Perinatal factors affect the gut microbiota up to four years after birth View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04-03

AUTHORS

Fiona Fouhy, Claire Watkins, Cian J. Hill, Carol-Anne O’Shea, Brid Nagle, Eugene M. Dempsey, Paul W. O’Toole, R. Paul Ross, C. Anthony Ryan, Catherine Stanton

ABSTRACT

Perinatal factors impact gut microbiota development in early life, however, little is known on the effects of these factors on microbes in later life. Here we sequence DNA from faecal samples of children over the first four years and reveal a perpetual evolution of the gut microbiota during this period. The significant impact of gestational age at birth and delivery mode on gut microbiota progression is evident in the first four years of life, while no measurable effects of antibiotics are found in the first year. Microbiota profiles are also characteristic in children dependant on gestational age and maturity. Full term delivery is characterised by Bacteroides (year one), Parabacteroides (year two) and Christensenellaceae (year four). Preterm delivery is characterised by Lactobacillus (year one), Streptococcus (year two) and Carnobacterium (year four). This study reveals that the gut retains distinct microbial profiles of perinatal factors up to four years of age. More... »

PAGES

1517

References to SciGraph publications

  • 2014-09-13. Varying gestational age patterns in cesarean delivery: an international comparison in BMC PREGNANCY AND CHILDBIRTH
  • 2018-05-23. The premature infant gut microbiome during the first 6 weeks of life differs based on gestational maturity at birth in PEDIATRIC RESEARCH
  • 2012-09-12. Diversity, stability and resilience of the human gut microbiota in NATURE
  • 2017-01-17. Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort in MICROBIOME
  • 2016-01-26. Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children in NATURE COMMUNICATIONS
  • 2014-01-28. Microbes in the neonatal intensive care unit resemble those found in the gut of premature infants in MICROBIOME
  • 2011-06-24. Metagenomic biomarker discovery and explanation in GENOME BIOLOGY
  • 2018-06-08. Individuality and convergence of the infant gut microbiota during the first year of life in NATURE COMMUNICATIONS
  • 2016-07-30. The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review in BMC GASTROENTEROLOGY
  • 2017-12-11. Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth in MICROBIOME
  • 2012-05-09. Human gut microbiome viewed across age and geography in NATURE
  • 2013-09-29. Differential abundance analysis for microbial marker-gene surveys in NATURE METHODS
  • 2018-02-06. Intestinal microbiota development and gestational age in preterm neonates in SCIENTIFIC REPORTS
  • 2018-10-24. Temporal development of the gut microbiome in early childhood from the TEDDY study in NATURE
  • 2017-03-03. Normalization and microbial differential abundance strategies depend upon data characteristics in MICROBIOME
  • 2014-10-13. Development of the preterm infant gut microbiome: a research priority in MICROBIOME
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-09252-4

    DOI

    http://dx.doi.org/10.1038/s41467-019-09252-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113182116

