RNA editing is abundant and correlates with task performance in a social bumblebee. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Hagit T Porath, Esther Hazan, Hagai Shpigler, Mira Cohen, Mark Band, Yehuda Ben-Shahar, Erez Y Levanon, Eli Eisenberg, Guy Bloch

ABSTRACT

Colonies of the bumblebee Bombus terrestris are characterized by wide phenotypic variability among genetically similar full-sister workers, suggesting a major role for epigenetic processes. Here, we report a high level of ADAR-mediated RNA editing in the bumblebee, despite the lack of an ADAR1-homolog. We identify 1.15 million unique genomic sites, and 164 recoding sites residing in 100 protein coding genes, including ion channels, transporters, and receptors predicted to affect brain function and behavior. Some edited sites are similarly edited in other insects, cephalopods and even mammals. The global editing level of protein coding and non-coding transcripts weakly correlates with task performance (brood care vs. foraging), but not affected by dominance rank or juvenile hormone known to influence physiology and behavior. Taken together, our findings show that brain editing levels are high in naturally behaving bees, and may be regulated by relatively short-term effects associated with brood care or foraging activities. More... »

PAGES

1605

References to SciGraph publications

  • 2010-12. Large-scale analysis of structural, sequence and thermodynamic characteristics of A-to-I RNA editing sites in human Alu repeats in BMC GENOMICS
  • 2012-10. Reversible switching between epigenetic states in honeybee behavioral subcastes in NATURE NEUROSCIENCE
  • 2012-01. Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila in NATURE COMMUNICATIONS
  • 2007-09. Size determines antennal sensitivity and behavioral threshold to odors in bumblebee workers in THE SCIENCE OF NATURE
  • 2007-03. Insect sodium channels and insecticide resistance in INVERTEBRATE NEUROSCIENCE
  • 2013-11. Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-09. Predicting sites of ADAR editing in double-stranded RNA in NATURE COMMUNICATIONS
  • 2017-10. Dynamic landscape and regulation of RNA editing in mammals in NATURE
  • 2016-02. A-to-I editing of coding and non-coding RNAs by ADARs in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-10. Social influences on body size and developmental time in the bumblebee Bombus terrestris in BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
  • 2018-08. A-to-I RNA editing — immune protector and transcriptome diversifier in NATURE REVIEWS GENETICS
  • 2014-12. Caste-specific RNA editomes in the leaf-cutting ant Acromyrmex echinatior in NATURE COMMUNICATIONS
  • 2016-01-27. ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity in NATURE COMMUNICATIONS
  • 2014-10. Eusocial insects as emerging models for behavioural epigenetics in NATURE REVIEWS GENETICS
  • 1999-05. Regulation of alternative splicing by RNA editing in NATURE
  • 2017-01. ADARB1 catalyzes circadian A-to-I editing and regulates RNA rhythm in NATURE GENETICS
  • 2014-12. A genome-wide map of hyper-edited RNA reveals numerous new sites in NATURE COMMUNICATIONS
  • 2013-03. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples in NATURE BIOTECHNOLOGY
  • 2017-12. Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance in GENOME BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-09543-w

    DOI

    http://dx.doi.org/10.1038/s41467-019-09543-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113300650

