Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Luigi Formisano, Yao Lu, Alberto Servetto, Ariella B. Hanker, Valerie M. Jansen, Joshua A. Bauer, Dhivya R. Sudhan, Angel L. Guerrero-Zotano, Sarah Croessmann, Yan Guo, Paula Gonzalez Ericsson, Kyung-min Lee, Mellissa J. Nixon, Luis J. Schwarz, Melinda E. Sanders, Teresa C. Dugger, Marcelo Rocha Cruz, Amir Behdad, Massimo Cristofanilli, Aditya Bardia, Joyce O’Shaughnessy, Rebecca J. Nagy, Richard B. Lanman, Nadia Solovieff, Wei He, Michelle Miller, Fei Su, Yu Shyr, Ingrid A. Mayer, Justin M. Balko, Carlos L. Arteaga

ABSTRACT

Using an ORF kinome screen in MCF-7 cells treated with the CDK4/6 inhibitor ribociclib plus fulvestrant, we identified FGFR1 as a mechanism of drug resistance. FGFR1-amplified/ER+ breast cancer cells and MCF-7 cells transduced with FGFR1 were resistant to fulvestrant ± ribociclib or palbociclib. This resistance was abrogated by treatment with the FGFR tyrosine kinase inhibitor (TKI) lucitanib. Addition of the FGFR TKI erdafitinib to palbociclib/fulvestrant induced complete responses of FGFR1-amplified/ER+ patient-derived-xenografts. Next generation sequencing of circulating tumor DNA (ctDNA) in 34 patients after progression on CDK4/6 inhibitors identified FGFR1/2 amplification or activating mutations in 14/34 (41%) post-progression specimens. Finally, ctDNA from patients enrolled in MONALEESA-2, the registration trial of ribociclib, showed that patients with FGFR1 amplification exhibited a shorter progression-free survival compared to patients with wild type FGFR1. Thus, we propose breast cancers with FGFR pathway alterations should be considered for trials using combinations of ER, CDK4/6 and FGFR antagonists. More... »

PAGES

1373

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-09068-2

DOI

http://dx.doi.org/10.1038/s41467-019-09068-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112990922

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30914635


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Formisano", 
        "givenName": "Luigi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Yao", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "UTSW Simmons Cancer Center, 75230, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Servetto", 
        "givenName": "Alberto", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA", 
            "UTSW Simmons Cancer Center, 75230, Dallas, TX, USA", 
            "Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hanker", 
        "givenName": "Ariella B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jansen", 
        "givenName": "Valerie M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Biochemistry, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bauer", 
        "givenName": "Joshua A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA", 
            "UTSW Simmons Cancer Center, 75230, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sudhan", 
        "givenName": "Dhivya R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guerrero-Zotano", 
        "givenName": "Angel L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Croessmann", 
        "givenName": "Sarah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Vanderbilt Center for Quantitative Sciences, Vanderbilt University School of Medicine, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Yan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ericsson", 
        "givenName": "Paula Gonzalez", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kyung-min", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nixon", 
        "givenName": "Mellissa J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwarz", 
        "givenName": "Luis J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA", 
            "Departments of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanders", 
        "givenName": "Melinda E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dugger", 
        "givenName": "Teresa C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwestern University", 
          "id": "https://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Robert H Lurie Comprehensive Cancer Center, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cruz", 
        "givenName": "Marcelo Rocha", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwestern University", 
          "id": "https://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Robert H Lurie Comprehensive Cancer Center, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Behdad", 
        "givenName": "Amir", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwestern University", 
          "id": "https://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Robert H Lurie Comprehensive Cancer Center, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cristofanilli", 
        "givenName": "Massimo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Massachusetts General Hospital Cancer Center, Harvard Medical School, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bardia", 
        "givenName": "Aditya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.411588.1", 
          "name": [
            "Baylor University Medical Center, Texas Oncology, US Oncology, 75246, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Shaughnessy", 
        "givenName": "Joyce", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Guardant Health, 94063, Redwood City, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagy", 
        "givenName": "Rebecca J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Guardant Health, 94063, Redwood City, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lanman", 
        "givenName": "Richard B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Novartis Institutes for Biomedical Research, 02139, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Solovieff", 
        "givenName": "Nadia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Novartis Institutes for Biomedical Research, 02139, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Wei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Novartis Pharmaceuticals Corporation, 07936, East Hanover, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miller", 
        "givenName": "Michelle", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Novartis Pharmaceuticals Corporation, 07936, East Hanover, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Su", 
        "givenName": "Fei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Vanderbilt Center for Quantitative Sciences, Vanderbilt University School of Medicine, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shyr", 
        "givenName": "Yu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA", 
            "Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayer", 
        "givenName": "Ingrid A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balko", 
        "givenName": "Justin M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA", 
            "UTSW Simmons Cancer Center, 75230, Dallas, TX, USA", 
            "Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arteaga", 
        "givenName": "Carlos L.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nbt.2514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000477771", 
          "https://doi.org/10.1038/nbt.2514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr3650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001714285", 
          "https://doi.org/10.1186/bcr3650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2015.117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002958014", 
          "https://doi.org/10.1038/nrclinonc.2015.117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004364113", 
          "https://doi.org/10.1038/onc.2009.34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004364113", 
          "https://doi.org/10.1038/onc.2009.34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-02-071266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004608649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1607303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005496514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005907434", 
          "https://doi.org/10.1038/nature09627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.5465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006947997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.2270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007950724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.3734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008724134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.60.7341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008993365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.60.7341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008993365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)74803-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009387731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010244476", 