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30944304


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Paediatrics and Reproductive Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Bacterial Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bacteria", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child, Preschool", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Feces", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastrointestinal Microbiome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastrointestinal Tract", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infant, Newborn", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microbiota", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pregnancy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Premature Birth", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Ribosomal, 16S", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Teagasc Food Research Centre, Moorepark, Fermoy, Co, P61 C996, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.6435.4", 
              "name": [
                "APC Microbiome Ireland, T12 YT20, Cork, Ireland", 
                "Teagasc Food Research Centre, Moorepark, Fermoy, Co, P61 C996, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fouhy", 
            "givenName": "Fiona", 
            "id": "sg:person.01255754763.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255754763.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teagasc Food Research Centre, Moorepark, Fermoy, Co, P61 C996, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.6435.4", 
              "name": [
                "APC Microbiome Ireland, T12 YT20, Cork, Ireland", 
                "Teagasc Food Research Centre, Moorepark, Fermoy, Co, P61 C996, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watkins", 
            "givenName": "Claire", 
            "id": "sg:person.0766265573.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766265573.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "APC Microbiome Ireland, T12 YT20, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "APC Microbiome Ireland, T12 YT20, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hill", 
            "givenName": "Cian J.", 
            "id": "sg:person.01361324337.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361324337.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neonatology, Cork University Maternity Hospital, T12 YE02, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.411916.a", 
              "name": [
                "Department of Neonatology, Cork University Maternity Hospital, T12 YE02, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "O\u2019Shea", 
            "givenName": "Carol-Anne", 
            "id": "sg:person.014177342423.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014177342423.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teagasc Food Research Centre, Moorepark, Fermoy, Co, P61 C996, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.6435.4", 
              "name": [
                "Teagasc Food Research Centre, Moorepark, Fermoy, Co, P61 C996, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagle", 
            "givenName": "Brid", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "INFANT Centre, University College Cork, T12 YT20, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "Department of Neonatology, Cork University Maternity Hospital, T12 YE02, Cork, Ireland", 
                "INFANT Centre, University College Cork, T12 YT20, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dempsey", 
            "givenName": "Eugene M.", 
            "id": "sg:person.01047107345.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047107345.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Microbiology, University College Cork, T12 YT20, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "APC Microbiome Ireland, T12 YT20, Cork, Ireland", 
                "School of Microbiology, University College Cork, T12 YT20, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "O\u2019Toole", 
            "givenName": "Paul W.", 
            "id": "sg:person.01305242542.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305242542.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Microbiology, University College Cork, T12 YT20, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "APC Microbiome Ireland, T12 YT20, Cork, Ireland", 
                "School of Microbiology, University College Cork, T12 YT20, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ross", 
            "givenName": "R. Paul", 
            "id": "sg:person.014605670062.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014605670062.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neonatology, Cork University Maternity Hospital, T12 YE02, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.411916.a", 
              "name": [
                "APC Microbiome Ireland, T12 YT20, Cork, Ireland", 
                "Department of Neonatology, Cork University Maternity Hospital, T12 YE02, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ryan", 
            "givenName": "C. Anthony", 
            "id": "sg:person.016467650022.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016467650022.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teagasc Food Research Centre, Moorepark, Fermoy, Co, P61 C996, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.6435.4", 
              "name": [
                "APC Microbiome Ireland, T12 YT20, Cork, Ireland", 
