Ventral tegmental area astrocytes orchestrate avoidance and approach behavior View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

J. A. Gomez, J. M. Perkins, G. M. Beaudoin, N. B. Cook, S. A. Quraishi, E. A. Szoeke, K. Thangamani, C. W. Tschumi, M. J. Wanat, A. M. Maroof, M. J. Beckstead, P. A. Rosenberg, C. A. Paladini

ABSTRACT

The ventral tegmental area (VTA) is a heterogeneous midbrain structure, containing neurons and astrocytes, that coordinates behaviors by integrating activity from numerous afferents. Within neuron-astrocyte networks, astrocytes control signals from distinct afferents in a circuit-specific manner, but whether this capacity scales up to drive motivated behavior has been undetermined. Using genetic and optical dissection strategies we report that VTA astrocytes tune glutamatergic signaling selectively on local inhibitory neurons to drive a functional circuit for learned avoidance. In this circuit, astrocytes facilitate excitation of VTA GABA neurons to increase inhibition of dopamine neurons, eliciting real-time and learned avoidance behavior that is sufficient to impede expression of preference for reward. Loss of one glutamate transporter (GLT-1) from VTA astrocytes selectively blocks these avoidance behaviors and spares preference for reward. Thus, VTA astrocytes selectively regulate excitation of local GABA neurons to drive a distinct avoidance circuit that opposes approach behavior. More... »

PAGES

1455

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-09131-y

DOI

http://dx.doi.org/10.1038/s41467-019-09131-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113056998