          "https://doi.org/10.1038/ng.806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2007.06.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010551449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201009094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010888789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014304136", 
          "https://doi.org/10.1038/onc.2010.154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014304136", 
          "https://doi.org/10.1038/onc.2010.154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0030801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014953441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.3364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015170387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1505270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016758516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2016.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020578590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-0110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021321766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-14-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022196002", 
          "https://doi.org/10.1186/1471-2105-14-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-14-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022196002", 
          "https://doi.org/10.1186/1471-2105-14-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-2700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022660219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024942368", 
          "https://doi.org/10.1038/nature11412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00613-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025211268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00613-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025211268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00613-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025211268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00613-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025211268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0140712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025337709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.12.094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030317953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.107524.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032096953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032266264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2004088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033807182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-07-0150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035271031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btt767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036259052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038266369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2014.05.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041312538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2016.379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044657964", 
          "https://doi.org/10.1038/onc.2016.379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1609709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045557388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048011065", 
          "https://doi.org/10.1038/nmeth.1638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-4559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048912946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-3746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052989529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2000021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062682092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-15-0728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063215798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.sabcs11-pd01-01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063220964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.sabcs11-pd01-02", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063220965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-16-0471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063225393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-16-1000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063281080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/15384101.2014.946841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072288067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074601068", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc.2017.8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129567", 
          "https://doi.org/10.1038/nrc.2017.8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-16-2653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084230809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2017.73.7585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085860547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-17-1232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090917778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aai7993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091132694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-017-00540-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091344460", 
          "https://doi.org/10.1038/s41467-017-00540-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2017.75.6155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092051908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdx784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099786039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-17-3831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103626575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-17-3837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104113715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2017.35.15_suppl.1038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106845644"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Using an ORF kinome screen in MCF-7 cells treated with the CDK4/6 inhibitor ribociclib plus fulvestrant, we identified FGFR1 as a mechanism of drug resistance. FGFR1-amplified/ER+ breast cancer cells and MCF-7 cells transduced with FGFR1 were resistant to fulvestrant\u2009\u00b1\u2009ribociclib or palbociclib. This resistance was abrogated by treatment with the FGFR tyrosine kinase inhibitor (TKI) lucitanib. Addition of the FGFR TKI erdafitinib to palbociclib/fulvestrant induced complete responses of FGFR1-amplified/ER+ patient-derived-xenografts. Next generation sequencing of circulating tumor DNA (ctDNA) in 34 patients after progression on CDK4/6 inhibitors identified FGFR1/2 amplification or activating mutations in 14/34 (41%) post-progression specimens. Finally, ctDNA from patients enrolled in MONALEESA-2, the registration trial of ribociclib, showed that patients with FGFR1 amplification exhibited a shorter progression-free survival compared to patients with wild type FGFR1. Thus, we propose breast cancers with FGFR pathway alterations should be considered for trials using combinations of ER, CDK4/6 and FGFR antagonists.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-019-09068-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7822461", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6443240", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2416446", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7822738", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440194", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438863", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer", 
    "pagination": "1373", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dfc1f6064d5fb91b99617f87042c7fb3c04ab2c529f750739feb4ea928c6cdd5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30914635"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-019-09068-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112990922"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-019-09068-2", 
      "https://app.dimensions.ai/details/publication/pub.1112990922"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130793_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-019-09068-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09068-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09068-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09068-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09068-2'


 

This table displays all metadata directly associated to this object as RDF triples.

