Metabolomic adaptations and correlates of survival to immune checkpoint blockade View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-09-25

AUTHORS

Haoxin Li, Kevin Bullock, Carino Gurjao, David Braun, Sachet A. Shukla, Dominick Bossé, Aly-Khan A. Lalani, Shuba Gopal, Chelsea Jin, Christine Horak, Megan Wind-Rotolo, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Eliezer M. Van Allen, Stuart L. Schreiber, F. Stephen Hodi, William R. Sellers, Levi A. Garraway, Clary B. Clish, Toni K. Choueiri, Marios Giannakis

ABSTRACT

Despite remarkable success of immune checkpoint inhibitors, the majority of cancer patients have yet to receive durable benefits. Here, in order to investigate the metabolic alterations in response to immune checkpoint blockade, we comprehensively profile serum metabolites in advanced melanoma and renal cell carcinoma patients treated with nivolumab, an antibody against programmed cell death protein 1 (PD1). We identify serum kynurenine/tryptophan ratio increases as an adaptive resistance mechanism associated with worse overall survival. This advocates for patient stratification and metabolic monitoring in immunotherapy clinical trials including those combining PD1 blockade with indoleamine 2,3-dioxygenase/tryptophan 2,3-dioxygenase (IDO/TDO) inhibitors. More... »

PAGES

4346

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-12361-9

DOI

http://dx.doi.org/10.1038/s41467-019-12361-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1121217344

