Metabolomic adaptations and correlates of survival to immune checkpoint blockade View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-09-25

AUTHORS

Haoxin Li, Kevin Bullock, Carino Gurjao, David Braun, Sachet A. Shukla, Dominick Bossé, Aly-Khan A. Lalani, Shuba Gopal, Chelsea Jin, Christine Horak, Megan Wind-Rotolo, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Eliezer M. Van Allen, Stuart L. Schreiber, F. Stephen Hodi, William R. Sellers, Levi A. Garraway, Clary B. Clish, Toni K. Choueiri, Marios Giannakis

ABSTRACT

Despite remarkable success of immune checkpoint inhibitors, the majority of cancer patients have yet to receive durable benefits. Here, in order to investigate the metabolic alterations in response to immune checkpoint blockade, we comprehensively profile serum metabolites in advanced melanoma and renal cell carcinoma patients treated with nivolumab, an antibody against programmed cell death protein 1 (PD1). We identify serum kynurenine/tryptophan ratio increases as an adaptive resistance mechanism associated with worse overall survival. This advocates for patient stratification and metabolic monitoring in immunotherapy clinical trials including those combining PD1 blockade with indoleamine 2,3-dioxygenase/tryptophan 2,3-dioxygenase (IDO/TDO) inhibitors. More... »

PAGES

4346

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-12361-9

DOI

http://dx.doi.org/10.1038/s41467-019-12361-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1121217344

