DNA-based artificial molecular signaling system that mimics basic elements of reception and response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-02-20

AUTHORS

Ruizi Peng, Liujun Xu, Huijing Wang, Yifan Lyu, Dan Wang, Cheng Bi, Cheng Cui, Chunhai Fan, Qiaoling Liu, Xiaobing Zhang, Weihong Tan

ABSTRACT

In order to maintain tissue homeostasis, cells communicate with the outside environment by receiving molecular signals, transmitting them, and responding accordingly with signaling pathways. Thus, one key challenge in engineering molecular signaling systems involves the design and construction of different modules into a rationally integrated system that mimics the cascade of molecular events. Herein, we rationally design a DNA-based artificial molecular signaling system that uses the confined microenvironment of a giant vesicle, derived from a living cell. This system consists of two main components. First, we build an adenosine triphosphate (ATP)-driven DNA nanogatekeeper. Second, we encapsulate a signaling network in the biomimetic vesicle, consisting of distinct modules, able to sequentially initiate a series of downstream reactions playing the roles of reception, transduction and response. Operationally, in the presence of ATP, nanogatekeeper switches from the closed to open state. The open state then triggers the sequential activation of confined downstream signaling modules. More... »

PAGES

978

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-020-14739-6

DOI

http://dx.doi.org/10.1038/s41467-020-14739-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1125026792

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32080196


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26 schema:description In order to maintain tissue homeostasis, cells communicate with the outside environment by receiving molecular signals, transmitting them, and responding accordingly with signaling pathways. Thus, one key challenge in engineering molecular signaling systems involves the design and construction of different modules into a rationally integrated system that mimics the cascade of molecular events. Herein, we rationally design a DNA-based artificial molecular signaling system that uses the confined microenvironment of a giant vesicle, derived from a living cell. This system consists of two main components. First, we build an adenosine triphosphate (ATP)-driven DNA nanogatekeeper. Second, we encapsulate a signaling network in the biomimetic vesicle, consisting of distinct modules, able to sequentially initiate a series of downstream reactions playing the roles of reception, transduction and response. Operationally, in the presence of ATP, nanogatekeeper switches from the closed to open state. The open state then triggers the sequential activation of confined downstream signaling modules.
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33 Herein
34 activation
35 adenosine triphosphate
36 basic elements
37 biomimetic vesicles
38 cascade
39 cells
40 challenges
41 components
42 confined microenvironment
43 construction
44 design
45 different modules
46 distinct modules
47 downstream reactions
48 elements
49 environment
50 events
51 giant vesicles
52 homeostasis
53 key challenges
54 living cells
55 main components
56 microenvironment
57 module
58 molecular events
59 molecular signaling systems
60 molecular signals
61 network
62 open state
63 order
64 outside environment
65 pathway
66 presence
67 presence of ATP
68 reaction
69 reception
70 response
71 role
72 role of reception
73 sequential activation
74 series
75 signaling system
76 signals
77 state
78 switch
79 system
80 tissue homeostasis
81 transduction
82 triphosphate
83 vesicles
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