Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-05-01

AUTHORS

George B. Saffouri, Robin R. Shields-Cutler, Jun Chen, Yi Yang, Heather R. Lekatz, Vanessa L. Hale, Janice M. Cho, Eric J. Battaglioli, Yogesh Bhattarai, Kevin J. Thompson, Krishna K. Kalari, Gaurav Behera, Jonathan C. Berry, Stephanie A. Peters, Robin Patel, Audrey N. Schuetz, Jeremiah J. Faith, Michael Camilleri, Justin L. Sonnenburg, Gianrico Farrugia, Jonathan R. Swann, Madhusudan Grover, Dan Knights, Purna C. Kashyap

ABSTRACT

Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an overgrowth of anaerobes, does not correspond with patient symptoms, and may be a result of dietary preferences. Small intestinal microbial composition, on the other hand, is significantly altered in symptomatic patients and does not correspond with aspirate culture results. In a pilot interventional study we found that switching from a high fiber diet to a low fiber, high simple sugar diet triggered FGID-related symptoms and decreased small intestinal microbial diversity while increasing small intestinal permeability. Our findings demonstrate that characterizing small intestinal microbiomes in patients with gastrointestinal symptoms may allow a more targeted antibacterial or a diet-based approach to treatment. More... »

PAGES

2012

References to SciGraph publications

  • 2013-08-25. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences in NATURE BIOTECHNOLOGY
  • 2010-04-11. QIIME allows analysis of high-throughput community sequencing data in NATURE METHODS
  • 2015-02-17. No difference in small bowel microbiota between patients with irritable bowel syndrome and healthy controls in SCIENTIFIC REPORTS
  • 2018-08-06. CLOUD: a non-parametric detection test for microbiome outliers in MICROBIOME
  • 2011-06-24. Metagenomic biomarker discovery and explanation in GENOME BIOLOGY
  • 2014-07-29. The Effect of Fiber Supplementation on Irritable Bowel Syndrome: A Systematic Review and Meta-analysis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2017-03-21. Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2012-05-09. Human gut microbiome viewed across age and geography in NATURE
  • 2016-07-25. Systematic improvement of amplicon marker gene methods for increased accuracy in microbiome studies in NATURE BIOTECHNOLOGY
  • 2014-06-27. MAP-RSeq: Mayo Analysis Pipeline for RNA sequencing in BMC BIOINFORMATICS
  • 2011-01-26. Bifidobacteria can protect from enteropathogenic infection through production of acetate in NATURE
  • 2005-07-01. Detection of Bacterial Overgrowth in IBS Using the Lactulose H2 Breath Test: Comparison with 14C-d-Xylose and Healthy Controls in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2002-01-01. Antibiotics increase functional abdominal symptoms in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2012-01-19. The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    10

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-09964-7

    DOI

    http://dx.doi.org/10.1038/s41467-019-09964-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113858689

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31043597


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Bacterial Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA, Bacterial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dietary Fiber", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dietary Sugars", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dysbiosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastrointestinal Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastrointestinal Microbiome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Healthy Volunteers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intestinal Mucosa", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intestine, Small", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Permeability", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pilot Projects", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saffouri", 
            "givenName": "George B.", 
            "id": "sg:person.01225577475.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225577475.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology, Macalester College, 55105, Saint Paul, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.259382.7", 
              "name": [
                "BioTechnology Institute, College of Biological Sciences, University of Minnesota, 55455, Minneapolis, MN, USA", 
                "Department of Biology, Macalester College, 55105, Saint Paul, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shields-Cutler", 
            "givenName": "Robin R.", 
            "id": "sg:person.01127372111.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127372111.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Jun", 
            "id": "sg:person.01023412627.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023412627.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Computational and Systems Medicine Section of the Department of Surgery and Cancer, Imperial College, (London), UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Computational and Systems Medicine Section of the Department of Surgery and Cancer, Imperial College, (London), UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Yi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lekatz", 
            "givenName": "Heather R.", 
            "id": "sg:person.011230701503.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011230701503.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Veterinary Preventive Medicine, The Ohio State University, 43210, Columbus, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.261331.4", 
              "name": [
                "Department of Veterinary Preventive Medicine, The Ohio State University, 43210, Columbus, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hale", 
            "givenName": "Vanessa L.", 
            "id": "sg:person.01270252531.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270252531.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Internal Medicine, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Internal Medicine, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cho", 
            "givenName": "Janice M.", 
            "id": "sg:person.07546710266.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07546710266.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Battaglioli", 
            "givenName": "Eric J.", 
            "id": "sg:person.010626056777.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010626056777.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhattarai", 
            "givenName": "Yogesh", 
            "id": "sg:person.01314147403.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314147403.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thompson", 
            "givenName": "Kevin J.", 
