Dietary fatty acids fine-tune Piezo1 mechanical response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Luis O. Romero, Andrew E. Massey, Alejandro D. Mata-Daboin, Francisco J. Sierra-Valdez, Subhash C. Chauhan, Julio F. Cordero-Morales, Valeria Vásquez

ABSTRACT

Mechanosensitive ion channels rely on membrane composition to transduce physical stimuli into electrical signals. The Piezo1 channel mediates mechanoelectrical transduction and regulates crucial physiological processes, including vascular architecture and remodeling, cell migration, and erythrocyte volume. The identity of the membrane components that modulate Piezo1 function remain largely unknown. Using lipid profiling analyses, we here identify dietary fatty acids that tune Piezo1 mechanical response. We find that margaric acid, a saturated fatty acid present in dairy products and fish, inhibits Piezo1 activation and polyunsaturated fatty acids (PUFAs), present in fish oils, modulate channel inactivation. Force measurements reveal that margaric acid increases membrane bending stiffness, whereas PUFAs decrease it. We use fatty acid supplementation to abrogate the phenotype of gain-of-function Piezo1 mutations causing human dehydrated hereditary stomatocytosis. Beyond Piezo1, our findings demonstrate that cell-intrinsic lipid profile and changes in the fatty acid metabolism can dictate the cell's response to mechanical cues. More... »

PAGES

1200

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-09055-7

DOI

http://dx.doi.org/10.1038/s41467-019-09055-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112734575

