The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Bernat Blasco-Moreno, Leire de Campos-Mata, René Böttcher, José García-Martínez, Jennifer Jungfleisch, Danny D. Nedialkova, Shiladitya Chattopadhyay, María-Eugenia Gas, Baldomero Oliva, José E. Pérez-Ortín, Sebastian A. Leidel, Mordechai Choder, Juana Díez

ABSTRACT

The highly conserved 5'-3' exonuclease Xrn1 regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating transcriptome-wide analyses of translation with biochemical and functional studies, we demonstrate an unanticipated regulatory role of Xrn1 in protein synthesis. Xrn1 promotes translation of a specific group of transcripts encoding membrane proteins. Xrn1-dependence for translation is linked to poor structural RNA contexts for translation initiation, is mediated by interactions with components of the translation initiation machinery and correlates with an Xrn1-dependence for mRNA localization at the endoplasmic reticulum, the translation compartment of membrane proteins. Importantly, for this group of mRNAs, Xrn1 stimulates transcription, mRNA translation and decay. Our results uncover a crosstalk between the three major stages of gene expression coordinated by Xrn1 to maintain appropriate levels of membrane proteins. More... »

PAGES

1298

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-09199-6

DOI

http://dx.doi.org/10.1038/s41467-019-09199-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112895344

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30899024


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endoplasmic Reticulum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exoribonucleases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Biosynthesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Stability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pompeu Fabra University", 
          "id": "https://www.grid.ac/institutes/grid.5612.0", 
          "name": [
            "Virology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blasco-Moreno", 
        "givenName": "Bernat", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pompeu Fabra University", 
          "id": "https://www.grid.ac/institutes/grid.5612.0", 
          "name": [
            "Virology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Campos-Mata", 
        "givenName": "Leire", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pompeu Fabra University", 
          "id": "https://www.grid.ac/institutes/grid.5612.0", 
          "name": [
            "Virology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00f6ttcher", 
        "givenName": "Ren\u00e9", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Valencia", 
          "id": "https://www.grid.ac/institutes/grid.5338.d", 
          "name": [
            "Departments of Genetics, Biochemistry and Molecular Biology, and ERI Biotecmed, Facultad de Biolog\u00eda, Universitat de Val\u00e8ncia, E-46100, Burjassot, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda-Mart\u00ednez", 
        "givenName": "Jos\u00e9", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pompeu Fabra University", 
          "id": "https://www.grid.ac/institutes/grid.5612.0", 
          "name": [
            "Virology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jungfleisch", 
        "givenName": "Jennifer", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.418615.f", 
          "name": [
            "Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, 48149, Muenster, Germany", 
            "Mechanisms of Protein Biogenesis Laboratory, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nedialkova", 
        "givenName": "Danny D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technion \u2013 Israel Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.6451.6", 
          "name": [
            "Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 31096, Haifa, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chattopadhyay", 
        "givenName": "Shiladitya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pompeu Fabra University", 
          "id": "https://www.grid.ac/institutes/grid.5612.0", 
          "name": [
            "Virology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gas", 
        "givenName": "Mar\u00eda-Eugenia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pompeu Fabra University", 
          "id": "https://www.grid.ac/institutes/grid.5612.0", 
          "name": [
            "Laboratory of Structural Bioinformatics (GRIB), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oliva", 
        "givenName": "Baldomero", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Valencia", 
          "id": "https://www.grid.ac/institutes/grid.5338.d", 
          "name": [
            "Departments of Genetics, Biochemistry and Molecular Biology, and ERI Biotecmed, Facultad de Biolog\u00eda, Universitat de Val\u00e8ncia, E-46100, Burjassot, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "P\u00e9rez-Ort\u00edn", 
        "givenName": "Jos\u00e9 E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bern", 
          "id": "https://www.grid.ac/institutes/grid.5734.5", 
          "name": [
            "Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, 48149, Muenster, Germany", 
            "Department of Chemistry and Biochemistry, University of Bern, 3012, Bern, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leidel", 
        "givenName": "Sebastian A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technion \u2013 Israel Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.6451.6", 
          "name": [
            "Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 31096, Haifa, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choder", 
        "givenName": "Mordechai", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pompeu Fabra University", 
          "id": "https://www.grid.ac/institutes/grid.5612.0", 
          "name": [
            "Virology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u00edez", 
        "givenName": "Juana", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.molcel.2011.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001273317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.227843.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001797216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbagrm.2015.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003322964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004008241", 
          "https://doi.org/10.1038/nature08265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004008241", 
          "https://doi.org/10.1038/nature08265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004223987", 
          "https://doi.org/10.1038/nature10118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.10.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004497729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/smvy.1997.0125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004997277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02246-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007294133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.25.13810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007650209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(92)90008-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007714264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(92)90008-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007714264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.20084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008225564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009060679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(02)51873-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009318865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkq313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010078089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010937907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.5.2227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011549492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.111.137265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011740458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.111.137265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011740458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fgene.2014.00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012322730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.9.5930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012714153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2013.02.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012770099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471143030.cb2009s64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014251428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015222646", 
