Genetic architecture of human plasma lipidome and its link to cardiovascular disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-09-24

AUTHORS

Rubina Tabassum, Joel T. Rämö, Pietari Ripatti, Jukka T. Koskela, Mitja Kurki, Juha Karjalainen, Priit Palta, Shabbeer Hassan, Javier Nunez-Fontarnau, Tuomo T. J. Kiiskinen, Sanni Söderlund, Niina Matikainen, Mathias J. Gerl, Michal A. Surma, Christian Klose, Nathan O. Stitziel, Hannele Laivuori, Aki S. Havulinna, Susan K. Service, Veikko Salomaa, Matti Pirinen, Matti Jauhiainen, Mark J. Daly, Nelson B. Freimer, Aarno Palotie, Marja-Riitta Taskinen, Kai Simons, Samuli Ripatti

ABSTRACT

Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD. More... »

PAGES

4329

References to SciGraph publications

  • 2012-07-22. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing in NATURE GENETICS
  • 2015-05-11. The impact of low-frequency and rare variants on lipid levels in NATURE GENETICS
  • 2018-10-10. The UK Biobank resource with deep phenotyping and genomic data in NATURE
  • 2015-06-12. Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels in NATURE COMMUNICATIONS
  • 2011-01-19. A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language in GENOME BIOLOGY
  • 2017-03-06. Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites in NATURE GENETICS
  • 2017-06-16. Heritability and responses to high fat diet of plasma lipidomics in a twin study in SCIENTIFIC REPORTS
  • 2018-08-13. Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies in NATURE GENETICS
  • 2014-05-11. An atlas of genetic influences on human blood metabolites in NATURE GENETICS
  • 1997-06. The validity of hospital discharge register data on coronary heart disease in Finland in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2009-12-27. A genome-wide perspective of genetic variation in human metabolism in NATURE GENETICS
  • 2017-10-30. Exome-wide association study of plasma lipids in >300,000 individuals in NATURE GENETICS
  • 2016-03-23. Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA in NATURE COMMUNICATIONS
  • 2010-06-02. Genotype imputation for genome-wide association studies in NATURE REVIEWS GENETICS
  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    10

    Author Affiliations

  • Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
  • Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
  • Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
  • Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
  • National Institute for Health and Welfare, Helsinki, Finland
  • Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland
  • Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland
  • Lipotype GmbH, Dresden, Germany
  • Łukasiewicz Research Network-PORT Polish Center for Technology Development, Stablowicka 147 Str., 54-066, Wroclaw, Poland
  • McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO, USA
  • Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  • Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
  • Helsinki Institute for Information Technology HIIT and Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland
  • Minerva Foundation Institute for Medical Research, Biomedicum, Helsinki, Finland
  • Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
  • Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Medicine, and the Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
  • Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
  • Department of Public Health, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-11954-8

    DOI

    http://dx.doi.org/10.1038/s41467-019-11954-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1121201724

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31551469


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1101", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Biochemistry and Metabolomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cardiovascular Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipidomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plasma", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.452494.a", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tabassum", 
            "givenName": "Rubina", 
            "id": "sg:person.0741777355.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741777355.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.452494.a", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "R\u00e4m\u00f6", 
            "givenName": "Joel T.", 
            "id": "sg:person.0674252445.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674252445.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.452494.a", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ripatti", 
            "givenName": "Pietari", 
            "id": "sg:person.01313572003.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313572003.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.452494.a", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koskela", 
            "givenName": "Jukka T.", 
            "id": "sg:person.01176171756.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176171756.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
                "Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
                "Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kurki", 
            "givenName": "Mitja", 
            "id": "sg:person.0640603220.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640603220.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
                "Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
                "Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karjalainen", 
            "givenName": "Juha", 
            "id": "sg:person.0646651114.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646651114.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia", 
              "id": "http://www.grid.ac/institutes/grid.10939.32", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
                "Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Palta", 
            "givenName": "Priit", 
            "id": "sg:person.01203401127.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203401127.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.452494.a", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hassan", 
            "givenName": "Shabbeer", 
            "id": "sg:person.01120564436.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120564436.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.452494.a", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nunez-Fontarnau", 
            "givenName": "Javier", 
            "id": "sg:person.0603260163.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603260163.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute for Health and Welfare, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.14758.3f", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
                "National Institute for Health and Welfare, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kiiskinen", 