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31554815


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptation, Physiological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Renal Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Everolimus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kynurenine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nivolumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Programmed Cell Death 1 Receptor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tryptophan", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
            "Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Haoxin", 
        "id": "sg:person.011200213360.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011200213360.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bullock", 
        "givenName": "Kevin", 
        "id": "sg:person.01250315201.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250315201.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gurjao", 
        "givenName": "Carino", 
        "id": "sg:person.010123454057.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010123454057.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braun", 
        "givenName": "David", 
        "id": "sg:person.015253207301.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015253207301.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shukla", 
        "givenName": "Sachet A.", 
        "id": "sg:person.01224564662.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224564662.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boss\u00e9", 
        "givenName": "Dominick", 
        "id": "sg:person.01252560751.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252560751.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lalani", 
        "givenName": "Aly-Khan A.", 
        "id": "sg:person.016444773747.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016444773747.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gopal", 
        "givenName": "Shuba", 
        "id": "sg:person.01111701200.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111701200.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol-Myers Squibb, 08540, Princeton, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.419971.3", 
          "name": [
            "Bristol-Myers Squibb, 08540, Princeton, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jin", 
        "givenName": "Chelsea", 
        "id": "sg:person.013174461616.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013174461616.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol-Myers Squibb, 08540, Princeton, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.419971.3", 
          "name": [
            "Bristol-Myers Squibb, 08540, Princeton, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horak", 
        "givenName": "Christine", 
        "id": "sg:person.0652605254.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652605254.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol-Myers Squibb, 08540, Princeton, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.419971.3", 
          "name": [
            "Bristol-Myers Squibb, 08540, Princeton, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wind-Rotolo", 
        "givenName": "Megan", 
        "id": "sg:person.0766213677.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766213677.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Signoretti", 
        "givenName": "Sabina", 
        "id": "sg:person.01011042064.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011042064.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beth Israel Deaconess Medical Center, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.239395.7", 
          "name": [
            "Beth Israel Deaconess Medical Center, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McDermott", 
        "givenName": "David F.", 
        "id": "sg:person.0656541200.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656541200.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Freeman", 
        "givenName": "Gordon J.", 
        "id": "sg:person.01134576722.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134576722.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
            "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Allen", 
        "givenName": "Eliezer M.", 
        "id": "sg:person.01274137244.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274137244.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
            "Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schreiber", 
        "givenName": "Stuart L.", 
        "id": "sg:person.01106217250.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106217250.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stephen Hodi", 
        "givenName": "F.", 
        "id": "sg:person.012666627747.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012666627747.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sellers", 
        "givenName": "William R.", 
        "id": "sg:person.01304365310.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304365310.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
            "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garraway", 
        "givenName": "Levi A.", 
        "id": "sg:person.01354065210.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354065210.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clish", 
        "givenName": "Clary B.", 
        "id": "sg:person.0764632420.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choueiri", 
        "givenName": "Toni K.", 
        "id": "sg:person.01155331400.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155331400.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
            "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giannakis", 
        "givenName": "Marios", 
        "id": "sg:person.01231141376.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231141376.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015972513", 
          "https://doi.org/10.1038/nm934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044085937", 
          "https://doi.org/10.1038/ni.3415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41591-019-0404-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1113954192", 
          "https://doi.org/10.1038/s41591-019-0404-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-09-25", 
    "datePublishedReg": "2019-09-25", 
    "description": "Despite remarkable success of immune checkpoint inhibitors, the majority of cancer patients have yet to receive durable benefits. Here, in order to investigate the metabolic alterations in response to immune checkpoint blockade, we comprehensively profile serum metabolites in advanced melanoma and renal cell carcinoma patients treated with nivolumab, an antibody against programmed cell death protein 1 (PD1). We identify serum kynurenine/tryptophan ratio increases as an adaptive resistance mechanism associated with worse overall survival. This advocates for patient stratification and metabolic monitoring in immunotherapy clinical trials including those combining PD1 blockade with\u00a0indoleamine 2,3-dioxygenase/tryptophan 2,3-dioxygenase \u00a0 (IDO/TDO) inhibitors.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41467-019-12361-9", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7825984", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438997", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440200", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7028040", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6443111", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "immune checkpoint blockade", 
      "checkpoint blockade", 
      "serum kynurenine/tryptophan ratio", 
      "kynurenine/tryptophan ratio", 
      "renal cell carcinoma patients", 
      "cell death protein 1", 
      "immunotherapy clinical trials", 
      "immune checkpoint inhibitors", 
      "cell carcinoma patients", 
      "death protein 1", 
      "worse overall survival", 
      "adaptive resistance mechanisms", 
      "correlates of survival", 
      "checkpoint inhibitors", 
      "overall survival", 
      "advanced melanoma", 
      "carcinoma patients", 
      "tryptophan ratio", 
      "cancer patients", 
      "clinical trials", 
      "serum metabolites", 
      "durable benefit", 
      "patient stratification", 
      "metabolic alterations", 
      "metabolic monitoring", 
      "protein 1", 
      "patients", 
      "blockade", 
      "metabolomic adaptation", 
      "resistance mechanisms", 
      "survival", 
      "inhibitors", 
      "nivolumab", 
      "indoleamine", 
      "melanoma", 
      "PD1", 
      "trials", 
      "antibodies", 
      "alterations", 
      "correlates", 
      "metabolites", 
      "majority", 
      "stratification", 
      "response", 
      "remarkable success", 
      "tryptophan", 
      "dioxygenase", 
      "benefits", 
      "mechanism", 
      "monitoring", 
      "ratio", 
      "success", 
      "adaptation", 
      "order"
    ], 
    "name": "Metabolomic adaptations and correlates of survival to immune checkpoint blockade", 
    "pagination": "4346", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1121217344"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-019-12361-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31554815"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-019-12361-9", 
      "https://app.dimensions.ai/details/publication/pub.1121217344"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_799.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41467-019-12361-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-12361-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-12361-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-12361-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-12361-9'


 

This table displays all metadata directly associated to this object as RDF triples.

