Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSSeung Jae Jeong, Shinhye Park, Loi T. Nguyen, Jungwon Hwang, Eun-Young Lee, Hoi-Khoanh Giong, Jeong-Soo Lee, Ina Yoon, Ji-Hyun Lee, Jong Hyun Kim, Hoi Kyoung Kim, Doyeun Kim, Won Suk Yang, Seon-Young Kim, Chan Yong Lee, Kweon Yu, Nahum Sonenberg, Myung Hee Kim, Sunghoon Kim
ABSTRACTA fundamental question in biology is how vertebrates evolved and differ from invertebrates, and little is known about differences in the regulation of translation in the two systems. Herein, we identify a threonyl-tRNA synthetase (TRS)-mediated translation initiation machinery that specifically interacts with eIF4E homologous protein, and forms machinery that is structurally analogous to the eIF4F-mediated translation initiation machinery via the recruitment of other translation initiation components. Biochemical and RNA immunoprecipitation analyses coupled to sequencing suggest that this machinery emerged as a gain-of-function event in the vertebrate lineage, and it positively regulates the translation of mRNAs required for vertebrate development. Collectively, our findings demonstrate that TRS evolved to regulate vertebrate translation initiation via its dual role as a scaffold for the assembly of initiation components and as a selector of target mRNAs. This work highlights the functional significance of aminoacyl-tRNA synthetases in the emergence and control of higher order organisms. More... »
PAGES1357
http://scigraph.springernature.com/pub.10.1038/s41467-019-09086-0
DOIhttp://dx.doi.org/10.1038/s41467-019-09086-0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112941524
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30902983
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Medicinal Bioconvergence Research Center, Seoul National University, 16229, Suwon, Korea",
"College of Pharmacy, Seoul National University, 08826, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Jeong",
"givenName": "Seung Jae",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Korea Research Institute of Bioscience and Biotechnology",
"id": "https://www.grid.ac/institutes/grid.249967.7",
"name": [
"Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 34141, Daejeon, Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Shinhye",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chungnam National University",
"id": "https://www.grid.ac/institutes/grid.254230.2",
"name": [
"Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 34141, Daejeon, Korea",
"Department of Biochemistry, Chungnam National University, 34134, Daejeon, Korea"
],
"type": "Organization"
},
"familyName": "Nguyen",
"givenName": "Loi T.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Korea Research Institute of Bioscience and Biotechnology",
"id": "https://www.grid.ac/institutes/grid.249967.7",
"name": [
"Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 34141, Daejeon, Korea"
],
"type": "Organization"
},
"familyName": "Hwang",
"givenName": "Jungwon",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Korea Research Institute of Bioscience and Biotechnology",
"id": "https://www.grid.ac/institutes/grid.249967.7",
"name": [
"Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 34141, Daejeon, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Eun-Young",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Korea University of Science and Technology",
"id": "https://www.grid.ac/institutes/grid.412786.e",
"name": [
"Disease Target Structure Research Center, KRIBB, 34141, Daejeon, Korea",
"Dementia DTC R&D Convergence Program, Korea Institute of Science and Technology, 02792, Seoul, Korea",
"KRIBB School of Bioscience, Korea University of Science and Technology, 34141, Daejeon, Korea"
],
"type": "Organization"
},
"familyName": "Giong",
"givenName": "Hoi-Khoanh",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Korea Institute of Science and Technology",
"id": "https://www.grid.ac/institutes/grid.35541.36",
"name": [
"Disease Target Structure Research Center, KRIBB, 34141, Daejeon, Korea",
"Dementia DTC R&D Convergence Program, Korea Institute of Science and Technology, 02792, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Jeong-Soo",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Medicinal Bioconvergence Research Center, Seoul National University, 16229, Suwon, Korea",
"College of Pharmacy, Seoul National University, 08826, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Yoon",
"givenName": "Ina",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Medicinal Bioconvergence Research Center, Seoul National University, 16229, Suwon, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Ji-Hyun",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Medicinal Bioconvergence Research Center, Seoul National University, 16229, Suwon, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Jong Hyun",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Medicinal Bioconvergence Research Center, Seoul National University, 16229, Suwon, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Hoi Kyoung",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Medicinal Bioconvergence Research Center, Seoul National University, 16229, Suwon, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Doyeun",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Medicinal Bioconvergence Research Center, Seoul National University, 16229, Suwon, Korea"
],
"type": "Organization"
},
"familyName": "Yang",
"givenName": "Won Suk",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Korea Research Institute of Bioscience and Biotechnology",
"id": "https://www.grid.ac/institutes/grid.249967.7",
"name": [
"KRIBB School of Bioscience, Korea University of Science and Technology, 34141, Daejeon, Korea",
"Personalized Genomic Medicine Research Center, KRIBB, 34141, Daejeon, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Seon-Young",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chungnam National University",
"id": "https://www.grid.ac/institutes/grid.254230.2",
"name": [
"Department of Biochemistry, Chungnam National University, 34134, Daejeon, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Chan Yong",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Korea University of Science and Technology",
"id": "https://www.grid.ac/institutes/grid.412786.e",
"name": [
"Disease Target Structure Research Center, KRIBB, 34141, Daejeon, Korea",
"Dementia DTC R&D Convergence Program, Korea Institute of Science and Technology, 02792, Seoul, Korea",
"KRIBB School of Bioscience, Korea University of Science and Technology, 34141, Daejeon, Korea"
],
"type": "Organization"
},
"familyName": "Yu",
"givenName": "Kweon",
"type": "Person"
},
{
"affiliation": {
"alternateName": "McGill University",
"id": "https://www.grid.ac/institutes/grid.14709.3b",
"name": [
"Department of Biochemistry, McGill University, Montreal, H3A 1A3, Quebec, Canada",
"Rosalind and Morris Goodman Cancer Research Centre, Montreal, H3A 1A3, Quebec, Canada"
],
"type": "Organization"
},
"familyName": "Sonenberg",
"givenName": "Nahum",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Korea Research Institute of Bioscience and Biotechnology",
"id": "https://www.grid.ac/institutes/grid.249967.7",
"name": [
"Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 34141, Daejeon, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Myung Hee",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Medicinal Bioconvergence Research Center, Seoul National University, 16229, Suwon, Korea",
"College of Pharmacy, Seoul National University, 08826, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Sunghoon",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s0076-6879(97)76066-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004907170"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm2956",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004944088",
"https://doi.org/10.1038/nrm2956"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm2956",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004944088",
"https://doi.org/10.1038/nrm2956"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2007.10.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005302156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.15.9.4990",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005559024"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms1686",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008044837",
"https://doi.org/10.1038/ncomms1686"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molonc.2014.06.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008545026"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2015.01.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009999101"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11055",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010107638",
"https://doi.org/10.1038/nature11055"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1110/ps.04644504",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010320806"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)80746-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012412174"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsb789",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012539435",