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30926783


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.215352.2", 
          "name": [
            "University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gomez", 
        "givenName": "J. A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.215352.2", 
          "name": [
            "University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perkins", 
        "givenName": "J. M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Trinity University", 
          "id": "https://www.grid.ac/institutes/grid.265172.5", 
          "name": [
            "University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA", 
            "Department of Biology, Trinity University, 78212, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beaudoin", 
        "givenName": "G. M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.215352.2", 
          "name": [
            "University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cook", 
        "givenName": "N. B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.215352.2", 
          "name": [
            "University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quraishi", 
        "givenName": "S. A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.215352.2", 
          "name": [
            "University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szoeke", 
        "givenName": "E. A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.215352.2", 
          "name": [
            "University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thangamani", 
        "givenName": "K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oklahoma Medical Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.274264.1", 
          "name": [
            "Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, 73104, Oklahoma City, OK, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tschumi", 
        "givenName": "C. W.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.215352.2", 
          "name": [
            "University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wanat", 
        "givenName": "M. J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.215352.2", 
          "name": [
            "University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maroof", 
        "givenName": "A. M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oklahoma Medical Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.274264.1", 
          "name": [
            "Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, 73104, Oklahoma City, OK, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beckstead", 
        "givenName": "M. J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Department of Neurology and the F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosenberg", 
        "givenName": "P. A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.215352.2", 
          "name": [
            "University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paladini", 
        "givenName": "C. A.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.1936192100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001065397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1213458109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004369101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006128806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1059162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006633803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2011.03.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007612982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.17328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007715585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2478/s13380-012-0040-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009269290", 
          "https://doi.org/10.2478/s13380-012-0040-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms4262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009293180", 
          "https://doi.org/10.1038/ncomms4262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009791786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011568023", 
          "https://doi.org/10.1038/nn.4043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2014.04.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012553014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(93)90538-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015187582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(93)90538-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015187582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-007-0207-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015879338", 
          "https://doi.org/10.1007/s00424-007-0207-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-007-0207-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015879338", 
          "https://doi.org/10.1007/s00424-007-0207-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2066-16.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016598196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6750-8-49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017252247", 
          "https://doi.org/10.1186/1472-6750-8-49"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.22294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017874622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaa7945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018792521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00517.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019268603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3965-04.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021504848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1586-03.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022377588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0510476103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022710215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002130000569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023053570", 
          "https://doi.org/10.1007/s002130000569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceca.2015.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024466603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.20344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025785327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2012.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026640230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00041.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026681917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2016.04.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027586848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2012.02.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029136845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(95)90340-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030605476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-1136(199709)21:1<56::aid-glia6>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036326050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1093360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037300426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2012.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038764072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2008.05.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038888293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041027426", 
          "https://doi.org/10.1038/nature12041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.05.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042875090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044273431", 
          "https://doi.org/10.1038/nn.4191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1460-9568.2000.00269.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044912444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4255-14.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045946335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2016.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046494113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2016.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046494113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.conb.2004.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048026212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.1997.335bk.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048292713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00204.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051089388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3082-16.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067643178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.23-05-01750.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075249781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.13-11-04660.1993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082711854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.16-01-00055.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082880187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.16-16-05073.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082940141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.17-12-04672.1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083096541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2017.01.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083699217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091913464", 
          "https://doi.org/10.1038/nn.4649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091913464", 
          "https://doi.org/10.1038/nn.4649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.32237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100713499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-018-4848-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101144975", 
          "https://doi.org/10.1007/s00213-018-4848-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-018-4848-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101144975", 
          "https://doi.org/10.1007/s00213-018-4848-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-018-4848-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101144975", 
          "https://doi.org/10.1007/s00213-018-4848-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-018-4848-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101144975", 
          "https://doi.org/10.1007/s00213-018-4848-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-018-4848-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101144975", 
          "https://doi.org/10.1007/s00213-018-4848-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2018.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103166738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2018.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103166738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fncel.2018.00141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104154785"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "The ventral tegmental area (VTA) is a heterogeneous midbrain structure, containing neurons and astrocytes, that coordinates behaviors by integrating activity from numerous afferents. Within neuron-astrocyte networks, astrocytes control signals from distinct afferents in a circuit-specific manner, but whether this capacity scales up to drive motivated behavior has been undetermined. Using genetic and optical dissection strategies we report that VTA astrocytes tune glutamatergic signaling selectively on local inhibitory neurons to drive a functional circuit for learned avoidance. In this circuit, astrocytes facilitate excitation of VTA GABA neurons to increase inhibition of dopamine neurons, eliciting real-time and learned avoidance behavior that is sufficient to impede expression of preference for reward. Loss of one glutamate transporter (GLT-1) from VTA astrocytes selectively blocks these avoidance behaviors and spares preference for reward. Thus, VTA astrocytes selectively regulate excitation of local GABA neurons to drive a distinct avoidance circuit that opposes approach behavior.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-019-09131-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3535226", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6810313", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2392348", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2562596", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5124890", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3935897", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2487007", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2487161", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2551360", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2422258", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3145774", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2623193", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7026604", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Ventral tegmental area astrocytes orchestrate avoidance and approach behavior", 
    "pagination": "1455", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9c1ad3ab603f8ef9af32a79c66758ae43948fcf982d94b9a547a9a2c836da3fa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30926783"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-019-09131-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113056998"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-019-09131-y", 
      "https://app.dimensions.ai/details/publication/pub.1113056998"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130808_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-019-09131-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09131-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09131-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09131-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09131-y'


 

This table displays all metadata directly associated to this object as RDF triples.