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31554815


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptation, Physiological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Renal Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Everolimus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kynurenine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nivolumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Programmed Cell Death 1 Receptor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tryptophan", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
            "Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Haoxin", 
        "id": "sg:person.011200213360.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011200213360.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bullock", 
        "givenName": "Kevin", 
        "id": "sg:person.01250315201.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250315201.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gurjao", 
        "givenName": "Carino", 
        "id": "sg:person.010123454057.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010123454057.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braun", 
        "givenName": "David", 
        "id": "sg:person.015253207301.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015253207301.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shukla", 
        "givenName": "Sachet A.", 
        "id": "sg:person.01224564662.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224564662.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boss\u00e9", 
        "givenName": "Dominick", 
        "id": "sg:person.01252560751.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252560751.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lalani", 
        "givenName": "Aly-Khan A.", 
        "id": "sg:person.016444773747.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016444773747.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gopal", 
        "givenName": "Shuba", 
        "id": "sg:person.01111701200.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111701200.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol-Myers Squibb, 08540, Princeton, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.419971.3", 
          "name": [
            "Bristol-Myers Squibb, 08540, Princeton, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jin", 
        "givenName": "Chelsea", 
        "id": "sg:person.013174461616.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013174461616.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol-Myers Squibb, 08540, Princeton, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.419971.3", 
          "name": [
            "Bristol-Myers Squibb, 08540, Princeton, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horak", 
        "givenName": "Christine", 
        "id": "sg:person.0652605254.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652605254.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol-Myers Squibb, 08540, Princeton, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.419971.3", 
          "name": [
            "Bristol-Myers Squibb, 08540, Princeton, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wind-Rotolo", 
        "givenName": "Megan", 
        "id": "sg:person.0766213677.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766213677.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Signoretti", 
        "givenName": "Sabina", 
        "id": "sg:person.01011042064.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011042064.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beth Israel Deaconess Medical Center, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.239395.7", 
          "name": [
            "Beth Israel Deaconess Medical Center, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McDermott", 
        "givenName": "David F.", 
        "id": "sg:person.0656541200.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656541200.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Freeman", 
        "givenName": "Gordon J.", 
        "id": "sg:person.01134576722.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134576722.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
            "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Allen", 
        "givenName": "Eliezer M.", 
        "id": "sg:person.01274137244.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274137244.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
            "Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schreiber", 
        "givenName": "Stuart L.", 
        "id": "sg:person.01106217250.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106217250.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stephen Hodi", 
        "givenName": "F.", 
        "id": "sg:person.012666627747.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012666627747.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sellers", 
        "givenName": "William R.", 
        "id": "sg:person.01304365310.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304365310.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
            "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garraway", 
        "givenName": "Levi A.", 
        "id": "sg:person.01354065210.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354065210.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clish", 
        "givenName": "Clary B.", 
        "id": "sg:person.0764632420.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choueiri", 
        "givenName": "Toni K.", 
        "id": "sg:person.01155331400.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155331400.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA", 
            "Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA", 
            "Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giannakis", 
        "givenName": "Marios", 
        "id": "sg:person.01231141376.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231141376.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ni.3415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044085937", 
          "https://doi.org/10.1038/ni.3415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41591-019-0404-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1113954192", 
          "https://doi.org/10.1038/s41591-019-0404-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015972513", 
          "https://doi.org/10.1038/nm934"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-09-25", 
    "datePublishedReg": "2019-09-25", 
    "description": "Despite remarkable success of immune checkpoint inhibitors, the majority of cancer patients have yet to receive durable benefits. Here, in order to investigate the metabolic alterations in response to immune checkpoint blockade, we comprehensively profile serum metabolites in advanced melanoma and renal cell carcinoma patients treated with nivolumab, an antibody against programmed cell death protein 1 (PD1). We identify serum kynurenine/tryptophan ratio increases as an adaptive resistance mechanism associated with worse overall survival. This advocates for patient stratification and metabolic monitoring in immunotherapy clinical trials including those combining PD1 blockade with\u00a0indoleamine 2,3-dioxygenase/tryptophan 2,3-dioxygenase \u00a0 (IDO/TDO) inhibitors.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41467-019-12361-9", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438997", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440200", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6443111", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7028040", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7825984", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "immune checkpoint blockade", 
      "checkpoint blockade", 
      "serum kynurenine/tryptophan ratio", 
      "kynurenine/tryptophan ratio", 
      "renal cell carcinoma patients", 
      "cell death protein 1", 
      "immunotherapy clinical trials", 
      "immune checkpoint inhibitors", 
      "cell carcinoma patients", 
      "death protein 1", 
      "worse overall survival", 
      "adaptive resistance mechanisms", 
      "correlates of survival", 
      "checkpoint inhibitors", 
      "overall survival", 
      "advanced melanoma", 
      "carcinoma patients", 
      "tryptophan ratio", 
      "cancer patients", 
      "clinical trials", 
      "serum metabolites", 
      "durable benefit", 
      "patient stratification", 
      "metabolic alterations", 
      "metabolic monitoring", 
      "protein 1", 
      "patients", 
      "blockade", 
      "metabolomic adaptation", 
      "resistance mechanisms", 
      "survival", 
      "inhibitors", 
      "nivolumab", 
      "indoleamine", 
      "melanoma", 
      "PD1", 
      "trials", 
      "antibodies", 
      "alterations", 
      "correlates", 
      "metabolites", 
      "majority", 
      "stratification", 
      "response", 
      "remarkable success", 
      "tryptophan", 
      "dioxygenase", 
      "benefits", 
      "mechanism", 
      "monitoring", 
      "ratio", 
      "success", 
      "adaptation", 
      "order"
    ], 
    "name": "Metabolomic adaptations and correlates of survival to immune checkpoint blockade", 
    "pagination": "4346", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1121217344"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-019-12361-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31554815"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-019-12361-9", 
      "https://app.dimensions.ai/details/publication/pub.1121217344"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_809.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41467-019-12361-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-12361-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-12361-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-12361-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-12361-9'


 

This table displays all metadata directly associated to this object as RDF triples.

