The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-11-05

AUTHORS

Pei Y. Liu, Andrew E. Tee, Giorgio Milazzo, Katherine M. Hannan, Jesper Maag, Sujanna Mondal, Bernard Atmadibrata, Nenad Bartonicek, Hui Peng, Nicholas Ho, Chelsea Mayoh, Roberto Ciaccio, Yuting Sun, Michelle J. Henderson, Jixuan Gao, Celine Everaert, Amy J. Hulme, Matthew Wong, Qing Lan, Belamy B. Cheung, Leming Shi, Jenny Y. Wang, Thorsten Simon, Matthias Fischer, Xu D. Zhang, Glenn M. Marshall, Murray D. Norris, Michelle Haber, Jo Vandesompele, Jinyan Li, Pieter Mestdagh, Ross D. Hannan, Marcel E. Dinger, Giovanni Perini, Tao Liu

ABSTRACT

The majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression die of the disease. Here our analyses of RNA sequencing data identify the long noncoding RNA lncNB1 as one of the transcripts most over-expressed in MYCN-amplified, compared with MYCN-non-amplified, human neuroblastoma cells and also the most over-expressed in neuroblastoma compared with all other cancers. lncNB1 binds to the ribosomal protein RPL35 to enhance E2F1 protein synthesis, leading to DEPDC1B gene transcription. The GTPase-activating protein DEPDC1B induces ERK protein phosphorylation and N-Myc protein stabilization. Importantly, lncNB1 knockdown abolishes neuroblastoma cell clonogenic capacity in vitro and leads to neuroblastoma tumor regression in mice, while high levels of lncNB1 and RPL35 in human neuroblastoma tissues predict poor patient prognosis. This study therefore identifies lncNB1 and its binding protein RPL35 as key factors for promoting E2F1 protein synthesis, N-Myc protein stability and N-Myc-driven oncogenesis, and as therapeutic targets. More... »

PAGES

5026

References to SciGraph publications

  • 2011-03-20. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression in NATURE
  • 2015-06-25. Comparison of RNA-seq and microarray-based models for clinical endpoint prediction in GENOME BIOLOGY
  • 2017-11-29. A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer in SCIENTIFIC REPORTS
  • 2014-08-05. A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-independent growth in oral cancer cells that is mediated by Rac1 and ERK in JOURNAL OF BIOMEDICAL SCIENCE
  • 2016-03-23. Melanoma addiction to the long non-coding RNA SAMMSON in NATURE
  • 2019-07-25. JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma in NATURE COMMUNICATIONS
  • 2010-01-25. Myc proteins as therapeutic targets in ONCOGENE
  • 2010-04. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis in NATURE
  • 2013-02-17. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription in NATURE
  • 2009-03-22. SUnSET, a nonradioactive method to monitor protein synthesis in NATURE METHODS
  • 2014-10-09. Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL in SCIENTIFIC REPORTS
  • 2014-11-19. RNA regulons in Hox 5′ UTRs confer ribosome specificity to gene regulation in NATURE
  • 2008-06-05. Analyzing real-time PCR data by the comparative CT method in NATURE PROTOCOLS
  • 2013-01-20. The genetic landscape of high-risk neuroblastoma in NATURE GENETICS
  • 2017-03-28. Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines in SCIENTIFIC DATA
  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    10

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-12971-3

    DOI

    http://dx.doi.org/10.1038/s41467-019-12971-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1122311439

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31690716


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