347 TRIPLES      21 PREDICATES      83 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-019-09131-y schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N883ee73e57144736bd01ce071ff3f4f4
4 schema:citation sg:pub.10.1007/s00213-018-4848-1
5 sg:pub.10.1007/s002130000569
6 sg:pub.10.1007/s00424-007-0207-5
7 sg:pub.10.1038/nature12041
8 sg:pub.10.1038/ncomms4262
9 sg:pub.10.1038/nn.4043
10 sg:pub.10.1038/nn.4191
11 sg:pub.10.1038/nn.4649
12 sg:pub.10.1186/1472-6750-8-49
13 sg:pub.10.2478/s13380-012-0040-y
14 https://doi.org/10.1002/(sici)1098-1136(199709)21:1<56::aid-glia6>3.0.co;2-#
15 https://doi.org/10.1002/glia.20622
16 https://doi.org/10.1002/glia.22294
17 https://doi.org/10.1002/hipo.20344
18 https://doi.org/10.1016/0306-4522(93)90538-q
19 https://doi.org/10.1016/0896-6273(95)90340-2
20 https://doi.org/10.1016/j.biopsych.2017.01.017
21 https://doi.org/10.1016/j.ceca.2015.06.008
22 https://doi.org/10.1016/j.celrep.2016.05.057
23 https://doi.org/10.1016/j.celrep.2016.08.007
24 https://doi.org/10.1016/j.conb.2004.05.007
25 https://doi.org/10.1016/j.neuron.2008.05.028
26 https://doi.org/10.1016/j.neuron.2011.03.025
27 https://doi.org/10.1016/j.neuron.2012.02.015
28 https://doi.org/10.1016/j.neuron.2012.02.016
29 https://doi.org/10.1016/j.neuron.2014.04.038
30 https://doi.org/10.1016/j.neuron.2016.04.035
31 https://doi.org/10.1016/j.neuron.2016.08.018
32 https://doi.org/10.1016/j.neuron.2018.03.003
33 https://doi.org/10.1016/j.tins.2012.04.003
34 https://doi.org/10.1046/j.1460-9568.2000.00269.x
35 https://doi.org/10.1073/pnas.0510476103
36 https://doi.org/10.1073/pnas.1213458109
37 https://doi.org/10.1073/pnas.1936192100
38 https://doi.org/10.1111/j.1469-7793.1997.335bk.x
39 https://doi.org/10.1126/science.1059162
40 https://doi.org/10.1126/science.1093360
41 https://doi.org/10.1126/science.aaa7945
42 https://doi.org/10.1152/jn.00204.2010
43 https://doi.org/10.1152/jn.00517.2012
44 https://doi.org/10.1152/physrev.00041.2013
45 https://doi.org/10.1523/jneurosci.13-11-04660.1993
46 https://doi.org/10.1523/jneurosci.1586-03.2004
47 https://doi.org/10.1523/jneurosci.16-01-00055.1996
48 https://doi.org/10.1523/jneurosci.16-16-05073.1996
49 https://doi.org/10.1523/jneurosci.17-12-04672.1997
50 https://doi.org/10.1523/jneurosci.2066-16.2016
51 https://doi.org/10.1523/jneurosci.23-05-01750.2003
52 https://doi.org/10.1523/jneurosci.3082-16.2016
53 https://doi.org/10.1523/jneurosci.3965-04.2005
54 https://doi.org/10.1523/jneurosci.4255-14.2015
55 https://doi.org/10.3389/fncel.2018.00141
56 https://doi.org/10.7554/elife.17328
57 https://doi.org/10.7554/elife.32237
58 schema:datePublished 2019-12
59 schema:datePublishedReg 2019-12-01
60 schema:description The ventral tegmental area (VTA) is a heterogeneous midbrain structure, containing neurons and astrocytes, that coordinates behaviors by integrating activity from numerous afferents. Within neuron-astrocyte networks, astrocytes control signals from distinct afferents in a circuit-specific manner, but whether this capacity scales up to drive motivated behavior has been undetermined. Using genetic and optical dissection strategies we report that VTA astrocytes tune glutamatergic signaling selectively on local inhibitory neurons to drive a functional circuit for learned avoidance. In this circuit, astrocytes facilitate excitation of VTA GABA neurons to increase inhibition of dopamine neurons, eliciting real-time and learned avoidance behavior that is sufficient to impede expression of preference for reward. Loss of one glutamate transporter (GLT-1) from VTA astrocytes selectively blocks these avoidance behaviors and spares preference for reward. Thus, VTA astrocytes selectively regulate excitation of local GABA neurons to drive a distinct avoidance circuit that opposes approach behavior.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N7e219d2a9c8a4cc6b15d6df959295059
65 Na07be5ade2e24059b332b7096256519a
66 sg:journal.1043282
67 schema:name Ventral tegmental area astrocytes orchestrate avoidance and approach behavior
68 schema:pagination 1455
69 schema:productId N10a672ac80a142f7be260972f7598a79
70 N57efaf31ec0d4713b9ec9e9ca3e52ac5
71 N7909b09c24e0444faf19747aec3c1ac7
72 N8f1a632757674796ab7bbca8c90c733f
73 Nebb8d2e7189c4677b91428fde3069392
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113056998
75 https://doi.org/10.1038/s41467-019-09131-y
76 schema:sdDatePublished 2019-04-11T13:54
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N754697d176f64a0384bd35130cc4c6b7
79 schema:url https://www.nature.com/articles/s41467-019-09131-y
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N10a672ac80a142f7be260972f7598a79 schema:name doi
84 schema:value 10.1038/s41467-019-09131-y
85 rdf:type schema:PropertyValue
86 N17f65a72b1f34877901b1a571ecfe29c rdf:first Nfc23cb3602eb496a9c5868352bbfd4d2
87 rdf:rest Nbd280a0aa09c4d2a8383594d5a0a768b
88 N222ca9ae3afa4fae91078226ceeae986 schema:affiliation https://www.grid.ac/institutes/grid.215352.2
