Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Xiaohong Ye, Hua Wu, Luoyan Sheng, Yi-xin Liu, Fang Ye, Mo Wang, Hu Zhou, Ying Su, Xiao-kun Zhang

ABSTRACT

Retinoid X receptor-alpha (RXRα) is a potent regulator of inflammatory responses; however, its therapeutic potential for inflammatory cancer remains to be explored. We previously discovered that RXRα is abnormally cleaved in tumor cells and tissues, producing a truncated RXRα (tRXRα). Here, we show that transgenic expression of tRXRα in mice accelerates the development of colitis-associated colon cancer (CAC). The tumorigenic effect of tRXRα is primarily dependent on its expression in myeloid cells, which results in interleukin-6 (IL-6) induction and STAT3 activation. Mechanistic studies reveal an extensive interaction between tRXRα and TRAF6 in the cytoplasm of macrophages, leading to TRAF6 ubiquitination and subsequent activation of the NF-κB inflammatory pathway. K-80003, a tRXRα modulator derived from nonsteroidal anti-inflammatory drug (NSAID) sulindac, suppresses the growth of tRXRα-mediated colorectal tumor by inhibiting the NF-κB-IL-6-STAT3 signaling cascade. These results provide new insight into tRXRα action and identify a promising tRXRα ligand for treating CAC. More... »

PAGES

1463

References to SciGraph publications

  • 1997-06. Clinical Pharmacokinetics of Sulindac in CLINICAL PHARMACOKINETICS
  • 2005-09. Cardiovascular and gastrointestinal effects of COX-2 inhibitors and NSAIDs: achieving a balance in ARTHRITIS RESEARCH & THERAPY
  • 2007-10. RAR and RXR modulation in cancer and metabolic disease in NATURE REVIEWS DRUG DISCOVERY
  • 1999-08. Conditional gene targeting in macrophages and granulocytes using LysMcre mice in TRANSGENIC RESEARCH
  • 2004-12. Endotoxin leads to rapid subcellular re-localization of hepatic RXRα: A novel mechanism for reduced hepatic gene expression in inflammation in NUCLEAR RECEPTOR
  • 2015-01. Regulation of the nongenomic actions of retinoid X receptor-α by targeting the coregulator-binding sites in ACTA PHARMACOLOGICA SINICA
  • 2008-07. Cancer-related inflammation in NATURE
  • 2014-12. Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon in NATURE COMMUNICATIONS
  • 2000-10. Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis in NATURE
  • 2018-02. Bexarotene, a Selective RXRα Agonist, Reverses Hypotension Associated with Inflammation and Tissue Injury in a Rat Model of Septic Shock in INFLAMMATION
  • 2007-08. An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression in NATURE PROTOCOLS
  • 2017-07-17. Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα in NATURE COMMUNICATIONS
  • 2007-05. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer in NATURE REVIEWS CANCER
  • 2000-09. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase in NATURE
  • 2007-10. Design of selective nuclear receptor modulators: RAR and RXR as a case study in NATURE REVIEWS DRUG DISCOVERY
  • 2004-12. Retinoid X receptors: X-ploring their (patho)physiological functions in CELL DEATH & DIFFERENTIATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-09375-8

    DOI

    http://dx.doi.org/10.1038/s41467-019-09375-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113159134

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30931933


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Xiamen University", 
              "id": "https://www.grid.ac/institutes/grid.12955.3a", 
              "name": [
                "School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, 361102, Xiamen, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ye", 
            "givenName": "Xiaohong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, 361102, Xiamen, China", 
                "Department of Pathology, Soochow University, 215123, Suzhou, China", 
                "Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, 92037, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Hua", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Xiamen University", 
              "id": "https://www.grid.ac/institutes/grid.12955.3a", 
              "name": [
                "School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, 361102, Xiamen, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sheng", 
            "givenName": "Luoyan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Xiamen University", 
              "id": "https://www.grid.ac/institutes/grid.12955.3a", 
              "name": [
                "School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, 361102, Xiamen, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Yi-xin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Xiamen University", 
              "id": "https://www.grid.ac/institutes/grid.12955.3a", 
              "name": [
                "School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, 361102, Xiamen, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ye", 
            "givenName": "Fang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Xiamen University", 
              "id": "https://www.grid.ac/institutes/grid.12955.3a", 
              "name": [
                "School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, 361102, Xiamen, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Mo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Xiamen University", 
              "id": "https://www.grid.ac/institutes/grid.12955.3a", 
              "name": [
                "School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, 361102, Xiamen, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhou", 
            "givenName": "Hu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, 92037, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Su", 
            "givenName": "Ying", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, 361102, Xiamen, China", 
                "Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, 92037, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Xiao-kun", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000455059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000455059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.114.092163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000516043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000677027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000677027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(09)70035-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001334388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2007.129858", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001878668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2007.279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002739485", 