            "givenName": "Tuomo T. J.", 
            "id": "sg:person.011332673350.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011332673350.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "S\u00f6derlund", 
            "givenName": "Sanni", 
            "id": "sg:person.0626772727.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626772727.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland", 
                "Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matikainen", 
            "givenName": "Niina", 
            "id": "sg:person.0640415633.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640415633.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lipotype GmbH, Dresden, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Lipotype GmbH, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gerl", 
            "givenName": "Mathias J.", 
            "id": "sg:person.01030334441.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030334441.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "\u0141ukasiewicz Research Network-PORT Polish Center for Technology Development, Stablowicka 147 Str., 54-066, Wroclaw, Poland", 
              "id": "http://www.grid.ac/institutes/grid.510509.8", 
              "name": [
                "Lipotype GmbH, Dresden, Germany", 
                "\u0141ukasiewicz Research Network-PORT Polish Center for Technology Development, Stablowicka 147 Str., 54-066, Wroclaw, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Surma", 
            "givenName": "Michal A.", 
            "id": "sg:person.01352024617.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352024617.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lipotype GmbH, Dresden, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Lipotype GmbH, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Klose", 
            "givenName": "Christian", 
            "id": "sg:person.0626420517.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626420517.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Cardiovascular Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA", 
                "Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA", 
                "McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stitziel", 
            "givenName": "Nathan O.", 
            "id": "sg:person.01065735320.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065735320.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
                "Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland", 
                "Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Laivuori", 
            "givenName": "Hannele", 
            "id": "sg:person.01260726106.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260726106.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute for Health and Welfare, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.14758.3f", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
                "National Institute for Health and Welfare, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Havulinna", 
            "givenName": "Aki S.", 
            "id": "sg:person.0677736440.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677736440.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Service", 
            "givenName": "Susan K.", 
            "id": "sg:person.0772520322.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772520322.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute for Health and Welfare, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.14758.3f", 
              "name": [
                "National Institute for Health and Welfare, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salomaa", 
            "givenName": "Veikko", 
            "id": "sg:person.01022740164.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022740164.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helsinki Institute for Information Technology HIIT and Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
                "Department of Public Health, University of Helsinki, Helsinki, Finland", 
                "Helsinki Institute for Information Technology HIIT and Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pirinen", 
            "givenName": "Matti", 
            "id": "sg:person.01155762022.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155762022.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Minerva Foundation Institute for Medical Research, Biomedicum, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.452540.2", 
              "name": [
                "National Institute for Health and Welfare, Helsinki, Finland", 
                "Minerva Foundation Institute for Medical Research, Biomedicum, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jauhiainen", 
            "givenName": "Matti", 
            "id": "sg:person.0605567007.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605567007.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
                "Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Daly", 
            "givenName": "Mark J.", 
            "id": "sg:person.011517303117.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011517303117.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Freimer", 
            "givenName": "Nelson B.", 
            "id": "sg:person.01356675577.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356675577.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Medicine, and the Department of Neurology, Massachusetts General Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
                "Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
                "Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Medicine, and the Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Palotie", 
            "givenName": "Aarno", 
            "id": "sg:person.01104742263.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104742263.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Taskinen", 
            "givenName": "Marja-Riitta", 
            "id": "sg:person.012272201145.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012272201145.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany", 
              "id": "http://www.grid.ac/institutes/grid.419537.d", 
              "name": [
                "Lipotype GmbH, Dresden, Germany", 
                "Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Simons", 
            "givenName": "Kai", 
            "id": "sg:person.0762631600.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762631600.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Public Health, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland", 
                "Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
                "Department of Public Health, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ripatti", 
            "givenName": "Samuli", 
