YAP and TAZ protect against white adipocyte cell death during obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-10-28

AUTHORS

Lei Wang, ShengPeng Wang, Yue Shi, Rui Li, Stefan Günther, Yu Ting Ong, Michael Potente, Zuyi Yuan, Enqi Liu, Stefan Offermanns

ABSTRACT

The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ target genes become activated during obesity. When fed a high-fat diet (HFD), mice lacking YAP/TAZ in white adipocytes develop severe lipodystrophy with adipocyte cell death. The pro-apoptotic factor BIM, which is downregulated in adipocytes of obese mice and humans, is strongly upregulated in YAP/TAZ-deficient adipocytes under HFD, and suppression of BIM expression reduces adipocyte apoptosis. In differentiated adipocytes, TNFα and IL-1β promote YAP/TAZ nuclear translocation via activation of RhoA-mediated actomyosin contractility and increase YAP/TAZ-mediated transcriptional regulation by activation of c-Jun N-terminal kinase (JNK) and AP-1. Our data indicate that the YAP/TAZ signaling pathway may be a target to control adipocyte cell death and compensatory adipogenesis during obesity. More... »

PAGES

5455

References to SciGraph publications

  • 2013-03-30. YAP-mediated regulation of the chondrogenic phenotype in response to matrix elasticity in JOURNAL OF MOLECULAR HISTOLOGY
  • 2004-02-10. TNFα release by the nonfat cells of human adipose tissue in INTERNATIONAL JOURNAL OF OBESITY
  • 2015-03-02. Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity in NATURE CELL BIOLOGY
  • 2013-09-01. Tracking adipogenesis during white adipose tissue development, expansion and regeneration in NATURE MEDICINE
  • 2006-12-13. Adipocytes as regulators of energy balance and glucose homeostasis in NATURE
  • 2016-04-11. Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity in NATURE CELL BIOLOGY
  • 2014-12-05. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2019-01-04. Adipogenesis and metabolic health in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2019-02-27. Obesity: global epidemiology and pathogenesis in NATURE REVIEWS ENDOCRINOLOGY
  • 2011-06-08. Role of YAP/TAZ in mechanotransduction in NATURE
  • 2017-09-27. Mechanobiology of YAP and TAZ in physiology and disease in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-08-10. Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth in NATURE CELL BIOLOGY
  • 2011-09-28. Forming functional fat: a growing understanding of adipocyte differentiation in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2018-07-26. YAP/TAZ upstream signals and downstream responses in NATURE CELL BIOLOGY
  • 2017-08-11. Adapting to obesity with adipose tissue inflammation in NATURE REVIEWS ENDOCRINOLOGY
  • 2017-06-15. Obesity in NATURE REVIEWS DISEASE PRIMERS
  • 2017-02-06. FAK signalling controls insulin sensitivity through regulation of adipocyte survival in NATURE COMMUNICATIONS
  • 2018-09-24. PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein in CELL DEATH & DISEASE
  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    11

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-020-19229-3

    DOI

    http://dx.doi.org/10.1038/s41467-020-19229-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1132060546