376 TRIPLES      21 PREDICATES      101 URIs      90 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-019-12361-9 schema:about N023e2e1c718f48519fe3853cb7180594
2 N0422d1e5f9ee4bd8bc0b524db8988c2e
3 N292e4ebec37b4d11a82fb06bd2e4401a
4 N2f82724516e947cfbb79e3755159191c
5 N30d08156605a475bb04332d455b9aed3
6 N30e062868a1c49c68cc14f98488a105d
7 N341e8da038d44a40a8cf171653f4eef8
8 N352c08679b664710bd5218f4a952f626
9 N3851b5c9bd524f96931c537bfd12baa7
10 N3fddb1ca9e004e7d946a307a602bfe4e
11 N414145cf26cb473a9b09814f226e26b2
12 N565a7362781f46ca80494545c54c2e09
13 N690a4c9230f64c15bb3a2d5b1c3062f5
14 N7a76195fe6a9435596a8f5cd31aec5e4
15 Nb40b2555964b47c28bab836b46b76dce
16 Nd4cc728a879249ed98c5fa564aff13f5
17 Ndec32cdbcefe4128a977ab7e382cf040
18 Nef61fe4994794d33ab843402e453665f
19 Nef8d4f8d012c4bc9abf23b418bfbc53b
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N857be40240334930bd553e9a0572694e
23 schema:citation sg:pub.10.1038/ni.3415
24 sg:pub.10.1038/nm934
25 sg:pub.10.1038/s41591-019-0404-8
26 schema:datePublished 2019-09-25
27 schema:datePublishedReg 2019-09-25
28 schema:description Despite remarkable success of immune checkpoint inhibitors, the majority of cancer patients have yet to receive durable benefits. Here, in order to investigate the metabolic alterations in response to immune checkpoint blockade, we comprehensively profile serum metabolites in advanced melanoma and renal cell carcinoma patients treated with nivolumab, an antibody against programmed cell death protein 1 (PD1). We identify serum kynurenine/tryptophan ratio increases as an adaptive resistance mechanism associated with worse overall survival. This advocates for patient stratification and metabolic monitoring in immunotherapy clinical trials including those combining PD1 blockade with indoleamine 2,3-dioxygenase/tryptophan 2,3-dioxygenase   (IDO/TDO) inhibitors.
29 schema:genre article
30 schema:isAccessibleForFree true
31 schema:isPartOf N75a9ae5da4324090b6abc75b4180f71b
32 N7cebdf25b9d0439c8db0af1b953207d3
33 sg:journal.1043282
34 schema:keywords PD1
35 adaptation
36 adaptive resistance mechanisms
37 advanced melanoma
38 alterations
39 antibodies
40 benefits
41 blockade
42 cancer patients
43 carcinoma patients
44 cell carcinoma patients
45 cell death protein 1
46 checkpoint blockade
47 checkpoint inhibitors
48 clinical trials
49 correlates
50 correlates of survival
51 death protein 1
52 dioxygenase
53 durable benefit
54 immune checkpoint blockade
55 immune checkpoint inhibitors
56 immunotherapy clinical trials
57 indoleamine
58 inhibitors
59 kynurenine/tryptophan ratio
60 majority
61 mechanism
62 melanoma
63 metabolic alterations
64 metabolic monitoring
65 metabolites
66 metabolomic adaptation
67 monitoring
68 nivolumab
69 order
70 overall survival
71 patient stratification
72 patients
73 protein 1
74 ratio
75 remarkable success
76 renal cell carcinoma patients
77 resistance mechanisms
78 response
79 serum kynurenine/tryptophan ratio
80 serum metabolites
81 stratification
82 success
83 survival
84 trials
85 tryptophan
86 tryptophan ratio
87 worse overall survival
88 schema:name Metabolomic adaptations and correlates of survival to immune checkpoint blockade
89 schema:pagination 4346
90 schema:productId N00b4e3a5d0d6420eac4a5a2a0b2cd61b
91 N02a7c312bef34bdcb6a5be48f570d904
92 N0b7c164144f64685a3dbb4f2d1d3b5b8
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1121217344
94 https://doi.org/10.1038/s41467-019-12361-9
95 schema:sdDatePublished 2022-11-24T21:05
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N652e3bf2dee1427a9133b016e0a27897
98 schema:url https://doi.org/10.1038/s41467-019-12361-9
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N00b4e3a5d0d6420eac4a5a2a0b2cd61b schema:name doi
103 schema:value 10.1038/s41467-019-12361-9
104 rdf:type schema:PropertyValue
105 N023e2e1c718f48519fe3853cb7180594 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Female
107 rdf:type schema:DefinedTerm
108 N02a7c312bef34bdcb6a5be48f570d904 schema:name dimensions_id
109 schema:value pub.1121217344
110 rdf:type schema:PropertyValue
111 N0422d1e5f9ee4bd8bc0b524db8988c2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Kynurenine
113 rdf:type schema:DefinedTerm
114 N06d95344c8bc442da2fcfd28b1a51af9 rdf:first sg:person.01252560751.47
115 rdf:rest Na0b08b386041407cab74d0cbdf59c793
116 N0b7c164144f64685a3dbb4f2d1d3b5b8 schema:name pubmed_id