            "id": "sg:person.01074100021.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074100021.48"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng.3977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092440097", 
              "https://doi.org/10.1038/ng.3977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129149", 
              "https://doi.org/10.1038/ng.3809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0579-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107363293", 
              "https://doi.org/10.1038/s41586-018-0579-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-03965-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086000821", 
              "https://doi.org/10.1038/s41598-017-03965-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002957734", 
              "https://doi.org/10.1038/ng.3300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms8208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003527515", 
              "https://doi.org/10.1038/ncomms8208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0184-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106070347", 
              "https://doi.org/10.1038/s41588-018-0184-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044995197", 
              "https://doi.org/10.1038/ng.2982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009739594", 
              "https://doi.org/10.1038/nrg2796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1007306110822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039078290", 
              "https://doi.org/10.1023/a:1007306110822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029723318", 
              "https://doi.org/10.1038/ng.2354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms11122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034394716", 
              "https://doi.org/10.1038/ncomms11122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-1-r8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041789727", 
              "https://doi.org/10.1186/gb-2011-12-1-r8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003091868", 
              "https://doi.org/10.1038/ng.507"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-09-24", 
        "datePublishedReg": "2019-09-24", 
        "description": "Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n\u2009=\u20092,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n\u2009=\u2009511,700 individuals). We identify 35 lipid-species-associated loci (P\u2009<5\u2009\u00d710\u22128), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41467-019-11954-8", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2543720", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4247484", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8844587", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5054530", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4250762", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3800516", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439022", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5051028", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "keywords": [
          "genetic architecture", 
          "lipid species", 
          "genome-wide association analysis", 
          "genetic correlations", 
          "genetic regulation", 
          "low genetic correlation", 
          "human plasma lipidome", 
          "high heritability", 
          "association analysis", 
          "phenome-wide scan", 
          "lipoprotein lipase", 
          "genetic variants", 
          "related phenotypes", 
          "species", 
          "SPTLC3", 
          "loci", 
          "lipid metabolism", 
          "lipidome", 
          "lipidomic profiles", 
          "plasma lipidome", 
          "lipids", 
          "triacylglycerides", 
          "traditional lipids", 
          "acid levels", 
          "heritability", 
          "phenotype", 
          "regulation", 
          "fatty acid levels", 
          "metabolism", 
          "better insight", 
          "variants", 
          "lipase", 
          "cardiovascular disease", 
          "MBOAT7", 
          "insights", 
          "levels", 
          "disease", 
          "link", 
          "lipid levels", 
          "risk of CVD", 
          "architecture", 
          "profile", 
          "analysis", 
          "e.", 
          "correlation", 
          "CVD risk", 
          "information", 
          "results", 
          "risk", 
          "scans"
        ], 
        "name": "Genetic architecture of human plasma lipidome and its link to cardiovascular disease", 
        "pagination": "4329", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1121201724"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-019-11954-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31551469"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-019-11954-8", 
          "https://app.dimensions.ai/details/publication/pub.1121201724"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_828.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41467-019-11954-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-11954-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-11954-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-11954-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-11954-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    468 TRIPLES      21 PREDICATES      97 URIs      73 LITERALS      13 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-019-11954-8 schema:about N04e53a760a214aa2a855413cb1aee682
    2 N10812dd23ee747c58679ce00bfb41da2
    3 N2492dd0004c043028da6937237a8a61e
    4 N2ef7afce125c4aa19196f53e936d0b48
    5 N8c68c8ada39c4effb6ee20d21416bb10
    6 Nf3f548cc351a4107b4c1716e591024cb
    7 anzsrc-for:06
    8 anzsrc-for:0604
    9 anzsrc-for:11
    10 anzsrc-for:1101
    11 schema:author N8b85515e8d5e4db1abc0f14afeb8025d
    12 schema:citation sg:pub.10.1023/a:1007306110822
    13 sg:pub.10.1038/ncomms11122
    14 sg:pub.10.1038/ncomms8208
    15 sg:pub.10.1038/ng.2354
    16 sg:pub.10.1038/ng.2982
    17 sg:pub.10.1038/ng.3300
    18 sg:pub.10.1038/ng.3809
    19 sg:pub.10.1038/ng.3977
    20 sg:pub.10.1038/ng.507
    21 sg:pub.10.1038/nrg2796
    22 sg:pub.10.1038/s41586-018-0579-z
    23 sg:pub.10.1038/s41588-018-0184-y
    24 sg:pub.10.1038/s41598-017-03965-6
    25 sg:pub.10.1186/gb-2011-12-1-r8
    26 schema:datePublished 2019-09-24
    27 schema:datePublishedReg 2019-09-24
    28 schema:description Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
    29 schema:genre article
    30 schema:isAccessibleForFree true
    31 schema:isPartOf N4a1272ea51c84c89ae674bf1c35ac139
    32 N4aa6570c72134a4e861c4c96bf6b37af
    33 sg:journal.1043282
    34 schema:keywords CVD risk
    35 MBOAT7
    36 SPTLC3
    37 acid levels
    38 analysis
    39 architecture
    40 association analysis
    41 better insight
    42 cardiovascular disease
    43 correlation
    44 disease
    45 e.