            "id": "sg:person.0615314610.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615314610.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kalari", 
            "givenName": "Krishna K.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Behera", 
            "givenName": "Gaurav", 
            "id": "sg:person.012204250011.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012204250011.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Berry", 
            "givenName": "Jonathan C.", 
            "id": "sg:person.013525526734.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013525526734.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peters", 
            "givenName": "Stephanie A.", 
            "id": "sg:person.014626453077.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014626453077.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Patel", 
            "givenName": "Robin", 
            "id": "sg:person.01314011732.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314011732.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schuetz", 
            "givenName": "Audrey N.", 
            "id": "sg:person.0752222374.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752222374.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics and Genomic Sciences, Medicine, and Clinical Immunology, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Department of Genetics and Genomic Sciences, Medicine, and Clinical Immunology, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Faith", 
            "givenName": "Jeremiah J.", 
            "id": "sg:person.01037222536.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037222536.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Physiology and Biomedical Engineering, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA", 
                "Department of Physiology and Biomedical Engineering, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Camilleri", 
            "givenName": "Michael", 
            "id": "sg:person.011530702337.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011530702337.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology and Immunology, Stanford University, 94305, Stanford, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Microbiology and Immunology, Stanford University, 94305, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sonnenburg", 
            "givenName": "Justin L.", 
            "id": "sg:person.01055644616.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055644616.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Mayo Clinic, 32224, Jacksonville, FL, USA", 
              "id": "http://www.grid.ac/institutes/grid.417467.7", 
              "name": [
                "Division of Gastroenterology, Mayo Clinic, 32224, Jacksonville, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Farrugia", 
            "givenName": "Gianrico", 
            "id": "sg:person.01327525757.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327525757.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Computational and Systems Medicine Section of the Department of Surgery and Cancer, Imperial College, (London), UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Computational and Systems Medicine Section of the Department of Surgery and Cancer, Imperial College, (London), UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Swann", 
            "givenName": "Jonathan R.", 
            "id": "sg:person.010444470137.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010444470137.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Physiology and Biomedical Engineering, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA", 
                "Department of Physiology and Biomedical Engineering, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grover", 
            "givenName": "Madhusudan", 
            "id": "sg:person.0637512173.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637512173.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Computer Science and Engineering, University of Minnesota, 55455, Minneapolis, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.17635.36", 
              "name": [
                "BioTechnology Institute, College of Biological Sciences, University of Minnesota, 55455, Minneapolis, MN, USA", 
                "Department of Computer Science and Engineering, University of Minnesota, 55455, Minneapolis, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knights", 
            "givenName": "Dan", 
            "id": "sg:person.01054701157.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054701157.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Physiology and Biomedical Engineering, Mayo Clinic, 55902, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA", 
                "Department of Physiology and Biomedical Engineering, Mayo Clinic, 55902, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kashyap", 
            "givenName": "Purna C.", 
            "id": "sg:person.01007613452.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007613452.86"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ajg.2014.195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009328873", 
              "https://doi.org/10.1038/ajg.2014.195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034019934", 
              "https://doi.org/10.1038/nbt.2676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep08508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022033465", 
              "https://doi.org/10.1038/srep08508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052378845", 
              "https://doi.org/10.1038/nature11053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009032055", 
              "https://doi.org/10.1038/nmeth.f.303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002490773", 
              "https://doi.org/10.1038/nbt.3601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-6-r60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000243423", 
              "https://doi.org/10.1186/gb-2011-12-6-r60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2005.40795.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019821180", 
              "https://doi.org/10.1111/j.1572-0241.2005.40795.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050719635", 
              "https://doi.org/10.1038/nature09646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ismej.2011.212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043234942", 
              "https://doi.org/10.1038/ismej.2011.212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40168-018-0514-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106015325", 
              "https://doi.org/10.1186/s40168-018-0514-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2002.05428.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013631469", 