              "https://doi.org/10.1038/nprot.2007.279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/imr.12302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004032363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004065710", 
              "https://doi.org/10.1038/sj.cdd.4401533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004065710", 
              "https://doi.org/10.1038/sj.cdd.4401533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005118064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.02-0732com", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007098776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007122758", 
              "https://doi.org/10.1038/ncomms6494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/aps.2014.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008280875", 
              "https://doi.org/10.1038/aps.2014.109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1008942828960", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011866095", 
              "https://doi.org/10.1023/a:1008942828960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvg.20357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012137306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-14-2435", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012527174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2012.01099.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012989080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0913545107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014639088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017079538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2014.04.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017284254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2014.04.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017284254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00162-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017869374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00162-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017869374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018115916", 
              "https://doi.org/10.1038/nrd2397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199305063281805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020972146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35035131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021020097", 
              "https://doi.org/10.1038/35035131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35035131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021020097", 
              "https://doi.org/10.1038/35035131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022223136", 
              "https://doi.org/10.1038/nrd2398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1998.9941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023907523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024729982", 
              "https://doi.org/10.1038/nature07205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1593/neo.111440", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026727449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2008.00085.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026845462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2008.00085.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026845462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1996.1276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027217456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027682596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2012.01108.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028562109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1478-1336-2-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031276286", 
              "https://doi.org/10.1186/1478-1336-2-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031376032", 
              "https://doi.org/10.1038/35036595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031376032", 
              "https://doi.org/10.1038/35036595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-2038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032316267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chembiol.2014.02.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033663842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036780372", 
              "https://doi.org/10.1038/nrc2129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejmech.2013.01.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037336739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003088-199732060-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037730805", 
              "https://doi.org/10.2165/00003088-199732060-00002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003088-199732060-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037730805", 
              "https://doi.org/10.2165/00003088-199732060-00002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgt043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042013254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci58818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042533043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0303-7207(96)03863-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042670699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.seminoncol.2015.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042879685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.50.33166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043265247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tem.2013.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044126132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0409721102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044442824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m508277200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044465123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044483442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045980277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045980277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m304761200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046880300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar1794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048005671", 