    46 fatty acid levels
    47 genetic architecture
    48 genetic correlations
    49 genetic regulation
    50 genetic variants
    51 genome-wide association analysis
    52 heritability
    53 high heritability
    54 human plasma lipidome
    55 information
    56 insights
    57 levels
    58 link
    59 lipase
    60 lipid levels
    61 lipid metabolism
    62 lipid species
    63 lipidome
    64 lipidomic profiles
    65 lipids
    66 lipoprotein lipase
    67 loci
    68 low genetic correlation
    69 metabolism
    70 phenome-wide scan
    71 phenotype
    72 plasma lipidome
    73 profile
    74 regulation
    75 related phenotypes
    76 results
    77 risk
    78 risk of CVD
    79 scans
    80 species
    81 traditional lipids
    82 triacylglycerides
    83 variants
    84 schema:name Genetic architecture of human plasma lipidome and its link to cardiovascular disease
    85 schema:pagination 4329
    86 schema:productId N09fe120ecc37490a987fe33ca927bace
    87 N1660a098864a45268c2605e2dc31269b
    88 N948a6f889a9f49c4b677e99c6d7bc4bc
    89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1121201724
    90 https://doi.org/10.1038/s41467-019-11954-8
    91 schema:sdDatePublished 2022-10-01T06:46
    92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    93 schema:sdPublisher Nb724af8f267346aebe4c8c8af04a0f52
    94 schema:url https://doi.org/10.1038/s41467-019-11954-8
    95 sgo:license sg:explorer/license/
    96 sgo:sdDataset articles
    97 rdf:type schema:ScholarlyArticle
    98 N00cede2722624c74b0a8a745c29f1fb8 rdf:first sg:person.011332673350.58
    99 rdf:rest N3becca97f4dd44f087adbaf2c536ccd3
    100 N04e53a760a214aa2a855413cb1aee682 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Genome-Wide Association Study
    102 rdf:type schema:DefinedTerm
    103 N050358abbd0b4dd1a81d84f9eae6b4fb rdf:first sg:person.01313572003.42
    104 rdf:rest N3084cf6e16d74512879316f3c00ba1ac
    105 N097b0ae9da7c45db8f21814012780345 rdf:first sg:person.01104742263.37
    106 rdf:rest N73731f6ce4c54e09880ca7313fd47c26
    107 N09e0ed05da534f3e8bbc0bba950217b4 rdf:first sg:person.0603260163.06
    108 rdf:rest N00cede2722624c74b0a8a745c29f1fb8
    109 N09fe120ecc37490a987fe33ca927bace schema:name dimensions_id
    110 schema:value pub.1121201724
    111 rdf:type schema:PropertyValue
    112 N10812dd23ee747c58679ce00bfb41da2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Plasma
    114 rdf:type schema:DefinedTerm
    115 N1660a098864a45268c2605e2dc31269b schema:name pubmed_id
    116 schema:value 31551469
    117 rdf:type schema:PropertyValue
    118 N1f802b9b694140fc8ed6ff21dcd823e6 rdf:first sg:person.01203401127.19
    119 rdf:rest Ne2b71120c8c84147b916a4b0707532ba
    120 N2102ff8905df4c85bc33abf2cd5acfd2 rdf:first sg:person.01356675577.09
    121 rdf:rest N097b0ae9da7c45db8f21814012780345
    122 N2492dd0004c043028da6937237a8a61e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Humans
    124 rdf:type schema:DefinedTerm
    125 N2a2d0de00ba041c0a6900fcea300d3ef rdf:first sg:person.01065735320.09
    126 rdf:rest Ndd31b24507304adba6073dbf8200ffc8
    127 N2ef7afce125c4aa19196f53e936d0b48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Lipids
    129 rdf:type schema:DefinedTerm
    130 N3084cf6e16d74512879316f3c00ba1ac rdf:first sg:person.01176171756.08
    131 rdf:rest N56a44d20cac240a99473a0f329bfc1fa
    132 N35d907410c064bea858ed5111b03543b rdf:first sg:person.0605567007.29
    133 rdf:rest Ne1e29a796e5e46a585f96c1eaefe144c
    134 N3becca97f4dd44f087adbaf2c536ccd3 rdf:first sg:person.0626772727.78