379 TRIPLES      21 PREDICATES      101 URIs      90 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-019-12361-9 schema:about N01877b79152c48c98beac27a04ae997f
2 N026a8420046943bead978445ecb3d6e6
3 N0d7d45d8f25e450e845f60ce391ee174
4 N2de2be51b03b41d18201eb0ef73ce51f
5 N30a26c90e9614eb0b08411229a436a3e
6 N5bee0669033248c9b0eb00db230edec4
7 N62b734be55a241cb8861ba3933b7971f
8 N6f5742751af74781a4082f27f2fd15ac
9 N77951820df7e478a9a3635a9bc82d0e6
10 N95f965d5742444769374cead86d0ec6e
11 Na3b206d75ffc464a90edd8fb37c58eae
12 Nb12edcf3a0074adb8ad1f79e02e06f82
13 Nb600a9c8d2ee4bcca453b14db1e1fc01
14 Nd25e29b3555346e480ba50d5fa47dd52
15 Ne31f87beab5745479be7f90c39962880
16 Ned9bc30935a14fc687f4539654e5305e
17 Nf08bed3aae334d6a916220c2cc722d7f
18 Nf31e759cf0f247329cf2f9e690e8aabe
19 Nf3cd5ccba3ff46268f8fa30cce2c8fb5
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N8706baddac094257b07f13020ed78dc6
23 schema:citation sg:pub.10.1038/ni.3415
24 sg:pub.10.1038/nm934
25 sg:pub.10.1038/s41591-019-0404-8
26 schema:datePublished 2019-09-25
27 schema:datePublishedReg 2019-09-25
28 schema:description Despite remarkable success of immune checkpoint inhibitors, the majority of cancer patients have yet to receive durable benefits. Here, in order to investigate the metabolic alterations in response to immune checkpoint blockade, we comprehensively profile serum metabolites in advanced melanoma and renal cell carcinoma patients treated with nivolumab, an antibody against programmed cell death protein 1 (PD1). We identify serum kynurenine/tryptophan ratio increases as an adaptive resistance mechanism associated with worse overall survival. This advocates for patient stratification and metabolic monitoring in immunotherapy clinical trials including those combining PD1 blockade with indoleamine 2,3-dioxygenase/tryptophan 2,3-dioxygenase   (IDO/TDO) inhibitors.
29 schema:genre article
30 schema:isAccessibleForFree true
31 schema:isPartOf N5dac69581b1e463f8182f8fd537dfe7c
32 Na8ae6fbcd0bd4e8eaae277886dcc6392
33 sg:journal.1043282
34 schema:keywords PD1
35 adaptation
36 adaptive resistance mechanisms
37 advanced melanoma
38 alterations
39 antibodies
40 benefits
41 blockade
42 cancer patients
43 carcinoma patients
44 cell carcinoma patients
45 cell death protein 1
46 checkpoint blockade
47 checkpoint inhibitors
48 clinical trials
49 correlates
50 correlates of survival
51 death protein 1
52 dioxygenase
53 durable benefit
54 immune checkpoint blockade
55 immune checkpoint inhibitors
56 immunotherapy clinical trials
57 indoleamine
58 inhibitors
59 kynurenine/tryptophan ratio
60 majority
61 mechanism
62 melanoma
63 metabolic alterations
64 metabolic monitoring
65 metabolites
66 metabolomic adaptation
67 monitoring
68 nivolumab
69 order
70 overall survival
71 patient stratification
72 patients
73 protein 1
74 ratio
75 remarkable success
76 renal cell carcinoma patients
77 resistance mechanisms
78 response
79 serum kynurenine/tryptophan ratio
80 serum metabolites
81 stratification
82 success
83 survival
84 trials
85 tryptophan
86 tryptophan ratio
87 worse overall survival
88 schema:name Metabolomic adaptations and correlates of survival to immune checkpoint blockade
89 schema:pagination 4346
90 schema:productId N28b17926041341458bf86724af821999
91 N946810837af8447abd1192131d7dfe0e
92 N98a94903555d47cd8d7bdf384942bb58
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1121217344
94 https://doi.org/10.1038/s41467-019-12361-9
95 schema:sdDatePublished 2022-10-01T06:45
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N7dc4cf5142a94974a198301126283f8e
98 schema:url https://doi.org/10.1038/s41467-019-12361-9
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N01877b79152c48c98beac27a04ae997f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Kaplan-Meier Estimate
104 rdf:type schema:DefinedTerm
105 N026a8420046943bead978445ecb3d6e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Programmed Cell Death 1 Receptor
107 rdf:type schema:DefinedTerm
108 N029cd9c44c6e40d2b49ae623c7b9f61b rdf:first sg:person.010123454057.05
109 rdf:rest Nda7cf092e3df425faad08c03adc828a6
110 N04adc40674cf4d33a6469cbf361fa719 rdf:first sg:person.013174461616.91
111 rdf:rest Ned66f284c79b46bc87601f7ce0c23ceb
112 N06b126338bd244f4b095aee6b52e0e17 rdf:first sg:person.01011042064.79
113 rdf:rest Ne09cc4a0dd2049b885ca682e0dc2da8d
114 N0d7d45d8f25e450e845f60ce391ee174 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Melanoma