          "https://doi.org/10.1186/s13059-014-0550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015222646", 
          "https://doi.org/10.1186/s13059-014-0550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.052209.115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018020953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018565479", 
          "https://doi.org/10.1038/nsmb.2303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2013.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020386213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbagrm.2013.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021866584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.12.4094-4106.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022069220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022424383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15252/embj.201490194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024413626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-61779-086-7_2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024877742", 
          "https://doi.org/10.1007/978-1-61779-086-7_2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0107085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025317459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/wrna.1190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027151556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030004014", 
          "https://doi.org/10.1038/nsmb.2413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1993.1626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030443070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.10629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031844765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-biochem-060713-035802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033035799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033775404", 
          "https://doi.org/10.1038/nature09322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033775404", 
          "https://doi.org/10.1038/nature09322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/28.1.235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035055456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.1712910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035443060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1168978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035665750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035947017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.phyto.41.052002.095717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036646297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200701165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037458948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.10.6122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037799669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1257521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039560253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2012.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039834486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2016.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043058002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2016.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043058002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043238114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.08.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047256933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1567-1364.12180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049072630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1654308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049535341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2009-10-3-r25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049583368", 
          "https://doi.org/10.1186/gb-2009-10-3-r25"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.240460897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053303072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1355838200001540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054923501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.209015.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060407477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18637/jss.v035.b01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068672522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074632769", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btx047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083534106"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "The highly conserved 5'-3' exonuclease Xrn1 regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating transcriptome-wide analyses of translation with biochemical and functional studies, we demonstrate an unanticipated regulatory role of Xrn1 in protein synthesis. Xrn1 promotes translation of a specific group of transcripts encoding membrane proteins. Xrn1-dependence for translation is linked to poor structural\u00a0RNA contexts for translation initiation, is mediated by interactions with components of the translation initiation machinery and correlates with an Xrn1-dependence for mRNA localization at the endoplasmic reticulum, the translation compartment of membrane proteins. Importantly, for this group of mRNAs, Xrn1 stimulates transcription, mRNA translation and decay. Our results uncover a crosstalk between the three major stages of gene expression coordinated by Xrn1 to maintain appropriate levels of membrane proteins.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-019-09199-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3794757", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins", 
    "pagination": "1298", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0032c04517e24709e1bdb4b4238e3285f7dfa2ff1c3818ab3f4f96ecc45916a1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30899024"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-019-09199-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112895344"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-019-09199-6", 
      "https://app.dimensions.ai/details/publication/pub.1112895344"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130801_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-019-09199-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09199-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09199-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09199-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09199-6'


 

This table displays all metadata directly associated to this object as RDF triples.