472 TRIPLES      21 PREDICATES      87 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-019-09068-2 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nb2eea1b6530f46a08f363e3dca9a8f03
4 schema:citation sg:pub.10.1038/nature09627
5 sg:pub.10.1038/nature11412
6 sg:pub.10.1038/nbt.2514
7 sg:pub.10.1038/ng.806
8 sg:pub.10.1038/nmeth.1638
9 sg:pub.10.1038/nrc.2017.8
10 sg:pub.10.1038/nrclinonc.2015.117
11 sg:pub.10.1038/onc.2009.34
12 sg:pub.10.1038/onc.2010.154
13 sg:pub.10.1038/onc.2016.379
14 sg:pub.10.1038/s41467-017-00540-5
15 sg:pub.10.1186/1471-2105-14-7
16 sg:pub.10.1186/bcr3650
17 https://app.dimensions.ai/details/publication/pub.1074601068
18 https://doi.org/10.1016/j.ccr.2014.05.020
19 https://doi.org/10.1016/j.celrep.2015.12.094
20 https://doi.org/10.1016/j.molcel.2007.06.028
21 https://doi.org/10.1016/j.molcel.2016.04.023
22 https://doi.org/10.1016/s0140-6736(05)74803-0
23 https://doi.org/10.1016/s1470-2045(15)00613-0
24 https://doi.org/10.1056/nejmoa1505270
25 https://doi.org/10.1056/nejmoa1607303
26 https://doi.org/10.1056/nejmoa1609709
27 https://doi.org/10.1083/jcb.201009094
28 https://doi.org/10.1093/annonc/mdx784
29 https://doi.org/10.1093/bioinformatics/btp324
30 https://doi.org/10.1093/bioinformatics/btp394
31 https://doi.org/10.1093/bioinformatics/btt767
32 https://doi.org/10.1101/gr.107524.110
33 https://doi.org/10.1126/scisignal.2000021
34 https://doi.org/10.1126/scisignal.2004088
35 https://doi.org/10.1126/scitranslmed.aai7993
36 https://doi.org/10.1158/0008-5472.can-09-3746
37 https://doi.org/10.1158/0008-5472.can-09-4559
38 https://doi.org/10.1158/0008-5472.can-10-2700
39 https://doi.org/10.1158/0008-5472.can-15-0728
40 https://doi.org/10.1158/0008-5472.can-16-2653
41 https://doi.org/10.1158/0008-5472.sabcs11-pd01-01
42 https://doi.org/10.1158/0008-5472.sabcs11-pd01-02
43 https://doi.org/10.1158/1078-0432.ccr-04-0110
44 https://doi.org/10.1158/1078-0432.ccr-16-0471
45 https://doi.org/10.1158/1078-0432.ccr-17-1232
46 https://doi.org/10.1158/1078-0432.ccr-17-3831
47 https://doi.org/10.1158/1078-0432.ccr-17-3837
48 https://doi.org/10.1158/1541-7786.mcr-07-0150
49 https://doi.org/10.1158/2159-8290.cd-16-1000
50 https://doi.org/10.1182/blood-2007-02-071266
51 https://doi.org/10.1200/jco.2009.23.3734
52 https://doi.org/10.1200/jco.2014.60.7341
53 https://doi.org/10.1200/jco.2017.35.15_suppl.1038
54 https://doi.org/10.1200/jco.2017.73.7585
55 https://doi.org/10.1200/jco.2017.75.6155
56 https://doi.org/10.1371/journal.pone.0030801
57 https://doi.org/10.1371/journal.pone.0140712
58 https://doi.org/10.18632/oncotarget.2270
59 https://doi.org/10.18632/oncotarget.3364
60 https://doi.org/10.18632/oncotarget.5465
61 https://doi.org/10.4161/15384101.2014.946841
62 schema:datePublished 2019-12
63 schema:datePublishedReg 2019-12-01
64 schema:description Using an ORF kinome screen in MCF-7 cells treated with the CDK4/6 inhibitor ribociclib plus fulvestrant, we identified FGFR1 as a mechanism of drug resistance. FGFR1-amplified/ER+ breast cancer cells and MCF-7 cells transduced with FGFR1 were resistant to fulvestrant ± ribociclib or palbociclib. This resistance was abrogated by treatment with the FGFR tyrosine kinase inhibitor (TKI) lucitanib. Addition of the FGFR TKI erdafitinib to palbociclib/fulvestrant induced complete responses of FGFR1-amplified/ER+ patient-derived-xenografts. Next generation sequencing of circulating tumor DNA (ctDNA) in 34 patients after progression on CDK4/6 inhibitors identified FGFR1/2 amplification or activating mutations in 14/34 (41%) post-progression specimens. Finally, ctDNA from patients enrolled in MONALEESA-2, the registration trial of ribociclib, showed that patients with FGFR1 amplification exhibited a shorter progression-free survival compared to patients with wild type FGFR1. Thus, we propose breast cancers with FGFR pathway alterations should be considered for trials using combinations of ER, CDK4/6 and FGFR antagonists.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree true