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30867417


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anemia, Hemolytic, Congenital", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dietary Fats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids, Unsaturated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gain of Function Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HEK293 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrops Fetalis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ion Channel Gating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ion Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipid Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Atomic Force", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patch-Clamp Techniques", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 71S. Manassas St., 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romero", 
        "givenName": "Luis O.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Pharmaceutical Sciences and Institute of Biomarker and Molecular Therapeutics (IBMT), College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave., 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Massey", 
        "givenName": "Andrew E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 71S. Manassas St., 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mata-Daboin", 
        "givenName": "Alejandro D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monterrey Institute of Technology and Higher Education", 
          "id": "https://www.grid.ac/institutes/grid.419886.a", 
          "name": [
            "Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 71S. Manassas St., 38163, Memphis, TN, USA", 
            "Centro de Investigaci\u00f3n Biom\u00e9dica, Hospital Zambrano Hellion, TecSalud, Ave. Batallon de San Patricio 112, 66278, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico", 
            "Tecn\u00f3logico de Monterrey, Escuela de Ingenier\u00eda y Ciencias, Ave. Eugenio Garza Sada 2501 Sur, 64849, Monterrey, Nuevo Le\u00f3n, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sierra-Valdez", 
        "givenName": "Francisco J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Pharmaceutical Sciences and Institute of Biomarker and Molecular Therapeutics (IBMT), College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave., 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chauhan", 
        "givenName": "Subhash C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 71S. Manassas St., 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cordero-Morales", 
        "givenName": "Julio F.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 71S. Manassas St., 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "V\u00e1squez", 
        "givenName": "Valeria", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0006-3495(00)76295-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001659056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2013.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002514910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1302018110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002590966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0701015104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003745894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004779862", 
          "https://doi.org/10.1038/nn1362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004779862", 
          "https://doi.org/10.1038/nn1362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.10.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004820740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0116195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005456613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0116195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005456613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminhematol.2004.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006469642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1412740111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007685387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.1998.037bz.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008728161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200803552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008863993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature15247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010081089", 
          "https://doi.org/10.1038/nature15247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(91)90343-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011111707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms2899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015159942", 
          "https://doi.org/10.1038/ncomms2899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1529/biophysj.104.058180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016212527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1085/jgp.113.4.525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018556897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2009.398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019622874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms4520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019832816", 
          "https://doi.org/10.1038/ncomms4520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/ajcn.112.036319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022689941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci87343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022743695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022749802", 
          "https://doi.org/10.1038/ncb2915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1150-14.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023557133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.07370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025250131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11689", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028971719", 
          "https://doi.org/10.1038/nature11689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.12088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029755198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-04-422253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034669221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-014-1530-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038753820", 
          "https://doi.org/10.1007/s00424-014-1530-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1193270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039293916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0132117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039945932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-02-482489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040406318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms10366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040635440", 
          "https://doi.org/10.1038/ncomms10366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.07369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042628248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1409233111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042698756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2005667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043888030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047160814", 
          "https://doi.org/10.1038/nature13701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2016.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047351173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamem.2016.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049145627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamem.2016.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049145627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1409802111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050781678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytochem.2003.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050959105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-7075-8-36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051162306", 
          "https://doi.org/10.1186/1743-7075-8-36"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1219777110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051394223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1414298111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051491860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi200770q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055204311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi200770q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055204311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja046453b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055836934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja046453b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055836934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.1143970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057671893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.21074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074248745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphys.2017.00043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083694711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep44845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084132720", 
          "https://doi.org/10.1038/srep44845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep44845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084132720", 
          "https://doi.org/10.1038/srep44845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/bs.ctm.2017.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084700761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2017.06.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090324868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2017-05-786004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090748388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2017-05-786004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090748388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dmm.030841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090862076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-017-00429-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091272885", 
          "https://doi.org/10.1038/s41467-017-00429-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-017-00429-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091272885", 
          "https://doi.org/10.1038/s41467-017-00429-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2017.09.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092053091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/sciadv.aao1193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092593312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2017.10.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093048875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2017.10.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093048875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2017.11.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099605998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.33660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099654859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1085/jgp.201711835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099659377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature25453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099723544", 
          "https://doi.org/10.1038/nature25453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature25453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099723544", 
          "https://doi.org/10.1038/nature25453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jp275718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100395604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jp275718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100395604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jp275718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100395604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jp275718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100395604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature25743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100554377", 
          "https://doi.org/10.1038/nature25743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature25743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100554377", 
          "https://doi.org/10.1038/nature25743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chemphyslip.2018.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100565168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.34396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100690044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.02.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101695500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.02.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101695500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.02.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101695500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.02.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101695500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.02.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101695500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sbi.2018.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101819366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sbi.2018.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101819366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2018.03.094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103396615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2018.03.094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103396615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-04436-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104156940", 
          "https://doi.org/10.1038/s41467-018-04436-w"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/377978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105861140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/377978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105861140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/377978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105861140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/377978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105861140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/377978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105861140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1105953181", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/bloodadvances.2018021444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106152949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/bloodadvances.2018021444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106152949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/bloodadvances.2018021444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106152949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.33149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106293638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stemcr.2018.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106804187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stemcr.2018.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106804187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stemcr.2018.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106804187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aau6324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107896180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.44003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111330946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.44003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111330946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.44003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111330946"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Mechanosensitive ion channels rely on membrane composition to transduce physical stimuli into electrical signals. The Piezo1 channel mediates mechanoelectrical transduction and regulates crucial physiological processes, including vascular architecture and remodeling, cell migration, and erythrocyte volume. The identity of the membrane components that modulate Piezo1 function remain largely unknown. Using lipid profiling analyses, we here identify dietary fatty acids that tune Piezo1 mechanical response. We find that margaric acid, a saturated fatty acid present in dairy products and fish, inhibits Piezo1 activation and polyunsaturated fatty acids (PUFAs), present in fish oils, modulate channel inactivation. Force measurements reveal that margaric acid increases membrane bending stiffness, whereas PUFAs decrease it. We use fatty acid supplementation to abrogate the phenotype of gain-of-function Piezo1 mutations causing human dehydrated hereditary stomatocytosis. Beyond Piezo1, our findings demonstrate that cell-intrinsic lipid profile and changes in the fatty acid metabolism can dictate the cell's response to mechanical cues.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-019-09055-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7172828", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5475286", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5475998", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5243906", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7172321", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Dietary fatty acids fine-tune Piezo1 mechanical response", 
    "pagination": "1200", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-019-09055-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112734575"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1b6d97da38846059df21775af0bce3f20008e1d1b87dc0f059acbaada9dd0894"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30867417"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-019-09055-7", 
      "https://app.dimensions.ai/details/publication/pub.1112734575"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106828_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-019-09055-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09055-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09055-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09055-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09055-7'


 

This table displays all metadata directly associated to this object as RDF triples.