401 TRIPLES      21 PREDICATES      103 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-019-09199-6 schema:about N0f927a87ef0c48a0aca75934c8d80e4e
2 N142331ee8ac44671b3e100c5f7c86de1
3 N3c80e23a14604c4c998f47cd7b900a53
4 N3d621993891f4ad380cba6a18a051578
5 N3f758e3156644f2886668255b216742c
6 N3fe7d7f37bba4593abf09401cc0b7073
7 N61bc7260914f4013a399c54caa5b7f3c
8 N655db1f980384c79847c4475d3ba8e12
9 N7adc224876fe44deb0d26eed36287035
10 Na626e4dc8cdf448bb457a04ee63dcf44
11 Nb4d005f51193428ab41017ac0e1949ec
12 Nc1e8521b492b4787998583eb7de40039
13 Nc71e72e9175644ada10da6a7d6cc3a49
14 Ndb57ba287ce747829572834ea9296055
15 Nef98cedc1cdd4a8db3fd806500add24b
16 Nffb7a46099dc428ea2f06693c69f7b4b
17 anzsrc-for:06
18 anzsrc-for:0604
19 schema:author Nd70803f9d0f447959ad21790ffd5bcf0
20 schema:citation sg:pub.10.1007/978-1-61779-086-7_2
21 sg:pub.10.1038/nature08265
22 sg:pub.10.1038/nature09322
23 sg:pub.10.1038/nature10118
24 sg:pub.10.1038/nsmb.2303
25 sg:pub.10.1038/nsmb.2413
26 sg:pub.10.1186/gb-2009-10-3-r25
27 sg:pub.10.1186/s13059-014-0550-8
28 https://app.dimensions.ai/details/publication/pub.1074632769
29 https://doi.org/10.1002/0471143030.cb2009s64
30 https://doi.org/10.1002/jcc.20084
31 https://doi.org/10.1002/prot.10629
32 https://doi.org/10.1002/wrna.1190
33 https://doi.org/10.1006/jmbi.1993.1626
34 https://doi.org/10.1006/smvy.1997.0125
35 https://doi.org/10.1016/0378-1119(92)90008-d
36 https://doi.org/10.1016/j.bbagrm.2013.03.005
37 https://doi.org/10.1016/j.bbagrm.2015.04.001
38 https://doi.org/10.1016/j.cell.2010.10.033
39 https://doi.org/10.1016/j.cell.2013.02.003
40 https://doi.org/10.1016/j.cell.2013.05.012
41 https://doi.org/10.1016/j.cell.2015.05.008
42 https://doi.org/10.1016/j.celrep.2015.08.016
43 https://doi.org/10.1016/j.jmb.2013.02.029
44 https://doi.org/10.1016/j.molcel.2004.06.004
45 https://doi.org/10.1016/j.molcel.2011.02.004
46 https://doi.org/10.1016/j.molcel.2013.09.010
47 https://doi.org/10.1016/j.tibs.2012.08.004
48 https://doi.org/10.1016/j.ymeth.2016.07.011
49 https://doi.org/10.1016/s0076-6879(02)51873-5
50 https://doi.org/10.1017/s1355838200001540
51 https://doi.org/10.1073/pnas.240460897
52 https://doi.org/10.1073/pnas.94.25.13810
53 https://doi.org/10.1073/pnas.95.5.2227
54 https://doi.org/10.1083/jcb.200701165
55 https://doi.org/10.1093/bioinformatics/btx047
56 https://doi.org/10.1093/nar/28.1.235
57 https://doi.org/10.1093/nar/gkq313
58 https://doi.org/10.1093/nar/gkv234
59 https://doi.org/10.1101/gad.1654308
60 https://doi.org/10.1101/gad.227843.113
61 https://doi.org/10.1101/gr.209015.116
62 https://doi.org/10.1111/1567-1364.12180
63 https://doi.org/10.1126/science.1168978
64 https://doi.org/10.1126/science.1257521
65 https://doi.org/10.1128/jvi.02246-06
66 https://doi.org/10.1128/mcb.17.10.6122
67 https://doi.org/10.1128/mcb.19.9.5930
68 https://doi.org/10.1128/mcb.23.12.4094-4106.2003
69 https://doi.org/10.1146/annurev-biochem-060713-035802
70 https://doi.org/10.1146/annurev.phyto.41.052002.095717
71 https://doi.org/10.1261/rna.052209.115
72 https://doi.org/10.1261/rna.1712910
73 https://doi.org/10.1371/journal.pone.0107085
74 https://doi.org/10.15252/embj.201490194
75 https://doi.org/10.1534/genetics.111.137265
76 https://doi.org/10.18637/jss.v035.b01
77 https://doi.org/10.3389/fgene.2014.00001
78 schema:datePublished 2019-12
79 schema:datePublishedReg 2019-12-01
80 schema:description The highly conserved 5'-3' exonuclease Xrn1 regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating transcriptome-wide analyses of translation with biochemical and functional studies, we demonstrate an unanticipated regulatory role of Xrn1 in protein synthesis. Xrn1 promotes translation of a specific group of transcripts encoding membrane proteins. Xrn1-dependence for translation is linked to poor structural RNA contexts for translation initiation, is mediated by interactions with components of the translation initiation machinery and correlates with an Xrn1-dependence for mRNA localization at the endoplasmic reticulum, the translation compartment of membrane proteins. Importantly, for this group of mRNAs, Xrn1 stimulates transcription, mRNA translation and decay. Our results uncover a crosstalk between the three major stages of gene expression coordinated by Xrn1 to maintain appropriate levels of membrane proteins.
