Specific inhibition of splicing factor activity by decoy RNA oligonucleotides. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Polina Denichenko, Maxim Mogilevsky, Antoine Cléry, Thomas Welte, Jakob Biran, Odelia Shimshon, Georgina D Barnabas, Miri Danan-Gotthold, Saran Kumar, Eylon Yavin, Erez Y Levanon, Frédéric H Allain, Tamar Geiger, Gil Levkowitz, Rotem Karni

ABSTRACT

Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there are no inhibitors that directly inhibit the activity of SFs. We designed decoy oligonucleotides, composed of several repeats of a RNA motif, which is recognized by a single SF. Here we show that decoy oligonucleotides targeting splicing factors RBFOX1/2, SRSF1 and PTBP1, can specifically bind to their respective SFs and inhibit their splicing and biological activities both in vitro and in vivo. These decoy oligonucleotides present an approach to specifically downregulate SF activity in conditions where SFs are either up-regulated or hyperactive. More... »

PAGES

1590

References to SciGraph publications

  • 2009-02. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2013-12. Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-03. The gene encoding the splicing factor SF2/ASF is a proto-oncogene in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-12. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification in NATURE BIOTECHNOLOGY
  • 2013-07. A compendium of RNA-binding motifs for decoding gene regulation in NATURE
  • 2004-04. Mitogen-activated protein kinases in apoptosis regulation in ONCOGENE
  • 2013-12. Protein analysis by time-resolved measurements with an electro-switchable DNA chip in NATURE COMMUNICATIONS
  • 2009-06. Cancer-associated regulation of alternative splicing in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-12. CUGBP1 and MBNL1 preferentially bind to 3′ UTRs and facilitate mRNA decay in SCIENTIFIC REPORTS
  • 2012-02. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2016-09. The Perseus computational platform for comprehensive analysis of (prote)omics data in NATURE METHODS
  • 2010-01. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer in NATURE
  • 2002-04. Listening to silence and understanding nonsense: exonic mutations that affect splicing in NATURE REVIEWS GENETICS
  • 2006-08. Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma in MODERN PATHOLOGY
  • 2012-02. RNA therapeutics: beyond RNA interference and antisense oligonucleotides in NATURE REVIEWS DRUG DISCOVERY
  • 2011-04. Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-β1 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-12. Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays in BMC GENOMICS
  • 2015-12. Differential connectivity of splicing activators and repressors to the human spliceosome in GENOME BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-09523-0

    DOI

    http://dx.doi.org/10.1038/s41467-019-09523-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113300668

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30962446


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