                "Teagasc Food Research Centre, Moorepark, Fermoy, Co, P61 C996, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stanton", 
            "givenName": "Catherine", 
            "id": "sg:person.0631363014.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631363014.01"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature11550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007512293", 
              "https://doi.org/10.1038/nature11550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-04641-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104381164", 
              "https://doi.org/10.1038/s41467-018-04641-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2049-2618-2-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020792879", 
              "https://doi.org/10.1186/2049-2618-2-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-6-r60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000243423", 
              "https://doi.org/10.1186/gb-2011-12-6-r60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002139060", 
              "https://doi.org/10.1038/nmeth.2658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40168-017-0237-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252802", 
              "https://doi.org/10.1186/s40168-017-0237-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms10410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045026422", 
              "https://doi.org/10.1038/ncomms10410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052378845", 
              "https://doi.org/10.1038/nature11053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2049-2618-2-38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005197171", 
              "https://doi.org/10.1186/2049-2618-2-38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40168-016-0213-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051872760", 
              "https://doi.org/10.1186/s40168-016-0213-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2393-14-321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038781880", 
              "https://doi.org/10.1186/1471-2393-14-321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0617-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107713169", 
              "https://doi.org/10.1038/s41586-018-0617-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41390-018-0022-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104162440", 
              "https://doi.org/10.1038/s41390-018-0022-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40168-017-0377-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099597213", 
              "https://doi.org/10.1186/s40168-017-0377-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-20827-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100756052", 
              "https://doi.org/10.1038/s41598-018-20827-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12876-016-0498-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029987285", 
              "https://doi.org/10.1186/s12876-016-0498-0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04-03", 
        "datePublishedReg": "2019-04-03", 
        "description": "Perinatal factors impact gut microbiota development in early life, however, little is known on the effects of these factors on microbes in later life. Here we sequence DNA from faecal samples of children over the first four years and reveal a perpetual evolution of the gut microbiota during this period. The significant impact of gestational age at birth and delivery mode on gut microbiota progression is evident in the first four years of life, while no measurable effects of antibiotics are found in the first year. Microbiota profiles are also characteristic in children dependant on gestational age and maturity. Full term delivery is characterised by Bacteroides (year one), Parabacteroides (year two) and Christensenellaceae\u00a0(year four). Preterm delivery is characterised by Lactobacillus (year one), Streptococcus (year two) and Carnobacterium (year four). This study reveals that the gut retains distinct microbial profiles of perinatal factors up to four years of age.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41467-019-09252-4", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "keywords": [
          "perinatal factors", 
          "distinct microbial profiles", 
          "gut microbiota", 
          "gestational age", 
          "gut microbiota development", 
          "microbial profiles", 
          "full-term delivery", 
          "years of age", 
          "years of life", 
          "preterm delivery", 
          "microbiota development", 
          "term delivery", 
          "microbiota profiles", 
          "microbiota", 
          "fecal samples", 
          "early life", 
          "later life", 
          "microbes", 
          "delivery mode", 
          "Carnobacterium", 
          "age", 
          "DNA", 
          "first year", 
          "birth", 
          "children", 
          "years", 
          "measurable effect", 
          "Christensenellaceae", 
          "gut", 
          "Bacteroides", 
          "delivery", 
          "Parabacteroides", 
          "factors", 
          "Lactobacillus", 
          "progression", 
          "evolution", 
          "life", 
          "maturity", 
          "streptococci", 
          "antibiotics", 
          "profile", 
          "effect", 
          "perpetual evolution", 
          "development", 
          "significant impact", 
          "period", 
          "study", 
          "samples", 