81 schema:genre research_article
82 schema:inLanguage en
83 schema:isAccessibleForFree true
84 schema:isPartOf N811543037ffa415782e2b4aad5ef2e26
85 N9d8d8cdf8318432bad53b13af99cc788
86 sg:journal.1043282
87 schema:name The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins
88 schema:pagination 1298
89 schema:productId N0b56ff80895645a4a94c06f235e61a77
90 N14286c8d901149a1ab71ca8d377cc03f
91 Na4955d14fdf345e0ad1aa00690dde9e8
92 Nc8ac1b7447264c78b8c417172620558d
93 Nf10adbdcc53d431fb48a7816bff5c969
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112895344
95 https://doi.org/10.1038/s41467-019-09199-6
96 schema:sdDatePublished 2019-04-11T13:52
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N3a0b7de19a7942b088163dd52fb0a650
99 schema:url https://www.nature.com/articles/s41467-019-09199-6
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N00c7b7cd7aea4433bf0eb6985cc21d89 rdf:first N962ae518690240bbb7de8ebf698a9a24
104 rdf:rest Nf7d38ea430c146ceb1db591ee959c1aa
105 N088ec637267047a4a3fc85f4ddc594a3 rdf:first Ne467be679a8d444f8621d4b906350660
106 rdf:rest N53350c6107544a68bcf78b47ed5bc097
107 N0b56ff80895645a4a94c06f235e61a77 schema:name doi
108 schema:value 10.1038/s41467-019-09199-6
109 rdf:type schema:PropertyValue
110 N0f927a87ef0c48a0aca75934c8d80e4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Recombinant Proteins
112 rdf:type schema:DefinedTerm
113 N13aa9fa314a64bbfaa0cae8bcbf40cbd schema:affiliation https://www.grid.ac/institutes/grid.5612.0
114 schema:familyName Oliva
115 schema:givenName Baldomero
116 rdf:type schema:Person
117 N142331ee8ac44671b3e100c5f7c86de1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name RNA Stability
119 rdf:type schema:DefinedTerm
120 N14286c8d901149a1ab71ca8d377cc03f schema:name dimensions_id
121 schema:value pub.1112895344
122 rdf:type schema:PropertyValue
123 N1e445ef86ccb47e2817aa4a6e3269c24 schema:affiliation https://www.grid.ac/institutes/grid.418615.f
124 schema:familyName Nedialkova
125 schema:givenName Danny D.