              "https://doi.org/10.1111/j.1572-0241.2002.05428.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-15-224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010371551", 
              "https://doi.org/10.1186/1471-2105-15-224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2017.48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084127623", 
              "https://doi.org/10.1038/ajg.2017.48"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-05-01", 
        "datePublishedReg": "2019-05-01", 
        "description": "Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an overgrowth of anaerobes, does not correspond with patient symptoms, and may be a result of dietary preferences. Small intestinal microbial composition, on the other hand, is significantly altered in symptomatic patients and does not correspond with aspirate culture results. In a pilot interventional study we found that switching from a high fiber diet to a low fiber, high simple sugar diet triggered FGID-related symptoms and decreased small intestinal microbial diversity while increasing small intestinal permeability. Our findings demonstrate that characterizing small intestinal microbiomes in patients with gastrointestinal symptoms may allow a more targeted antibacterial or a diet-based approach to treatment.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41467-019-09964-7", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4889010", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2499982", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6617248", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4243414", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6502754", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6503035", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7027893", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7171606", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6541688", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "keywords": [
          "small intestinal bacterial overgrowth", 
          "functional gastrointestinal disorders", 
          "gastrointestinal disorders", 
          "non-specific antibiotics", 
          "duodenal aspirate culture", 
          "small intestinal microbiome", 
          "intestinal bacterial overgrowth", 
          "small intestinal permeability", 
          "pilot interventional study", 
          "diet-based approaches", 
          "intestinal microbial composition", 
          "overgrowth of anaerobes", 
          "high-fiber diet", 
          "intestinal microbial diversity", 
          "gastrointestinal symptoms", 
          "symptomatic patients", 
          "bacterial overgrowth", 
          "patient's symptoms", 
          "aspirate cultures", 
          "interventional study", 
          "intestinal permeability", 
          "intestinal microbiome", 
          "sugar diet", 
          "culture results", 
          "symptoms", 
          "fiber diet", 
          "patients", 
          "disorders", 
          "low fiber", 
          "diet", 
          "treatment", 
          "microbial composition", 
          "overgrowth", 
          "antibiotics", 
          "dietary preferences", 
          "anaerobes", 
          "microbiome", 
          "findings", 
          "study", 
          "results", 
          "culture", 
          "mechanism", 
          "microbial diversity", 
          "permeability", 
          "fibers", 
          "hand", 
          "preferences", 
          "approach", 
          "composition", 
          "diversity"
        ], 
        "name": "Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders", 
        "pagination": "2012", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113858689"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-019-09964-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31043597"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-019-09964-7", 
          "https://app.dimensions.ai/details/publication/pub.1113858689"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_793.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41467-019-09964-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09964-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09964-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09964-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09964-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    458 TRIPLES      21 PREDICATES      110 URIs      88 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-019-09964-7 schema:about N06e2fdddc38744d5984200bca9cf7893
    2 N10dd6d49ad2d417b8eb3cfd8a94c12b3
    3 N3463482658214601971e1b4f87c85d41
    4 N38b8396d9fd54995a246aa31c760aa60
    5 N4df036b39b034270add054d5d50a194f
    6 N520f3e1dda844e3581b26c709064accf
    7 N5588efc0dbdb4745b80aebacdc711c01
    8 N5907a58112b349d1a9358e76dbb4841d
    9 N75a5142d21a34b2bba85ed6358e25fda
    10 N8204d903c83e4797843eab4bf8e9f6c5
    11 N85947ac1906840d9849be16a36ebe99c
    12 Na878ee8d6de24801a2f66a22f0bca46e
    13 Nb1e297e496ab48d6865c8908627eb684
    14 Nb8fa3cd3400b441286f103e987e0fa5f
    15 Nc28b561377e84fa5ad1bc06a8b524ff6
    16 Nc58c2c47e4ff47dda73808d43f8c902c
    17 Ncaf79a7436534c0ca1117384b67d0893
    18 Ndb869dd8d3e241008bc14ca11e9f1d93
    19 Ndbe0136dc0cc4acbab254b15e176f2d7
    20 Nec345c5471e54f2887dc3f244d360314
    21 Nfd1556637d174efc8f7de2982e26e94b
    22 anzsrc-for:11
    23 anzsrc-for:1103
    24 schema:author Ncd6c42674d554298a41aa354a52a945f
    25 schema:citation sg:pub.10.1038/ajg.2014.195
    26 sg:pub.10.1038/ajg.2017.48
    27 sg:pub.10.1038/ismej.2011.212
    28 sg:pub.10.1038/nature09646
    29 sg:pub.10.1038/nature11053
    30 sg:pub.10.1038/nbt.2676
    31 sg:pub.10.1038/nbt.3601
    32 sg:pub.10.1038/nmeth.f.303
    33 sg:pub.10.1038/srep08508
    34 sg:pub.10.1111/j.1572-0241.2002.05428.x
    35 sg:pub.10.1111/j.1572-0241.2005.40795.x
    36 sg:pub.10.1186/1471-2105-15-224
    37 sg:pub.10.1186/gb-2011-12-6-r60
    38 sg:pub.10.1186/s40168-018-0514-4
    39 schema:datePublished 2019-05-01
    40 schema:datePublishedReg 2019-05-01
    41 schema:description Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an overgrowth of anaerobes, does not correspond with patient symptoms, and may be a result of dietary preferences. Small intestinal microbial composition, on the other hand, is significantly altered in symptomatic patients and does not correspond with aspirate culture results. In a pilot interventional study we found that switching from a high fiber diet to a low fiber, high simple sugar diet triggered FGID-related symptoms and decreased small intestinal microbial diversity while increasing small intestinal permeability. Our findings demonstrate that characterizing small intestinal microbiomes in patients with gastrointestinal symptoms may allow a more targeted antibacterial or a diet-based approach to treatment.