          "impact", 
          "mode"
        ], 
        "name": "Perinatal factors affect the gut microbiota up to four years after birth", 
        "pagination": "1517", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113182116"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-019-09252-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30944304"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-019-09252-4", 
          "https://app.dimensions.ai/details/publication/pub.1113182116"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-10T10:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_799.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41467-019-09252-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09252-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09252-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09252-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09252-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    312 TRIPLES      22 PREDICATES      107 URIs      83 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-019-09252-4 schema:about N07681122b01c4dd7be403e1117ce4d63
    2 N10d975a11267450bafcf2023adea87a4
    3 N358c8c853e75431b9ef102fa082e3173
    4 N4c857263aa424bd686464d4472e248fa
    5 N5047efca0be247ff873936ad698090b3
    6 N59bc702c27e34c8cb4cda1e47b428a79
    7 N5da51a30a94a47babb317387bb8556e4
    8 N72f1c4d84aff41b2a4c4de82c41eff78
    9 Nb70e160c44ab46d89e456c95da78a39f
    10 Nf01ed9afdd6a4a04878351713461e011
    11 Nf02d2255cb85499da41202fec2579d4f
    12 Nf196193644ed47f8a8bbf69478b19192
    13 Nf450440987224a9484243f923069b090
    14 Nfc2152135916483b9633f823159f87b9
    15 Nfc937a2ea1f64212a0ba5f424618ba05
    16 anzsrc-for:11
    17 anzsrc-for:1114
    18 schema:author N328fa8f168694be7bb5a73792a522783
    19 schema:citation sg:pub.10.1038/nature11053
    20 sg:pub.10.1038/nature11550
    21 sg:pub.10.1038/ncomms10410
    22 sg:pub.10.1038/nmeth.2658
    23 sg:pub.10.1038/s41390-018-0022-z
    24 sg:pub.10.1038/s41467-018-04641-7
    25 sg:pub.10.1038/s41586-018-0617-x
    26 sg:pub.10.1038/s41598-018-20827-x
    27 sg:pub.10.1186/1471-2393-14-321
    28 sg:pub.10.1186/2049-2618-2-1
    29 sg:pub.10.1186/2049-2618-2-38
    30 sg:pub.10.1186/gb-2011-12-6-r60
    31 sg:pub.10.1186/s12876-016-0498-0
    32 sg:pub.10.1186/s40168-016-0213-y
    33 sg:pub.10.1186/s40168-017-0237-y
    34 sg:pub.10.1186/s40168-017-0377-0
    35 schema:datePublished 2019-04-03
    36 schema:datePublishedReg 2019-04-03
    37 schema:description Perinatal factors impact gut microbiota development in early life, however, little is known on the effects of these factors on microbes in later life. Here we sequence DNA from faecal samples of children over the first four years and reveal a perpetual evolution of the gut microbiota during this period. The significant impact of gestational age at birth and delivery mode on gut microbiota progression is evident in the first four years of life, while no measurable effects of antibiotics are found in the first year. Microbiota profiles are also characteristic in children dependant on gestational age and maturity. Full term delivery is characterised by Bacteroides (year one), Parabacteroides (year two) and Christensenellaceae (year four). Preterm delivery is characterised by Lactobacillus (year one), Streptococcus (year two) and Carnobacterium (year four). This study reveals that the gut retains distinct microbial profiles of perinatal factors up to four years of age.
    38 schema:genre article
    39 schema:inLanguage en
    40 schema:isAccessibleForFree true
    41 schema:isPartOf N2b40deb6f663413b98a5a4911cf4782c
    42 N4d2ac8f2fcdd4dd8b0865f7e5d877ed6
    43 sg:journal.1043282
    44 schema:keywords Bacteroides
    45 Carnobacterium
    46 Christensenellaceae
    47 DNA
    48 Lactobacillus
    49 Parabacteroides
    50 age
    51 antibiotics
    52 birth
    53 children
    54 delivery
    55 delivery mode
    56 development
    57 distinct microbial profiles
    58 early life
    59 effect
    60 evolution
    61 factors
    62 fecal samples
    63 first year
    64 full-term delivery
    65 gestational age
    66 gut
    67 gut microbiota
    68 gut microbiota development
    69 impact
    70 later life
    71 life
    72 maturity
    73 measurable effect
    74 microbes
    75 microbial profiles
    76 microbiota
    77 microbiota development
    78 microbiota profiles
    79 mode
    80 perinatal factors
    81 period
    82 perpetual evolution
    83 preterm delivery
    84 profile
    85 progression
    86 samples
    87 significant impact
    88 streptococci
    89 study
    90 term delivery
    91 years
    92 years of age
    93 years of life
    94 schema:name Perinatal factors affect the gut microbiota up to four years after birth
    95 schema:pagination 1517
    96 schema:productId N1bc47905421a41c5bc7ff5c285a8b6b9
    97 Na4c2fcbb95bf451a839d3ec769ec44b0
    98 Ne0a7330ecb4a4917bd3dd714859bf658
    99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113182116
    100 https://doi.org/10.1038/s41467-019-09252-4
    101 schema:sdDatePublished 2022-05-10T10:20
    102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    103 schema:sdPublisher Ndbcd9193c6bc430786207b651a965ca3
    104 schema:url https://doi.org/10.1038/s41467-019-09252-4
    105 sgo:license sg:explorer/license/
    106 sgo:sdDataset articles
    107 rdf:type schema:ScholarlyArticle
    108 N0717ccc9b556429189eb593c8658508c rdf:first sg:person.0766265573.04
    109 rdf:rest N2c4fa629d58742a981d550af5d195240