126 rdf:type schema:Person
127 N299f608e4d83491390ef4f385893d4d9 schema:affiliation https://www.grid.ac/institutes/grid.5612.0
128 schema:familyName Böttcher
129 schema:givenName René
130 rdf:type schema:Person
131 N336a5fceef704bebbabef1e523f8059d rdf:first Na00a77b3c0e249e187bf62326c44d2cd
132 rdf:rest Nd6d6c791642c43d9a07a21558541913b
133 N3a0b7de19a7942b088163dd52fb0a650 schema:name Springer Nature - SN SciGraph project
134 rdf:type schema:Organization
135 N3c80e23a14604c4c998f47cd7b900a53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Protein Biosynthesis
137 rdf:type schema:DefinedTerm
138 N3d621993891f4ad380cba6a18a051578 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name RNA, Messenger
140 rdf:type schema:DefinedTerm
141 N3dd2de677fc84523a30a5015d5bd71c0 rdf:first Nc4d62c55b8d54601b5258cbead474321
142 rdf:rest rdf:nil
143 N3f758e3156644f2886668255b216742c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Transcription, Genetic
145 rdf:type schema:DefinedTerm
146 N3fe7d7f37bba4593abf09401cc0b7073 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Gene Expression Regulation, Fungal
148 rdf:type schema:DefinedTerm
149 N42fdf9965e9c4087a35f81506555f7d7 schema:affiliation https://www.grid.ac/institutes/grid.5612.0
150 schema:familyName Gas
151 schema:givenName María-Eugenia
152 rdf:type schema:Person
153 N430ced57fd0a4d27902e911b03bb1173 rdf:first N52803c7c00314c78b4575550a32b3bbb
154 rdf:rest N3dd2de677fc84523a30a5015d5bd71c0
155 N52803c7c00314c78b4575550a32b3bbb schema:affiliation https://www.grid.ac/institutes/grid.6451.6
156 schema:familyName Choder
157 schema:givenName Mordechai
158 rdf:type schema:Person
159 N53350c6107544a68bcf78b47ed5bc097 rdf:first N9df0cd94427c4aa498ab3e108a612531
160 rdf:rest N430ced57fd0a4d27902e911b03bb1173
161 N61bc7260914f4013a399c54caa5b7f3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Saccharomyces cerevisiae
163 rdf:type schema:DefinedTerm
164 N63b94f9a99a1487688b5292da2eb8d73 rdf:first Ne7cb3419a2104f51bbad4a8c549c32b5
165 rdf:rest N336a5fceef704bebbabef1e523f8059d
166 N655db1f980384c79847c4475d3ba8e12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Membrane Proteins
168 rdf:type schema:DefinedTerm
169 N75176e17caf34457b7d9d53d5154fb06 rdf:first Nc5576c1ec8e24bdd90f6a8b87e1dfa72
170 rdf:rest N7aca3ddec6a24817a86b7a4621ff3278
171 N7aca3ddec6a24817a86b7a4621ff3278 rdf:first N42fdf9965e9c4087a35f81506555f7d7
172 rdf:rest Naf94bad11dd44105b227fc5c9d0a320c
173 N7adc224876fe44deb0d26eed36287035 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Gene Expression
175 rdf:type schema:DefinedTerm
176 N811543037ffa415782e2b4aad5ef2e26 schema:volumeNumber 10
177 rdf:type schema:PublicationVolume
178 N81cb74783d5d4b2e827f5c40b099ce3b schema:affiliation https://www.grid.ac/institutes/grid.5612.0
179 schema:familyName Blasco-Moreno
180 schema:givenName Bernat
181 rdf:type schema:Person
182 N962ae518690240bbb7de8ebf698a9a24 schema:affiliation https://www.grid.ac/institutes/grid.5612.0
183 schema:familyName de Campos-Mata
184 schema:givenName Leire
185 rdf:type schema:Person
186 N9d8d8cdf8318432bad53b13af99cc788 schema:issueNumber 1
187 rdf:type schema:PublicationIssue
188 N9df0cd94427c4aa498ab3e108a612531 schema:affiliation https://www.grid.ac/institutes/grid.5734.5
189 schema:familyName Leidel
190 schema:givenName Sebastian A.
