
50 changes
51 cortex
52 cortical integrity
53 decrease
54 density
55 diameter
56 diameter of microvessels
57 endothelial cell shape
58 endothelial overexpression
59 expression levels
60 extensive changes
61 findings
62 flow
63 force
64 formation
65 haemodynamic forces
66 high-resolution imaging reveal
67 imaging reveals
68 increase
69 integrity
70 levels
71 linear
72 linear actin bundles
73 lumen formation
74 mechanical properties
75 mechanoresponse
76 membrane
77 microvessels
78 network
79 overexpression
80 properties
81 protein
82 reduced blood flow
83 results
84 reveals
85 role
86 shape
87 size
88 structure
89 tube
90 vascular tubes
91 vessel shape
92 vessel structure
93 vivo results
94 schema:name Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size
95 schema:pagination 5476
96 schema:productId N3a1c3fc29e5b405a90b9e4ffcdbbc291
97 N508b9e77a1d346888f9c623f333ce99d
98 N986650727dff411ea4be932de63f2ec3
99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132148523
100 https://doi.org/10.1038/s41467-020-19308-5
101 schema:sdDatePublished 2022-11-24T21:04
102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
103 schema:sdPublisher N184fc741be2b4e9aad580638c55b9e23
104 schema:url https://doi.org/10.1038/s41467-020-19308-5
105 sgo:license sg:explorer/license/
106 sgo:sdDataset articles
107 rdf:type schema:ScholarlyArticle
108 N00570df00ff34b82b6bb777465fb08ef rdf:first sg:person.01365250605.58
109 rdf:rest rdf:nil
110 N0c35740a0f8e499cacb06de66c3a4f64 rdf:first sg:person.07672123647.36
111 rdf:rest N48fa870b94ad43d3a0e72d590c9656bd
112 N184fc741be2b4e9aad580638c55b9e23 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N1937c8a2f8b24f02b530770af34bb2c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Animals
116 rdf:type schema:DefinedTerm
117 N1981ac415766415c95285b6d771e4072 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Zebrafish
119 rdf:type schema:DefinedTerm
120 N1b2d7495728a4af380f91e3dd3f44f27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Endothelial Cells
122 rdf:type schema:DefinedTerm
123 N31a597ea39144969aa47252b4fb8f128 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Animals, Genetically Modified
125 rdf:type schema:DefinedTerm
126 N3a1c3fc29e5b405a90b9e4ffcdbbc291 schema:name pubmed_id
127 schema:value 33127887
128 rdf:type schema:PropertyValue
129 N3a240be1d7e74a6bb9dede1b025ef219 schema:issueNumber 1
130 rdf:type schema:PublicationIssue
131 N48fa870b94ad43d3a0e72d590c9656bd rdf:first sg:person.010467504247.94
132 rdf:rest N4f6e7e0f2edd4ef1aaa71cb5734ee749
133 N4f6e7e0f2edd4ef1aaa71cb5734ee749 rdf:first sg:person.0715762471.09
134 rdf:rest N00570df00ff34b82b6bb777465fb08ef
135 N508b9e77a1d346888f9c623f333ce99d schema:name doi
136 schema:value 10.1038/s41467-020-19308-5
137 rdf:type schema:PropertyValue
138 N632aa7c2011a44acbe45c970991ee132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Gene Expression Regulation, Developmental
140 rdf:type schema:DefinedTerm
141 N89e1c459913c416186bf8f987ba5b327 rdf:first sg:person.0615620174.32
142 rdf:rest Nba2e6adafc0f4abb843190090769fc10
143 N986650727dff411ea4be932de63f2ec3 schema:name dimensions_id
144 schema:value pub.1132148523
145 rdf:type schema:PropertyValue
146 N987181f4de8c43049956c9f9ae52b62c rdf:first sg:person.0624217516.82
147 rdf:rest Nb5eaf56f83b74b0d8f0700e2c8b98ef5
148 N9da321da38524756bb38ffe30f0e53ed rdf:first sg:person.012343265742.69
149 rdf:rest Na93bd6f95f8f4f5c8316d70a29b9a251
150 Na93bd6f95f8f4f5c8316d70a29b9a251 rdf:first sg:person.0730713622.14
151 rdf:rest N987181f4de8c43049956c9f9ae52b62c
152 Nad2753cab6814c238424bfe26cb3b955 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Microfilament Proteins
154 rdf:type schema:DefinedTerm
155 Nb5eaf56f83b74b0d8f0700e2c8b98ef5 rdf:first sg:person.010107155771.01
156 rdf:rest N0c35740a0f8e499cacb06de66c3a4f64
157 Nba2e6adafc0f4abb843190090769fc10 rdf:first sg:person.013407273047.29
158 rdf:rest N9da321da38524756bb38ffe30f0e53ed
159 Nc1fe46de41be4ee2b41e2f5abee2e479 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Actins
161 rdf:type schema:DefinedTerm
162 Nc4eb566e80714192a15a23f4ac67d654 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Calmodulin-Binding Proteins
164 rdf:type schema:DefinedTerm
165 Nc854bba948be4e549f4b9e093f4970b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Blood Vessels
167 rdf:type schema:DefinedTerm
168 Ncdf9efca3d824622bcb6c391e4c778cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Models, Animal
170 rdf:type schema:DefinedTerm
171 Ne513c6e6d5c740e6a710add66a05cbde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Actomyosin
173 rdf:type schema:DefinedTerm
174 Ne55ac03eb820424494c859d71509f8c4 schema:volumeNumber 11
175 rdf:type schema:PublicationVolume
176 Ne7e2ae0176104120b712a0e9a135033a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Transcriptome
178 rdf:type schema:DefinedTerm
179 Nf31775f1f80d466b9666c58374f8f825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Hemodynamics
181 rdf:type schema:DefinedTerm
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
186 schema:name Cardiorespiratory Medicine and Haematology
187 rdf:type schema:DefinedTerm
188 sg:grant.7533102 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-020-19308-5
189 rdf:type schema:MonetaryGrant
190 sg:grant.8426096 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-020-19308-5
191 rdf:type schema:MonetaryGrant