116 rdf:type schema:DefinedTerm
117 N0dd023a147454eb6942c7c2263ac381c rdf:first sg:person.01304365310.13
118 rdf:rest N54af4cbd0ca54c1c9dc4ecc328cc13eb
119 N21b541af75934daa98fd4baf4b339a17 rdf:first sg:person.01134576722.91
120 rdf:rest Na2f8fab354134f539e4ab376d9b63456
121 N28b17926041341458bf86724af821999 schema:name doi
122 schema:value 10.1038/s41467-019-12361-9
123 rdf:type schema:PropertyValue
124 N2cc400944c9e4981a8d67a1e646fb1f2 rdf:first sg:person.01111701200.23
125 rdf:rest N04adc40674cf4d33a6469cbf361fa719
126 N2de2be51b03b41d18201eb0ef73ce51f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Male
128 rdf:type schema:DefinedTerm
129 N30a26c90e9614eb0b08411229a436a3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Antineoplastic Agents
131 rdf:type schema:DefinedTerm
132 N472d25eda8bf4e4b923bcb1c11d8938d rdf:first sg:person.01231141376.51
133 rdf:rest rdf:nil
134 N4af190d30e954fd0808f8df02acb9abf rdf:first sg:person.01155331400.39
135 rdf:rest N472d25eda8bf4e4b923bcb1c11d8938d
136 N54af4cbd0ca54c1c9dc4ecc328cc13eb rdf:first sg:person.01354065210.34
137 rdf:rest Nba170feb55b0452c85a3fbffeedbbb2b
138 N56929fbf91484172b0c04351271267e9 rdf:first sg:person.016444773747.08
139 rdf:rest N2cc400944c9e4981a8d67a1e646fb1f2
140 N5bee0669033248c9b0eb00db230edec4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Aged
142 rdf:type schema:DefinedTerm
143 N5dac69581b1e463f8182f8fd537dfe7c schema:volumeNumber 10
144 rdf:type schema:PublicationVolume
145 N62b734be55a241cb8861ba3933b7971f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Middle Aged
147 rdf:type schema:DefinedTerm
148 N633568b159eb4d4f8023461a6e61322c rdf:first sg:person.01250315201.08
149 rdf:rest N029cd9c44c6e40d2b49ae623c7b9f61b
150 N64d5a79b30d543acab271e4b0094d4ee rdf:first sg:person.0766213677.21
151 rdf:rest N06b126338bd244f4b095aee6b52e0e17
152 N6762dbd5b5b545afb53706ca7fb9f30f rdf:first sg:person.01106217250.35
153 rdf:rest Nc53dde1eae7b4f1c9863fd3e0f925e62
154 N6f5742751af74781a4082f27f2fd15ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Treatment Outcome
156 rdf:type schema:DefinedTerm
157 N77951820df7e478a9a3635a9bc82d0e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Clinical Trials as Topic
159 rdf:type schema:DefinedTerm
160 N7dc4cf5142a94974a198301126283f8e schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 N8706baddac094257b07f13020ed78dc6 rdf:first sg:person.011200213360.36
163 rdf:rest N633568b159eb4d4f8023461a6e61322c
164 N946810837af8447abd1192131d7dfe0e schema:name dimensions_id
165 schema:value pub.1121217344
166 rdf:type schema:PropertyValue
167 N95f965d5742444769374cead86d0ec6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Kynurenine
169 rdf:type schema:DefinedTerm
170 N98a94903555d47cd8d7bdf384942bb58 schema:name pubmed_id
171 schema:value 31554815
172 rdf:type schema:PropertyValue
173 Na2f8fab354134f539e4ab376d9b63456 rdf:first sg:person.01274137244.17
174 rdf:rest N6762dbd5b5b545afb53706ca7fb9f30f
175 Na3b206d75ffc464a90edd8fb37c58eae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Humans
177 rdf:type schema:DefinedTerm
178 Na8ae6fbcd0bd4e8eaae277886dcc6392 schema:issueNumber 1
179 rdf:type schema:PublicationIssue
180 Nb12edcf3a0074adb8ad1f79e02e06f82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Tryptophan
182 rdf:type schema:DefinedTerm
183 Nb600a9c8d2ee4bcca453b14db1e1fc01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Adaptation, Physiological
185 rdf:type schema:DefinedTerm
186 Nb71d8145c34c45d4bfea54d890e5b80c rdf:first sg:person.01252560751.47
187 rdf:rest N56929fbf91484172b0c04351271267e9
188 Nba170feb55b0452c85a3fbffeedbbb2b rdf:first sg:person.0764632420.16
189 rdf:rest N4af190d30e954fd0808f8df02acb9abf
190 Nc53dde1eae7b4f1c9863fd3e0f925e62 rdf:first sg:person.012666627747.31
191 rdf:rest N0dd023a147454eb6942c7c2263ac381c
192 Nd25e29b3555346e480ba50d5fa47dd52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Metabolomics
194 rdf:type schema:DefinedTerm
195 Nda7cf092e3df425faad08c03adc828a6 rdf:first sg:person.015253207301.40
196 rdf:rest Nf9b99c0b0e5d4d97933b16084cea01c1
197 Ne09cc4a0dd2049b885ca682e0dc2da8d rdf:first sg:person.0656541200.82
198 rdf:rest N21b541af75934daa98fd4baf4b339a17
199 Ne31f87beab5745479be7f90c39962880 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Everolimus
201 rdf:type schema:DefinedTerm
202 Ned66f284c79b46bc87601f7ce0c23ceb rdf:first sg:person.0652605254.72
