Ontology type: schema:ScholarlyArticle Open Access: True
2020-02-20
AUTHORSRuizi Peng, Liujun Xu, Huijing Wang, Yifan Lyu, Dan Wang, Cheng Bi, Cheng Cui, Chunhai Fan, Qiaoling Liu, Xiaobing Zhang, Weihong Tan
ABSTRACTIn order to maintain tissue homeostasis, cells communicate with the outside environment by receiving molecular signals, transmitting them, and responding accordingly with signaling pathways. Thus, one key challenge in engineering molecular signaling systems involves the design and construction of different modules into a rationally integrated system that mimics the cascade of molecular events. Herein, we rationally design a DNA-based artificial molecular signaling system that uses the confined microenvironment of a giant vesicle, derived from a living cell. This system consists of two main components. First, we build an adenosine triphosphate (ATP)-driven DNA nanogatekeeper. Second, we encapsulate a signaling network in the biomimetic vesicle, consisting of distinct modules, able to sequentially initiate a series of downstream reactions playing the roles of reception, transduction and response. Operationally, in the presence of ATP, nanogatekeeper switches from the closed to open state. The open state then triggers the sequential activation of confined downstream signaling modules. More... »
PAGES978
http://scigraph.springernature.com/pub.10.1038/s41467-020-14739-6
DOIhttp://dx.doi.org/10.1038/s41467-020-14739-6
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