Mechanical stretch induces hair regeneration through the alternative activation of macrophages View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04-03

AUTHORS

Szu-Ying Chu, Chih-Hung Chou, Hsien-Da Huang, Meng-Hua Yen, Hsiao-Chin Hong, Po-Han Chao, Yu-Hsuan Wang, Po-Yu Chen, Shi-Xin Nian, Yu-Ru Chen, Li-Ying Liou, Yu-Chen Liu, Hui-Mei Chen, Feng-Mao Lin, Yun-Ting Chang, Chih-Chiang Chen, Oscar K. Lee

ABSTRACT

Tissues and cells in organism are continuously exposed to complex mechanical cues from the environment. Mechanical stimulations affect cell proliferation, differentiation, and migration, as well as determining tissue homeostasis and repair. By using a specially designed skin-stretching device, we discover that hair stem cells proliferate in response to stretch and hair regeneration occurs only when applying proper strain for an appropriate duration. A counterbalance between WNT and BMP-2 and the subsequent two-step mechanism are identified through molecular and genetic analyses. Macrophages are first recruited by chemokines produced by stretch and polarized to M2 phenotype. Growth factors such as HGF and IGF-1, released by M2 macrophages, then activate stem cells and facilitate hair regeneration. A hierarchical control system is revealed, from mechanical and chemical signals to cell behaviors and tissue responses, elucidating avenues of regenerative medicine and disease control by demonstrating the potential to manipulate cellular processes through simple mechanical stimulation. More... »

PAGES

1524

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-09402-8

DOI

http://dx.doi.org/10.1038/s41467-019-09402-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113182117

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30944305


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09402-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09402-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09402-8'


 

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