68 schema:isPartOf N4a2d9923c70b4a7dacf6ecf8a98eaaac
69 Nd9d40b30d07b4a438f155283b14fae1b
70 sg:journal.1043282
71 schema:name Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer
72 schema:pagination 1373
73 schema:productId N11993220303e4b0e919389d6a7ac9e3f
74 N7b5c455b4eb348fba1895bb85c0516d2
75 N81bb21f32be44063a74b98ae64dce17f
76 N88000152c335492c841026cf0f827697
77 Nfa7849b1461f4715b3514c7b4465c066
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112990922
79 https://doi.org/10.1038/s41467-019-09068-2
80 schema:sdDatePublished 2019-04-11T13:49
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N26f2d89a314c44168a60dd167d27d6a0
83 schema:url https://www.nature.com/articles/s41467-019-09068-2
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N09f7dc77c0194097b5bdb169b92951e4 rdf:first N96d42af56d4c47e2a97b405497934690
88 rdf:rest N514bc7f7afd1471c9244ce8fd948f93b
89 N0e6afa0909c4492a9824f15defe4872c rdf:first N9316785df3e74be296846b57c773aec3
90 rdf:rest rdf:nil
91 N11993220303e4b0e919389d6a7ac9e3f schema:name pubmed_id
92 schema:value 30914635
93 rdf:type schema:PropertyValue
94 N127335d3a02e4a0ab0001655a311f6ab schema:affiliation https://www.grid.ac/institutes/grid.267313.2
95 schema:familyName Sudhan
96 schema:givenName Dhivya R.
97 rdf:type schema:Person
98 N1722c01ad90c463d8953afd4c8d64815 rdf:first Nda5a7d01d1d2482d92f1dcc3ecdd54a7
99 rdf:rest Nd7262bdf239643c1a2ffcae368901dcf
100 N219a307fff124ad99239c074a0a887b4 rdf:first N7b606b90382c4636b26d967ddf147dbd
101 rdf:rest N678febc252224a07af5b197aff3c7b56
102 N230fa7076fcc4052b7358e880ef2f460 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
103 schema:familyName Su
104 schema:givenName Fei
105 rdf:type schema:Person
106 N24d157b65826486e9a1a94f109eec2b0 rdf:first N7efdad8528d747f0b8712406d52892c9
107 rdf:rest N63d9d395f20f4247baa6cb4ca6ace980
108 N26f2d89a314c44168a60dd167d27d6a0 schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 N29d0cd2b317147d2b98586acb7324ba0 schema:name Massachusetts General Hospital Cancer Center, Harvard Medical School, 02114, Boston, MA, USA
111 rdf:type schema:Organization
112 N2c799d77502245199eb744f8a819be19 rdf:first N380d1bedd70a467d8c9e8b9c87c27a8b
113 rdf:rest Nb347dd9d649640048077e81511890340
114 N30f1c1c356b241569e3aeed5d44aa30b schema:affiliation https://www.grid.ac/institutes/grid.412807.8
115 schema:familyName Schwarz
116 schema:givenName Luis J.
117 rdf:type schema:Person
118 N372ea4dd8d344fa08dca5c4c2cb077d9 rdf:first Ne553d87eb96c438e80d81402792e25ab
119 rdf:rest Na57e84be5e4b4d7b8f9f33730ccb96f4
120 N380d1bedd70a467d8c9e8b9c87c27a8b schema:affiliation N29d0cd2b317147d2b98586acb7324ba0
121 schema:familyName Bardia
122 schema:givenName Aditya
123 rdf:type schema:Person
124 N3965efb650ff45f19b694fdd7e66632e rdf:first N665719c45bf1407d9f371719fcd1d4b2
125 rdf:rest N8d4531fbcecb4378999e86b5ba3f5ad4
126 N3d8b71a99c3c4550b74b43349f405450 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
127 schema:familyName Sanders
128 schema:givenName Melinda E.