89 schema:familyName Wanat
90 schema:givenName M. J.
91 rdf:type schema:Person
92 N23e8327cb9db47bda6fa27b5b8935976 schema:affiliation https://www.grid.ac/institutes/grid.274264.1
93 schema:familyName Tschumi
94 schema:givenName C. W.
95 rdf:type schema:Person
96 N2c22e8ac998a455bbe87af9c0ca48cc4 schema:affiliation https://www.grid.ac/institutes/grid.215352.2
97 schema:familyName Quraishi
98 schema:givenName S. A.
99 rdf:type schema:Person
100 N57efaf31ec0d4713b9ec9e9ca3e52ac5 schema:name nlm_unique_id
101 schema:value 101528555
102 rdf:type schema:PropertyValue
103 N58df5d54d07f4669b450a93680038dfe schema:affiliation https://www.grid.ac/institutes/grid.215352.2
104 schema:familyName Gomez
105 schema:givenName J. A.
106 rdf:type schema:Person
107 N6f64b7b35753447d81eb29be53a331ec schema:affiliation https://www.grid.ac/institutes/grid.265172.5
108 schema:familyName Beaudoin
109 schema:givenName G. M.
110 rdf:type schema:Person
111 N74775431fdf246bd8097dea3db85a4c5 rdf:first Nd8fc2f615f814211a4f3f5274f656c30
112 rdf:rest Nee48381ced4e493c92447d175c69df55
113 N74e9cad6d8984ab6b1d53656223e63ac schema:affiliation https://www.grid.ac/institutes/grid.215352.2
114 schema:familyName Maroof
115 schema:givenName A. M.
116 rdf:type schema:Person
117 N754697d176f64a0384bd35130cc4c6b7 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N78712164c7b9469a924181fe8e6e74c4 schema:affiliation https://www.grid.ac/institutes/grid.215352.2
120 schema:familyName Thangamani
121 schema:givenName K.
122 rdf:type schema:Person
123 N7909b09c24e0444faf19747aec3c1ac7 schema:name readcube_id
124 schema:value 9c1ad3ab603f8ef9af32a79c66758ae43948fcf982d94b9a547a9a2c836da3fa
125 rdf:type schema:PropertyValue
126 N7d08aa49eec34c4986cae356f929781a rdf:first Nc0f31e8c1a874644bf55b20a5e52fba4
127 rdf:rest N8978b938762f414c967de20096b43564
128 N7e219d2a9c8a4cc6b15d6df959295059 schema:issueNumber 1
129 rdf:type schema:PublicationIssue
130 N7fe47b60fc80445d8c3c2a6143c47304 rdf:first N23e8327cb9db47bda6fa27b5b8935976
131 rdf:rest N94b80733e3be418ca8154409b53df609
132 N883ee73e57144736bd01ce071ff3f4f4 rdf:first N58df5d54d07f4669b450a93680038dfe
133 rdf:rest N17f65a72b1f34877901b1a571ecfe29c
134 N8978b938762f414c967de20096b43564 rdf:first N2c22e8ac998a455bbe87af9c0ca48cc4
135 rdf:rest N74775431fdf246bd8097dea3db85a4c5
136 N8df2ce420af946bf8fcaff7dccc8cf4a rdf:first Na9af1aa8cd6d4b86822ce391b2d861a4
137 rdf:rest rdf:nil
138 N8f1a632757674796ab7bbca8c90c733f schema:name dimensions_id
139 schema:value pub.1113056998
140 rdf:type schema:PropertyValue
141 N94b80733e3be418ca8154409b53df609 rdf:first N222ca9ae3afa4fae91078226ceeae986
142 rdf:rest Ne5e512b67c7b4f5aa69839b4612c7c86
143 Na07be5ade2e24059b332b7096256519a schema:volumeNumber 10
144 rdf:type schema:PublicationVolume
145 Na9af1aa8cd6d4b86822ce391b2d861a4 schema:affiliation https://www.grid.ac/institutes/grid.215352.2
146 schema:familyName Paladini
147 schema:givenName C. A.
148 rdf:type schema:Person
149 Nbd280a0aa09c4d2a8383594d5a0a768b rdf:first N6f64b7b35753447d81eb29be53a331ec
150 rdf:rest N7d08aa49eec34c4986cae356f929781a
151 Nc0f31e8c1a874644bf55b20a5e52fba4 schema:affiliation https://www.grid.ac/institutes/grid.215352.2
152 schema:familyName Cook
153 schema:givenName N. B.
154 rdf:type schema:Person
155 Nc37ae0cf6b3845c09abaf45d3b4e44cb rdf:first Nf93fc248a3304a9f98c6f13091b11169
156 rdf:rest Nfd2ee79aeb97436f9dd3416810c198d4
157 Nc6fd75139a574a108ab126d188caa7fa schema:affiliation https://www.grid.ac/institutes/grid.2515.3
158 schema:familyName Rosenberg
159 schema:givenName P. A.
160 rdf:type schema:Person
161 Nd8fc2f615f814211a4f3f5274f656c30 schema:affiliation https://www.grid.ac/institutes/grid.215352.2
162 schema:familyName Szoeke
163 schema:givenName E. A.
164 rdf:type schema:Person
165 Ne5e512b67c7b4f5aa69839b4612c7c86 rdf:first N74e9cad6d8984ab6b1d53656223e63ac
166 rdf:rest Nc37ae0cf6b3845c09abaf45d3b4e44cb
167 Nebb8d2e7189c4677b91428fde3069392 schema:name pubmed_id
168 schema:value 30926783
169 rdf:type schema:PropertyValue
170 Nee48381ced4e493c92447d175c69df55 rdf:first N78712164c7b9469a924181fe8e6e74c4
171 rdf:rest N7fe47b60fc80445d8c3c2a6143c47304
172 Nf93fc248a3304a9f98c6f13091b11169 schema:affiliation https://www.grid.ac/institutes/grid.274264.1
173 schema:familyName Beckstead
174 schema:givenName M. J.
175 rdf:type schema:Person
176 Nfc23cb3602eb496a9c5868352bbfd4d2 schema:affiliation https://www.grid.ac/institutes/grid.215352.2
177 schema:familyName Perkins
178 schema:givenName J. M.
179 rdf:type schema:Person
180 Nfd2ee79aeb97436f9dd3416810c198d4 rdf:first Nc6fd75139a574a108ab126d188caa7fa
181 rdf:rest N8df2ce420af946bf8fcaff7dccc8cf4a
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
186 schema:name Neurosciences
187 rdf:type schema:DefinedTerm
188 sg:grant.2392348 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
189 rdf:type schema:MonetaryGrant
190 sg:grant.2422258 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
