Strength of immune selection in tumors varies with sex and age View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-08-17

AUTHORS

Andrea Castro, Rachel Marty Pyke, Xinlian Zhang, Wesley Kurt Thompson, Chi-Ping Day, Ludmil B. Alexandrov, Maurizio Zanetti, Hannah Carter

ABSTRACT

Individual MHC genotype constrains the mutational landscape during tumorigenesis. Immune checkpoint inhibition reactivates immunity against tumors that escaped immune surveillance in approximately 30% of cases. Recent studies demonstrated poorer response rates in female and younger patients. Although immune responses differ with sex and age, the role of MHC-based immune selection in this context is unknown. We find that tumors in younger and female individuals accumulate more poorly presented driver mutations than those in older and male patients, despite no differences in MHC genotype. Younger patients show the strongest effects of MHC-based driver mutation selection, with younger females showing compounded effects and nearly twice as much MHC-II based selection. This study presents evidence that strength of immune selection during tumor development varies with sex and age, and may influence the availability of mutant peptides capable of driving effective response to immune checkpoint inhibitor therapy. More... »

PAGES

4128

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-020-17981-0

DOI

http://dx.doi.org/10.1038/s41467-020-17981-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1130147157

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32807809


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