129 rdf:type schema:Person
130 N447dd1ec550e4e29ab95d4d511f26f09 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
131 schema:familyName Miller
132 schema:givenName Michelle
133 rdf:type schema:Person
134 N4a2d9923c70b4a7dacf6ecf8a98eaaac schema:issueNumber 1
135 rdf:type schema:PublicationIssue
136 N514bc7f7afd1471c9244ce8fd948f93b rdf:first N7b116779e9f74a618fc7a2d3d637d3c7
137 rdf:rest Nbfe3a092530443579a7f32da080e1d9c
138 N56ffea7df58941a3a29464cf71ca49b0 rdf:first Ndde1051d00ed408da834804f5be85174
139 rdf:rest Na210767743834bfcaef9ef7181784f21
140 N594ca8dc394e4dccb83c1fc940a2265e schema:affiliation https://www.grid.ac/institutes/grid.412807.8
141 schema:familyName Jansen
142 schema:givenName Valerie M.
143 rdf:type schema:Person
144 N62b2cbd8b6ea4c989d05e1983f1b5a77 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
145 schema:familyName Nixon
146 schema:givenName Mellissa J.
147 rdf:type schema:Person
148 N63d9d395f20f4247baa6cb4ca6ace980 rdf:first N127335d3a02e4a0ab0001655a311f6ab
149 rdf:rest Na2fb5b75d901405889503f9366bc9419
150 N665719c45bf1407d9f371719fcd1d4b2 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
151 schema:familyName Lee
152 schema:givenName Kyung-min
153 rdf:type schema:Person
154 N678febc252224a07af5b197aff3c7b56 rdf:first Nea19648d089e44d4b41c98f55ea5ec08
155 rdf:rest Nff22684da3d74831a98cfb957efd9fbf
156 N78527949c47f40beb97a1465c6590314 schema:affiliation Na4b1d0df58d54b2d9c1aa86aa2253c9f
157 schema:familyName Lanman
158 schema:givenName Richard B.
159 rdf:type schema:Person
160 N78f3d9fcf0c447cba6796e712b9399d2 schema:name Guardant Health, 94063, Redwood City, CA, USA
161 rdf:type schema:Organization
162 N7a8dc3a2c7014e9892cf6a69f009033e rdf:first N78527949c47f40beb97a1465c6590314
163 rdf:rest N1722c01ad90c463d8953afd4c8d64815
164 N7b116779e9f74a618fc7a2d3d637d3c7 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
165 schema:familyName Guo
166 schema:givenName Yan
167 rdf:type schema:Person
168 N7b5c455b4eb348fba1895bb85c0516d2 schema:name nlm_unique_id
169 schema:value 101528555
170 rdf:type schema:PropertyValue
171 N7b606b90382c4636b26d967ddf147dbd schema:affiliation https://www.grid.ac/institutes/grid.412807.8
172 schema:familyName Dugger
173 schema:givenName Teresa C.
174 rdf:type schema:Person
175 N7efdad8528d747f0b8712406d52892c9 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
176 schema:familyName Bauer
177 schema:givenName Joshua A.
178 rdf:type schema:Person
179 N7ff6d07c8cd840ebb351cd9654e3d9fc schema:affiliation https://www.grid.ac/institutes/grid.412807.8
180 schema:familyName Formisano
181 schema:givenName Luigi
182 rdf:type schema:Person
183 N81bb21f32be44063a74b98ae64dce17f schema:name readcube_id
184 schema:value dfc1f6064d5fb91b99617f87042c7fb3c04ab2c529f750739feb4ea928c6cdd5
185 rdf:type schema:PropertyValue
186 N88000152c335492c841026cf0f827697 schema:name doi
187 schema:value 10.1038/s41467-019-09068-2
188 rdf:type schema:PropertyValue
189 N89338bf338014842ba277076b4cc34e2 schema:affiliation N78f3d9fcf0c447cba6796e712b9399d2
190 schema:familyName Nagy
191 schema:givenName Rebecca J.
192 rdf:type schema:Person
193 N8cdc66ac80f641e38a55e388c09f1ffb schema:affiliation https://www.grid.ac/institutes/grid.418424.f
194 schema:familyName He
195 schema:givenName Wei
196 rdf:type schema:Person
197 N8d4531fbcecb4378999e86b5ba3f5ad4 rdf:first N62b2cbd8b6ea4c989d05e1983f1b5a77
198 rdf:rest Nf6e97641e0ab48b5a59ec2abf40c2e6b
199 N9316785df3e74be296846b57c773aec3 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
200 schema:familyName Arteaga
201 schema:givenName Carlos L.