191 rdf:type schema:MonetaryGrant
192 sg:grant.2487007 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
193 rdf:type schema:MonetaryGrant
194 sg:grant.2487161 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
195 rdf:type schema:MonetaryGrant
196 sg:grant.2551360 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
197 rdf:type schema:MonetaryGrant
198 sg:grant.2562596 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
199 rdf:type schema:MonetaryGrant
200 sg:grant.2623193 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
201 rdf:type schema:MonetaryGrant
202 sg:grant.3145774 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
203 rdf:type schema:MonetaryGrant
204 sg:grant.3535226 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
205 rdf:type schema:MonetaryGrant
206 sg:grant.3935897 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
207 rdf:type schema:MonetaryGrant
208 sg:grant.5124890 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
209 rdf:type schema:MonetaryGrant
210 sg:grant.6810313 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
211 rdf:type schema:MonetaryGrant
212 sg:grant.7026604 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09131-y
213 rdf:type schema:MonetaryGrant
214 sg:journal.1043282 schema:issn 2041-1723
215 schema:name Nature Communications
216 rdf:type schema:Periodical
217 sg:pub.10.1007/s00213-018-4848-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101144975
218 https://doi.org/10.1007/s00213-018-4848-1
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/s002130000569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023053570
221 https://doi.org/10.1007/s002130000569
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/s00424-007-0207-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015879338
224 https://doi.org/10.1007/s00424-007-0207-5
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/nature12041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041027426
227 https://doi.org/10.1038/nature12041
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/ncomms4262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009293180
230 https://doi.org/10.1038/ncomms4262
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/nn.4043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011568023
233 https://doi.org/10.1038/nn.4043
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/nn.4191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044273431
236 https://doi.org/10.1038/nn.4191
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/nn.4649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091913464
239 https://doi.org/10.1038/nn.4649
240 rdf:type schema:CreativeWork
241 sg:pub.10.1186/1472-6750-8-49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017252247
242 https://doi.org/10.1186/1472-6750-8-49
243 rdf:type schema:CreativeWork
244 sg:pub.10.2478/s13380-012-0040-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1009269290
245 https://doi.org/10.2478/s13380-012-0040-y
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/(sici)1098-1136(199709)21:1<56::aid-glia6>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1036326050
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/glia.20622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009791786
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/glia.22294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017874622
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/hipo.20344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025785327
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0306-4522(93)90538-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1015187582
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/0896-6273(95)90340-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030605476
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.biopsych.2017.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083699217
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.ceca.2015.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024466603
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.celrep.2016.05.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042875090
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.celrep.2016.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006128806
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.conb.2004.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048026212
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.neuron.2008.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038888293
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.neuron.2011.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007612982
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.neuron.2012.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026640230
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.neuron.2012.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029136845