    135 rdf:rest Nd206279fd3e44e7395dd5b4c793b8bb7
    136 N49480e8c253a4d9caea6466ae370d2d1 rdf:first sg:person.01022740164.96
    137 rdf:rest N89bf97b96752470fa3ce846bb1254c65
    138 N4a1272ea51c84c89ae674bf1c35ac139 schema:volumeNumber 10
    139 rdf:type schema:PublicationVolume
    140 N4aa6570c72134a4e861c4c96bf6b37af schema:issueNumber 1
    141 rdf:type schema:PublicationIssue
    142 N54f378002ecd40bea6453df88c80a493 rdf:first sg:person.0626420517.21
    143 rdf:rest N2a2d0de00ba041c0a6900fcea300d3ef
    144 N56a44d20cac240a99473a0f329bfc1fa rdf:first sg:person.0640603220.83
    145 rdf:rest N9f733933929f4baabf4ff9ca4d069aab
    146 N65326007a1914459b938de75863bdbe4 rdf:first sg:person.01074100021.48
    147 rdf:rest rdf:nil
    148 N73731f6ce4c54e09880ca7313fd47c26 rdf:first sg:person.012272201145.45
    149 rdf:rest Nb4d5d7e4249846f0bee0d481242b3b2d
    150 N88f43cb8f92444e1807d02f80216dbab rdf:first sg:person.01352024617.85
    151 rdf:rest N54f378002ecd40bea6453df88c80a493
    152 N89bf97b96752470fa3ce846bb1254c65 rdf:first sg:person.01155762022.03
    153 rdf:rest N35d907410c064bea858ed5111b03543b
    154 N8b85515e8d5e4db1abc0f14afeb8025d rdf:first sg:person.0741777355.51
    155 rdf:rest Na30fd18b3d3045f8a5a22ab47235b180
    156 N8c68c8ada39c4effb6ee20d21416bb10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Cardiovascular Diseases
    158 rdf:type schema:DefinedTerm
    159 N948a6f889a9f49c4b677e99c6d7bc4bc schema:name doi
    160 schema:value 10.1038/s41467-019-11954-8
    161 rdf:type schema:PropertyValue
    162 N9ca93e8e1cbb4d52a1dde49cda9df498 rdf:first sg:person.0677736440.29
    163 rdf:rest Nefbb1bccd9ab4bf782f56a4d5153c0a9
    164 N9f733933929f4baabf4ff9ca4d069aab rdf:first sg:person.0646651114.37
    165 rdf:rest N1f802b9b694140fc8ed6ff21dcd823e6
    166 Na30fd18b3d3045f8a5a22ab47235b180 rdf:first sg:person.0674252445.91
    167 rdf:rest N050358abbd0b4dd1a81d84f9eae6b4fb
    168 Na53ee14db89348e596e1ae180e9519ef rdf:first sg:person.01030334441.51
    169 rdf:rest N88f43cb8f92444e1807d02f80216dbab
    170 Nb4d5d7e4249846f0bee0d481242b3b2d rdf:first sg:person.0762631600.77
    171 rdf:rest N65326007a1914459b938de75863bdbe4
    172 Nb724af8f267346aebe4c8c8af04a0f52 schema:name Springer Nature - SN SciGraph project
    173 rdf:type schema:Organization
    174 Nd206279fd3e44e7395dd5b4c793b8bb7 rdf:first sg:person.0640415633.43
    175 rdf:rest Na53ee14db89348e596e1ae180e9519ef
    176 Ndd31b24507304adba6073dbf8200ffc8 rdf:first sg:person.01260726106.00
    177 rdf:rest N9ca93e8e1cbb4d52a1dde49cda9df498
    178 Ne1e29a796e5e46a585f96c1eaefe144c rdf:first sg:person.011517303117.07
    179 rdf:rest N2102ff8905df4c85bc33abf2cd5acfd2
    180 Ne2b71120c8c84147b916a4b0707532ba rdf:first sg:person.01120564436.36
    181 rdf:rest N09e0ed05da534f3e8bbc0bba950217b4
    182 Nefbb1bccd9ab4bf782f56a4d5153c0a9 rdf:first sg:person.0772520322.28
    183 rdf:rest N49480e8c253a4d9caea6466ae370d2d1
    184 Nf3f548cc351a4107b4c1716e591024cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Lipidomics
    186 rdf:type schema:DefinedTerm
    187 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    188 schema:name Biological Sciences
    189 rdf:type schema:DefinedTerm
    190 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    191 schema:name Genetics
    192 rdf:type schema:DefinedTerm
    193 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    194 schema:name Medical and Health Sciences
    195 rdf:type schema:DefinedTerm
    196 anzsrc-for:1101 schema:inDefinedTermSet anzsrc-for:
