A temporary indwelling intravascular aphaeretic system for in vivo enrichment of circulating tumor cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Tae Hyun Kim, Yang Wang, C. Ryan Oliver, Douglas H. Thamm, Laura Cooling, Costanza Paoletti, Kaylee J. Smith, Sunitha Nagrath, Daniel F. Hayes

ABSTRACT

Circulating tumor cells (CTCs) have become an established biomarker for prognosis in patients with various carcinomas. However, current ex vivo CTC isolation technologies rely on small blood volumes from a single venipuncture limiting the number of captured CTCs. This produces statistical variability and inaccurate reflection of tumor cell heterogeneity. Here, we describe an in vivo indwelling intravascular aphaeretic CTC isolation system to continuously collect CTCs directly from a peripheral vein. The system returns the remaining blood products after CTC enrichment, permitting interrogation of larger blood volumes than classic phlebotomy specimens over a prolonged period of time. The system is validated in canine models showing capability to screen 1-2% of the entire blood over 2 h. Our result shows substantial increase in CTC capture, compared with serial blood draws. This technology could potentially be used to analyze large number of CTCs to facilitate translation of analytical information into future clinical decisions. More... »

PAGES

1478

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-09439-9

DOI

http://dx.doi.org/10.1038/s41467-019-09439-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113159646

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30932020


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