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30962428


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Bar-Ilan University", 
              "id": "https://www.grid.ac/institutes/grid.22098.31", 
              "name": [
                "The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, 52900, Israel."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Porath", 
            "givenName": "Hagit T", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hebrew University of Jerusalem", 
              "id": "https://www.grid.ac/institutes/grid.9619.7", 
              "name": [
                "Department of Ecology, Evolution & Behavior, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, 91904, Israel."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hazan", 
            "givenName": "Esther", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hebrew University of Jerusalem", 
              "id": "https://www.grid.ac/institutes/grid.9619.7", 
              "name": [
                "Department of Ecology, Evolution & Behavior, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, 91904, Israel."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shpigler", 
            "givenName": "Hagai", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hebrew University of Jerusalem", 
              "id": "https://www.grid.ac/institutes/grid.9619.7", 
              "name": [
                "Department of Ecology, Evolution & Behavior, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, 91904, Israel."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cohen", 
            "givenName": "Mira", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Haifa", 
              "id": "https://www.grid.ac/institutes/grid.18098.38", 
              "name": [
                "Roy J Carver Biotechnology Center, The University of Illinois at Urbana-Champaign, Champaign, 61801, IL, USA.", 
                "Institute of Evolution, University of Haifa, Haifa, 3498838, Israel."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Band", 
            "givenName": "Mark", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Biology, Washington University in St. Louis, St. Louis, 63130-4899, MO, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ben-Shahar", 
            "givenName": "Yehuda", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bar-Ilan University", 
              "id": "https://www.grid.ac/institutes/grid.22098.31", 
              "name": [
                "The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, 52900, Israel."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Levanon", 
            "givenName": "Erez Y", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tel Aviv University", 
              "id": "https://www.grid.ac/institutes/grid.12136.37", 
              "name": [
                "Raymond and Beverly Sackler School of Physics and Astronomy and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 6997801, Israel. elieis@post.tau.ac.il."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eisenberg", 
            "givenName": "Eli", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hebrew University of Jerusalem", 
              "id": "https://www.grid.ac/institutes/grid.9619.7", 
              "name": [
                "Department of Ecology, Evolution & Behavior, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, 91904, Israel. guy.bloch@mail.huji.ac.il."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bloch", 
            "givenName": "Guy", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.cois.2016.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000239274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000477771", 
              "https://doi.org/10.1038/nbt.2514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002794403", 
              "https://doi.org/10.1038/ncomms1324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2012.04.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003049927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00049-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003520522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkp731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004580304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bfgp/elt050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005084278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005869307", 
              "https://doi.org/10.1038/ncomms1789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ibmb.2007.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006559239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jeb.02125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006811631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/074873001129002123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008256212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/074873001129002123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008256212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008344700", 
              "https://doi.org/10.1038/nsmb.2675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-11-453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010312745", 
              "https://doi.org/10.1186/1471-2164-11-453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00265-013-1571-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010668077", 
              "https://doi.org/10.1007/s00265-013-1571-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fgene.2015.00193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012523056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms5726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014949244", 
              "https://doi.org/10.1038/ncomms5726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btt287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017451122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btt287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017451122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.200810133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019333096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms10512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020019597", 
              "https://doi.org/10.1038/ncomms10512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gku414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020773830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6968.1999.tb13575.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020936444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6968.1999.tb13575.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020936444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.186817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021065783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jeb.00570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021799334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2014.10.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021949151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/brv.12074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022378625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/19992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023347639", 
              "https://doi.org/10.1038/19992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10158-006-0036-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024685589", 
              "https://doi.org/10.1007/s10158-006-0036-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10158-006-0036-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024685589", 
              "https://doi.org/10.1007/s10158-006-0036-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rspb.1999.0947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026253341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms5943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026624060", 