    42 schema:genre article
    43 schema:isAccessibleForFree true
    44 schema:isPartOf N0919e581f5f84b158d6e192cb6474307
    45 N11fa83a80ba249e29eda0f8e6ec057fb
    46 sg:journal.1043282
    47 schema:keywords anaerobes
    48 antibiotics
    49 approach
    50 aspirate cultures
    51 bacterial overgrowth
    52 composition
    53 culture
    54 culture results
    55 diet
    56 diet-based approaches
    57 dietary preferences
    58 disorders
    59 diversity
    60 duodenal aspirate culture
    61 fiber diet
    62 fibers
    63 findings
    64 functional gastrointestinal disorders
    65 gastrointestinal disorders
    66 gastrointestinal symptoms
    67 hand
    68 high-fiber diet
    69 interventional study
    70 intestinal bacterial overgrowth
    71 intestinal microbial composition
    72 intestinal microbial diversity
    73 intestinal microbiome
    74 intestinal permeability
    75 low fiber
    76 mechanism
    77 microbial composition
    78 microbial diversity
    79 microbiome
    80 non-specific antibiotics
    81 overgrowth
    82 overgrowth of anaerobes
    83 patient's symptoms
    84 patients
    85 permeability
    86 pilot interventional study
    87 preferences
    88 results
    89 small intestinal bacterial overgrowth
    90 small intestinal microbiome
    91 small intestinal permeability
    92 study
    93 sugar diet
    94 symptomatic patients
    95 symptoms
    96 treatment
    97 schema:name Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
    98 schema:pagination 2012
    99 schema:productId N038524d3395944eea477511b15eeb5e9
    100 N2f18cab2fd1e41a68fd7f089f32caff2
    101 Na3fe1b4d56794b4db37a97b524f5e756
    102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113858689
    103 https://doi.org/10.1038/s41467-019-09964-7
    104 schema:sdDatePublished 2022-12-01T06:38
    105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    106 schema:sdPublisher Nf3ca600b86d2429f95a36593c2c8a867
    107 schema:url https://doi.org/10.1038/s41467-019-09964-7
    108 sgo:license sg:explorer/license/
    109 sgo:sdDataset articles
    110 rdf:type schema:ScholarlyArticle
    111 N038524d3395944eea477511b15eeb5e9 schema:name dimensions_id
    112 schema:value pub.1113858689
    113 rdf:type schema:PropertyValue
    114 N06e2fdddc38744d5984200bca9cf7893 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Anti-Bacterial Agents
    116 rdf:type schema:DefinedTerm
    117 N0919e581f5f84b158d6e192cb6474307 schema:issueNumber 1
    118 rdf:type schema:PublicationIssue
    119 N10dd6d49ad2d417b8eb3cfd8a94c12b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Female
    121 rdf:type schema:DefinedTerm
    122 N11fa83a80ba249e29eda0f8e6ec057fb schema:volumeNumber 10
    123 rdf:type schema:PublicationVolume
    124 N168fdd737fa24033b99b2a8e8e5b55c0 rdf:first sg:person.01023412627.52
    125 rdf:rest N7d720e2856394c9cb63b52d33f4831bd
    126 N1d096bfb37044546be5b73e48d24b0f1 rdf:first sg:person.01007613452.86
    127 rdf:rest rdf:nil
    128 N1d4c21d46a944c96bcb68d407a6727e2 rdf:first sg:person.012204250011.06
    129 rdf:rest N38df6bde52d54beda1d8c2d20a521ad2
    130 N206ede490c3547be94352e70bcc66f86 rdf:first sg:person.01127372111.61
