Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSElizabeth L. Christie, Swetansu Pattnaik, Jessica Beach, Anthony Copeland, Nineveh Rashoo, Sian Fereday, Joy Hendley, Kathryn Alsop, Samuel L. Brady, Greg Lamb, Ahwan Pandey, Anna deFazio, Heather Thorne, Andrea Bild, David D. L. Bowtell
ABSTRACTABCB1 encodes Multidrug Resistance protein (MDR1), an ATP-binding cassette member involved in the cellular efflux of chemotherapeutic drugs. Here we report that ovarian and breast samples from chemotherapy treated patients are positive for multiple transcriptional fusions involving ABCB1, placing it under the control of a strong promoter while leaving its open reading frame intact. We identified 15 different transcriptional fusion partners involving ABCB1, as well as patients with multiple distinct fusion events. The partner gene selected depended on its structure, promoter strength, and chromosomal proximity to ABCB1. Fusion positivity was strongly associated with the number of lines of MDR1-substrate chemotherapy given. MDR1 inhibition in a fusion positive ovarian cancer cell line increased sensitivity to paclitaxel more than 50-fold. Convergent evolution of ABCB1 fusion is therefore frequent in chemotherapy resistant recurrent ovarian cancer. As most currently approved PARP inhibitors (PARPi) are MDR1 substrates, prior chemotherapy may precondition resistance to PARPi. More... »
PAGES1295
http://scigraph.springernature.com/pub.10.1038/s41467-019-09312-9
DOIhttp://dx.doi.org/10.1038/s41467-019-09312-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112880978
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30894541
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "ATP Binding Cassette Transporter, Subfamily B",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cohort Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cystadenocarcinoma, Serous",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Resistance, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Neoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Grading",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oncogene Proteins, Fusion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ovarian Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Paclitaxel",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Poly(ADP-ribose) Polymerases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Promoter Regions, Genetic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recurrence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transcription, Genetic",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Melbourne",
"id": "https://www.grid.ac/institutes/grid.1008.9",
"name": [
"Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia",
"Sir Peter MacCallum Department of Oncology, The University of Melbourne, 3010, Parkville, VIC, Australia"
],
"type": "Organization"
},
"familyName": "Christie",
"givenName": "Elizabeth L.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Garvan Institute of Medical Research",
"id": "https://www.grid.ac/institutes/grid.415306.5",
"name": [
"Kinghorn Cancer Centre, Garvan Institute for Medical Research, 2010, Darlinghurst, NSW, Australia"
],
"type": "Organization"
},
"familyName": "Pattnaik",
"givenName": "Swetansu",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Peter MacCallum Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.1055.1",
"name": [
"Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia"
],
"type": "Organization"
},
"familyName": "Beach",
"givenName": "Jessica",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Peter MacCallum Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.1055.1",
"name": [
"Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia"
],
"type": "Organization"
},
"familyName": "Copeland",
"givenName": "Anthony",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Peter MacCallum Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.1055.1",
"name": [
"Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia"
],
"type": "Organization"
},
"familyName": "Rashoo",
"givenName": "Nineveh",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Peter MacCallum Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.1055.1",
"name": [
"Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia"
],
"type": "Organization"
},
"familyName": "Fereday",
"givenName": "Sian",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Peter MacCallum Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.1055.1",
"name": [
"Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia"
],
"type": "Organization"
},
"familyName": "Hendley",
"givenName": "Joy",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Peter MacCallum Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.1055.1",
"name": [
"Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia"
],
"type": "Organization"
},
"familyName": "Alsop",
"givenName": "Kathryn",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Utah",
"id": "https://www.grid.ac/institutes/grid.223827.e",
"name": [
"The University of Utah, 84112, Salt Lake City, UT, USA"
],
"type": "Organization"
},
"familyName": "Brady",
"givenName": "Samuel L.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Utah",
"id": "https://www.grid.ac/institutes/grid.223827.e",
"name": [
"The University of Utah, 84112, Salt Lake City, UT, USA"
],
"type": "Organization"
},
"familyName": "Lamb",
"givenName": "Greg",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Peter MacCallum Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.1055.1",
"name": [
"Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia"
],
"type": "Organization"
},
"familyName": "Pandey",
"givenName": "Ahwan",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Sydney",
"id": "https://www.grid.ac/institutes/grid.1013.3",
"name": [
"Centre for Cancer Research, The Westmead Institute for Medical Research, 2145, Westmead, NSW, Australia",
"Department of Gynaecological Oncology, Westmead Hospital, 2145, Westmead, NSW, Australia",
"The University of Sydney, 2052, Sydney, NSW, Australia"
],
"type": "Organization"
},
"familyName": "deFazio",
"givenName": "Anna",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Peter MacCallum Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.1055.1",
"name": [
"Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia"
],
"type": "Organization"
},
"familyName": "Thorne",
"givenName": "Heather",
"type": "Person"
},
{
"affiliation": {
"alternateName": "City Of Hope National Medical Center",
"id": "https://www.grid.ac/institutes/grid.410425.6",
"name": [
"The University of Utah, 84112, Salt Lake City, UT, USA",
"City of Hope, 91010, Los Angeles, CA, USA"
],
"type": "Organization"
},
"familyName": "Bild",
"givenName": "Andrea",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Garvan Institute of Medical Research",
"id": "https://www.grid.ac/institutes/grid.415306.5",
"name": [
"Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia",
"Sir Peter MacCallum Department of Oncology, The University of Melbourne, 3010, Parkville, VIC, Australia",
"Kinghorn Cancer Centre, Garvan Institute for Medical Research, 2010, Darlinghurst, NSW, Australia"
],
"type": "Organization"
},
"familyName": "Bowtell",