422 TRIPLES      21 PREDICATES      120 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-019-09055-7 schema:about N02662588207741bc945c151ccd93effc
2 N0463e06f922747ddb5050bd744948119
3 N0948a5cc640e4aaa84e0bd926d4448b7
4 N0a7906c31032474887bd08a4e368cc65
5 N3f11192773e24ee59b9f5734133b9132
6 N44f52c38352a4289af374072c3024b7b
7 N4f4562edcd9047268b93efdefd774783
8 N9c9e1896f6f941be8c7e230c00b5795f
9 Na2a4cdaaf479472280b63aa19c960439
10 Nc0a3cb1f59854117919cec7f09c24a96
11 Nc1fef49bc1eb48189cd66c58b4e78df4
12 Ncd76d19187e6438dbc0d911aa5859766
13 Nd2d5807345294d33b0244626937eb0a6
14 Necd7b15e66a24ed48f2baf5ec702df17
15 Needb47e942c54a5984adf0a884b5e022
16 Nf817d022940747d6a16f2a0fc276d343
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author N6ab8571a3c5e4c249f4986caf53157d1
20 schema:citation sg:pub.10.1007/s00424-014-1530-2
21 sg:pub.10.1038/nature11689
22 sg:pub.10.1038/nature13701
23 sg:pub.10.1038/nature15247
24 sg:pub.10.1038/nature25453
25 sg:pub.10.1038/nature25743
26 sg:pub.10.1038/ncb2915
27 sg:pub.10.1038/ncomms10366
28 sg:pub.10.1038/ncomms2899
29 sg:pub.10.1038/ncomms4520
30 sg:pub.10.1038/nn1362
31 sg:pub.10.1038/s41467-017-00429-3
32 sg:pub.10.1038/s41467-018-04436-w
33 sg:pub.10.1038/srep44845
34 sg:pub.10.1186/1743-7075-8-36
35 https://app.dimensions.ai/details/publication/pub.1105953181
36 https://doi.org/10.1002/anie.200803552
37 https://doi.org/10.1016/0896-6273(91)90343-x
38 https://doi.org/10.1016/bs.ctm.2017.01.001
39 https://doi.org/10.1016/j.bbamem.2016.10.002
40 https://doi.org/10.1016/j.cell.2018.02.047
41 https://doi.org/10.1016/j.celrep.2013.12.012
42 https://doi.org/10.1016/j.celrep.2016.10.033
43 https://doi.org/10.1016/j.celrep.2017.09.029
44 https://doi.org/10.1016/j.celrep.2017.10.120
45 https://doi.org/10.1016/j.celrep.2017.11.035
46 https://doi.org/10.1016/j.celrep.2018.03.094
47 https://doi.org/10.1016/j.chemphyslip.2018.01.002
48 https://doi.org/10.1016/j.phytochem.2003.10.017
49 https://doi.org/10.1016/j.sbi.2018.03.015
50 https://doi.org/10.1016/j.semcdb.2017.06.018
51 https://doi.org/10.1016/j.stemcr.2018.08.010
52 https://doi.org/10.1016/j.tibs.2016.09.004
53 https://doi.org/10.1016/s0006-3495(00)76295-3
54 https://doi.org/10.1021/bi200770q
55 https://doi.org/10.1021/ja046453b
56 https://doi.org/10.1038/emboj.2009.398
57 https://doi.org/10.1053/j.seminhematol.2004.02.005
58 https://doi.org/10.1063/1.1143970
59 https://doi.org/10.1073/pnas.0701015104
60 https://doi.org/10.1073/pnas.1219777110
61 https://doi.org/10.1073/pnas.1302018110
62 https://doi.org/10.1073/pnas.1409233111
63 https://doi.org/10.1073/pnas.1409802111
64 https://doi.org/10.1073/pnas.1412740111
65 https://doi.org/10.1073/pnas.1414298111
66 https://doi.org/10.1085/jgp.113.4.525
67 https://doi.org/10.1085/jgp.201711835
68 https://doi.org/10.1101/377978
69 https://doi.org/10.1111/j.1469-7793.1998.037bz.x
70 https://doi.org/10.1113/jp275718
71 https://doi.org/10.1126/sciadv.aao1193
72 https://doi.org/10.1126/science.1193270
73 https://doi.org/10.1126/science.aau6324
74 https://doi.org/10.1126/scisignal.2005667
75 https://doi.org/10.1172/jci87343
76 https://doi.org/10.1182/blood-2012-04-422253
77 https://doi.org/10.1182/blood-2013-02-482489
78 https://doi.org/10.1182/blood-2017-05-786004
79 https://doi.org/10.1182/bloodadvances.2018021444
80 https://doi.org/10.1242/dmm.030841
81 https://doi.org/10.1371/journal.pone.0116195
82 https://doi.org/10.1371/journal.pone.0132117
83 https://doi.org/10.1523/jneurosci.1150-14.2015
84 https://doi.org/10.1529/biophysj.104.058180
85 https://doi.org/10.3389/fphys.2017.00043
86 https://doi.org/10.3945/ajcn.112.036319
87 https://doi.org/10.7554/elife.07369
88 https://doi.org/10.7554/elife.07370
89 https://doi.org/10.7554/elife.12088
