Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSBernat Blasco-Moreno, Leire de Campos-Mata, René Böttcher, José García-Martínez, Jennifer Jungfleisch, Danny D. Nedialkova, Shiladitya Chattopadhyay, María-Eugenia Gas, Baldomero Oliva, José E. Pérez-Ortín, Sebastian A. Leidel, Mordechai Choder, Juana Díez
ABSTRACTThe highly conserved 5'-3' exonuclease Xrn1 regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating transcriptome-wide analyses of translation with biochemical and functional studies, we demonstrate an unanticipated regulatory role of Xrn1 in protein synthesis. Xrn1 promotes translation of a specific group of transcripts encoding membrane proteins. Xrn1-dependence for translation is linked to poor structural RNA contexts for translation initiation, is mediated by interactions with components of the translation initiation machinery and correlates with an Xrn1-dependence for mRNA localization at the endoplasmic reticulum, the translation compartment of membrane proteins. Importantly, for this group of mRNAs, Xrn1 stimulates transcription, mRNA translation and decay. Our results uncover a crosstalk between the three major stages of gene expression coordinated by Xrn1 to maintain appropriate levels of membrane proteins. More... »
PAGES1298
http://scigraph.springernature.com/pub.10.1038/s41467-019-09199-6
DOIhttp://dx.doi.org/10.1038/s41467-019-09199-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112895344
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30899024
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
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This table displays all metadata directly associated to this object as RDF triples.
401 TRIPLES
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103 URIs
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25 BLANK NODES