117 schema:value 31554815
118 rdf:type schema:PropertyValue
119 N0ba3e3e9bb7b44cf94ae3df073dc10cc rdf:first sg:person.01134576722.91
120 rdf:rest N31f54eea3f64418896555b6b43c4bb13
121 N243bbd480c1d47d7ab5fa1619a52f09c rdf:first sg:person.0764632420.16
122 rdf:rest N3677ef4313fb4acd9c27c4531d494d92
123 N25c5f01c7da44dbca6cdfe3a8a627490 rdf:first sg:person.01106217250.35
124 rdf:rest Nd3a56e170b0a4f5a92d88c1766951839
125 N26a88fea179e408a8503630c3c953341 rdf:first sg:person.01354065210.34
126 rdf:rest N243bbd480c1d47d7ab5fa1619a52f09c
127 N292e4ebec37b4d11a82fb06bd2e4401a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N2f82724516e947cfbb79e3755159191c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Middle Aged
132 rdf:type schema:DefinedTerm
133 N30d08156605a475bb04332d455b9aed3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Clinical Trials as Topic
135 rdf:type schema:DefinedTerm
136 N30e062868a1c49c68cc14f98488a105d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Kidney Neoplasms
138 rdf:type schema:DefinedTerm
139 N31f54eea3f64418896555b6b43c4bb13 rdf:first sg:person.01274137244.17
140 rdf:rest N25c5f01c7da44dbca6cdfe3a8a627490
141 N341e8da038d44a40a8cf171653f4eef8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Everolimus
143 rdf:type schema:DefinedTerm
144 N352c08679b664710bd5218f4a952f626 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Kaplan-Meier Estimate
146 rdf:type schema:DefinedTerm
147 N3677ef4313fb4acd9c27c4531d494d92 rdf:first sg:person.01155331400.39
148 rdf:rest Nb13d0583be97446e95d0a49676be93a5
149 N3851b5c9bd524f96931c537bfd12baa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Antineoplastic Agents
151 rdf:type schema:DefinedTerm
152 N3fddb1ca9e004e7d946a307a602bfe4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Programmed Cell Death 1 Receptor
154 rdf:type schema:DefinedTerm
155 N414145cf26cb473a9b09814f226e26b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Melanoma
157 rdf:type schema:DefinedTerm
158 N565a7362781f46ca80494545c54c2e09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Adaptation, Physiological
160 rdf:type schema:DefinedTerm
161 N652e3bf2dee1427a9133b016e0a27897 schema:name Springer Nature - SN SciGraph project
162 rdf:type schema:Organization
163 N690a4c9230f64c15bb3a2d5b1c3062f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Nivolumab
165 rdf:type schema:DefinedTerm
166 N6c57966743544c6799f4728f014b3b5c rdf:first sg:person.0766213677.21
167 rdf:rest Nb3f117414e9f4d9c976884f8fe98709f
168 N75a9ae5da4324090b6abc75b4180f71b schema:volumeNumber 10
169 rdf:type schema:PublicationVolume
170 N7995af93cd4e4b36b98e35f23ea14905 rdf:first sg:person.013174461616.91
171 rdf:rest Ncc8cef4a8db1430c8bb6bdc758eba64c
172 N7a76195fe6a9435596a8f5cd31aec5e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Male
174 rdf:type schema:DefinedTerm
175 N7cebdf25b9d0439c8db0af1b953207d3 schema:issueNumber 1
176 rdf:type schema:PublicationIssue
177 N857be40240334930bd553e9a0572694e rdf:first sg:person.011200213360.36
178 rdf:rest Nacc47370400d4ee4bfcae252ed7494bc
179 N8bb11d84eba343cbbc9cbef74ecf4668 rdf:first sg:person.01224564662.27
180 rdf:rest N06d95344c8bc442da2fcfd28b1a51af9
181 N9005d5c15b6d413c805ad8353bec5afd rdf:first sg:person.01111701200.23
182 rdf:rest N7995af93cd4e4b36b98e35f23ea14905
183 N959a858611a54a2d8ad122a950b81b28 rdf:first sg:person.0656541200.82
184 rdf:rest N0ba3e3e9bb7b44cf94ae3df073dc10cc
185 Na0b08b386041407cab74d0cbdf59c793 rdf:first sg:person.016444773747.08
186 rdf:rest N9005d5c15b6d413c805ad8353bec5afd
187 Na822b60b1fd249f29b13a041d8d034e4 rdf:first sg:person.010123454057.05
188 rdf:rest Nbe14ad99fc7c48b98246b65b0632fc16
189 Nacc47370400d4ee4bfcae252ed7494bc rdf:first sg:person.01250315201.08
190 rdf:rest Na822b60b1fd249f29b13a041d8d034e4
191 Nb13d0583be97446e95d0a49676be93a5 rdf:first sg:person.01231141376.51
192 rdf:rest rdf:nil
193 Nb3f117414e9f4d9c976884f8fe98709f rdf:first sg:person.01011042064.79
194 rdf:rest N959a858611a54a2d8ad122a950b81b28
195 Nb40b2555964b47c28bab836b46b76dce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Tryptophan
197 rdf:type schema:DefinedTerm
198 Nbe14ad99fc7c48b98246b65b0632fc16 rdf:first sg:person.015253207301.40
199 rdf:rest N8bb11d84eba343cbbc9cbef74ecf4668
200 Nc3025c19e0754f33b0c94fd148aade94 rdf:first sg:person.01304365310.13
201 rdf:rest N26a88fea179e408a8503630c3c953341
