Nanomechanical DNA resonators for sensing and structural analysis of DNA-ligand complexes. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Stefano Stassi, Monica Marini, Marco Allione, Sergei Lopatin, Domenico Marson, Erik Laurini, Sabrina Pricl, Candido Fabrizio Pirri, Carlo Ricciardi, Enzo Di Fabrizio

ABSTRACT

The effect of direct or indirect binding of intercalant molecules on DNA structure is of fundamental importance in understanding the biological functioning of DNA. Here we report on self-suspended DNA nanobundles as ultrasensitive nanomechanical resonators for structural studies of DNA-ligand complexes. Such vibrating nanostructures represent the smallest mechanical resonator entirely composed of DNA. A correlative analysis between the mechanical and structural properties is exploited to study the intrinsic changes of double strand DNA, when interacting with different intercalant molecules (YOYO-1 and GelRed) and a chemotherapeutic drug (Cisplatin), at different concentrations. Possible implications of our findings are related to the study of interaction mechanism of a wide category of molecules with DNA, and to further applications in medicine, such as optimal titration of chemotherapeutic drugs and environmental studies for the detection of heavy metals in human serum. More... »

PAGES

1690

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-09612-0

    DOI

    http://dx.doi.org/10.1038/s41467-019-09612-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113380249

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30979901


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