    197 schema:name Medical Biochemistry and Metabolomics
    198 rdf:type schema:DefinedTerm
    199 sg:grant.2439022 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-11954-8
    200 rdf:type schema:MonetaryGrant
    201 sg:grant.2543720 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-11954-8
    202 rdf:type schema:MonetaryGrant
    203 sg:grant.3800516 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-11954-8
    204 rdf:type schema:MonetaryGrant
    205 sg:grant.4247484 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-11954-8
    206 rdf:type schema:MonetaryGrant
    207 sg:grant.4250762 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-11954-8
    208 rdf:type schema:MonetaryGrant
    209 sg:grant.5051028 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-11954-8
    210 rdf:type schema:MonetaryGrant
    211 sg:grant.5054530 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-11954-8
    212 rdf:type schema:MonetaryGrant
    213 sg:grant.8844587 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-11954-8
    214 rdf:type schema:MonetaryGrant
    215 sg:journal.1043282 schema:issn 2041-1723
    216 schema:name Nature Communications
    217 schema:publisher Springer Nature
    218 rdf:type schema:Periodical
    219 sg:person.01022740164.96 schema:affiliation grid-institutes:grid.14758.3f
    220 schema:familyName Salomaa
    221 schema:givenName Veikko
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022740164.96
    223 rdf:type schema:Person
    224 sg:person.01030334441.51 schema:affiliation grid-institutes:None
    225 schema:familyName Gerl
    226 schema:givenName Mathias J.
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030334441.51
    228 rdf:type schema:Person
    229 sg:person.01065735320.09 schema:affiliation grid-institutes:grid.4367.6
    230 schema:familyName Stitziel
    231 schema:givenName Nathan O.
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065735320.09
    233 rdf:type schema:Person
    234 sg:person.01074100021.48 schema:affiliation grid-institutes:grid.7737.4
    235 schema:familyName Ripatti
    236 schema:givenName Samuli
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074100021.48
    238 rdf:type schema:Person
    239 sg:person.01104742263.37 schema:affiliation grid-institutes:grid.32224.35
    240 schema:familyName Palotie
    241 schema:givenName Aarno
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104742263.37
    243 rdf:type schema:Person
    244 sg:person.01120564436.36 schema:affiliation grid-institutes:grid.452494.a
    245 schema:familyName Hassan
    246 schema:givenName Shabbeer
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120564436.36
    248 rdf:type schema:Person
    249 sg:person.011332673350.58 schema:affiliation grid-institutes:grid.14758.3f
    250 schema:familyName Kiiskinen
    251 schema:givenName Tuomo T. J.
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011332673350.58
    253 rdf:type schema:Person
    254 sg:person.011517303117.07 schema:affiliation grid-institutes:grid.66859.34
    255 schema:familyName Daly
    256 schema:givenName Mark J.
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011517303117.07
    258 rdf:type schema:Person
    259 sg:person.01155762022.03 schema:affiliation grid-institutes:grid.7737.4
    260 schema:familyName Pirinen
    261 schema:givenName Matti
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155762022.03
    263 rdf:type schema:Person
    264 sg:person.01176171756.08 schema:affiliation grid-institutes:grid.452494.a
    265 schema:familyName Koskela
    266 schema:givenName Jukka T.
