Plug-and-play metabolic transducers expand the chemical detection space of cell-free biosensors. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Peter L Voyvodic, Amir Pandi, Mathilde Koch, Ismael Conejero, Emmanuel Valjent, Philippe Courtet, Eric Renard, Jean-Loup Faulon, Jerome Bonnet

ABSTRACT

Cell-free transcription-translation systems have great potential for biosensing, yet the range of detectable chemicals is limited. Here we provide a workflow to expand the range of molecules detectable by cell-free biosensors through combining synthetic metabolic cascades with transcription factor-based networks. These hybrid cell-free biosensors have a fast response time, strong signal response, and a high dynamic range. In addition, they are capable of functioning in a variety of complex media, including commercial beverages and human urine, in which they can be used to detect clinically relevant concentrations of small molecules. This work provides a foundation to engineer modular cell-free biosensors tailored for many applications. More... »

PAGES

1697

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-09722-9

DOI

http://dx.doi.org/10.1038/s41467-019-09722-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113380254

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30979906


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