203 rdf:rest N64d5a79b30d543acab271e4b0094d4ee
204 Ned9bc30935a14fc687f4539654e5305e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Nivolumab
206 rdf:type schema:DefinedTerm
207 Nf08bed3aae334d6a916220c2cc722d7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Carcinoma, Renal Cell
209 rdf:type schema:DefinedTerm
210 Nf31e759cf0f247329cf2f9e690e8aabe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Kidney Neoplasms
212 rdf:type schema:DefinedTerm
213 Nf3cd5ccba3ff46268f8fa30cce2c8fb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Female
215 rdf:type schema:DefinedTerm
216 Nf9b99c0b0e5d4d97933b16084cea01c1 rdf:first sg:person.01224564662.27
217 rdf:rest Nb71d8145c34c45d4bfea54d890e5b80c
218 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
219 schema:name Medical and Health Sciences
220 rdf:type schema:DefinedTerm
221 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
222 schema:name Oncology and Carcinogenesis
223 rdf:type schema:DefinedTerm
224 sg:grant.2438997 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-12361-9
225 rdf:type schema:MonetaryGrant
226 sg:grant.2440200 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-12361-9
227 rdf:type schema:MonetaryGrant
228 sg:grant.6443111 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-12361-9
229 rdf:type schema:MonetaryGrant
230 sg:grant.7028040 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-12361-9
231 rdf:type schema:MonetaryGrant
232 sg:grant.7825984 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-12361-9
233 rdf:type schema:MonetaryGrant
234 sg:journal.1043282 schema:issn 2041-1723
235 schema:name Nature Communications
236 schema:publisher Springer Nature
237 rdf:type schema:Periodical
238 sg:person.01011042064.79 schema:affiliation grid-institutes:grid.65499.37
239 schema:familyName Signoretti
240 schema:givenName Sabina
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011042064.79
242 rdf:type schema:Person
243 sg:person.010123454057.05 schema:affiliation grid-institutes:grid.66859.34
244 schema:familyName Gurjao
245 schema:givenName Carino
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010123454057.05
247 rdf:type schema:Person
248 sg:person.01106217250.35 schema:affiliation grid-institutes:grid.38142.3c
249 schema:familyName Schreiber
250 schema:givenName Stuart L.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106217250.35
252 rdf:type schema:Person
253 sg:person.01111701200.23 schema:affiliation grid-institutes:grid.66859.34
254 schema:familyName Gopal
255 schema:givenName Shuba
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111701200.23
257 rdf:type schema:Person
258 sg:person.011200213360.36 schema:affiliation grid-institutes:grid.38142.3c
259 schema:familyName Li
260 schema:givenName Haoxin
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011200213360.36
262 rdf:type schema:Person
263 sg:person.01134576722.91 schema:affiliation grid-institutes:grid.65499.37
264 schema:familyName Freeman
265 schema:givenName Gordon J.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134576722.91
267 rdf:type schema:Person
268 sg:person.01155331400.39 schema:affiliation grid-institutes:grid.62560.37
269 schema:familyName Choueiri
270 schema:givenName Toni K.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155331400.39
272 rdf:type schema:Person
273 sg:person.01224564662.27 schema:affiliation grid-institutes:grid.65499.37
274 schema:familyName Shukla
275 schema:givenName Sachet A.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224564662.27
277 rdf:type schema:Person
278 sg:person.01231141376.51 schema:affiliation grid-institutes:grid.62560.37
279 schema:familyName Giannakis
280 schema:givenName Marios
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231141376.51
282 rdf:type schema:Person
283 sg:person.01250315201.08 schema:affiliation grid-institutes:grid.66859.34
284 schema:familyName Bullock
285 schema:givenName Kevin
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250315201.08
287 rdf:type schema:Person
288 sg:person.01252560751.47 schema:affiliation grid-institutes:grid.65499.37
289 schema:familyName Bossé
290 schema:givenName Dominick
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252560751.47
292 rdf:type schema:Person
293 sg:person.012666627747.31 schema:affiliation grid-institutes:grid.62560.37
294 schema:familyName Stephen Hodi
295 schema:givenName F.
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012666627747.31
297 rdf:type schema:Person