    131 rdf:rest N168fdd737fa24033b99b2a8e8e5b55c0
    132 N29ce03f2bab24dd9a950fcf1b4f22204 rdf:first sg:person.0637512173.38
    133 rdf:rest N680250db94434e9dabfb8e32da003f55
    134 N2e375959f8404e1c93e5a096cce7d1e4 rdf:first sg:person.01314147403.44
    135 rdf:rest Nd0fba8a71ce949ecbb5205e04db75113
    136 N2f18cab2fd1e41a68fd7f089f32caff2 schema:name pubmed_id
    137 schema:value 31043597
    138 rdf:type schema:PropertyValue
    139 N3463482658214601971e1b4f87c85d41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Adult
    141 rdf:type schema:DefinedTerm
    142 N38b8396d9fd54995a246aa31c760aa60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Intestine, Small
    144 rdf:type schema:DefinedTerm
    145 N38df6bde52d54beda1d8c2d20a521ad2 rdf:first sg:person.013525526734.05
    146 rdf:rest N633697a2440a41bfa773915fa577665d
    147 N3cfc694017804a7fada5832f174471e4 schema:affiliation grid-institutes:grid.7445.2
    148 schema:familyName Yang
    149 schema:givenName Yi
    150 rdf:type schema:Person
    151 N4df036b39b034270add054d5d50a194f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Pilot Projects
    153 rdf:type schema:DefinedTerm
    154 N5203b8d5f0f4442199fbfd1dd1de927a rdf:first sg:person.01314011732.26
    155 rdf:rest N6376c08f4e694854b84d8a3095827191
    156 N520f3e1dda844e3581b26c709064accf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Aged
    158 rdf:type schema:DefinedTerm
    159 N5588efc0dbdb4745b80aebacdc711c01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Aged, 80 and over
    161 rdf:type schema:DefinedTerm
    162 N5907a58112b349d1a9358e76dbb4841d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Young Adult
    164 rdf:type schema:DefinedTerm
    165 N61e5d6d04548436c8a52bf214383c1cc rdf:first sg:person.011530702337.74
    166 rdf:rest Nd875548433684268ae11513378c81fc0
    167 N633697a2440a41bfa773915fa577665d rdf:first sg:person.014626453077.12
    168 rdf:rest N5203b8d5f0f4442199fbfd1dd1de927a
    169 N6376c08f4e694854b84d8a3095827191 rdf:first sg:person.0752222374.34
    170 rdf:rest N9c62d057b40f4ae1b070e57cebbe6959
    171 N646cf192cbf14d128e5d8248116677d3 rdf:first sg:person.01270252531.25
    172 rdf:rest N7e2dfee90be243a1acfbe88160b438bc
    173 N680250db94434e9dabfb8e32da003f55 rdf:first sg:person.01054701157.41
    174 rdf:rest N1d096bfb37044546be5b73e48d24b0f1
    175 N75a5142d21a34b2bba85ed6358e25fda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Healthy Volunteers
    177 rdf:type schema:DefinedTerm
    178 N7d720e2856394c9cb63b52d33f4831bd rdf:first N3cfc694017804a7fada5832f174471e4
    179 rdf:rest Nd4aafeb9e7a84ce59364cd6ec092bd9a
    180 N7e2dfee90be243a1acfbe88160b438bc rdf:first sg:person.07546710266.38
    181 rdf:rest Ndb09c184444f49b997f09b734a01d509
    182 N8204d903c83e4797843eab4bf8e9f6c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Male
    184 rdf:type schema:DefinedTerm
    185 N85947ac1906840d9849be16a36ebe99c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Gastrointestinal Microbiome
    187 rdf:type schema:DefinedTerm
    188 N8b850324295e40ffb4e8d09119258b62 schema:affiliation grid-institutes:grid.66875.3a
    189 schema:familyName Kalari
    190 schema:givenName Krishna K.