              "https://doi.org/10.1186/ar1794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ml5000405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049860763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ml5000405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049860763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ml5000405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049860763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5812/ircmj.23931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050252473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/toxsci/kfi313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051233619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)08100-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054615095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/abbs/gmv104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059352817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.289.5482.1159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062570669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.290.5499.2140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062572478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1940-6207.capr-15-0325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063279450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2003-032036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064287515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/mend.16.5.0821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064332342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/0929867023370789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069159932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1568026616666160617092241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069195562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cbt.2.2.281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072292655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075108950", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.176.9.5161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077224491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2017.03.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084533114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms16066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090738605", 
              "https://doi.org/10.1038/ncomms16066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10753-017-0691-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093076065", 
              "https://doi.org/10.1007/s10753-017-0691-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaoncol.2017.5431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100923661"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Retinoid X receptor-alpha (RXR\u03b1) is a potent regulator of inflammatory responses; however, its therapeutic potential for inflammatory cancer remains to be explored. We previously discovered that RXR\u03b1 is abnormally cleaved in tumor cells and tissues, producing a truncated RXR\u03b1 (tRXR\u03b1). Here, we show that transgenic expression of tRXR\u03b1 in mice accelerates the development of colitis-associated colon cancer (CAC). The tumorigenic effect of tRXR\u03b1 is primarily dependent on its expression in myeloid cells, which results in interleukin-6 (IL-6) induction and STAT3 activation. Mechanistic studies reveal an extensive interaction between tRXR\u03b1 and TRAF6 in the cytoplasm of macrophages, leading to TRAF6 ubiquitination and subsequent activation of the NF-\u03baB inflammatory pathway. K-80003, a tRXR\u03b1 modulator derived from nonsteroidal anti-inflammatory drug (NSAID) sulindac, suppresses the growth of tRXR\u03b1-mediated colorectal tumor by inhibiting the NF-\u03baB-IL-6-STAT3 signaling cascade. These results provide new insight into tRXR\u03b1 action and identify a promising tRXR\u03b1 ligand for treating CAC.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-019-09375-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7172490", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "Oncogenic potential of truncated RXR\u03b1 during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling", 
        "pagination": "1463", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-019-09375-8"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "656505120b6e82caa99370624a7dd493c72c7c6dfd774c7cdc91ab6c0d9de4f9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113159134"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30931933"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-019-09375-8", 
          "https://app.dimensions.ai/details/publication/pub.1113159134"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T08:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91432_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41467-019-09375-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09375-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09375-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09375-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09375-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    344 TRIPLES      21 PREDICATES      98 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-019-09375-8 schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author N80f3ec77a86947afab60d4b330fe4f2e
    4 schema:citation sg:pub.10.1007/s10753-017-0691-5
    5 sg:pub.10.1023/a:1008942828960
    6 sg:pub.10.1038/35035131
    7 sg:pub.10.1038/35036595
    8 sg:pub.10.1038/aps.2014.109
    9 sg:pub.10.1038/nature07205
    10 sg:pub.10.1038/ncomms16066
    11 sg:pub.10.1038/ncomms6494
    12 sg:pub.10.1038/nprot.2007.279
    13 sg:pub.10.1038/nrc2129
    14 sg:pub.10.1038/nrd2397
    15 sg:pub.10.1038/nrd2398
    16 sg:pub.10.1038/sj.cdd.4401533
    17 sg:pub.10.1186/1478-1336-2-4
    18 sg:pub.10.1186/ar1794
    19 sg:pub.10.2165/00003088-199732060-00002
    20 https://app.dimensions.ai/details/publication/pub.1075108950
    21 https://doi.org/10.1001/jamaoncol.2017.5431
    22 https://doi.org/10.1002/dvg.20357
    23 https://doi.org/10.1002/path.4670
    24 https://doi.org/10.1006/bbrc.1996.1276
    25 https://doi.org/10.1006/bbrc.1998.9941