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33116140


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adaptor Proteins, Signal Transducing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adipocytes, White", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adipogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bcl-2-Like Protein 11", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Death", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diet, High-Fat", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Obesity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Trans-Activators", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptional Coactivator with PDZ-Binding Motif Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "YAP-Signaling Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Lei", 
            "id": "sg:person.013547275012.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013547275012.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cardiovascular Research Center, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Yanta District, Xi\u2019an, China", 
              "id": "http://www.grid.ac/institutes/grid.43169.39", 
              "name": [
                "Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany", 
                "Cardiovascular Research Center, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Yanta District, Xi\u2019an, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "ShengPeng", 
            "id": "sg:person.01115661641.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115661641.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cardiovascular Research Center, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Yanta District, Xi\u2019an, China", 
              "id": "http://www.grid.ac/institutes/grid.43169.39", 
              "name": [
                "Cardiovascular Research Center, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Yanta District, Xi\u2019an, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shi", 
            "givenName": "Yue", 
            "id": "sg:person.07416741771.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07416741771.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Rui", 
            "id": "sg:person.01111125263.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111125263.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "G\u00fcnther", 
            "givenName": "Stefan", 
            "id": "sg:person.0625433476.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625433476.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ong", 
            "givenName": "Yu Ting", 
            "id": "sg:person.01226266152.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226266152.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Potente", 
            "givenName": "Michael", 
            "id": "sg:person.01336144700.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336144700.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China", 
              "id": "http://www.grid.ac/institutes/grid.452438.c", 
              "name": [
                "Department of Cardiology, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yuan", 
            "givenName": "Zuyi", 
            "id": "sg:person.01010246732.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010246732.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory Animal Center, Xi\u2019an Jiaotong University Health Science Center Xi\u2019an Jiaotong University, Xi\u2019an, China", 
              "id": "http://www.grid.ac/institutes/grid.43169.39", 
              "name": [
                "Laboratory Animal Center, Xi\u2019an Jiaotong University Health Science Center Xi\u2019an Jiaotong University, Xi\u2019an, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Enqi", 
            "id": "sg:person.016446245112.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016446245112.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Molecular Medicine, Medical Faculty, Goethe University, 60590, Frankfurt am Main, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany", 
                "Center for Molecular Medicine, Medical Faculty, Goethe University, 60590, Frankfurt am Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Offermanns", 
            "givenName": "Stefan", 
            "id": "sg:person.01061047340.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061047340.49"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ncomms14360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083685768", 
              "https://doi.org/10.1038/ncomms14360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022417218", 
              "https://doi.org/10.1038/ncb3216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrendo.2017.90", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091159330", 
              "https://doi.org/10.1038/nrendo.2017.90"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41419-018-1005-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107216354", 
              "https://doi.org/10.1038/s41419-018-1005-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0802594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042544929", 
              "https://doi.org/10.1038/sj.ijo.0802594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009900316", 
              "https://doi.org/10.1038/ncb3122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003794730", 
              "https://doi.org/10.1038/nature05483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028063527", 
              "https://doi.org/10.1038/nature10137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024600139", 