    191 rdf:type schema:Person
    192 N9c62d057b40f4ae1b070e57cebbe6959 rdf:first sg:person.01037222536.11
    193 rdf:rest N61e5d6d04548436c8a52bf214383c1cc
    194 Na2e2d8507ce84baeab7fbca063390338 rdf:first N8b850324295e40ffb4e8d09119258b62
    195 rdf:rest N1d4c21d46a944c96bcb68d407a6727e2
    196 Na3fe1b4d56794b4db37a97b524f5e756 schema:name doi
    197 schema:value 10.1038/s41467-019-09964-7
    198 rdf:type schema:PropertyValue
    199 Na878ee8d6de24801a2f66a22f0bca46e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name DNA, Bacterial
    201 rdf:type schema:DefinedTerm
    202 Nb1e297e496ab48d6865c8908627eb684 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Gastrointestinal Diseases
    204 rdf:type schema:DefinedTerm
    205 Nb8fa3cd3400b441286f103e987e0fa5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Dysbiosis
    207 rdf:type schema:DefinedTerm
    208 Nbf3e611041504fce94479403184c39a9 rdf:first sg:person.010444470137.17
    209 rdf:rest N29ce03f2bab24dd9a950fcf1b4f22204
    210 Nc28b561377e84fa5ad1bc06a8b524ff6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Dietary Fiber
    212 rdf:type schema:DefinedTerm
    213 Nc58c2c47e4ff47dda73808d43f8c902c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Permeability
    215 rdf:type schema:DefinedTerm
    216 Ncaf79a7436534c0ca1117384b67d0893 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Dietary Sugars
    218 rdf:type schema:DefinedTerm
    219 Nccafffcb50554a01b15e931ae092b85e rdf:first sg:person.01327525757.14
    220 rdf:rest Nbf3e611041504fce94479403184c39a9
    221 Ncd6c42674d554298a41aa354a52a945f rdf:first sg:person.01225577475.61
    222 rdf:rest N206ede490c3547be94352e70bcc66f86
    223 Nd0fba8a71ce949ecbb5205e04db75113 rdf:first sg:person.0615314610.13
    224 rdf:rest Na2e2d8507ce84baeab7fbca063390338
    225 Nd4aafeb9e7a84ce59364cd6ec092bd9a rdf:first sg:person.011230701503.12
    226 rdf:rest N646cf192cbf14d128e5d8248116677d3
    227 Nd875548433684268ae11513378c81fc0 rdf:first sg:person.01055644616.45
    228 rdf:rest Nccafffcb50554a01b15e931ae092b85e
    229 Ndb09c184444f49b997f09b734a01d509 rdf:first sg:person.010626056777.95
    230 rdf:rest N2e375959f8404e1c93e5a096cce7d1e4
    231 Ndb869dd8d3e241008bc14ca11e9f1d93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Humans
    233 rdf:type schema:DefinedTerm
    234 Ndbe0136dc0cc4acbab254b15e176f2d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Adolescent
    236 rdf:type schema:DefinedTerm
    237 Nec345c5471e54f2887dc3f244d360314 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    238 schema:name Middle Aged
    239 rdf:type schema:DefinedTerm
    240 Nf3ca600b86d2429f95a36593c2c8a867 schema:name Springer Nature - SN SciGraph project
    241 rdf:type schema:Organization
    242 Nfd1556637d174efc8f7de2982e26e94b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    243 schema:name Intestinal Mucosa
    244 rdf:type schema:DefinedTerm
    245 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    246 schema:name Medical and Health Sciences
    247 rdf:type schema:DefinedTerm
    248 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    249 schema:name Clinical Sciences
    250 rdf:type schema:DefinedTerm
    251 sg:grant.2499982 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09964-7
    252 rdf:type schema:MonetaryGrant
    253 sg:grant.4243414 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09964-7
    254 rdf:type schema:MonetaryGrant
    255 sg:grant.4889010 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09964-7
    256 rdf:type schema:MonetaryGrant
    257 sg:grant.6502754 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09964-7
    258 rdf:type schema:MonetaryGrant
    259 sg:grant.6503035 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09964-7
    260 rdf:type schema:MonetaryGrant
    261 sg:grant.6541688 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09964-7
    262 rdf:type schema:MonetaryGrant
    263 sg:grant.6617248 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09964-7
    264 rdf:type schema:MonetaryGrant
    265 sg:grant.7027893 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09964-7
    266 rdf:type schema:MonetaryGrant
    267 sg:grant.7171606 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09964-7
    268 rdf:type schema:MonetaryGrant
    269 sg:journal.1043282 schema:issn 2041-1723
    270 schema:name Nature Communications
    271 schema:publisher Springer Nature
    272 rdf:type schema:Periodical
    273 sg:person.01007613452.86 schema:affiliation grid-institutes:grid.66875.3a
    274 schema:familyName Kashyap
    275 schema:givenName Purna C.
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007613452.86
    277 rdf:type schema:Person
    278 sg:person.01023412627.52 schema:affiliation grid-institutes:grid.66875.3a
    279 schema:familyName Chen
    280 schema:givenName Jun
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023412627.52
    282 rdf:type schema:Person
    283 sg:person.01037222536.11 schema:affiliation grid-institutes:grid.59734.3c
    284 schema:familyName Faith
    285 schema:givenName Jeremiah J.
