Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD View Full Text


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Article Info

DATE

2020-10-05

AUTHORS

Giljae Lee, Hyun Ju You, Jasmohan S. Bajaj, Sae Kyung Joo, Junsun Yu, Seoyeon Park, Hyena Kang, Jeong Hwan Park, Jung Ho Kim, Dong Hyeon Lee, Seonhwa Lee, Won Kim, GwangPyo Ko

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or fibrosis severity. Significant alterations in microbiome diversity are observed according to fibrosis severity in non-obese, but not obese, subjects. Ruminococcaceae and Veillonellaceae are the main microbiota associated with fibrosis severity in non-obese subjects. Furthermore, stool bile acids and propionate are elevated, especially in non-obese subjects with significant fibrosis. Fibrosis-related Ruminococcaceae and Veillonellaceae species undergo metagenome sequencing, and four representative species are administered in three mouse NAFLD models to evaluate their effects on liver damage. This study provides the evidence for the role of the microbiome in the liver fibrosis pathogenesis, especially in non-obese subjects. More... »

PAGES

4982

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/s41467-020-18754-5

    DOI

    http://dx.doi.org/10.1038/s41467-020-18754-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1131430064

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33020474


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    350 Department of Pathology, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, 07061 Republic of Korea
    351 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, 07061 Republic of Korea
    352 Institute of Health and Environment, Seoul National University, Seoul, 08826 Republic of Korea
    353 KoBioLabs, Inc., Seoul, 08826 Republic of Korea
    354 rdf:type schema:Organization
    355 grid-institutes:grid.413640.4 schema:alternateName Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249 USA
    356 schema:name Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249 USA
    357 rdf:type schema:Organization
     




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