              "https://doi.org/10.1038/ncomms5943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aac7049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029622473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.71.110601.135501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030620370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)81135-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030883899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/g3.115.017012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031334919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/g3.115.017012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031334919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-3032.1989.tb00954.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031799300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2015.4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035150855", 
              "https://doi.org/10.1038/nrm.2015.4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038266369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90512-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039310282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2015.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039952152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2015.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039952152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(00)02169-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041191349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044148903", 
              "https://doi.org/10.1038/ng.3731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00114-007-0251-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045424890", 
              "https://doi.org/10.1007/s00114-007-0251-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00114-007-0251-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045424890", 
              "https://doi.org/10.1007/s00114-007-0251-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.embor.7401011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045656471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.5094806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045828085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1163/156853988x00340", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047594159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1163/156853988x00340", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047594159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047953003", 
              "https://doi.org/10.1038/nrg3787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5251-08.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048783756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-3032.1996.tb00863.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049818380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.112704299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050461778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.1063708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050699401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052311924", 
              "https://doi.org/10.1038/nn.3218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2012.07.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052672108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bts635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053365587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053453744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdf607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053730962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1355838200000248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054923426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.21775/cimb.017.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069253073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/chan.2.3.6386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072301602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/chan.22314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072301664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1006563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083686836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1006648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084272003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2017.03.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084524343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2017.03.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084524343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-017-1315-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092053945", 
              "https://doi.org/10.1186/s13059-017-1315-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092152716", 
              "https://doi.org/10.1038/nature24041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092152716", 
              "https://doi.org/10.1038/nature24041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkx1176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092670688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41576-018-0006-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103607846", 
              "https://doi.org/10.1038/s41576-018-0006-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/embj.201694813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106020690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1811768116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111504705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1811768116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111504705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1811768116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111504705"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Colonies of the bumblebee Bombus terrestris are characterized by wide phenotypic variability among genetically similar full-sister workers, suggesting a major role for epigenetic processes. Here, we report a high level of ADAR-mediated RNA editing in the bumblebee, despite the lack of an ADAR1-homolog. We identify 1.15 million unique genomic sites, and 164 recoding sites residing in 100 protein coding genes, including ion channels, transporters, and receptors predicted to affect brain function and behavior. Some edited sites are similarly edited in other insects, cephalopods and even mammals. The global editing level of protein coding and non-coding transcripts weakly correlates with task performance (brood care vs. foraging), but not affected by dominance rank or juvenile hormone known to influence physiology and behavior. Taken together, our findings show that brain editing levels are high in naturally behaving bees, and may be regulated by relatively short-term effects associated with brood care or foraging activities.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-019-09543-w", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3487163", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "RNA editing is abundant and correlates with task performance in a social bumblebee.", 
        "pagination": "1605", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-019-09543-w"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113300650"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30962428"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-019-09543-w", 
          "https://app.dimensions.ai/details/publication/pub.1113300650"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-16T06:22", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106810_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/s41467-019-09543-w"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09543-w'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09543-w'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09543-w'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09543-w'