202 rdf:type schema:Person
203 N96d42af56d4c47e2a97b405497934690 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
204 schema:familyName Croessmann
205 schema:givenName Sarah
206 rdf:type schema:Person
207 Na210767743834bfcaef9ef7181784f21 rdf:first Nb8fd6ad848b44abeb281cf91395dc32e
208 rdf:rest Nfc3a5f3ea6bd462680f84b44db8c65a8
209 Na2fb5b75d901405889503f9366bc9419 rdf:first Nc47cd1417be047559baf28616d78bf4a
210 rdf:rest N09f7dc77c0194097b5bdb169b92951e4
211 Na4b1d0df58d54b2d9c1aa86aa2253c9f schema:name Guardant Health, 94063, Redwood City, CA, USA
212 rdf:type schema:Organization
213 Na57e84be5e4b4d7b8f9f33730ccb96f4 rdf:first Nb38e36e042d1453ebee346906d033c93
214 rdf:rest Nf3bca06ba58244d799748e8ebd7ef6bd
215 Na7c7d6fb853e4b5180e0a978177d824d schema:affiliation https://www.grid.ac/institutes/grid.412807.8
216 schema:familyName Hanker
217 schema:givenName Ariella B.
218 rdf:type schema:Person
219 Naefe12896cfa41d6985b1a263a8d71e6 schema:affiliation https://www.grid.ac/institutes/grid.411588.1
220 schema:familyName O’Shaughnessy
221 schema:givenName Joyce
222 rdf:type schema:Person
223 Nb0e1fe76ad8f4a22b141c1f9ed98f2d8 rdf:first N89338bf338014842ba277076b4cc34e2
224 rdf:rest N7a8dc3a2c7014e9892cf6a69f009033e
225 Nb17243e08a8f43608dcdb8fc0b61010f schema:affiliation https://www.grid.ac/institutes/grid.16753.36
226 schema:familyName Behdad
227 schema:givenName Amir
228 rdf:type schema:Person
229 Nb2eea1b6530f46a08f363e3dca9a8f03 rdf:first N7ff6d07c8cd840ebb351cd9654e3d9fc
230 rdf:rest N372ea4dd8d344fa08dca5c4c2cb077d9
231 Nb347dd9d649640048077e81511890340 rdf:first Naefe12896cfa41d6985b1a263a8d71e6
232 rdf:rest Nb0e1fe76ad8f4a22b141c1f9ed98f2d8
233 Nb38e36e042d1453ebee346906d033c93 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
234 schema:familyName Servetto
235 schema:givenName Alberto
236 rdf:type schema:Person
237 Nb8fd6ad848b44abeb281cf91395dc32e schema:affiliation https://www.grid.ac/institutes/grid.412807.8
238 schema:familyName Mayer
239 schema:givenName Ingrid A.
240 rdf:type schema:Person
241 Nbbe3a91fcd30461d87ec58999f5a9c41 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
242 schema:familyName Balko
243 schema:givenName Justin M.
244 rdf:type schema:Person
245 Nbfe3a092530443579a7f32da080e1d9c rdf:first Nd00b57ace9124ec79859f418562ba8c0
246 rdf:rest N3965efb650ff45f19b694fdd7e66632e
247 Nc47cd1417be047559baf28616d78bf4a schema:affiliation https://www.grid.ac/institutes/grid.412807.8
248 schema:familyName Guerrero-Zotano
249 schema:givenName Angel L.
250 rdf:type schema:Person
251 Ncc1818bc496e4c5ba5099f105c68a9fd rdf:first N594ca8dc394e4dccb83c1fc940a2265e
252 rdf:rest N24d157b65826486e9a1a94f109eec2b0
253 Nd00b57ace9124ec79859f418562ba8c0 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
254 schema:familyName Ericsson
255 schema:givenName Paula Gonzalez
256 rdf:type schema:Person
257 Nd7262bdf239643c1a2ffcae368901dcf rdf:first N8cdc66ac80f641e38a55e388c09f1ffb
258 rdf:rest Nf31bd2632d5342c987fa1796cbd0426a
259 Nd9d40b30d07b4a438f155283b14fae1b schema:volumeNumber 10
260 rdf:type schema:PublicationVolume
261 Nda5a7d01d1d2482d92f1dcc3ecdd54a7 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
262 schema:familyName Solovieff
263 schema:givenName Nadia
264 rdf:type schema:Person
265 Ndd043043d547432fa3c759463156af03 rdf:first N3d8b71a99c3c4550b74b43349f405450
266 rdf:rest N219a307fff124ad99239c074a0a887b4
267 Ndde1051d00ed408da834804f5be85174 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
268 schema:familyName Shyr
269 schema:givenName Yu
270 rdf:type schema:Person
271 Ne553d87eb96c438e80d81402792e25ab schema:affiliation https://www.grid.ac/institutes/grid.412807.8
272 schema:familyName Lu
273 schema:givenName Yao
274 rdf:type schema:Person
275 Ne756811343e744b599aeb4c165413872 rdf:first Ned0c912305374427a0e54e16e56622dc
276 rdf:rest N2c799d77502245199eb744f8a819be19
277 Nea19648d089e44d4b41c98f55ea5ec08 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
278 schema:familyName Cruz
279 schema:givenName Marcelo Rocha
280 rdf:type schema:Person
281 Ned0c912305374427a0e54e16e56622dc schema:affiliation https://www.grid.ac/institutes/grid.16753.36
282 schema:familyName Cristofanilli
283 schema:givenName Massimo
284 rdf:type schema:Person
285 Nf31bd2632d5342c987fa1796cbd0426a rdf:first N447dd1ec550e4e29ab95d4d511f26f09
286 rdf:rest Nf658d828bc984d95b4c101ddd525a5f0
287 Nf3bca06ba58244d799748e8ebd7ef6bd rdf:first Na7c7d6fb853e4b5180e0a978177d824d
288 rdf:rest Ncc1818bc496e4c5ba5099f105c68a9fd
289 Nf658d828bc984d95b4c101ddd525a5f0 rdf:first N230fa7076fcc4052b7358e880ef2f460
290 rdf:rest N56ffea7df58941a3a29464cf71ca49b0
291 Nf6e97641e0ab48b5a59ec2abf40c2e6b rdf:first N30f1c1c356b241569e3aeed5d44aa30b
292 rdf:rest Ndd043043d547432fa3c759463156af03
293 Nfa7849b1461f4715b3514c7b4465c066 schema:name dimensions_id
294 schema:value pub.1112990922
295 rdf:type schema:PropertyValue
296 Nfc3a5f3ea6bd462680f84b44db8c65a8 rdf:first Nbbe3a91fcd30461d87ec58999f5a9c41
297 rdf:rest N0e6afa0909c4492a9824f15defe4872c
298 Nff22684da3d74831a98cfb957efd9fbf rdf:first Nb17243e08a8f43608dcdb8fc0b61010f
299 rdf:rest Ne756811343e744b599aeb4c165413872
300 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
301 schema:name Medical and Health Sciences
302 rdf:type schema:DefinedTerm
303 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
304 schema:name Oncology and Carcinogenesis