90 https://doi.org/10.7554/elife.21074
91 https://doi.org/10.7554/elife.33149
92 https://doi.org/10.7554/elife.33660
93 https://doi.org/10.7554/elife.34396
94 https://doi.org/10.7554/elife.44003
95 schema:datePublished 2019-12
96 schema:datePublishedReg 2019-12-01
97 schema:description Mechanosensitive ion channels rely on membrane composition to transduce physical stimuli into electrical signals. The Piezo1 channel mediates mechanoelectrical transduction and regulates crucial physiological processes, including vascular architecture and remodeling, cell migration, and erythrocyte volume. The identity of the membrane components that modulate Piezo1 function remain largely unknown. Using lipid profiling analyses, we here identify dietary fatty acids that tune Piezo1 mechanical response. We find that margaric acid, a saturated fatty acid present in dairy products and fish, inhibits Piezo1 activation and polyunsaturated fatty acids (PUFAs), present in fish oils, modulate channel inactivation. Force measurements reveal that margaric acid increases membrane bending stiffness, whereas PUFAs decrease it. We use fatty acid supplementation to abrogate the phenotype of gain-of-function Piezo1 mutations causing human dehydrated hereditary stomatocytosis. Beyond Piezo1, our findings demonstrate that cell-intrinsic lipid profile and changes in the fatty acid metabolism can dictate the cell's response to mechanical cues.
98 schema:genre research_article
99 schema:inLanguage en
100 schema:isAccessibleForFree true
101 schema:isPartOf N9d79825c2ada4d109e3aab425d3a23ac
102 Na21c7ed8445c4f24936198997a912513
103 sg:journal.1043282
104 schema:name Dietary fatty acids fine-tune Piezo1 mechanical response
105 schema:pagination 1200
106 schema:productId N01b063864c1347769938007ea3898003
107 N868adaa932b54dfca5c99c3b1df91949
108 Na172f8096d604596b7b841c646c4e866
109 Na29b4ec52ca54a308e0f82acb153dd51
110 Ndf6d2d1ecf2e4831a96bae4841a60429
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112734575
112 https://doi.org/10.1038/s41467-019-09055-7
113 schema:sdDatePublished 2019-04-16T06:24
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher N92c15248f4bc4590b825d355ed71c4f7
116 schema:url https://www.nature.com/articles/s41467-019-09055-7
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N01b063864c1347769938007ea3898003 schema:name readcube_id
121 schema:value 1b6d97da38846059df21775af0bce3f20008e1d1b87dc0f059acbaada9dd0894
122 rdf:type schema:PropertyValue
123 N02662588207741bc945c151ccd93effc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Ion Channel Gating
125 rdf:type schema:DefinedTerm
126 N0463e06f922747ddb5050bd744948119 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Microscopy, Atomic Force
128 rdf:type schema:DefinedTerm
129 N0595e721a6064f3c8eadfb7f07353365 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
130 schema:familyName Mata-Daboin
131 schema:givenName Alejandro D.
132 rdf:type schema:Person
133 N0736f896bfa848a2858fc356c09f508f rdf:first N52a9603beb214e4b8b3abcee411c4860
134 rdf:rest N57e4bbe3867e46688c86e80fcba50da8
135 N0948a5cc640e4aaa84e0bd926d4448b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Ion Channels
137 rdf:type schema:DefinedTerm
138 N0a7906c31032474887bd08a4e368cc65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Fatty Acids
140 rdf:type schema:DefinedTerm
141 N1457e8b99d96409fa160562e0324a340 rdf:first N5818be0797c94e6fb1a825cececf3036
142 rdf:rest Na6668398e0b142c28e2e4ad6628c4c20
143 N2c46d9366d104aa4a3b8b9dd4fac5b1a rdf:first N0595e721a6064f3c8eadfb7f07353365
144 rdf:rest N1457e8b99d96409fa160562e0324a340
145 N34b3345df2ff49f1a862e8e0f5f1db06 rdf:first N3a415c86ab1e4424a2a3b1b6df21f751