     

    This table displays all metadata directly associated to this object as RDF triples.

    347 TRIPLES      21 PREDICATES      95 URIs      20 LITERALS      8 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-019-09543-w schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N8c9c00def2724f96952ada83222a2aeb
    4 schema:citation sg:pub.10.1007/s00114-007-0251-1
    5 sg:pub.10.1007/s00265-013-1571-0
    6 sg:pub.10.1007/s10158-006-0036-9
    7 sg:pub.10.1038/19992
    8 sg:pub.10.1038/nature24041
    9 sg:pub.10.1038/nbt.2514
    10 sg:pub.10.1038/ncomms10512
    11 sg:pub.10.1038/ncomms1324
    12 sg:pub.10.1038/ncomms1789
    13 sg:pub.10.1038/ncomms5726
    14 sg:pub.10.1038/ncomms5943
    15 sg:pub.10.1038/ng.3731
    16 sg:pub.10.1038/nn.3218
    17 sg:pub.10.1038/nrg3787
    18 sg:pub.10.1038/nrm.2015.4
    19 sg:pub.10.1038/nsmb.2675
    20 sg:pub.10.1038/s41576-018-0006-1
    21 sg:pub.10.1186/1471-2164-11-453
    22 sg:pub.10.1186/s13059-017-1315-y
    23 https://doi.org/10.1016/0092-8674(89)90512-6
    24 https://doi.org/10.1016/j.cell.2017.03.025
    25 https://doi.org/10.1016/j.celrep.2014.10.041
    26 https://doi.org/10.1016/j.cois.2016.03.003
    27 https://doi.org/10.1016/j.cub.2012.07.042
    28 https://doi.org/10.1016/j.ibmb.2007.04.002
    29 https://doi.org/10.1016/j.immuni.2015.11.001
    30 https://doi.org/10.1016/j.neuron.2012.04.010
    31 https://doi.org/10.1016/s0092-8674(00)00049-0
    32 https://doi.org/10.1016/s0168-9525(00)02169-7
    33 https://doi.org/10.1016/s0896-6273(00)81135-6
    34 https://doi.org/10.1017/s1355838200000248
    35 https://doi.org/10.1038/sj.embor.7401011
    36 https://doi.org/10.1073/pnas.112704299
    37 https://doi.org/10.1073/pnas.1811768116
    38 https://doi.org/10.1074/jbc.m110.186817
    39 https://doi.org/10.1085/jgp.200810133
    40 https://doi.org/10.1093/bfgp/elt050
    41 https://doi.org/10.1093/bioinformatics/btp324
    42 https://doi.org/10.1093/bioinformatics/bts635
    43 https://doi.org/10.1093/bioinformatics/btt287
    44 https://doi.org/10.1093/emboj/cdf607
    45 https://doi.org/10.1093/nar/gkp731
    46 https://doi.org/10.1093/nar/gkr423
    47 https://doi.org/10.1093/nar/gku414
    48 https://doi.org/10.1093/nar/gkx1176
    49 https://doi.org/10.1098/rspb.1999.0947
    50 https://doi.org/10.1101/gr.5094806
    51 https://doi.org/10.1111/brv.12074
    52 https://doi.org/10.1111/j.1365-3032.1989.tb00954.x
    53 https://doi.org/10.1111/j.1365-3032.1996.tb00863.x
    54 https://doi.org/10.1111/j.1574-6968.1999.tb13575.x
    55 https://doi.org/10.1126/science.aac7049
    56 https://doi.org/10.1146/annurev.biochem.71.110601.135501
    57 https://doi.org/10.1163/156853988x00340
    58 https://doi.org/10.1177/074873001129002123
    59 https://doi.org/10.1242/jeb.00570
    60 https://doi.org/10.1242/jeb.02125
    61 https://doi.org/10.1261/rna.1063708
    62 https://doi.org/10.1371/journal.pgen.1006563
    63 https://doi.org/10.1371/journal.pgen.1006648
    64 https://doi.org/10.1523/jneurosci.5251-08.2009
    65 https://doi.org/10.15252/embj.201694813
    66 https://doi.org/10.1534/g3.115.017012
    67 https://doi.org/10.21775/cimb.017.023
    68 https://doi.org/10.3389/fgene.2015.00193
    69 https://doi.org/10.4161/chan.2.3.6386
    70 https://doi.org/10.4161/chan.22314
    71 schema:datePublished 2019-12
    72 schema:datePublishedReg 2019-12-01
    73 schema:description Colonies of the bumblebee Bombus terrestris are characterized by wide phenotypic variability among genetically similar full-sister workers, suggesting a major role for epigenetic processes. Here, we report a high level of ADAR-mediated RNA editing in the bumblebee, despite the lack of an ADAR1-homolog. We identify 1.15 million unique genomic sites, and 164 recoding sites residing in 100 protein coding genes, including ion channels, transporters, and receptors predicted to affect brain function and behavior. Some edited sites are similarly edited in other insects, cephalopods and even mammals. The global editing level of protein coding and non-coding transcripts weakly correlates with task performance (brood care vs. foraging), but not affected by dominance rank or juvenile hormone known to influence physiology and behavior. Taken together, our findings show that brain editing levels are high in naturally behaving bees, and may be regulated by relatively short-term effects associated with brood care or foraging activities.
    74 schema:genre research_article
    75 schema:inLanguage en
    76 schema:isAccessibleForFree true
    77 schema:isPartOf N5be40b2c89d6491ea178c807babf41e6
    78 Nd77fbf5d8aad464ca9755a406e9bb6b0
    79 sg:journal.1043282
    80 schema:name RNA editing is abundant and correlates with task performance in a social bumblebee.
    81 schema:pagination 1605
    82 schema:productId N5559162ec08d42048527a62c6cd64925
    83 N9817e544738c4565b7fb19fcb74c418e
    84 Nbe5fb464e4464f26a3dd508ade336adf
    85 Nce9b23b9b3844ec3a6775f17cc6db235
    86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113300650
    87 https://doi.org/10.1038/s41467-019-09543-w
    88 schema:sdDatePublished 2019-04-16T06:22
    89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    90 schema:sdPublisher Ndacb14900b18441c98ae1e5a9739411d