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.neuron.2014.04.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012553014
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.neuron.2016.04.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027586848
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.neuron.2016.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046494113
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.neuron.2018.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103166738
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.tins.2012.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038764072
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1046/j.1460-9568.2000.00269.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044912444
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1073/pnas.0510476103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022710215
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1073/pnas.1213458109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004369101
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1073/pnas.1936192100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001065397
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1111/j.1469-7793.1997.335bk.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048292713
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1126/science.1059162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006633803
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1126/science.1093360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037300426
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1126/science.aaa7945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018792521
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1152/jn.00204.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051089388
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1152/jn.00517.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019268603
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1152/physrev.00041.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026681917
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1523/jneurosci.13-11-04660.1993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082711854
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1523/jneurosci.1586-03.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022377588
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1523/jneurosci.16-01-00055.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082880187
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1523/jneurosci.16-16-05073.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082940141
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1523/jneurosci.17-12-04672.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083096541
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1523/jneurosci.2066-16.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016598196
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1523/jneurosci.23-05-01750.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075249781
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1523/jneurosci.3082-16.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067643178
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1523/jneurosci.3965-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021504848
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1523/jneurosci.4255-14.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045946335
328 rdf:type schema:CreativeWork
329 https://doi.org/10.3389/fncel.2018.00141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104154785
330 rdf:type schema:CreativeWork
331 https://doi.org/10.7554/elife.17328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007715585
332 rdf:type schema:CreativeWork
333 https://doi.org/10.7554/elife.32237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100713499
334 rdf:type schema:CreativeWork
335 https://www.grid.ac/institutes/grid.215352.2 schema:alternateName The University of Texas at San Antonio
336 schema:name University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.2515.3 schema:alternateName Boston Children's Hospital
339 schema:name Department of Neurology and the F.M. Kirby Neurobiology Center, Boston Children’s Hospital, 02115, Boston, MA, USA
340 rdf:type schema:Organization
341 https://www.grid.ac/institutes/grid.265172.5 schema:alternateName Trinity University
342 schema:name Department of Biology, Trinity University, 78212, San Antonio, TX, USA
343 University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San Antonio, 78249, San Antonio, TX, USA
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.274264.1 schema:alternateName Oklahoma Medical Research Foundation
346 schema:name Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, 73104, Oklahoma City, OK, USA
347 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...