191 rdf:type schema:Person
192 Na00a77b3c0e249e187bf62326c44d2cd schema:affiliation https://www.grid.ac/institutes/grid.5612.0
193 schema:familyName Jungfleisch
194 schema:givenName Jennifer
195 rdf:type schema:Person
196 Na4955d14fdf345e0ad1aa00690dde9e8 schema:name nlm_unique_id
197 schema:value 101528555
198 rdf:type schema:PropertyValue
199 Na626e4dc8cdf448bb457a04ee63dcf44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Saccharomyces cerevisiae Proteins
201 rdf:type schema:DefinedTerm
202 Naf94bad11dd44105b227fc5c9d0a320c rdf:first N13aa9fa314a64bbfaa0cae8bcbf40cbd
203 rdf:rest N088ec637267047a4a3fc85f4ddc594a3
204 Nb4d005f51193428ab41017ac0e1949ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Endoplasmic Reticulum
206 rdf:type schema:DefinedTerm
207 Nc1e8521b492b4787998583eb7de40039 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Genetic Vectors
209 rdf:type schema:DefinedTerm
210 Nc4d62c55b8d54601b5258cbead474321 schema:affiliation https://www.grid.ac/institutes/grid.5612.0
211 schema:familyName Díez
212 schema:givenName Juana
213 rdf:type schema:Person
214 Nc5576c1ec8e24bdd90f6a8b87e1dfa72 schema:affiliation https://www.grid.ac/institutes/grid.6451.6
215 schema:familyName Chattopadhyay
216 schema:givenName Shiladitya
217 rdf:type schema:Person
218 Nc71e72e9175644ada10da6a7d6cc3a49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Signal Transduction
220 rdf:type schema:DefinedTerm
221 Nc8ac1b7447264c78b8c417172620558d schema:name pubmed_id
222 schema:value 30899024
223 rdf:type schema:PropertyValue
224 Nd6d6c791642c43d9a07a21558541913b rdf:first N1e445ef86ccb47e2817aa4a6e3269c24
225 rdf:rest N75176e17caf34457b7d9d53d5154fb06
226 Nd70803f9d0f447959ad21790ffd5bcf0 rdf:first N81cb74783d5d4b2e827f5c40b099ce3b
227 rdf:rest N00c7b7cd7aea4433bf0eb6985cc21d89
228 Ndb57ba287ce747829572834ea9296055 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Exoribonucleases
230 rdf:type schema:DefinedTerm
231 Ne467be679a8d444f8621d4b906350660 schema:affiliation https://www.grid.ac/institutes/grid.5338.d
232 schema:familyName Pérez-Ortín
233 schema:givenName José E.
234 rdf:type schema:Person
235 Ne7cb3419a2104f51bbad4a8c549c32b5 schema:affiliation https://www.grid.ac/institutes/grid.5338.d
236 schema:familyName García-Martínez
237 schema:givenName José
238 rdf:type schema:Person
239 Nef98cedc1cdd4a8db3fd806500add24b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Gene Expression Profiling
241 rdf:type schema:DefinedTerm
242 Nf10adbdcc53d431fb48a7816bff5c969 schema:name readcube_id
243 schema:value 0032c04517e24709e1bdb4b4238e3285f7dfa2ff1c3818ab3f4f96ecc45916a1
244 rdf:type schema:PropertyValue
245 Nf7d38ea430c146ceb1db591ee959c1aa rdf:first N299f608e4d83491390ef4f385893d4d9
246 rdf:rest N63b94f9a99a1487688b5292da2eb8d73
247 Nffb7a46099dc428ea2f06693c69f7b4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
248 schema:name Cloning, Molecular
249 rdf:type schema:DefinedTerm
250 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
251 schema:name Biological Sciences
252 rdf:type schema:DefinedTerm
253 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
254 schema:name Genetics
255 rdf:type schema:DefinedTerm
256 sg:grant.3794757 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09199-6
257 rdf:type schema:MonetaryGrant
258 sg:journal.1043282 schema:issn 2041-1723
259 schema:name Nature Communications
260 rdf:type schema:Periodical
261 sg:pub.10.1007/978-1-61779-086-7_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024877742
262 https://doi.org/10.1007/978-1-61779-086-7_2
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/nature08265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004008241
265 https://doi.org/10.1038/nature08265
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/nature09322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033775404
268 https://doi.org/10.1038/nature09322
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/nature10118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004223987
271 https://doi.org/10.1038/nature10118
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nsmb.2303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018565479
274 https://doi.org/10.1038/nsmb.2303
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nsmb.2413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030004014
277 https://doi.org/10.1038/nsmb.2413
278 rdf:type schema:CreativeWork
279 sg:pub.10.1186/gb-2009-10-3-r25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049583368
280 https://doi.org/10.1186/gb-2009-10-3-r25
281 rdf:type schema:CreativeWork
282 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
283 https://doi.org/10.1186/s13059-014-0550-8
284 rdf:type schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1074632769 schema:CreativeWork
286 https://doi.org/10.1002/0471143030.cb2009s64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014251428
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1002/prot.10629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031844765
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1002/wrna.1190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027151556
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1006/jmbi.1993.1626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443070
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1006/smvy.1997.0125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004997277
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/0378-1119(92)90008-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1007714264
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.bbagrm.2013.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021866584
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.bbagrm.2015.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003322964
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.cell.2010.10.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004497729
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.cell.2013.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010937907
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.cell.2013.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043238114
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.cell.2015.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009060679