305 rdf:type schema:DefinedTerm
306 sg:grant.2416446 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09068-2
307 rdf:type schema:MonetaryGrant
308 sg:grant.2438863 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09068-2
309 rdf:type schema:MonetaryGrant
310 sg:grant.2440194 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09068-2
311 rdf:type schema:MonetaryGrant
312 sg:grant.6443240 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09068-2
313 rdf:type schema:MonetaryGrant
314 sg:grant.7822461 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09068-2
315 rdf:type schema:MonetaryGrant
316 sg:grant.7822738 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09068-2
317 rdf:type schema:MonetaryGrant
318 sg:journal.1043282 schema:issn 2041-1723
319 schema:name Nature Communications
320 rdf:type schema:Periodical
321 sg:pub.10.1038/nature09627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005907434
322 https://doi.org/10.1038/nature09627
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
325 https://doi.org/10.1038/nature11412
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/nbt.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000477771
328 https://doi.org/10.1038/nbt.2514
329 rdf:type schema:CreativeWork
330 sg:pub.10.1038/ng.806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010244476
331 https://doi.org/10.1038/ng.806
332 rdf:type schema:CreativeWork
333 sg:pub.10.1038/nmeth.1638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048011065
334 https://doi.org/10.1038/nmeth.1638
335 rdf:type schema:CreativeWork
336 sg:pub.10.1038/nrc.2017.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129567
337 https://doi.org/10.1038/nrc.2017.8
338 rdf:type schema:CreativeWork
339 sg:pub.10.1038/nrclinonc.2015.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002958014
340 https://doi.org/10.1038/nrclinonc.2015.117
341 rdf:type schema:CreativeWork
342 sg:pub.10.1038/onc.2009.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004364113
343 https://doi.org/10.1038/onc.2009.34
344 rdf:type schema:CreativeWork
345 sg:pub.10.1038/onc.2010.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014304136
346 https://doi.org/10.1038/onc.2010.154
347 rdf:type schema:CreativeWork
348 sg:pub.10.1038/onc.2016.379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044657964
349 https://doi.org/10.1038/onc.2016.379
350 rdf:type schema:CreativeWork
351 sg:pub.10.1038/s41467-017-00540-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091344460
352 https://doi.org/10.1038/s41467-017-00540-5
353 rdf:type schema:CreativeWork
354 sg:pub.10.1186/1471-2105-14-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022196002
355 https://doi.org/10.1186/1471-2105-14-7
356 rdf:type schema:CreativeWork
357 sg:pub.10.1186/bcr3650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001714285
358 https://doi.org/10.1186/bcr3650
359 rdf:type schema:CreativeWork
360 https://app.dimensions.ai/details/publication/pub.1074601068 schema:CreativeWork
361 https://doi.org/10.1016/j.ccr.2014.05.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041312538
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/j.celrep.2015.12.094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030317953
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1016/j.molcel.2007.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010551449
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1016/j.molcel.2016.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020578590
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1016/s0140-6736(05)74803-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009387731
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1016/s1470-2045(15)00613-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025211268
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1056/nejmoa1505270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016758516
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1056/nejmoa1607303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005496514
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1056/nejmoa1609709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045557388
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1083/jcb.201009094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010888789
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1093/annonc/mdx784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099786039
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1093/bioinformatics/btp394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032266264
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1093/bioinformatics/btt767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036259052
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1101/gr.107524.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032096953
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1126/scisignal.2000021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062682092
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1126/scisignal.2004088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033807182
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1126/scitranslmed.aai7993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091132694
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1158/0008-5472.can-09-3746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052989529