    26 https://doi.org/10.1016/0303-7207(96)03863-4
    27 https://doi.org/10.1016/j.biocel.2014.04.010
    28 https://doi.org/10.1016/j.ccr.2007.06.004
    29 https://doi.org/10.1016/j.ccr.2007.06.006
    30 https://doi.org/10.1016/j.ccr.2009.01.001
    31 https://doi.org/10.1016/j.ccr.2009.01.002
    32 https://doi.org/10.1016/j.ccr.2010.04.023
    33 https://doi.org/10.1016/j.cell.2014.03.012
    34 https://doi.org/10.1016/j.chembiol.2014.02.017
    35 https://doi.org/10.1016/j.ejmech.2013.01.012
    36 https://doi.org/10.1016/j.molcel.2017.03.008
    37 https://doi.org/10.1016/j.tem.2013.04.004
    38 https://doi.org/10.1016/s0092-8674(02)08100-x
    39 https://doi.org/10.1016/s0092-8674(04)00162-x
    40 https://doi.org/10.1016/s1470-2045(09)70035-x
    41 https://doi.org/10.1021/ml5000405
    42 https://doi.org/10.1053/j.seminoncol.2015.09.002
    43 https://doi.org/10.1056/nejm199305063281805
    44 https://doi.org/10.1073/pnas.0409721102
    45 https://doi.org/10.1073/pnas.0913545107
    46 https://doi.org/10.1074/jbc.273.50.33166
    47 https://doi.org/10.1074/jbc.m304761200
    48 https://doi.org/10.1074/jbc.m508277200
    49 https://doi.org/10.1093/abbs/gmv104
    50 https://doi.org/10.1093/carcin/bgt043
    51 https://doi.org/10.1093/toxsci/kfi313
    52 https://doi.org/10.1096/fj.02-0732com
    53 https://doi.org/10.1111/imr.12302
    54 https://doi.org/10.1111/j.1476-5381.2008.00085.x
    55 https://doi.org/10.1111/j.1600-065x.2012.01099.x
    56 https://doi.org/10.1111/j.1600-065x.2012.01108.x
    57 https://doi.org/10.1124/mol.114.092163
    58 https://doi.org/10.1126/science.289.5482.1159
    59 https://doi.org/10.1126/science.290.5499.2140
    60 https://doi.org/10.1136/gut.2007.129858
    61 https://doi.org/10.1158/0008-5472.can-12-2038
    62 https://doi.org/10.1158/0008-5472.can-14-2435
    63 https://doi.org/10.1158/1940-6207.capr-15-0325
    64 https://doi.org/10.1172/jci58818
    65 https://doi.org/10.1210/jc.2003-032036
    66 https://doi.org/10.1210/mend.16.5.0821
    67 https://doi.org/10.1593/neo.111440
    68 https://doi.org/10.2174/0929867023370789
    69 https://doi.org/10.2174/1568026616666160617092241
    70 https://doi.org/10.4049/jimmunol.176.9.5161
    71 https://doi.org/10.4161/cbt.2.2.281
    72 https://doi.org/10.5812/ircmj.23931
    73 schema:datePublished 2019-12
    74 schema:datePublishedReg 2019-12-01
    75 schema:description Retinoid X receptor-alpha (RXRα) is a potent regulator of inflammatory responses; however, its therapeutic potential for inflammatory cancer remains to be explored. We previously discovered that RXRα is abnormally cleaved in tumor cells and tissues, producing a truncated RXRα (tRXRα). Here, we show that transgenic expression of tRXRα in mice accelerates the development of colitis-associated colon cancer (CAC). The tumorigenic effect of tRXRα is primarily dependent on its expression in myeloid cells, which results in interleukin-6 (IL-6) induction and STAT3 activation. Mechanistic studies reveal an extensive interaction between tRXRα and TRAF6 in the cytoplasm of macrophages, leading to TRAF6 ubiquitination and subsequent activation of the NF-κB inflammatory pathway. K-80003, a tRXRα modulator derived from nonsteroidal anti-inflammatory drug (NSAID) sulindac, suppresses the growth of tRXRα-mediated colorectal tumor by inhibiting the NF-κB-IL-6-STAT3 signaling cascade. These results provide new insight into tRXRα action and identify a promising tRXRα ligand for treating CAC.
    76 schema:genre research_article
    77 schema:inLanguage en
    78 schema:isAccessibleForFree true
    79 schema:isPartOf N0c43ecdf75844d8ab448522b012a0686
    80 Nd5ab811ffff14202ba940b98e46088b7
    81 sg:journal.1043282
    82 schema:name Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling
    83 schema:pagination 1463
    84 schema:productId N073268e50a9c47adb880b759f9776c58
    85 N15273eac7cd74763b6b18ad74a4ddf96
    86 N5f1458c8e42140039cacfbbc23b6236d
    87 Nf7bb0ac3c0cb4092b448f4263eaac785
    88 Nfd15274cf82149d19bf28ad47db57c02
    89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113159134
    90 https://doi.org/10.1038/s41467-019-09375-8
    91 schema:sdDatePublished 2019-04-15T08:59
    92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    93 schema:sdPublisher N808f30312ff640ad9936dabcd7035397
    94 schema:url https://www.nature.com/articles/s41467-019-09375-8
    95 sgo:license sg:explorer/license/
    96 sgo:sdDataset articles
    97 rdf:type schema:ScholarlyArticle
    98 N073268e50a9c47adb880b759f9776c58 schema:name pubmed_id
    99 schema:value 30931933
    100 rdf:type schema:PropertyValue
    101 N0c43ecdf75844d8ab448522b012a0686 schema:issueNumber 1
    102 rdf:type schema:PublicationIssue
    103 N151792378dc74cfd8ae8b1eef6806d22 schema:affiliation https://www.grid.ac/institutes/grid.12955.3a
    104 schema:familyName Sheng
    105 schema:givenName Luoyan
    106 rdf:type schema:Person
    107 N15273eac7cd74763b6b18ad74a4ddf96 schema:name dimensions_id
    108 schema:value pub.1113159134
    109 rdf:type schema:PropertyValue
    110 N1fa9e5285e114b96afe9bae74717da0c rdf:first Nf6274e91517a4a86b5ebfbfc63e27e25
    111 rdf:rest N84de54a41d524a9d8577f609c3284f4a
    112 N30eb5c987b084ea1a3b54087f2a52e24 rdf:first N7b7285de82944a15a55730ec0219af84
    113 rdf:rest N7ea30085395f4622a8267d8b1c8acccb
    114 N5f1458c8e42140039cacfbbc23b6236d schema:name nlm_unique_id
    115 schema:value 101528555
    116 rdf:type schema:PropertyValue
    117 N652ca58a3ec641a7bcdd3fe45a5b1517 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    118 schema:familyName Zhang
    119 schema:givenName Xiao-kun
    120 rdf:type schema:Person
    121 N6ed89f87aacf4912ab3b05a0341db467 schema:affiliation https://www.grid.ac/institutes/grid.12955.3a
    122 schema:familyName Ye
    123 schema:givenName Fang
    124 rdf:type schema:Person
    125 N7b7285de82944a15a55730ec0219af84 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    126 schema:familyName Wu
    127 schema:givenName Hua
    128 rdf:type schema:Person
    129 N7ea30085395f4622a8267d8b1c8acccb rdf:first N151792378dc74cfd8ae8b1eef6806d22
    130 rdf:rest N912402ed57434a66a53fdaeb12e61c0f
    131 N808f30312ff640ad9936dabcd7035397 schema:name Springer Nature - SN SciGraph project
    132 rdf:type schema:Organization
    133 N80f3ec77a86947afab60d4b330fe4f2e rdf:first N99e7f2f9226d4926989e3ba859457932
    134 rdf:rest N30eb5c987b084ea1a3b54087f2a52e24
    135 N84de54a41d524a9d8577f609c3284f4a rdf:first Nf1b7826f059d4434ae6a7975e632960e