    110 N07681122b01c4dd7be403e1117ce4d63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Infant, Newborn
    112 rdf:type schema:DefinedTerm
    113 N10d975a11267450bafcf2023adea87a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Female
    115 rdf:type schema:DefinedTerm
    116 N119d1509c0174c9c92b5e419bdd82b90 rdf:first sg:person.016467650022.43
    117 rdf:rest N2a19f74d56724e8584415fa5a557f9c6
    118 N1bc47905421a41c5bc7ff5c285a8b6b9 schema:name pubmed_id
    119 schema:value 30944304
    120 rdf:type schema:PropertyValue
    121 N2a19f74d56724e8584415fa5a557f9c6 rdf:first sg:person.0631363014.01
    122 rdf:rest rdf:nil
    123 N2b40deb6f663413b98a5a4911cf4782c schema:volumeNumber 10
    124 rdf:type schema:PublicationVolume
    125 N2c4fa629d58742a981d550af5d195240 rdf:first sg:person.01361324337.34
    126 rdf:rest N6334cffca48640f1b6cf01da35c1609e
    127 N328fa8f168694be7bb5a73792a522783 rdf:first sg:person.01255754763.94
    128 rdf:rest N0717ccc9b556429189eb593c8658508c
    129 N358c8c853e75431b9ef102fa082e3173 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Bacteria
    131 rdf:type schema:DefinedTerm
    132 N4c857263aa424bd686464d4472e248fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Gastrointestinal Tract
    134 rdf:type schema:DefinedTerm
    135 N4d2ac8f2fcdd4dd8b0865f7e5d877ed6 schema:issueNumber 1
    136 rdf:type schema:PublicationIssue
    137 N5047efca0be247ff873936ad698090b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Male
    139 rdf:type schema:DefinedTerm
    140 N59bc702c27e34c8cb4cda1e47b428a79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Premature Birth
    142 rdf:type schema:DefinedTerm
    143 N5da51a30a94a47babb317387bb8556e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Anti-Bacterial Agents
    145 rdf:type schema:DefinedTerm
    146 N6334cffca48640f1b6cf01da35c1609e rdf:first sg:person.014177342423.01
    147 rdf:rest Nfbc306c43ae04509a0042751ed368c3e
    148 N72f1c4d84aff41b2a4c4de82c41eff78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Humans
    150 rdf:type schema:DefinedTerm
    151 N8e51ecbf8a374b389ad9313597011005 rdf:first sg:person.014605670062.43
    152 rdf:rest N119d1509c0174c9c92b5e419bdd82b90
    153 Na4c2fcbb95bf451a839d3ec769ec44b0 schema:name doi
    154 schema:value 10.1038/s41467-019-09252-4
    155 rdf:type schema:PropertyValue
    156 Nb70e160c44ab46d89e456c95da78a39f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name RNA, Ribosomal, 16S
    158 rdf:type schema:DefinedTerm
    159 Nbc94ad2813bf49b1b56357052440abf6 schema:affiliation grid-institutes:grid.6435.4
    160 schema:familyName Nagle
    161 schema:givenName Brid
    162 rdf:type schema:Person
    163 Ndbcd9193c6bc430786207b651a965ca3 schema:name Springer Nature - SN SciGraph project
    164 rdf:type schema:Organization
    165 Ndc97f9f6dec540648b1b99043a20259c rdf:first sg:person.01305242542.02
    166 rdf:rest N8e51ecbf8a374b389ad9313597011005
    167 Ne0a7330ecb4a4917bd3dd714859bf658 schema:name dimensions_id
    168 schema:value pub.1113182116
    169 rdf:type schema:PropertyValue
    170 Ne3746221d07c4f40bdd7f4d85d5d354b rdf:first sg:person.01047107345.59
    171 rdf:rest Ndc97f9f6dec540648b1b99043a20259c
    172 Nf01ed9afdd6a4a04878351713461e011 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Child, Preschool
    174 rdf:type schema:DefinedTerm
    175 Nf02d2255cb85499da41202fec2579d4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Gastrointestinal Microbiome
    177 rdf:type schema:DefinedTerm
    178 Nf196193644ed47f8a8bbf69478b19192 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Pregnancy
    180 rdf:type schema:DefinedTerm
    181 Nf450440987224a9484243f923069b090 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Microbiota
    183 rdf:type schema:DefinedTerm
    184 Nfbc306c43ae04509a0042751ed368c3e rdf:first Nbc94ad2813bf49b1b56357052440abf6
    185 rdf:rest Ne3746221d07c4f40bdd7f4d85d5d354b
    186 Nfc2152135916483b9633f823159f87b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Infant
    188 rdf:type schema:DefinedTerm
    189 Nfc937a2ea1f64212a0ba5f424618ba05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Feces
    191 rdf:type schema:DefinedTerm
    192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    193 schema:name Medical and Health Sciences
    194 rdf:type schema:DefinedTerm
    195 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
    196 schema:name Paediatrics and Reproductive Medicine
    197 rdf:type schema:DefinedTerm
    198 sg:journal.1043282 schema:issn 2041-1723
    199 schema:name Nature Communications
    200 schema:publisher Springer Nature
    201 rdf:type schema:Periodical
    202 sg:person.01047107345.59 schema:affiliation grid-institutes:grid.7872.a
    203 schema:familyName Dempsey
    204 schema:givenName Eugene M.
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047107345.59
    206 rdf:type schema:Person
    207 sg:person.01255754763.94 schema:affiliation grid-institutes:grid.6435.4
    208 schema:familyName Fouhy
    209 schema:givenName Fiona
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255754763.94
    211 rdf:type schema:Person
    212 sg:person.01305242542.02 schema:affiliation grid-institutes:grid.7872.a
    213 schema:familyName O’Toole
    214 schema:givenName Paul W.
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305242542.02
    216 rdf:type schema:Person
    217 sg:person.01361324337.34 schema:affiliation grid-institutes:None
    218 schema:familyName Hill
    219 schema:givenName Cian J.
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361324337.34