"https://doi.org/10.1038/nsb789"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1165/ajrcmb.22.2.3766",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013247703"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1103922108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013631619"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms6413",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014444412",
"https://doi.org/10.1038/ncomms6413"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ac0341261",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015001215"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ac0341261",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015001215"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(93)90498-f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015819686"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05732",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016015496",
"https://doi.org/10.1038/nature05732"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.01248-06",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016116665"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2016.01.036",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019819236"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444904019158",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020281098"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.00455-12",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020295281"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/128_2013_424",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020510626",
"https://doi.org/10.1007/128_2013_424"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909052925",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020777046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909052925",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020777046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1097-2765(01)80003-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021652488"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.1314",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025610368",
"https://doi.org/10.1038/nmeth.1314"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/prep.1998.1003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025877571"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1262905",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026567253"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkv350",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026744197"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2105-9-122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027407930",
"https://doi.org/10.1186/1471-2105-9-122"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2105-9-122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027407930",
"https://doi.org/10.1186/1471-2105-9-122"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2005.02.024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029859616"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ac025747h",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030226321"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ac025747h",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030226321"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jmb.2007.02.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031069578"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep01317",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032706907",
"https://doi.org/10.1038/srep01317"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.12-207639",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033431536"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mod.2005.04.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034727213"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mod.2005.04.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034727213"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm2838",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036173966",
"https://doi.org/10.1038/nrm2838"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm2838",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036173966",
"https://doi.org/10.1038/nrm2838"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2009.01.042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039455743"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2008.211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039987283",
"https://doi.org/10.1038/nprot.2008.211"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkn188",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040192872"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1261/rna.453107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040256475"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2006.08.093",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042306587"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.biophys.37.032807.125842",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042382907"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.94.17.9046",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045354135"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2016.09.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047698874"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2016.09.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047698874"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth1118",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048077604",
"https://doi.org/10.1038/nmeth1118"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms7402",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048801637",
"https://doi.org/10.1038/ncomms7402"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tibs.2016.05.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049334263"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.1541",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052274565",
"https://doi.org/10.1038/nmeth.1541"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2007.514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052648190",
"https://doi.org/10.1038/nprot.2007.514"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11083",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053542503",
"https://doi.org/10.1038/nature11083"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0008-6363(95)00215-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054579182"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/rna.8.5.16325",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072310723"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074507383",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/j.1460-2075.1996.tb01108.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083035104"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083144819",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.299420.117",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090619403"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "A fundamental question in biology is how vertebrates evolved and differ from invertebrates, and little is known about differences in the regulation of translation in the two systems. Herein, we identify a threonyl-tRNA synthetase (TRS)-mediated translation initiation machinery that specifically interacts with eIF4E homologous protein, and forms machinery that is structurally analogous to the eIF4F-mediated translation initiation machinery via the recruitment of other translation initiation components. Biochemical and RNA immunoprecipitation analyses coupled to sequencing suggest that this machinery emerged as a gain-of-function event in the vertebrate lineage, and it positively regulates the translation of mRNAs required for vertebrate development. Collectively, our findings demonstrate that TRS evolved to regulate vertebrate translation initiation via its dual role as a scaffold for the assembly of initiation components and as a selector of target mRNAs. This work highlights the functional significance of aminoacyl-tRNA synthetases in the emergence and control of higher order organisms.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41467-019-09086-0",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1043282",
"issn": [
"2041-1723"
],
"name": "Nature Communications",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "10"
}
],
"name": "A threonyl-tRNA synthetase-mediated translation initiation machinery",
"pagination": "1357",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"0495916de2eb81c0c47aa00959fe97d5768e9fcee2844c705226a05911287a9b"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30902983"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101528555"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41467-019-09086-0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112941524"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41467-019-09086-0",
"https://app.dimensions.ai/details/publication/pub.1112941524"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T14:00",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130826_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41467-019-09086-0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09086-0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09086-0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09086-0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09086-0'
This table displays all metadata directly associated to this object as RDF triples.
381 TRIPLES
21 PREDICATES
85 URIs
21 LITERALS
9 BLANK NODES