              "https://doi.org/10.1038/nrm3198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41580-018-0093-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111099512", 
              "https://doi.org/10.1038/s41580-018-0093-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10735-013-9502-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041819020", 
              "https://doi.org/10.1007/s10735-013-9502-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrdp.2017.34", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086031448", 
              "https://doi.org/10.1038/nrdp.2017.34"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008947444", 
              "https://doi.org/10.1038/nm.3324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015003077", 
              "https://doi.org/10.1038/ncb3336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41574-019-0176-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112395586", 
              "https://doi.org/10.1038/s41574-019-0176-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41556-018-0142-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105714124", 
              "https://doi.org/10.1038/s41556-018-0142-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2017.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091927971", 
              "https://doi.org/10.1038/nrm.2017.87"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-10-28", 
        "datePublishedReg": "2020-10-28", 
        "description": "The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ target genes become activated during obesity. When fed a high-fat diet (HFD), mice lacking YAP/TAZ in white adipocytes develop severe lipodystrophy with adipocyte cell death. The pro-apoptotic factor BIM, which is downregulated in adipocytes of obese mice and humans, is strongly upregulated in YAP/TAZ-deficient adipocytes under HFD, and suppression of BIM expression reduces adipocyte apoptosis. In differentiated adipocytes, TNF\u03b1 and IL-1\u03b2 promote YAP/TAZ nuclear translocation via activation of RhoA-mediated actomyosin contractility and increase YAP/TAZ-mediated transcriptional regulation by activation of c-Jun N-terminal kinase (JNK) and AP-1. Our data indicate that the YAP/TAZ signaling pathway may be a target to control adipocyte cell death and compensatory adipogenesis during obesity.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41467-020-19229-3", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8876755", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7506739", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "keywords": [
          "YAP/TAZ", 
          "adipocyte cell death", 
          "high-fat diet", 
          "cell death", 
          "YAP/TAZ target genes", 
          "transcriptional co-activators YAP/TAZ", 
          "white adipose tissue", 
          "YAP/TAZ nuclear translocation", 
          "TAZ target genes", 
          "pro-apoptotic factor Bim", 
          "c-Jun N-terminal kinase", 
          "N-terminal kinase", 
          "activation of RhoA", 
          "transcriptional regulation", 
          "actomyosin contractility", 
          "target genes", 
          "Bim expression", 
          "TAZ", 
          "AP-1", 
          "mouse adipocytes", 
          "nuclear translocation", 
          "differentiated adipocytes", 
          "severe lipodystrophy", 
          "obese mice", 
          "IL-1\u03b2", 
          "inflammatory stress", 
          "adipocyte apoptosis", 
          "adipose tissue", 
          "white adipocytes", 
          "obesity", 
          "adipocytes", 
          "death", 
          "mice", 
          "activation", 
          "kinase", 
          "RhoA", 
          "genes", 
          "YAP", 
          "adipogenesis", 
          "translocation", 
          "apoptosis", 
          "regulation", 
          "pathway", 
          "humans", 
          "lipodystrophy", 
          "TNF\u03b1", 
          "contractility", 
          "stress", 
          "expression", 
          "diet", 
          "tissue", 
          "target", 
          "BIM", 
          "suppression", 
          "expansion", 
          "data"
        ], 
        "name": "YAP and TAZ protect against white adipocyte cell death during obesity", 
        "pagination": "5455", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1132060546"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-020-19229-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "33116140"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-020-19229-3", 
          "https://app.dimensions.ai/details/publication/pub.1132060546"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:47", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_875.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41467-020-19229-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-19229-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-19229-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-19229-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-020-19229-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    352 TRIPLES      21 PREDICATES      119 URIs      93 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-020-19229-3 schema:about N101f714d08b74d8a805cc2375601e8a8
    2 N20af8bcce7d845078468d3fea9dacf69
    3 N22f4bc6526c14411ac71fabc0c710a68
    4 N2b7d04d20342432db15687d95452d1ae
    5 N333656e5dc064a6d8f713f88af144245
    6 N41e43470a150429085b993e1f7420f8b
    7 N44b4235ac9a14d0e9c933d3c585421a7
    8 N58803b11b520444bbbdc346eb685c013
    9 N5ea3b42d1bb844878d12be9aa3a5f7b3
    10 N646ceaa4f96748f3aa3a4cafae78d033
    11 N6c3e83ab46c242efa56bc590cd857374
