Impact of commonly used drugs on the composition and metabolic function of the gut microbiota View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-01-17

AUTHORS

Arnau Vich Vila, Valerie Collij, Serena Sanna, Trishla Sinha, Floris Imhann, Arno R. Bourgonje, Zlatan Mujagic, Daisy M. A. E. Jonkers, Ad A. M. Masclee, Jingyuan Fu, Alexander Kurilshikov, Cisca Wijmenga, Alexandra Zhernakova, Rinse K. Weersma

ABSTRACT

The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. However, drug–microbe interactions are still understudied in the clinical context, where polypharmacy and comorbidities co-occur. Here, we report relations between commonly used drugs and the gut microbiome. We performed metagenomics sequencing of faecal samples from a population cohort and two gastrointestinal disease cohorts. Differences between users and non-users were analysed per cohort, followed by a meta-analysis. While 19 of 41 drugs are found to be associated with microbial features, when controlling for the use of multiple medications, proton-pump inhibitors, metformin, antibiotics and laxatives show the strongest associations with the microbiome. We here provide evidence for extensive changes in taxonomy, metabolic potential and resistome in relation to commonly used drugs. This paves the way for future studies and has implications for current microbiome studies by demonstrating the need to correct for multiple drug use. More... »

PAGES

362

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-14177-z

    DOI

    http://dx.doi.org/10.1038/s41467-019-14177-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1124147887

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31953381


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    357 grid-institutes:grid.4494.d schema:alternateName Dept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    358 Dept. of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    359 schema:name Dept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    360 Dept. of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    361 rdf:type schema:Organization
     




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