    221 rdf:type schema:Person
    222 sg:person.014177342423.01 schema:affiliation grid-institutes:grid.411916.a
    223 schema:familyName O’Shea
    224 schema:givenName Carol-Anne
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014177342423.01
    226 rdf:type schema:Person
    227 sg:person.014605670062.43 schema:affiliation grid-institutes:grid.7872.a
    228 schema:familyName Ross
    229 schema:givenName R. Paul
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014605670062.43
    231 rdf:type schema:Person
    232 sg:person.016467650022.43 schema:affiliation grid-institutes:grid.411916.a
    233 schema:familyName Ryan
    234 schema:givenName C. Anthony
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016467650022.43
    236 rdf:type schema:Person
    237 sg:person.0631363014.01 schema:affiliation grid-institutes:grid.6435.4
    238 schema:familyName Stanton
    239 schema:givenName Catherine
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631363014.01
    241 rdf:type schema:Person
    242 sg:person.0766265573.04 schema:affiliation grid-institutes:grid.6435.4
    243 schema:familyName Watkins
    244 schema:givenName Claire
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766265573.04
    246 rdf:type schema:Person
    247 sg:pub.10.1038/nature11053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052378845
    248 https://doi.org/10.1038/nature11053
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/nature11550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007512293
    251 https://doi.org/10.1038/nature11550
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/ncomms10410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045026422
    254 https://doi.org/10.1038/ncomms10410
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nmeth.2658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002139060
    257 https://doi.org/10.1038/nmeth.2658
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/s41390-018-0022-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1104162440
    260 https://doi.org/10.1038/s41390-018-0022-z
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/s41467-018-04641-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104381164
    263 https://doi.org/10.1038/s41467-018-04641-7
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/s41586-018-0617-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1107713169
    266 https://doi.org/10.1038/s41586-018-0617-x
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/s41598-018-20827-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1100756052
    269 https://doi.org/10.1038/s41598-018-20827-x
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1186/1471-2393-14-321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038781880
    272 https://doi.org/10.1186/1471-2393-14-321
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1186/2049-2618-2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020792879
    275 https://doi.org/10.1186/2049-2618-2-1
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1186/2049-2618-2-38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005197171
    278 https://doi.org/10.1186/2049-2618-2-38
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1186/gb-2011-12-6-r60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000243423
    281 https://doi.org/10.1186/gb-2011-12-6-r60
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1186/s12876-016-0498-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029987285
    284 https://doi.org/10.1186/s12876-016-0498-0
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1186/s40168-016-0213-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051872760
    287 https://doi.org/10.1186/s40168-016-0213-y
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1186/s40168-017-0237-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1084252802
    290 https://doi.org/10.1186/s40168-017-0237-y
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1186/s40168-017-0377-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099597213
    293 https://doi.org/10.1186/s40168-017-0377-0
    294 rdf:type schema:CreativeWork
    295 grid-institutes:None schema:alternateName APC Microbiome Ireland, T12 YT20, Cork, Ireland
    296 schema:name APC Microbiome Ireland, T12 YT20, Cork, Ireland
    297 rdf:type schema:Organization
    298 grid-institutes:grid.411916.a schema:alternateName Department of Neonatology, Cork University Maternity Hospital, T12 YE02, Cork, Ireland
    299 schema:name APC Microbiome Ireland, T12 YT20, Cork, Ireland
    300 Department of Neonatology, Cork University Maternity Hospital, T12 YE02, Cork, Ireland
    301 rdf:type schema:Organization
    302 grid-institutes:grid.6435.4 schema:alternateName Teagasc Food Research Centre, Moorepark, Fermoy, Co, P61 C996, Cork, Ireland
    303 schema:name APC Microbiome Ireland, T12 YT20, Cork, Ireland
    304 Teagasc Food Research Centre, Moorepark, Fermoy, Co, P61 C996, Cork, Ireland
    305 rdf:type schema:Organization
    306 grid-institutes:grid.7872.a schema:alternateName INFANT Centre, University College Cork, T12 YT20, Cork, Ireland
    307 School of Microbiology, University College Cork, T12 YT20, Cork, Ireland
    308 schema:name APC Microbiome Ireland, T12 YT20, Cork, Ireland
    309 Department of Neonatology, Cork University Maternity Hospital, T12 YE02, Cork, Ireland
    310 INFANT Centre, University College Cork, T12 YT20, Cork, Ireland
    311 School of Microbiology, University College Cork, T12 YT20, Cork, Ireland
    312 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...