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037222536.11
    287 rdf:type schema:Person
    288 sg:person.010444470137.17 schema:affiliation grid-institutes:grid.7445.2
    289 schema:familyName Swann
    290 schema:givenName Jonathan R.
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010444470137.17
    292 rdf:type schema:Person
    293 sg:person.01054701157.41 schema:affiliation grid-institutes:grid.17635.36
    294 schema:familyName Knights
    295 schema:givenName Dan
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054701157.41
    297 rdf:type schema:Person
    298 sg:person.01055644616.45 schema:affiliation grid-institutes:grid.168010.e
    299 schema:familyName Sonnenburg
    300 schema:givenName Justin L.
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055644616.45
    302 rdf:type schema:Person
    303 sg:person.010626056777.95 schema:affiliation grid-institutes:grid.66875.3a
    304 schema:familyName Battaglioli
    305 schema:givenName Eric J.
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010626056777.95
    307 rdf:type schema:Person
    308 sg:person.011230701503.12 schema:affiliation grid-institutes:grid.66875.3a
    309 schema:familyName Lekatz
    310 schema:givenName Heather R.
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011230701503.12
    312 rdf:type schema:Person
    313 sg:person.01127372111.61 schema:affiliation grid-institutes:grid.259382.7
    314 schema:familyName Shields-Cutler
    315 schema:givenName Robin R.
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127372111.61
    317 rdf:type schema:Person
    318 sg:person.011530702337.74 schema:affiliation grid-institutes:grid.66875.3a
    319 schema:familyName Camilleri
    320 schema:givenName Michael
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011530702337.74
    322 rdf:type schema:Person
    323 sg:person.012204250011.06 schema:affiliation grid-institutes:grid.66875.3a
    324 schema:familyName Behera
    325 schema:givenName Gaurav
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012204250011.06
    327 rdf:type schema:Person
    328 sg:person.01225577475.61 schema:affiliation grid-institutes:grid.66875.3a
    329 schema:familyName Saffouri
    330 schema:givenName George B.
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225577475.61
    332 rdf:type schema:Person
    333 sg:person.01270252531.25 schema:affiliation grid-institutes:grid.261331.4
    334 schema:familyName Hale
    335 schema:givenName Vanessa L.
    336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270252531.25
    337 rdf:type schema:Person
    338 sg:person.01314011732.26 schema:affiliation grid-institutes:grid.66875.3a
    339 schema:familyName Patel
    340 schema:givenName Robin
    341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314011732.26
    342 rdf:type schema:Person
    343 sg:person.01314147403.44 schema:affiliation grid-institutes:grid.66875.3a
    344 schema:familyName Bhattarai
    345 schema:givenName Yogesh
    346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314147403.44
    347 rdf:type schema:Person
    348 sg:person.01327525757.14 schema:affiliation grid-institutes:grid.417467.7
    349 schema:familyName Farrugia
    350 schema:givenName Gianrico
    351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327525757.14
    352 rdf:type schema:Person
    353 sg:person.013525526734.05 schema:affiliation grid-institutes:grid.66875.3a
    354 schema:familyName Berry
    355 schema:givenName Jonathan C.
    356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013525526734.05
    357 rdf:type schema:Person
    358 sg:person.014626453077.12 schema:affiliation grid-institutes:grid.66875.3a
    359 schema:familyName Peters
    360 schema:givenName Stephanie A.
    361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014626453077.12
    362 rdf:type schema:Person
    363 sg:person.0615314610.13 schema:affiliation grid-institutes:grid.66875.3a
    364 schema:familyName Thompson
    365 schema:givenName Kevin J.
    366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615314610.13
    367 rdf:type schema:Person
    368 sg:person.0637512173.38 schema:affiliation grid-institutes:grid.66875.3a
    369 schema:familyName Grover
    370 schema:givenName Madhusudan
    371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637512173.38
    372 rdf:type schema:Person
    373 sg:person.0752222374.34 schema:affiliation grid-institutes:grid.66875.3a
    374 schema:familyName Schuetz
    375 schema:givenName Audrey N.
    376 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752222374.34
    377 rdf:type schema:Person
    378 sg:person.07546710266.38 schema:affiliation grid-institutes:grid.66875.3a
    379 schema:familyName Cho
    380 schema:givenName Janice M.
