Dynamic control of enhancer activity drives stage-specific gene expression during flower morphogenesis. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Wenhao Yan, Dijun Chen, Julia Schumacher, Diego Durantini, Julia Engelhorn, Ming Chen, Cristel C Carles, Kerstin Kaufmann

ABSTRACT

Enhancers are critical for developmental stage-specific gene expression, but their dynamic regulation in plants remains poorly understood. Here we compare genome-wide localization of H3K27ac, chromatin accessibility and transcriptomic changes during flower development in Arabidopsis. H3K27ac prevalently marks promoter-proximal regions, suggesting that H3K27ac is not a hallmark for enhancers in Arabidopsis. We provide computational and experimental evidence to confirm that distal DNase І hypersensitive sites are predictive of enhancers. The predicted enhancers are highly stage-specific across flower development, significantly associated with SNPs for flowering-related phenotypes, and conserved across crucifer species. Through the integration of genome-wide transcription factor (TF) binding datasets, we find that floral master regulators and stage-specific TFs are largely enriched at developmentally dynamic enhancers. Finally, we show that enhancer clusters and intronic enhancers significantly associate with stage-specific gene regulation by floral master TFs. Our study provides insights into the functional flexibility of enhancers during plant development, as well as hints to annotate plant enhancers. More... »

PAGES

1705

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-09513-2

    DOI

    http://dx.doi.org/10.1038/s41467-019-09513-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113380218

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30979870


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