    91 schema:url http://www.nature.com/articles/s41467-019-09543-w
    92 sgo:license sg:explorer/license/
    93 sgo:sdDataset articles
    94 rdf:type schema:ScholarlyArticle
    95 N0afe8b984bfb41ac95294b7bb644e01a schema:affiliation https://www.grid.ac/institutes/grid.18098.38
    96 schema:familyName Band
    97 schema:givenName Mark
    98 rdf:type schema:Person
    99 N108280650e744320932c38105a90d6ba rdf:first N9237dda0d7124d418d1e6c94ab3e106b
    100 rdf:rest N3ebbd6e9ab7f4201a48be6c340b3095f
    101 N11c0ef1086bc400c896a9bd23adcf98f rdf:first N0afe8b984bfb41ac95294b7bb644e01a
    102 rdf:rest N19ddff9b5b084d7ab7510c1c60980e70
    103 N19ddff9b5b084d7ab7510c1c60980e70 rdf:first N9aa33002fbc546fdb6d60e534c6b0687
    104 rdf:rest Na5a39e12d494401b8d2957298847d9ad
    105 N3b309f2dca3f4495a79f3137ebcf9264 schema:affiliation https://www.grid.ac/institutes/grid.9619.7
    106 schema:familyName Bloch
    107 schema:givenName Guy
    108 rdf:type schema:Person
    109 N3ebbd6e9ab7f4201a48be6c340b3095f rdf:first N4516b57f7ce242d0b6962d7c2f42599d
    110 rdf:rest Ne8a50516dffe4373bbbf0a2eda13d3ff
    111 N4516b57f7ce242d0b6962d7c2f42599d schema:affiliation https://www.grid.ac/institutes/grid.9619.7
    112 schema:familyName Shpigler
    113 schema:givenName Hagai
    114 rdf:type schema:Person
    115 N5559162ec08d42048527a62c6cd64925 schema:name dimensions_id
    116 schema:value pub.1113300650
    117 rdf:type schema:PropertyValue
    118 N5be40b2c89d6491ea178c807babf41e6 schema:issueNumber 1
    119 rdf:type schema:PublicationIssue
    120 N6961ea4fb03c48eeacc2bace200d5ae2 rdf:first N3b309f2dca3f4495a79f3137ebcf9264
    121 rdf:rest rdf:nil
    122 N746c2225d2aa477285855619abe39386 schema:affiliation https://www.grid.ac/institutes/grid.12136.37
    123 schema:familyName Eisenberg
    124 schema:givenName Eli
    125 rdf:type schema:Person
    126 N8c9c00def2724f96952ada83222a2aeb rdf:first Nd6d275c55ad34346a1373c64305d7030
    127 rdf:rest N108280650e744320932c38105a90d6ba
    128 N90a92fdbcc844ce3887dd8e4c0a6c218 rdf:first N746c2225d2aa477285855619abe39386
    129 rdf:rest N6961ea4fb03c48eeacc2bace200d5ae2
    130 N9237dda0d7124d418d1e6c94ab3e106b schema:affiliation https://www.grid.ac/institutes/grid.9619.7
    131 schema:familyName Hazan
    132 schema:givenName Esther
    133 rdf:type schema:Person
    134 N9817e544738c4565b7fb19fcb74c418e schema:name pubmed_id
    135 schema:value 30962428
    136 rdf:type schema:PropertyValue
    137 N9a2a7605f5ca44ee91e91f3e2ee8fa53 schema:affiliation https://www.grid.ac/institutes/grid.22098.31
    138 schema:familyName Levanon
    139 schema:givenName Erez Y
    140 rdf:type schema:Person
    141 N9aa33002fbc546fdb6d60e534c6b0687 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    142 schema:familyName Ben-Shahar
    143 schema:givenName Yehuda
    144 rdf:type schema:Person
    145 Na5a39e12d494401b8d2957298847d9ad rdf:first N9a2a7605f5ca44ee91e91f3e2ee8fa53
    146 rdf:rest N90a92fdbcc844ce3887dd8e4c0a6c218
    147 Nbe5fb464e4464f26a3dd508ade336adf schema:name doi
    148 schema:value 10.1038/s41467-019-09543-w
    149 rdf:type schema:PropertyValue
    150 Nce9b23b9b3844ec3a6775f17cc6db235 schema:name nlm_unique_id
    151 schema:value 101528555
    152 rdf:type schema:PropertyValue
    153 Nd6d275c55ad34346a1373c64305d7030 schema:affiliation https://www.grid.ac/institutes/grid.22098.31
    154 schema:familyName Porath
    155 schema:givenName Hagit T
    156 rdf:type schema:Person
    157 Nd77fbf5d8aad464ca9755a406e9bb6b0 schema:volumeNumber 10
    158 rdf:type schema:PublicationVolume
    159 Ndacb14900b18441c98ae1e5a9739411d schema:name Springer Nature - SN SciGraph project
    160 rdf:type schema:Organization
    161 Ne8a50516dffe4373bbbf0a2eda13d3ff rdf:first Nee87e7ab04824789b91b7b9c447bebd0
    162 rdf:rest N11c0ef1086bc400c896a9bd23adcf98f
    163 Nee87e7ab04824789b91b7b9c447bebd0 schema:affiliation https://www.grid.ac/institutes/grid.9619.7
    164 schema:familyName Cohen
    165 schema:givenName Mira
    166 rdf:type schema:Person
    167 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Biological Sciences
    169 rdf:type schema:DefinedTerm
    170 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Genetics
    172 rdf:type schema:DefinedTerm
    173 sg:grant.3487163 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09543-w
    174 rdf:type schema:MonetaryGrant
    175 sg:journal.1043282 schema:issn 2041-1723
    176 schema:name Nature Communications
    177 rdf:type schema:Periodical
    178 sg:pub.10.1007/s00114-007-0251-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045424890
    179 https://doi.org/10.1007/s00114-007-0251-1
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/s00265-013-1571-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010668077
    182 https://doi.org/10.1007/s00265-013-1571-0
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s10158-006-0036-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024685589
    185 https://doi.org/10.1007/s10158-006-0036-9
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/19992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023347639
    188 https://doi.org/10.1038/19992