    12 N6df88f7bb50d43bdaaef5ba8249167f4
    13 N7aaa6d619cf14c56b378b0371e5507a5
    14 N8731775dc0134ca38d3629407bddf894
    15 N8a341f68ba7e4039ad174d5cf0f9bd5a
    16 Na2dbbb5dc2fc421290ae41d4c1da7438
    17 Nb53bb9f49a54468fbc461531bb4224b4
    18 Nc889043ef3634f8e89d01aab88d57235
    19 Ne4e5ee3ee9d34b61bd5194fedff74f19
    20 Nebe2fe5c9ec446f4bf1eca1abcd18beb
    21 anzsrc-for:06
    22 anzsrc-for:0601
    23 schema:author N2575f610c032484fa4de9a425c8ceb17
    24 schema:citation sg:pub.10.1007/s10735-013-9502-y
    25 sg:pub.10.1038/nature05483
    26 sg:pub.10.1038/nature10137
    27 sg:pub.10.1038/ncb3122
    28 sg:pub.10.1038/ncb3216
    29 sg:pub.10.1038/ncb3336
    30 sg:pub.10.1038/ncomms14360
    31 sg:pub.10.1038/nm.3324
    32 sg:pub.10.1038/nrdp.2017.34
    33 sg:pub.10.1038/nrendo.2017.90
    34 sg:pub.10.1038/nrm.2017.87
    35 sg:pub.10.1038/nrm3198
    36 sg:pub.10.1038/s41419-018-1005-z
    37 sg:pub.10.1038/s41556-018-0142-z
    38 sg:pub.10.1038/s41574-019-0176-8
    39 sg:pub.10.1038/s41580-018-0093-z
    40 sg:pub.10.1038/sj.ijo.0802594
    41 sg:pub.10.1186/s13059-014-0550-8
    42 schema:datePublished 2020-10-28
    43 schema:datePublishedReg 2020-10-28
    44 schema:description The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ target genes become activated during obesity. When fed a high-fat diet (HFD), mice lacking YAP/TAZ in white adipocytes develop severe lipodystrophy with adipocyte cell death. The pro-apoptotic factor BIM, which is downregulated in adipocytes of obese mice and humans, is strongly upregulated in YAP/TAZ-deficient adipocytes under HFD, and suppression of BIM expression reduces adipocyte apoptosis. In differentiated adipocytes, TNFα and IL-1β promote YAP/TAZ nuclear translocation via activation of RhoA-mediated actomyosin contractility and increase YAP/TAZ-mediated transcriptional regulation by activation of c-Jun N-terminal kinase (JNK) and AP-1. Our data indicate that the YAP/TAZ signaling pathway may be a target to control adipocyte cell death and compensatory adipogenesis during obesity.
    45 schema:genre article
    46 schema:isAccessibleForFree true
    47 schema:isPartOf N93f1997cf3f541d6942eb845fe7caa4f
    48 N9faf56c0f8fc4bfb937aeb15a1a9247e
    49 sg:journal.1043282
    50 schema:keywords AP-1
    51 BIM
    52 Bim expression
    53 IL-1β
    54 N-terminal kinase
    55 RhoA
    56 TAZ
    57 TAZ target genes
    58 TNFα
    59 YAP
    60 YAP/TAZ
    61 YAP/TAZ nuclear translocation
    62 YAP/TAZ target genes
    63 activation
    64 activation of RhoA
    65 actomyosin contractility
    66 adipocyte apoptosis
    67 adipocyte cell death
    68 adipocytes
    69 adipogenesis
    70 adipose tissue
    71 apoptosis
    72 c-Jun N-terminal kinase
    73 cell death
    74 contractility
    75 data
    76 death
    77 diet
    78 differentiated adipocytes
    79 expansion
    80 expression
    81 genes
    82 high-fat diet
    83 humans
    84 inflammatory stress
    85 kinase
    86 lipodystrophy
    87 mice
    88 mouse adipocytes
    89 nuclear translocation
    90 obese mice
    91 obesity
    92 pathway
    93 pro-apoptotic factor Bim
    94 regulation
    95 severe lipodystrophy
    96 stress
    97 suppression
    98 target
    99 target genes
    100 tissue
    101 transcriptional co-activators YAP/TAZ
    102 transcriptional regulation
    103 translocation
    104 white adipocytes
    105 white adipose tissue
    106 schema:name YAP and TAZ protect against white adipocyte cell death during obesity
    107 schema:pagination 5455
    108 schema:productId N90597a7e0f3842c5b78397688929bf74
    109 N95ea1f2466ef420596372a404461da0e
    110 Nb5dd27b283b04c788b5bf747b21b922a
    111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132060546
    112 https://doi.org/10.1038/s41467-020-19229-3
    113 schema:sdDatePublished 2022-10-01T06:47
    114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    115 schema:sdPublisher Naa5e2b2a120e4e83841d5a53f0d00f48
    116 schema:url https://doi.org/10.1038/s41467-020-19229-3
    117 sgo:license sg:explorer/license/
    118 sgo:sdDataset articles
    119 rdf:type schema:ScholarlyArticle
    120 N101f714d08b74d8a805cc2375601e8a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Humans
    122 rdf:type schema:DefinedTerm
    123 N17bb135bb0b9453fb797d19ffb2fa126 rdf:first sg:person.01061047340.49
    124 rdf:rest rdf:nil
    125 N1c612ed173784622a4145e26184b7aa2 rdf:first sg:person.01111125263.24
    126 rdf:rest Ne79b6f1c27cd40c08a9c448b8298c5d0
    127 N20af8bcce7d845078468d3fea9dacf69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Mice, Inbred C57BL
    129 rdf:type schema:DefinedTerm
    130 N22f4bc6526c14411ac71fabc0c710a68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name YAP-Signaling Proteins
    132 rdf:type schema:DefinedTerm
    133 N2575f610c032484fa4de9a425c8ceb17 rdf:first sg:person.013547275012.14
    134 rdf:rest N9903e175bb824f079976049b8ebd9ae5
    135 N2b7d04d20342432db15687d95452d1ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Adipogenesis
    137 rdf:type schema:DefinedTerm
    138 N333656e5dc064a6d8f713f88af144245 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Transcription Factors
    140 rdf:type schema:DefinedTerm
    141 N406f11c75c384a7490dd6e61fa605cab rdf:first sg:person.016446245112.43
    142 rdf:rest N17bb135bb0b9453fb797d19ffb2fa126
    143 N41e43470a150429085b993e1f7420f8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Diet, High-Fat
    145 rdf:type schema:DefinedTerm
    146 N44b4235ac9a14d0e9c933d3c585421a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Transcriptional Coactivator with PDZ-Binding Motif Proteins