146 rdf:rest N2c46d9366d104aa4a3b8b9dd4fac5b1a
147 N3a415c86ab1e4424a2a3b1b6df21f751 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
148 schema:familyName Massey
149 schema:givenName Andrew E.
150 rdf:type schema:Person
151 N3f11192773e24ee59b9f5734133b9132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Gain of Function Mutation
153 rdf:type schema:DefinedTerm
154 N44f52c38352a4289af374072c3024b7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Cell Membrane
156 rdf:type schema:DefinedTerm
157 N4f4562edcd9047268b93efdefd774783 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mice
159 rdf:type schema:DefinedTerm
160 N52a9603beb214e4b8b3abcee411c4860 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
161 schema:familyName Cordero-Morales
162 schema:givenName Julio F.
163 rdf:type schema:Person
164 N57e4bbe3867e46688c86e80fcba50da8 rdf:first Nbef7a7a83c51412ab1ade33881b7dee2
165 rdf:rest rdf:nil
166 N5818be0797c94e6fb1a825cececf3036 schema:affiliation https://www.grid.ac/institutes/grid.419886.a
167 schema:familyName Sierra-Valdez
168 schema:givenName Francisco J.
169 rdf:type schema:Person
170 N6ab8571a3c5e4c249f4986caf53157d1 rdf:first N77c7798a6a2a44a79dc266b15c6d2d78
171 rdf:rest N34b3345df2ff49f1a862e8e0f5f1db06
172 N77c7798a6a2a44a79dc266b15c6d2d78 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
173 schema:familyName Romero
174 schema:givenName Luis O.
175 rdf:type schema:Person
176 N868adaa932b54dfca5c99c3b1df91949 schema:name nlm_unique_id
177 schema:value 101528555
178 rdf:type schema:PropertyValue
179 N8ee366d835cd4f7d907242d59cc0ed4a schema:affiliation https://www.grid.ac/institutes/grid.267301.1
180 schema:familyName Chauhan
181 schema:givenName Subhash C.
182 rdf:type schema:Person
183 N92c15248f4bc4590b825d355ed71c4f7 schema:name Springer Nature - SN SciGraph project
184 rdf:type schema:Organization
185 N9c9e1896f6f941be8c7e230c00b5795f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Hydrops Fetalis
187 rdf:type schema:DefinedTerm
188 N9d79825c2ada4d109e3aab425d3a23ac schema:issueNumber 1
189 rdf:type schema:PublicationIssue
190 Na172f8096d604596b7b841c646c4e866 schema:name pubmed_id
191 schema:value 30867417
192 rdf:type schema:PropertyValue
193 Na21c7ed8445c4f24936198997a912513 schema:volumeNumber 10
194 rdf:type schema:PublicationVolume
195 Na29b4ec52ca54a308e0f82acb153dd51 schema:name dimensions_id
196 schema:value pub.1112734575
197 rdf:type schema:PropertyValue
198 Na2a4cdaaf479472280b63aa19c960439 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Anemia, Hemolytic, Congenital
200 rdf:type schema:DefinedTerm
201 Na6668398e0b142c28e2e4ad6628c4c20 rdf:first N8ee366d835cd4f7d907242d59cc0ed4a
202 rdf:rest N0736f896bfa848a2858fc356c09f508f
203 Nbef7a7a83c51412ab1ade33881b7dee2 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
204 schema:familyName Vásquez
205 schema:givenName Valeria
206 rdf:type schema:Person
207 Nc0a3cb1f59854117919cec7f09c24a96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Fatty Acids, Unsaturated
209 rdf:type schema:DefinedTerm
210 Nc1fef49bc1eb48189cd66c58b4e78df4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name HEK293 Cells
212 rdf:type schema:DefinedTerm
213 Ncd76d19187e6438dbc0d911aa5859766 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Patch-Clamp Techniques
215 rdf:type schema:DefinedTerm
216 Nd2d5807345294d33b0244626937eb0a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Lipid Metabolism
218 rdf:type schema:DefinedTerm
219 Ndf6d2d1ecf2e4831a96bae4841a60429 schema:name doi
220 schema:value 10.1038/s41467-019-09055-7
221 rdf:type schema:PropertyValue
222 Necd7b15e66a24ed48f2baf5ec702df17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Dietary Fats
224 rdf:type schema:DefinedTerm