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.celrep.2015.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047256933
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.jmb.2013.02.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012770099
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.molcel.2004.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035947017
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.molcel.2011.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001273317
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.molcel.2013.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020386213
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.tibs.2012.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039834486
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.ymeth.2016.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043058002
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s0076-6879(02)51873-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009318865
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1017/s1355838200001540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054923501
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1073/pnas.240460897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053303072
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1073/pnas.94.25.13810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007650209
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1073/pnas.95.5.2227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011549492
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1083/jcb.200701165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037458948
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/bioinformatics/btx047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083534106
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/nar/28.1.235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035055456
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1093/nar/gkq313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010078089
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1093/nar/gkv234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022424383
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1101/gad.1654308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049535341
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1101/gad.227843.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001797216
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1101/gr.209015.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060407477
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1111/1567-1364.12180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049072630
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1126/science.1168978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035665750
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1126/science.1257521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039560253
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1128/jvi.02246-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007294133
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1128/mcb.17.10.6122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037799669
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1128/mcb.19.9.5930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012714153
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1128/mcb.23.12.4094-4106.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022069220
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1146/annurev-biochem-060713-035802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033035799
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1146/annurev.phyto.41.052002.095717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036646297
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1261/rna.052209.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018020953
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1261/rna.1712910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035443060
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1371/journal.pone.0107085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025317459
375 rdf:type schema:CreativeWork
376 https://doi.org/10.15252/embj.201490194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024413626
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1534/genetics.111.137265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011740458
379 rdf:type schema:CreativeWork
380 https://doi.org/10.18637/jss.v035.b01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068672522
381 rdf:type schema:CreativeWork
382 https://doi.org/10.3389/fgene.2014.00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012322730
383 rdf:type schema:CreativeWork
384 https://www.grid.ac/institutes/grid.418615.f schema:alternateName Max Planck Institute of Biochemistry
385 schema:name Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, 48149, Muenster, Germany
386 Mechanisms of Protein Biogenesis Laboratory, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany
387 rdf:type schema:Organization
388 https://www.grid.ac/institutes/grid.5338.d schema:alternateName University of Valencia
389 schema:name Departments of Genetics, Biochemistry and Molecular Biology, and ERI Biotecmed, Facultad de Biología, Universitat de València, E-46100, Burjassot, Spain
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.5612.0 schema:alternateName Pompeu Fabra University
392 schema:name Laboratory of Structural Bioinformatics (GRIB), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain
393 Virology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain
394 rdf:type schema:Organization
395 https://www.grid.ac/institutes/grid.5734.5 schema:alternateName University of Bern
396 schema:name Department of Chemistry and Biochemistry, University of Bern, 3012, Bern, Switzerland
397 Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, 48149, Muenster, Germany
398 rdf:type schema:Organization
399 https://www.grid.ac/institutes/grid.6451.6 schema:alternateName Technion – Israel Institute of Technology
400 schema:name Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 31096, Haifa, Israel
401 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...