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176171756.08
    268 rdf:type schema:Person
    269 sg:person.01203401127.19 schema:affiliation grid-institutes:grid.10939.32
    270 schema:familyName Palta
    271 schema:givenName Priit
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203401127.19
    273 rdf:type schema:Person
    274 sg:person.012272201145.45 schema:affiliation grid-institutes:grid.15485.3d
    275 schema:familyName Taskinen
    276 schema:givenName Marja-Riitta
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012272201145.45
    278 rdf:type schema:Person
    279 sg:person.01260726106.00 schema:affiliation grid-institutes:grid.15485.3d
    280 schema:familyName Laivuori
    281 schema:givenName Hannele
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260726106.00
    283 rdf:type schema:Person
    284 sg:person.01313572003.42 schema:affiliation grid-institutes:grid.452494.a
    285 schema:familyName Ripatti
    286 schema:givenName Pietari
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313572003.42
    288 rdf:type schema:Person
    289 sg:person.01352024617.85 schema:affiliation grid-institutes:grid.510509.8
    290 schema:familyName Surma
    291 schema:givenName Michal A.
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352024617.85
    293 rdf:type schema:Person
    294 sg:person.01356675577.09 schema:affiliation grid-institutes:grid.19006.3e
    295 schema:familyName Freimer
    296 schema:givenName Nelson B.
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356675577.09
    298 rdf:type schema:Person
    299 sg:person.0603260163.06 schema:affiliation grid-institutes:grid.452494.a
    300 schema:familyName Nunez-Fontarnau
    301 schema:givenName Javier
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603260163.06
    303 rdf:type schema:Person
    304 sg:person.0605567007.29 schema:affiliation grid-institutes:grid.452540.2
    305 schema:familyName Jauhiainen
    306 schema:givenName Matti
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605567007.29
    308 rdf:type schema:Person
    309 sg:person.0626420517.21 schema:affiliation grid-institutes:None
    310 schema:familyName Klose
    311 schema:givenName Christian
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626420517.21
    313 rdf:type schema:Person
    314 sg:person.0626772727.78 schema:affiliation grid-institutes:grid.15485.3d
    315 schema:familyName Söderlund
    316 schema:givenName Sanni
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626772727.78
    318 rdf:type schema:Person
    319 sg:person.0640415633.43 schema:affiliation grid-institutes:grid.15485.3d
    320 schema:familyName Matikainen
    321 schema:givenName Niina
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640415633.43
    323 rdf:type schema:Person
    324 sg:person.0640603220.83 schema:affiliation grid-institutes:grid.32224.35
    325 schema:familyName Kurki
    326 schema:givenName Mitja
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640603220.83
    328 rdf:type schema:Person
    329 sg:person.0646651114.37 schema:affiliation grid-institutes:grid.38142.3c
    330 schema:familyName Karjalainen
    331 schema:givenName Juha
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646651114.37
    333 rdf:type schema:Person
    334 sg:person.0674252445.91 schema:affiliation grid-institutes:grid.452494.a
    335 schema:familyName Rämö
    336 schema:givenName Joel T.
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674252445.91
    338 rdf:type schema:Person
    339 sg:person.0677736440.29 schema:affiliation grid-institutes:grid.14758.3f
    340 schema:familyName Havulinna
    341 schema:givenName Aki S.
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677736440.29
    343 rdf:type schema:Person
    344 sg:person.0741777355.51 schema:affiliation grid-institutes:grid.452494.a
    345 schema:familyName Tabassum
    346 schema:givenName Rubina
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741777355.51
    348 rdf:type schema:Person
    349 sg:person.0762631600.77 schema:affiliation grid-institutes:grid.419537.d
    350 schema:familyName Simons
    351 schema:givenName Kai
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762631600.77
    353 rdf:type schema:Person
    354 sg:person.0772520322.28 schema:affiliation grid-institutes:grid.19006.3e
    355 schema:familyName Service
    356 schema:givenName Susan K.
