Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-06-17

AUTHORS

Amol C. Shetty, Christopher G. Jacob, Fang Huang, Yao Li, Sonia Agrawal, David L. Saunders, Chanthap Lon, Mark M. Fukuda, Pascal Ringwald, Elizabeth A. Ashley, Kay Thwe Han, Tin Maung Hlaing, Myaing M. Nyunt, Joana C. Silva, Kathleen E. Stewart, Christopher V. Plowe, Timothy D. O’Connor, Shannon Takala-Harrison

ABSTRACT

Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites. More... »

PAGES

2665

References to SciGraph publications

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  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    10

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-10121-3

    DOI

    http://dx.doi.org/10.1038/s41467-019-10121-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1117288732

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31209259


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