    381 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07546710266.38
    382 rdf:type schema:Person
    383 sg:pub.10.1038/ajg.2014.195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009328873
    384 https://doi.org/10.1038/ajg.2014.195
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/ajg.2017.48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084127623
    387 https://doi.org/10.1038/ajg.2017.48
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/ismej.2011.212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043234942
    390 https://doi.org/10.1038/ismej.2011.212
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/nature09646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050719635
    393 https://doi.org/10.1038/nature09646
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/nature11053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052378845
    396 https://doi.org/10.1038/nature11053
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/nbt.2676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034019934
    399 https://doi.org/10.1038/nbt.2676
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/nbt.3601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002490773
    402 https://doi.org/10.1038/nbt.3601
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/nmeth.f.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009032055
    405 https://doi.org/10.1038/nmeth.f.303
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/srep08508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022033465
    408 https://doi.org/10.1038/srep08508
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1111/j.1572-0241.2002.05428.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013631469
    411 https://doi.org/10.1111/j.1572-0241.2002.05428.x
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1111/j.1572-0241.2005.40795.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019821180
    414 https://doi.org/10.1111/j.1572-0241.2005.40795.x
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1186/1471-2105-15-224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010371551
    417 https://doi.org/10.1186/1471-2105-15-224
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1186/gb-2011-12-6-r60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000243423
    420 https://doi.org/10.1186/gb-2011-12-6-r60
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1186/s40168-018-0514-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106015325
    423 https://doi.org/10.1186/s40168-018-0514-4
    424 rdf:type schema:CreativeWork
    425 grid-institutes:grid.168010.e schema:alternateName Department of Microbiology and Immunology, Stanford University, 94305, Stanford, CA, USA
    426 schema:name Department of Microbiology and Immunology, Stanford University, 94305, Stanford, CA, USA
    427 rdf:type schema:Organization
    428 grid-institutes:grid.17635.36 schema:alternateName Department of Computer Science and Engineering, University of Minnesota, 55455, Minneapolis, MN, USA
    429 schema:name BioTechnology Institute, College of Biological Sciences, University of Minnesota, 55455, Minneapolis, MN, USA
    430 Department of Computer Science and Engineering, University of Minnesota, 55455, Minneapolis, MN, USA
    431 rdf:type schema:Organization
    432 grid-institutes:grid.259382.7 schema:alternateName Department of Biology, Macalester College, 55105, Saint Paul, MN, USA
    433 schema:name BioTechnology Institute, College of Biological Sciences, University of Minnesota, 55455, Minneapolis, MN, USA
    434 Department of Biology, Macalester College, 55105, Saint Paul, MN, USA
    435 rdf:type schema:Organization
    436 grid-institutes:grid.261331.4 schema:alternateName Department of Veterinary Preventive Medicine, The Ohio State University, 43210, Columbus, OH, USA
    437 schema:name Department of Veterinary Preventive Medicine, The Ohio State University, 43210, Columbus, OH, USA
    438 rdf:type schema:Organization
    439 grid-institutes:grid.417467.7 schema:alternateName Division of Gastroenterology, Mayo Clinic, 32224, Jacksonville, FL, USA
    440 schema:name Division of Gastroenterology, Mayo Clinic, 32224, Jacksonville, FL, USA
    441 rdf:type schema:Organization
    442 grid-institutes:grid.59734.3c schema:alternateName Department of Genetics and Genomic Sciences, Medicine, and Clinical Immunology, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA
    443 schema:name Department of Genetics and Genomic Sciences, Medicine, and Clinical Immunology, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA
    444 rdf:type schema:Organization
    445 grid-institutes:grid.66875.3a schema:alternateName Department of Physiology and Biomedical Engineering, Mayo Clinic, 55902, Rochester, MN, USA
    446 Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 55902, Rochester, MN, USA
    447 Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 55902, Rochester, MN, USA
    448 Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA
    449 Division of Internal Medicine, Mayo Clinic, 55902, Rochester, MN, USA
    450 schema:name Department of Physiology and Biomedical Engineering, Mayo Clinic, 55902, Rochester, MN, USA
    451 Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 55902, Rochester, MN, USA
    452 Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 55902, Rochester, MN, USA
    453 Division of Gastroenterology and Hepatology, Mayo Clinic, 55902, Rochester, MN, USA
    454 Division of Internal Medicine, Mayo Clinic, 55902, Rochester, MN, USA
    455 rdf:type schema:Organization
    456 grid-institutes:grid.7445.2 schema:alternateName Computational and Systems Medicine Section of the Department of Surgery and Cancer, Imperial College, (London), UK
    457 schema:name Computational and Systems Medicine Section of the Department of Surgery and Cancer, Imperial College, (London), UK
    458 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...