202 Ncc8cef4a8db1430c8bb6bdc758eba64c rdf:first sg:person.0652605254.72
203 rdf:rest N6c57966743544c6799f4728f014b3b5c
204 Nd3a56e170b0a4f5a92d88c1766951839 rdf:first sg:person.012666627747.31
205 rdf:rest Nc3025c19e0754f33b0c94fd148aade94
206 Nd4cc728a879249ed98c5fa564aff13f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Treatment Outcome
208 rdf:type schema:DefinedTerm
209 Ndec32cdbcefe4128a977ab7e382cf040 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Aged
211 rdf:type schema:DefinedTerm
212 Nef61fe4994794d33ab843402e453665f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Carcinoma, Renal Cell
214 rdf:type schema:DefinedTerm
215 Nef8d4f8d012c4bc9abf23b418bfbc53b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Metabolomics
217 rdf:type schema:DefinedTerm
218 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
219 schema:name Medical and Health Sciences
220 rdf:type schema:DefinedTerm
221 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
222 schema:name Oncology and Carcinogenesis
223 rdf:type schema:DefinedTerm
224 sg:grant.2438997 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-12361-9
225 rdf:type schema:MonetaryGrant
226 sg:grant.2440200 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-12361-9
227 rdf:type schema:MonetaryGrant
228 sg:grant.6443111 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-12361-9
229 rdf:type schema:MonetaryGrant
230 sg:grant.7028040 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-12361-9
231 rdf:type schema:MonetaryGrant
232 sg:grant.7825984 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-12361-9
233 rdf:type schema:MonetaryGrant
234 sg:journal.1043282 schema:issn 2041-1723
235 schema:name Nature Communications
236 schema:publisher Springer Nature
237 rdf:type schema:Periodical
238 sg:person.01011042064.79 schema:affiliation grid-institutes:grid.65499.37
239 schema:familyName Signoretti
240 schema:givenName Sabina
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011042064.79
242 rdf:type schema:Person
243 sg:person.010123454057.05 schema:affiliation grid-institutes:grid.66859.34
244 schema:familyName Gurjao
245 schema:givenName Carino
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010123454057.05
247 rdf:type schema:Person
248 sg:person.01106217250.35 schema:affiliation grid-institutes:grid.38142.3c
249 schema:familyName Schreiber
250 schema:givenName Stuart L.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106217250.35
252 rdf:type schema:Person
253 sg:person.01111701200.23 schema:affiliation grid-institutes:grid.66859.34
254 schema:familyName Gopal
255 schema:givenName Shuba
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111701200.23
257 rdf:type schema:Person
258 sg:person.011200213360.36 schema:affiliation grid-institutes:grid.38142.3c
259 schema:familyName Li
260 schema:givenName Haoxin
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011200213360.36
262 rdf:type schema:Person
263 sg:person.01134576722.91 schema:affiliation grid-institutes:grid.65499.37
264 schema:familyName Freeman
265 schema:givenName Gordon J.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134576722.91
267 rdf:type schema:Person
268 sg:person.01155331400.39 schema:affiliation grid-institutes:grid.38142.3c
269 schema:familyName Choueiri
270 schema:givenName Toni K.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155331400.39
272 rdf:type schema:Person
273 sg:person.01224564662.27 schema:affiliation grid-institutes:grid.65499.37
274 schema:familyName Shukla
275 schema:givenName Sachet A.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224564662.27
277 rdf:type schema:Person
278 sg:person.01231141376.51 schema:affiliation grid-institutes:grid.38142.3c
279 schema:familyName Giannakis
280 schema:givenName Marios
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231141376.51
282 rdf:type schema:Person
283 sg:person.01250315201.08 schema:affiliation grid-institutes:grid.66859.34
284 schema:familyName Bullock
285 schema:givenName Kevin
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250315201.08
287 rdf:type schema:Person
288 sg:person.01252560751.47 schema:affiliation grid-institutes:grid.65499.37
289 schema:familyName Bossé
290 schema:givenName Dominick
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252560751.47
292 rdf:type schema:Person
293 sg:person.012666627747.31 schema:affiliation grid-institutes:grid.38142.3c
294 schema:familyName Stephen Hodi