    148 rdf:type schema:DefinedTerm
    149 N58803b11b520444bbbdc346eb685c013 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Cell Cycle Proteins
    151 rdf:type schema:DefinedTerm
    152 N5ea3b42d1bb844878d12be9aa3a5f7b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Animals
    154 rdf:type schema:DefinedTerm
    155 N63f80cb74de1491794874752a8bc5bde rdf:first sg:person.01226266152.74
    156 rdf:rest Nec5cac5e878b44f4ae943eaa464335ad
    157 N646ceaa4f96748f3aa3a4cafae78d033 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Adipocytes, White
    159 rdf:type schema:DefinedTerm
    160 N6c3e83ab46c242efa56bc590cd857374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Cell Death
    162 rdf:type schema:DefinedTerm
    163 N6df88f7bb50d43bdaaef5ba8249167f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Mice
    165 rdf:type schema:DefinedTerm
    166 N7aaa6d619cf14c56b378b0371e5507a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Obesity
    168 rdf:type schema:DefinedTerm
    169 N8731775dc0134ca38d3629407bddf894 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Mice, Knockout
    171 rdf:type schema:DefinedTerm
    172 N8a341f68ba7e4039ad174d5cf0f9bd5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Bcl-2-Like Protein 11
    174 rdf:type schema:DefinedTerm
    175 N90597a7e0f3842c5b78397688929bf74 schema:name dimensions_id
    176 schema:value pub.1132060546
    177 rdf:type schema:PropertyValue
    178 N93f1997cf3f541d6942eb845fe7caa4f schema:volumeNumber 11
    179 rdf:type schema:PublicationVolume
    180 N95ea1f2466ef420596372a404461da0e schema:name doi
    181 schema:value 10.1038/s41467-020-19229-3
    182 rdf:type schema:PropertyValue
    183 N9903e175bb824f079976049b8ebd9ae5 rdf:first sg:person.01115661641.77
    184 rdf:rest Na20afb56288549f683f2e11c81d67daa
    185 N9faf56c0f8fc4bfb937aeb15a1a9247e schema:issueNumber 1
    186 rdf:type schema:PublicationIssue
    187 Na20afb56288549f683f2e11c81d67daa rdf:first sg:person.07416741771.09
    188 rdf:rest N1c612ed173784622a4145e26184b7aa2
    189 Na2dbbb5dc2fc421290ae41d4c1da7438 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Trans-Activators
    191 rdf:type schema:DefinedTerm
    192 Na8dfd335c3944a6c8897cc3d781c1749 rdf:first sg:person.01010246732.43
    193 rdf:rest N406f11c75c384a7490dd6e61fa605cab
    194 Naa5e2b2a120e4e83841d5a53f0d00f48 schema:name Springer Nature - SN SciGraph project
    195 rdf:type schema:Organization
    196 Nb53bb9f49a54468fbc461531bb4224b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Disease Models, Animal
    198 rdf:type schema:DefinedTerm
    199 Nb5dd27b283b04c788b5bf747b21b922a schema:name pubmed_id
    200 schema:value 33116140
    201 rdf:type schema:PropertyValue
    202 Nc889043ef3634f8e89d01aab88d57235 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Cells, Cultured
    204 rdf:type schema:DefinedTerm
    205 Ne4e5ee3ee9d34b61bd5194fedff74f19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Adaptor Proteins, Signal Transducing
    207 rdf:type schema:DefinedTerm
    208 Ne79b6f1c27cd40c08a9c448b8298c5d0 rdf:first sg:person.0625433476.37
    209 rdf:rest N63f80cb74de1491794874752a8bc5bde
    210 Nebe2fe5c9ec446f4bf1eca1abcd18beb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Gene Expression Regulation
    212 rdf:type schema:DefinedTerm
    213 Nec5cac5e878b44f4ae943eaa464335ad rdf:first sg:person.01336144700.82
    214 rdf:rest Na8dfd335c3944a6c8897cc3d781c1749
    215 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Biological Sciences
    217 rdf:type schema:DefinedTerm
    218 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    219 schema:name Biochemistry and Cell Biology
    220 rdf:type schema:DefinedTerm
    221 sg:grant.7506739 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-020-19229-3
    222 rdf:type schema:MonetaryGrant
    223 sg:grant.8876755 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-020-19229-3
    224 rdf:type schema:MonetaryGrant
    225 sg:journal.1043282 schema:issn 2041-1723
    226 schema:name Nature Communications
    227 schema:publisher Springer Nature
    228 rdf:type schema:Periodical
    229 sg:person.01010246732.43 schema:affiliation grid-institutes:grid.452438.c
    230 schema:familyName Yuan
    231 schema:givenName Zuyi
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010246732.43
    233 rdf:type schema:Person
    234 sg:person.01061047340.49 schema:affiliation grid-institutes:grid.7839.5
    235 schema:familyName Offermanns
    236 schema:givenName Stefan
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061047340.49
    238 rdf:type schema:Person
    239 sg:person.01111125263.24 schema:affiliation grid-institutes:grid.418032.c
    240 schema:familyName Li
    241 schema:givenName Rui
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111125263.24
    243 rdf:type schema:Person
    244 sg:person.01115661641.77 schema:affiliation grid-institutes:grid.43169.39
    245 schema:familyName Wang
    246 schema:givenName ShengPeng
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115661641.77
    248 rdf:type schema:Person
    249 sg:person.01226266152.74 schema:affiliation grid-institutes:grid.418032.c
    250 schema:familyName Ong
    251 schema:givenName Yu Ting
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226266152.74
    253 rdf:type schema:Person
    254 sg:person.01336144700.82 schema:affiliation grid-institutes:grid.418032.c
    255 schema:familyName Potente
    256 schema:givenName Michael
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336144700.82
    258 rdf:type schema:Person
    259 sg:person.013547275012.14 schema:affiliation grid-institutes:grid.418032.c