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nature24041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092152716
    191 https://doi.org/10.1038/nature24041
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nbt.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000477771
    194 https://doi.org/10.1038/nbt.2514
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/ncomms10512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020019597
    197 https://doi.org/10.1038/ncomms10512
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/ncomms1324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002794403
    200 https://doi.org/10.1038/ncomms1324
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/ncomms1789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005869307
    203 https://doi.org/10.1038/ncomms1789
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/ncomms5726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014949244
    206 https://doi.org/10.1038/ncomms5726
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/ncomms5943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026624060
    209 https://doi.org/10.1038/ncomms5943
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/ng.3731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044148903
    212 https://doi.org/10.1038/ng.3731
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nn.3218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052311924
    215 https://doi.org/10.1038/nn.3218
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/nrg3787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047953003
    218 https://doi.org/10.1038/nrg3787
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/nrm.2015.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035150855
    221 https://doi.org/10.1038/nrm.2015.4
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/nsmb.2675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008344700
    224 https://doi.org/10.1038/nsmb.2675
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/s41576-018-0006-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103607846
    227 https://doi.org/10.1038/s41576-018-0006-1
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1186/1471-2164-11-453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010312745
    230 https://doi.org/10.1186/1471-2164-11-453
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1186/s13059-017-1315-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1092053945
    233 https://doi.org/10.1186/s13059-017-1315-y
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/0092-8674(89)90512-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039310282
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.cell.2017.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084524343
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.celrep.2014.10.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021949151
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.cois.2016.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000239274
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.cub.2012.07.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052672108
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.ibmb.2007.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006559239
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.immuni.2015.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039952152
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.neuron.2012.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003049927
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/s0092-8674(00)00049-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003520522
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/s0168-9525(00)02169-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041191349
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/s0896-6273(00)81135-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030883899
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1017/s1355838200000248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054923426
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1038/sj.embor.7401011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045656471
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1073/pnas.112704299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050461778
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1073/pnas.1811768116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111504705
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1074/jbc.m110.186817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021065783
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1085/jgp.200810133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019333096
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1093/bfgp/elt050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005084278
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1093/bioinformatics/bts635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053365587
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1093/bioinformatics/btt287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017451122