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1158/0008-5472.can-09-4559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048912946
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1158/0008-5472.can-10-2700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022660219
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1158/0008-5472.can-15-0728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063215798
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1158/0008-5472.can-16-2653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084230809
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1158/0008-5472.sabcs11-pd01-01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063220964
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1158/0008-5472.sabcs11-pd01-02 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063220965
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1158/1078-0432.ccr-04-0110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021321766
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1158/1078-0432.ccr-16-0471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063225393
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1158/1078-0432.ccr-17-1232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090917778
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1158/1078-0432.ccr-17-3831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103626575
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1158/1078-0432.ccr-17-3837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104113715
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1158/1541-7786.mcr-07-0150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035271031
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1158/2159-8290.cd-16-1000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063281080
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1182/blood-2007-02-071266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004608649
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1200/jco.2009.23.3734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008724134
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1200/jco.2014.60.7341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008993365
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1200/jco.2017.35.15_suppl.1038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106845644
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1200/jco.2017.73.7585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085860547
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1200/jco.2017.75.6155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092051908
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1371/journal.pone.0030801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014953441
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1371/journal.pone.0140712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025337709
440 rdf:type schema:CreativeWork
441 https://doi.org/10.18632/oncotarget.2270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007950724
442 rdf:type schema:CreativeWork
443 https://doi.org/10.18632/oncotarget.3364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015170387
444 rdf:type schema:CreativeWork
445 https://doi.org/10.18632/oncotarget.5465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006947997
446 rdf:type schema:CreativeWork
447 https://doi.org/10.4161/15384101.2014.946841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072288067
448 rdf:type schema:CreativeWork
449 https://www.grid.ac/institutes/grid.152326.1 schema:alternateName Vanderbilt University
450 schema:name Vanderbilt Center for Quantitative Sciences, Vanderbilt University School of Medicine, 37232-6307, Nashville, TN, USA
451 rdf:type schema:Organization
452 https://www.grid.ac/institutes/grid.16753.36 schema:alternateName Northwestern University
453 schema:name Robert H Lurie Comprehensive Cancer Center, 60611, Chicago, IL, USA
454 rdf:type schema:Organization
455 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
456 schema:name Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA
457 UTSW Simmons Cancer Center, 75230, Dallas, TX, USA
458 rdf:type schema:Organization
459 https://www.grid.ac/institutes/grid.411588.1 schema:alternateName Baylor University Medical Center
460 schema:name Baylor University Medical Center, Texas Oncology, US Oncology, 75246, Dallas, TX, USA
461 rdf:type schema:Organization
462 https://www.grid.ac/institutes/grid.412807.8 schema:alternateName Vanderbilt University Medical Center
463 schema:name Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA
464 Departments of Biochemistry, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA
465 Departments of Medicine, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA
466 Departments of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, 37232-6307, Nashville, TN, USA
467 UTSW Simmons Cancer Center, 75230, Dallas, TX, USA
468 rdf:type schema:Organization
469 https://www.grid.ac/institutes/grid.418424.f schema:alternateName Novartis (United States)
470 schema:name Novartis Institutes for Biomedical Research, 02139, Cambridge, MA, USA
471 Novartis Pharmaceuticals Corporation, 07936, East Hanover, NJ, USA
472 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...