"givenName": "David D. L.",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1371/journal.pcbi.1004274",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000693037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jps.23952",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001681229"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bioinformatics/bts196",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002683055"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djv222",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004277738"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.3317",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005140994",
"https://doi.org/10.1038/nmeth.3317"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-12-0203",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005406683"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1009843107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007646723"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13073-015-0167-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008933384",
"https://doi.org/10.1186/s13073-015-0167-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13073-015-0167-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008933384",
"https://doi.org/10.1186/s13073-015-0167-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkt214",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011464256"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkv007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016098431"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.3729",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016683041",
"https://doi.org/10.1038/nm.3729"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.1363",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020581697",
"https://doi.org/10.1038/nmeth.1363"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.1363",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020581697",
"https://doi.org/10.1038/nmeth.1363"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bioinformatics/btp352",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023014918"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bioinformatics/btp616",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023247882"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.critrevonc.2015.05.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024870184"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0045835",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047293040"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-08-0196",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049534215"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.6703",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049737289"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature14410",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051129444",
"https://doi.org/10.1038/nature14410"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0702955104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051148014"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jncimonographs/lgr042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059822080"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/138945011795378540",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069181865"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082791809",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/esmoopen-2016-000117",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083507874"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/esmoopen-2016-000117",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083507874"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdx011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083930463"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdx011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083930463"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/120295",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085104907"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/120295",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085104907"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/120295",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085104907"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-16-2224",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1086151969"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41467-017-01174-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092421717",
"https://doi.org/10.1038/s41467-017-01174-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-17-0337",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092476421"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gr.222109.117",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092505592"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41568-018-0005-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103209608",
"https://doi.org/10.1038/s41568-018-0005-8"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "ABCB1 encodes Multidrug Resistance protein (MDR1), an ATP-binding cassette member involved in the cellular efflux of chemotherapeutic drugs. Here we report that ovarian and breast samples from chemotherapy treated patients are positive for multiple transcriptional fusions involving ABCB1, placing it under the control of a strong promoter while leaving its open reading frame intact. We identified 15 different transcriptional fusion partners involving ABCB1, as well as patients with multiple distinct fusion events. The partner gene selected depended on its structure, promoter strength, and chromosomal proximity to ABCB1. Fusion positivity was strongly associated with the number of lines of MDR1-substrate chemotherapy given. MDR1 inhibition in a fusion positive ovarian cancer cell line increased sensitivity to paclitaxel more than 50-fold. Convergent evolution of ABCB1 fusion is therefore frequent in chemotherapy resistant recurrent ovarian cancer. As most currently approved PARP inhibitors (PARPi) are MDR1 substrates, prior chemotherapy may precondition resistance to PARPi.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41467-019-09312-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.6810355",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6940050",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.4293906",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6715190",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1043282",
"issn": [
"2041-1723"
],
"name": "Nature Communications",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "10"
}
],
"name": "Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer",
"pagination": "1295",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"df826abe1ef913dbf3bbe1d3493f67079e441a31ce6488c4f5b16dd41501faa6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30894541"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101528555"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41467-019-09312-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112880978"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41467-019-09312-9",
"https://app.dimensions.ai/details/publication/pub.1112880978"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T14:20",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117121_00000003.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41467-019-09312-9"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09312-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09312-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09312-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09312-9'
This table displays all metadata directly associated to this object as RDF triples.
363 TRIPLES
21 PREDICATES
81 URIs
42 LITERALS
30 BLANK NODES