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772520322.28
    358 rdf:type schema:Person
    359 sg:pub.10.1023/a:1007306110822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039078290
    360 https://doi.org/10.1023/a:1007306110822
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/ncomms11122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034394716
    363 https://doi.org/10.1038/ncomms11122
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/ncomms8208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003527515
    366 https://doi.org/10.1038/ncomms8208
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/ng.2354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029723318
    369 https://doi.org/10.1038/ng.2354
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/ng.2982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044995197
    372 https://doi.org/10.1038/ng.2982
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/ng.3300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002957734
    375 https://doi.org/10.1038/ng.3300
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/ng.3809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129149
    378 https://doi.org/10.1038/ng.3809
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/ng.3977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092440097
    381 https://doi.org/10.1038/ng.3977
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/ng.507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003091868
    384 https://doi.org/10.1038/ng.507
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/nrg2796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009739594
    387 https://doi.org/10.1038/nrg2796
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/s41586-018-0579-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1107363293
    390 https://doi.org/10.1038/s41586-018-0579-z
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/s41588-018-0184-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1106070347
    393 https://doi.org/10.1038/s41588-018-0184-y
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/s41598-017-03965-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086000821
    396 https://doi.org/10.1038/s41598-017-03965-6
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1186/gb-2011-12-1-r8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041789727
    399 https://doi.org/10.1186/gb-2011-12-1-r8
    400 rdf:type schema:CreativeWork
    401 grid-institutes:None schema:alternateName Lipotype GmbH, Dresden, Germany
    402 schema:name Lipotype GmbH, Dresden, Germany
    403 rdf:type schema:Organization
    404 grid-institutes:grid.10939.32 schema:alternateName Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
    405 schema:name Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
    406 Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
    407 rdf:type schema:Organization
    408 grid-institutes:grid.14758.3f schema:alternateName National Institute for Health and Welfare, Helsinki, Finland
    409 schema:name Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
    410 National Institute for Health and Welfare, Helsinki, Finland
    411 rdf:type schema:Organization
    412 grid-institutes:grid.15485.3d schema:alternateName Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland
    413 Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    414 Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland
    415 schema:name Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland
    416 Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland
    417 Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
    418 Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    419 Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland
    420 rdf:type schema:Organization
    421 grid-institutes:grid.19006.3e schema:alternateName Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
    422 schema:name Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
    423 rdf:type schema:Organization
    424 grid-institutes:grid.32224.35 schema:alternateName Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Medicine, and the Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    425 Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
    426 schema:name Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    427 Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
    428 Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    429 Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Medicine, and the Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    430 Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
    431 rdf:type schema:Organization
    432 grid-institutes:grid.38142.3c schema:alternateName Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    433 schema:name Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    434 Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    435 Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
    436 rdf:type schema:Organization
    437 grid-institutes:grid.419537.d schema:alternateName Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    438 schema:name Lipotype GmbH, Dresden, Germany
    439 Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    440 rdf:type schema:Organization
    441 grid-institutes:grid.4367.6 schema:alternateName McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO, USA
    442 schema:name Cardiovascular Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA
    443 Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA
    444 McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO, USA
    445 rdf:type schema:Organization
    446 grid-institutes:grid.452494.a schema:alternateName Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
    447 schema:name Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
    448 rdf:type schema:Organization
    449 grid-institutes:grid.452540.2 schema:alternateName Minerva Foundation Institute for Medical Research, Biomedicum, Helsinki, Finland
    450 schema:name Minerva Foundation Institute for Medical Research, Biomedicum, Helsinki, Finland
    451 National Institute for Health and Welfare, Helsinki, Finland
    452 rdf:type schema:Organization
    453 grid-institutes:grid.510509.8 schema:alternateName Łukasiewicz Research Network-PORT Polish Center for Technology Development, Stablowicka 147 Str., 54-066, Wroclaw, Poland
    454 schema:name Lipotype GmbH, Dresden, Germany
    455 Łukasiewicz Research Network-PORT Polish Center for Technology Development, Stablowicka 147 Str., 54-066, Wroclaw, Poland
    456 rdf:type schema:Organization
    457 grid-institutes:grid.66859.34 schema:alternateName Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    458 schema:name Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    459 Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
    460 rdf:type schema:Organization
    461 grid-institutes:grid.7737.4 schema:alternateName Department of Public Health, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    462 Helsinki Institute for Information Technology HIIT and Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland
    463 schema:name Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    464 Department of Public Health, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    465 Department of Public Health, University of Helsinki, Helsinki, Finland
    466 Helsinki Institute for Information Technology HIIT and Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland
    467 Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
    468 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...