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1093/emboj/cdf607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053730962
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1093/nar/gkp731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004580304
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1093/nar/gkr423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053453744
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1093/nar/gku414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020773830
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1093/nar/gkx1176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092670688
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1098/rspb.1999.0947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026253341
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1101/gr.5094806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045828085
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1111/brv.12074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022378625
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1111/j.1365-3032.1989.tb00954.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031799300
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1111/j.1365-3032.1996.tb00863.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049818380
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1111/j.1574-6968.1999.tb13575.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020936444
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1126/science.aac7049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029622473
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1146/annurev.biochem.71.110601.135501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030620370
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1163/156853988x00340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047594159
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1177/074873001129002123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008256212
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1242/jeb.00570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021799334
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1242/jeb.02125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006811631
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1261/rna.1063708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050699401
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1371/journal.pgen.1006563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083686836
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1371/journal.pgen.1006648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084272003
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1523/jneurosci.5251-08.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048783756
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.15252/embj.201694813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106020690
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1534/g3.115.017012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031334919
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.21775/cimb.017.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069253073
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.3389/fgene.2015.00193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012523056
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.4161/chan.2.3.6386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072301602
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.4161/chan.22314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072301664
    330 rdf:type schema:CreativeWork
    331 https://www.grid.ac/institutes/grid.12136.37 schema:alternateName Tel Aviv University
    332 schema:name Raymond and Beverly Sackler School of Physics and Astronomy and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 6997801, Israel. elieis@post.tau.ac.il.
    333 rdf:type schema:Organization
    334 https://www.grid.ac/institutes/grid.18098.38 schema:alternateName University of Haifa
    335 schema:name Institute of Evolution, University of Haifa, Haifa, 3498838, Israel.
    336 Roy J Carver Biotechnology Center, The University of Illinois at Urbana-Champaign, Champaign, 61801, IL, USA.
    337 rdf:type schema:Organization
    338 https://www.grid.ac/institutes/grid.22098.31 schema:alternateName Bar-Ilan University
    339 schema:name The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, 52900, Israel.
    340 rdf:type schema:Organization
    341 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
    342 schema:name Department of Biology, Washington University in St. Louis, St. Louis, 63130-4899, MO, USA.
    343 rdf:type schema:Organization
    344 https://www.grid.ac/institutes/grid.9619.7 schema:alternateName Hebrew University of Jerusalem
    345 schema:name Department of Ecology, Evolution & Behavior, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
    346 Department of Ecology, Evolution & Behavior, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, 91904, Israel. guy.bloch@mail.huji.ac.il.
    347 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...