Intestinal microbiome composition and its relation to joint pain and inflammation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-10-25

AUTHORS

Cindy G. Boer, Djawad Radjabzadeh, Carolina Medina-Gomez, Sanzhima Garmaeva, Dieuwke Schiphof, Pascal Arp, Thomas Koet, Alexander Kurilshikov, Jingyuan Fu, M. Arfan Ikram, Sita Bierma-Zeinstra, André G. Uitterlinden, Robert Kraaij, Alexandra Zhernakova, Joyce B. J. van Meurs

ABSTRACT

Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain. More... »

PAGES

4881

References to SciGraph publications

  • 2008-11-30. A core gut microbiome in obese and lean twins in NATURE
  • 2015-05-15. Immune modulation by bacterial outer membrane vesicles in NATURE REVIEWS IMMUNOLOGY
  • 2015-12-09. The microbiome quality control project: baseline study design and future directions in GENOME BIOLOGY
  • 2012-09-26. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment in GENOME BIOLOGY
  • 2016-04-01. Association between biomarkers of tissue inflammation and progression of osteoarthritis: evidence from the Rotterdam study cohort in ARTHRITIS RESEARCH & THERAPY
  • 2013-08-18. UPARSE: highly accurate OTU sequences from microbial amplicon reads in NATURE METHODS
  • 2015-09-01. Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi in NATURE REVIEWS MICROBIOLOGY
  • 2014-02-24. An improved dual-indexing approach for multiplexed 16S rRNA gene sequencing on the Illumina MiSeq platform in MICROBIOME
  • 2015-12-10. Does lipopolysaccharide-mediated inflammation have a role in OA? in NATURE REVIEWS RHEUMATOLOGY
  • 1986-06. A preliminary evaluation of the dimensionality and clinical importance of pain and disability in osteoarthritis of the hip and knee in CLINICAL RHEUMATOLOGY
  • 2010-04-11. QIIME allows analysis of high-throughput community sequencing data in NATURE METHODS
  • 2017-09. The Rotterdam Study: 2018 update on objectives, design and main results in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2017-11-01. Quantitative microbiome profiling links gut community variation to microbial load in NATURE
  • 2013-04-09. Rheumatic Fever and Post-Group A Streptococcal Arthritis in Children in CURRENT INFECTIOUS DISEASE REPORTS
  • 2013-01-15. Revisiting the pathogenesis of rheumatic fever and carditis in NATURE REVIEWS CARDIOLOGY
  • 2018-08-27. Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-12873-4

    DOI

    http://dx.doi.org/10.1038/s41467-019-12873-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1122098268

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31653850


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