298 sg:person.01274137244.17 schema:affiliation grid-institutes:grid.62560.37
299 schema:familyName Van Allen
300 schema:givenName Eliezer M.
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274137244.17
302 rdf:type schema:Person
303 sg:person.01304365310.13 schema:affiliation grid-institutes:grid.66859.34
304 schema:familyName Sellers
305 schema:givenName William R.
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304365310.13
307 rdf:type schema:Person
308 sg:person.013174461616.91 schema:affiliation grid-institutes:grid.419971.3
309 schema:familyName Jin
310 schema:givenName Chelsea
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013174461616.91
312 rdf:type schema:Person
313 sg:person.01354065210.34 schema:affiliation grid-institutes:grid.62560.37
314 schema:familyName Garraway
315 schema:givenName Levi A.
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354065210.34
317 rdf:type schema:Person
318 sg:person.015253207301.40 schema:affiliation grid-institutes:grid.65499.37
319 schema:familyName Braun
320 schema:givenName David
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015253207301.40
322 rdf:type schema:Person
323 sg:person.016444773747.08 schema:affiliation grid-institutes:grid.65499.37
324 schema:familyName Lalani
325 schema:givenName Aly-Khan A.
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016444773747.08
327 rdf:type schema:Person
328 sg:person.0652605254.72 schema:affiliation grid-institutes:grid.419971.3
329 schema:familyName Horak
330 schema:givenName Christine
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652605254.72
332 rdf:type schema:Person
333 sg:person.0656541200.82 schema:affiliation grid-institutes:grid.239395.7
334 schema:familyName McDermott
335 schema:givenName David F.
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656541200.82
337 rdf:type schema:Person
338 sg:person.0764632420.16 schema:affiliation grid-institutes:grid.66859.34
339 schema:familyName Clish
340 schema:givenName Clary B.
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16
342 rdf:type schema:Person
343 sg:person.0766213677.21 schema:affiliation grid-institutes:grid.419971.3
344 schema:familyName Wind-Rotolo
345 schema:givenName Megan
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766213677.21
347 rdf:type schema:Person
348 sg:pub.10.1038/ni.3415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044085937
349 https://doi.org/10.1038/ni.3415
350 rdf:type schema:CreativeWork
351 sg:pub.10.1038/nm934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015972513
352 https://doi.org/10.1038/nm934
353 rdf:type schema:CreativeWork
354 sg:pub.10.1038/s41591-019-0404-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113954192
355 https://doi.org/10.1038/s41591-019-0404-8
356 rdf:type schema:CreativeWork
357 grid-institutes:grid.239395.7 schema:alternateName Beth Israel Deaconess Medical Center, 02215, Boston, MA, USA
358 schema:name Beth Israel Deaconess Medical Center, 02215, Boston, MA, USA
359 rdf:type schema:Organization
360 grid-institutes:grid.38142.3c schema:alternateName Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA
361 schema:name Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA
362 Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA
363 Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA
364 rdf:type schema:Organization
365 grid-institutes:grid.419971.3 schema:alternateName Bristol-Myers Squibb, 08540, Princeton, NJ, USA
366 schema:name Bristol-Myers Squibb, 08540, Princeton, NJ, USA
367 rdf:type schema:Organization
368 grid-institutes:grid.62560.37 schema:alternateName Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 02115, Boston, MA, USA
369 schema:name Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA
370 Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA
371 Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 02115, Boston, MA, USA
372 rdf:type schema:Organization
373 grid-institutes:grid.65499.37 schema:alternateName Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA
374 schema:name Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA
375 rdf:type schema:Organization
376 grid-institutes:grid.66859.34 schema:alternateName Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA
377 schema:name Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA
378 Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA
379 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...