    136 rdf:rest N9f3bf1fdae314acd97d0cb96faa71283
    137 N912402ed57434a66a53fdaeb12e61c0f rdf:first Nc73d2048669f48ab91e88d3aecde2c78
    138 rdf:rest N98a51f2880264a63ac165767589deb10
    139 N98a51f2880264a63ac165767589deb10 rdf:first N6ed89f87aacf4912ab3b05a0341db467
    140 rdf:rest N1fa9e5285e114b96afe9bae74717da0c
    141 N99e7f2f9226d4926989e3ba859457932 schema:affiliation https://www.grid.ac/institutes/grid.12955.3a
    142 schema:familyName Ye
    143 schema:givenName Xiaohong
    144 rdf:type schema:Person
    145 N9f3bf1fdae314acd97d0cb96faa71283 rdf:first Na470fb402d3745c2a7e4ffdd80f52476
    146 rdf:rest Nad1ace9bd39447d8abb4aa7701337211
    147 Na470fb402d3745c2a7e4ffdd80f52476 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    148 schema:familyName Su
    149 schema:givenName Ying
    150 rdf:type schema:Person
    151 Nad1ace9bd39447d8abb4aa7701337211 rdf:first N652ca58a3ec641a7bcdd3fe45a5b1517
    152 rdf:rest rdf:nil
    153 Nc73d2048669f48ab91e88d3aecde2c78 schema:affiliation https://www.grid.ac/institutes/grid.12955.3a
    154 schema:familyName Liu
    155 schema:givenName Yi-xin
    156 rdf:type schema:Person
    157 Nd5ab811ffff14202ba940b98e46088b7 schema:volumeNumber 10
    158 rdf:type schema:PublicationVolume
    159 Nf1b7826f059d4434ae6a7975e632960e schema:affiliation https://www.grid.ac/institutes/grid.12955.3a
    160 schema:familyName Zhou
    161 schema:givenName Hu
    162 rdf:type schema:Person
    163 Nf6274e91517a4a86b5ebfbfc63e27e25 schema:affiliation https://www.grid.ac/institutes/grid.12955.3a
    164 schema:familyName Wang
    165 schema:givenName Mo
    166 rdf:type schema:Person
    167 Nf7bb0ac3c0cb4092b448f4263eaac785 schema:name readcube_id
    168 schema:value 656505120b6e82caa99370624a7dd493c72c7c6dfd774c7cdc91ab6c0d9de4f9
    169 rdf:type schema:PropertyValue
    170 Nfd15274cf82149d19bf28ad47db57c02 schema:name doi
    171 schema:value 10.1038/s41467-019-09375-8
    172 rdf:type schema:PropertyValue
    173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Medical and Health Sciences
    175 rdf:type schema:DefinedTerm
    176 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Immunology
    178 rdf:type schema:DefinedTerm
    179 sg:grant.7172490 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09375-8
    180 rdf:type schema:MonetaryGrant
    181 sg:journal.1043282 schema:issn 2041-1723
    182 schema:name Nature Communications
    183 rdf:type schema:Periodical
    184 sg:pub.10.1007/s10753-017-0691-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093076065
    185 https://doi.org/10.1007/s10753-017-0691-5
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1023/a:1008942828960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011866095
    188 https://doi.org/10.1023/a:1008942828960
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/35035131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021020097
    191 https://doi.org/10.1038/35035131
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/35036595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031376032
    194 https://doi.org/10.1038/35036595
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/aps.2014.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008280875
    197 https://doi.org/10.1038/aps.2014.109
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/nature07205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024729982
    200 https://doi.org/10.1038/nature07205
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/ncomms16066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090738605
    203 https://doi.org/10.1038/ncomms16066
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/ncomms6494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007122758
    206 https://doi.org/10.1038/ncomms6494
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nprot.2007.279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002739485
    209 https://doi.org/10.1038/nprot.2007.279
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/nrc2129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036780372
    212 https://doi.org/10.1038/nrc2129
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nrd2397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018115916
    215 https://doi.org/10.1038/nrd2397
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/nrd2398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022223136
    218 https://doi.org/10.1038/nrd2398
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/sj.cdd.4401533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004065710
    221 https://doi.org/10.1038/sj.cdd.4401533
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1186/1478-1336-2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031276286
    224 https://doi.org/10.1186/1478-1336-2-4
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1186/ar1794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048005671
    227 https://doi.org/10.1186/ar1794
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.2165/00003088-199732060-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037730805
    230 https://doi.org/10.2165/00003088-199732060-00002
    231 rdf:type schema:CreativeWork
    232 https://app.dimensions.ai/details/publication/pub.1075108950 schema:CreativeWork
    233 https://doi.org/10.1001/jamaoncol.2017.5431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100923661
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1002/dvg.20357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012137306
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1002/path.4670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005118064
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1006/bbrc.1996.1276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027217456
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1006/bbrc.1998.9941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023907523
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/0303-7207(96)03863-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042670699
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.biocel.2014.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017284254
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.ccr.2007.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044483442
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.ccr.2007.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045980277