295 schema:givenName F.
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012666627747.31
297 rdf:type schema:Person
298 sg:person.01274137244.17 schema:affiliation grid-institutes:grid.38142.3c
299 schema:familyName Van Allen
300 schema:givenName Eliezer M.
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274137244.17
302 rdf:type schema:Person
303 sg:person.01304365310.13 schema:affiliation grid-institutes:grid.66859.34
304 schema:familyName Sellers
305 schema:givenName William R.
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304365310.13
307 rdf:type schema:Person
308 sg:person.013174461616.91 schema:affiliation grid-institutes:grid.419971.3
309 schema:familyName Jin
310 schema:givenName Chelsea
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013174461616.91
312 rdf:type schema:Person
313 sg:person.01354065210.34 schema:affiliation grid-institutes:grid.38142.3c
314 schema:familyName Garraway
315 schema:givenName Levi A.
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354065210.34
317 rdf:type schema:Person
318 sg:person.015253207301.40 schema:affiliation grid-institutes:grid.65499.37
319 schema:familyName Braun
320 schema:givenName David
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015253207301.40
322 rdf:type schema:Person
323 sg:person.016444773747.08 schema:affiliation grid-institutes:grid.65499.37
324 schema:familyName Lalani
325 schema:givenName Aly-Khan A.
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016444773747.08
327 rdf:type schema:Person
328 sg:person.0652605254.72 schema:affiliation grid-institutes:grid.419971.3
329 schema:familyName Horak
330 schema:givenName Christine
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652605254.72
332 rdf:type schema:Person
333 sg:person.0656541200.82 schema:affiliation grid-institutes:grid.239395.7
334 schema:familyName McDermott
335 schema:givenName David F.
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656541200.82
337 rdf:type schema:Person
338 sg:person.0764632420.16 schema:affiliation grid-institutes:grid.66859.34
339 schema:familyName Clish
340 schema:givenName Clary B.
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16
342 rdf:type schema:Person
343 sg:person.0766213677.21 schema:affiliation grid-institutes:grid.419971.3
344 schema:familyName Wind-Rotolo
345 schema:givenName Megan
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766213677.21
347 rdf:type schema:Person
348 sg:pub.10.1038/ni.3415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044085937
349 https://doi.org/10.1038/ni.3415
350 rdf:type schema:CreativeWork
351 sg:pub.10.1038/nm934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015972513
352 https://doi.org/10.1038/nm934
353 rdf:type schema:CreativeWork
354 sg:pub.10.1038/s41591-019-0404-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113954192
355 https://doi.org/10.1038/s41591-019-0404-8
356 rdf:type schema:CreativeWork
357 grid-institutes:grid.239395.7 schema:alternateName Beth Israel Deaconess Medical Center, 02215, Boston, MA, USA
358 schema:name Beth Israel Deaconess Medical Center, 02215, Boston, MA, USA
359 rdf:type schema:Organization
360 grid-institutes:grid.38142.3c schema:alternateName Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA
361 Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 02115, Boston, MA, USA
362 schema:name Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA
363 Department of Chemistry and Chemical Biology, Harvard University, 02138, Cambridge, MA, USA
364 Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA
365 Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 02115, Boston, MA, USA
366 rdf:type schema:Organization
367 grid-institutes:grid.419971.3 schema:alternateName Bristol-Myers Squibb, 08540, Princeton, NJ, USA
368 schema:name Bristol-Myers Squibb, 08540, Princeton, NJ, USA
369 rdf:type schema:Organization
370 grid-institutes:grid.65499.37 schema:alternateName Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA
371 schema:name Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA
372 rdf:type schema:Organization
373 grid-institutes:grid.66859.34 schema:alternateName Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA
374 schema:name Broad Institute of MIT and Harvard, 02142, Cambridge, MA, USA
375 Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA
376 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...