192 sg:grant.8437046 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-020-19308-5
193 rdf:type schema:MonetaryGrant
194 sg:journal.1043282 schema:issn 2041-1723
195 schema:name Nature Communications
196 schema:publisher Springer Nature
197 rdf:type schema:Periodical
198 sg:person.010107155771.01 schema:affiliation grid-institutes:grid.508743.d
199 schema:familyName Chong
200 schema:givenName Jeronica
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010107155771.01
202 rdf:type schema:Person
203 sg:person.010467504247.94 schema:affiliation grid-institutes:grid.9707.9
204 schema:familyName Okuda
205 schema:givenName Satoru
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010467504247.94
207 rdf:type schema:Person
208 sg:person.012343265742.69 schema:affiliation grid-institutes:grid.508743.d
209 schema:familyName Carretero
210 schema:givenName Núria Taberner
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012343265742.69
212 rdf:type schema:Person
213 sg:person.013407273047.29 schema:affiliation grid-institutes:grid.508743.d
214 schema:familyName Kelly
215 schema:givenName Douglas J.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013407273047.29
217 rdf:type schema:Person
218 sg:person.01365250605.58 schema:affiliation grid-institutes:grid.508743.d
219 schema:familyName Phng
220 schema:givenName Li-Kun
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365250605.58
222 rdf:type schema:Person
223 sg:person.0615620174.32 schema:affiliation grid-institutes:grid.508743.d
224 schema:familyName Kondrychyn
225 schema:givenName Igor
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615620174.32
227 rdf:type schema:Person
228 sg:person.0624217516.82 schema:affiliation grid-institutes:grid.419396.0
229 schema:familyName Kato
230 schema:givenName Kagayaki
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624217516.82
232 rdf:type schema:Person
233 sg:person.0715762471.09 schema:affiliation grid-institutes:grid.410796.d
234 schema:familyName Mochizuki
235 schema:givenName Naoki
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715762471.09
237 rdf:type schema:Person
238 sg:person.0730713622.14 schema:affiliation grid-institutes:grid.508743.d
239 schema:familyName Nomori
240 schema:givenName Akane
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730713622.14
242 rdf:type schema:Person
243 sg:person.07672123647.36 schema:affiliation grid-institutes:grid.410796.d
244 schema:familyName Nakajima
245 schema:givenName Hiroyuki
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07672123647.36
247 rdf:type schema:Person
248 sg:pub.10.1038/348728a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049560900
249 https://doi.org/10.1038/348728a0
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nature16974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053579355
252 https://doi.org/10.1038/nature16974
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nbt.4096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101885942
255 https://doi.org/10.1038/nbt.4096
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/ncb3320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017492426
258 https://doi.org/10.1038/ncb3320
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/ncb3528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085462291
261 https://doi.org/10.1038/ncb3528
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/ng.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046251645
264 https://doi.org/10.1038/ng.321
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nm.2022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017222272
267 https://doi.org/10.1038/nm.2022
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/nprot.2007.514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052648190
270 https://doi.org/10.1038/nprot.2007.514
271 rdf:type schema:CreativeWork
272 sg:pub.10.1186/1472-6750-8-77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028939436
273 https://doi.org/10.1186/1472-6750-8-77
274 rdf:type schema:CreativeWork
275 sg:pub.10.1186/s12929-018-0445-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104089330
276 https://doi.org/10.1186/s12929-018-0445-1
277 rdf:type schema:CreativeWork
278 grid-institutes:grid.410796.d schema:alternateName Department of Cell Biology and AMED-CREST, National Cerebral and Cardiovascular Center, Research Institute, 565-8565, Suita, Osaka, Japan
279 schema:name Department of Cell Biology and AMED-CREST, National Cerebral and Cardiovascular Center, Research Institute, 565-8565, Suita, Osaka, Japan
280 rdf:type schema:Organization
281 grid-institutes:grid.419396.0 schema:alternateName Laboratory of Biological Diversity, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan
282 schema:name Bioimage Informatics Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan
283 Laboratory of Biological Diversity, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan
284 rdf:type schema:Organization
285 grid-institutes:grid.508743.d schema:alternateName Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan
286 schema:name Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Japan
287 rdf:type schema:Organization
288 grid-institutes:grid.9707.9 schema:alternateName WPI Nano Life Science Institute, Kanazawa University, 920-1192, Kanazawa, Japan
289 schema:name WPI Nano Life Science Institute, Kanazawa University, 920-1192, Kanazawa, Japan
290 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...