    260 schema:familyName Wang
    261 schema:givenName Lei
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013547275012.14
    263 rdf:type schema:Person
    264 sg:person.016446245112.43 schema:affiliation grid-institutes:grid.43169.39
    265 schema:familyName Liu
    266 schema:givenName Enqi
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016446245112.43
    268 rdf:type schema:Person
    269 sg:person.0625433476.37 schema:affiliation grid-institutes:grid.418032.c
    270 schema:familyName Günther
    271 schema:givenName Stefan
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625433476.37
    273 rdf:type schema:Person
    274 sg:person.07416741771.09 schema:affiliation grid-institutes:grid.43169.39
    275 schema:familyName Shi
    276 schema:givenName Yue
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07416741771.09
    278 rdf:type schema:Person
    279 sg:pub.10.1007/s10735-013-9502-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1041819020
    280 https://doi.org/10.1007/s10735-013-9502-y
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/nature05483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003794730
    283 https://doi.org/10.1038/nature05483
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/nature10137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028063527
    286 https://doi.org/10.1038/nature10137
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/ncb3122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009900316
    289 https://doi.org/10.1038/ncb3122
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/ncb3216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022417218
    292 https://doi.org/10.1038/ncb3216
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/ncb3336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015003077
    295 https://doi.org/10.1038/ncb3336
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/ncomms14360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083685768
    298 https://doi.org/10.1038/ncomms14360
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/nm.3324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008947444
    301 https://doi.org/10.1038/nm.3324
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/nrdp.2017.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086031448
    304 https://doi.org/10.1038/nrdp.2017.34
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/nrendo.2017.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091159330
    307 https://doi.org/10.1038/nrendo.2017.90
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/nrm.2017.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091927971
    310 https://doi.org/10.1038/nrm.2017.87
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/nrm3198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024600139
    313 https://doi.org/10.1038/nrm3198
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/s41419-018-1005-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1107216354
    316 https://doi.org/10.1038/s41419-018-1005-z
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/s41556-018-0142-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1105714124
    319 https://doi.org/10.1038/s41556-018-0142-z
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/s41574-019-0176-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112395586
    322 https://doi.org/10.1038/s41574-019-0176-8
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/s41580-018-0093-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1111099512
    325 https://doi.org/10.1038/s41580-018-0093-z
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/sj.ijo.0802594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042544929
    328 https://doi.org/10.1038/sj.ijo.0802594
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
    331 https://doi.org/10.1186/s13059-014-0550-8
    332 rdf:type schema:CreativeWork
    333 grid-institutes:grid.418032.c schema:alternateName Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany
    334 Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany
    335 Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany
    336 schema:name Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany
    337 Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany
    338 Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany
    339 rdf:type schema:Organization
    340 grid-institutes:grid.43169.39 schema:alternateName Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Yanta District, Xi’an, China
    341 Laboratory Animal Center, Xi’an Jiaotong University Health Science Center Xi’an Jiaotong University, Xi’an, China
    342 schema:name Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Yanta District, Xi’an, China
    343 Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany
    344 Laboratory Animal Center, Xi’an Jiaotong University Health Science Center Xi’an Jiaotong University, Xi’an, China
    345 rdf:type schema:Organization
    346 grid-institutes:grid.452438.c schema:alternateName Department of Cardiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
    347 schema:name Department of Cardiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
    348 rdf:type schema:Organization
    349 grid-institutes:grid.7839.5 schema:alternateName Center for Molecular Medicine, Medical Faculty, Goethe University, 60590, Frankfurt am Main, Germany
    350 schema:name Center for Molecular Medicine, Medical Faculty, Goethe University, 60590, Frankfurt am Main, Germany
    351 Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany
    352 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...