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.ccr.2009.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000677027
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.ccr.2009.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000455059
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.ccr.2010.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027682596
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.cell.2014.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017079538
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.chembiol.2014.02.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033663842
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.ejmech.2013.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037336739
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.molcel.2017.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084533114
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.tem.2013.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044126132
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/s0092-8674(02)08100-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1054615095
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/s0092-8674(04)00162-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017869374
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/s1470-2045(09)70035-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001334388
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1021/ml5000405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049860763
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1053/j.seminoncol.2015.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042879685
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1056/nejm199305063281805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020972146
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1073/pnas.0409721102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044442824
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1073/pnas.0913545107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014639088
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1074/jbc.273.50.33166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043265247
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1074/jbc.m304761200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046880300
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1074/jbc.m508277200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044465123
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1093/abbs/gmv104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059352817
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1093/carcin/bgt043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042013254
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1093/toxsci/kfi313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051233619
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1096/fj.02-0732com schema:sameAs https://app.dimensions.ai/details/publication/pub.1007098776
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1111/imr.12302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004032363
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1111/j.1476-5381.2008.00085.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026845462
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1111/j.1600-065x.2012.01099.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012989080
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1111/j.1600-065x.2012.01108.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028562109
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1124/mol.114.092163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000516043
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1126/science.289.5482.1159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062570669
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1126/science.290.5499.2140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062572478
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1136/gut.2007.129858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001878668
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1158/0008-5472.can-12-2038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032316267
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1158/0008-5472.can-14-2435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012527174
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1158/1940-6207.capr-15-0325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063279450
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1172/jci58818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042533043
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1210/jc.2003-032036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064287515
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1210/mend.16.5.0821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064332342
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1593/neo.111440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026727449
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.2174/0929867023370789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069159932
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.2174/1568026616666160617092241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069195562
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.4049/jimmunol.176.9.5161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077224491
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.4161/cbt.2.2.281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072292655
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.5812/ircmj.23931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050252473
    336 rdf:type schema:CreativeWork
    337 https://www.grid.ac/institutes/grid.12955.3a schema:alternateName Xiamen University
    338 schema:name School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, 361102, Xiamen, China
    339 rdf:type schema:Organization
    340 https://www.grid.ac/institutes/grid.479509.6 schema:alternateName Sanford Burnham Prebys Medical Discovery Institute
    341 schema:name Department of Pathology, Soochow University, 215123, Suzhou, China
    342 Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, 92037, La Jolla, CA, USA
    343 School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, 361102, Xiamen, China
    344 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...