225 Needb47e942c54a5984adf0a884b5e022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Humans
227 rdf:type schema:DefinedTerm
228 Nf817d022940747d6a16f2a0fc276d343 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Animals
230 rdf:type schema:DefinedTerm
231 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
232 schema:name Biological Sciences
233 rdf:type schema:DefinedTerm
234 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
235 schema:name Biochemistry and Cell Biology
236 rdf:type schema:DefinedTerm
237 sg:grant.5243906 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09055-7
238 rdf:type schema:MonetaryGrant
239 sg:grant.5475286 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09055-7
240 rdf:type schema:MonetaryGrant
241 sg:grant.5475998 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09055-7
242 rdf:type schema:MonetaryGrant
243 sg:grant.7172321 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09055-7
244 rdf:type schema:MonetaryGrant
245 sg:grant.7172828 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-09055-7
246 rdf:type schema:MonetaryGrant
247 sg:journal.1043282 schema:issn 2041-1723
248 schema:name Nature Communications
249 rdf:type schema:Periodical
250 sg:pub.10.1007/s00424-014-1530-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038753820
251 https://doi.org/10.1007/s00424-014-1530-2
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nature11689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028971719
254 https://doi.org/10.1038/nature11689
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nature13701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047160814
257 https://doi.org/10.1038/nature13701
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nature15247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010081089
260 https://doi.org/10.1038/nature15247
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nature25453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099723544
263 https://doi.org/10.1038/nature25453
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nature25743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100554377
266 https://doi.org/10.1038/nature25743
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/ncb2915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022749802
269 https://doi.org/10.1038/ncb2915
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/ncomms10366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040635440
272 https://doi.org/10.1038/ncomms10366
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/ncomms2899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015159942
275 https://doi.org/10.1038/ncomms2899
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/ncomms4520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019832816
278 https://doi.org/10.1038/ncomms4520
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nn1362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004779862
281 https://doi.org/10.1038/nn1362
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/s41467-017-00429-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091272885
284 https://doi.org/10.1038/s41467-017-00429-3
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/s41467-018-04436-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1104156940
287 https://doi.org/10.1038/s41467-018-04436-w
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/srep44845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084132720
290 https://doi.org/10.1038/srep44845
291 rdf:type schema:CreativeWork
292 sg:pub.10.1186/1743-7075-8-36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051162306
293 https://doi.org/10.1186/1743-7075-8-36
294 rdf:type schema:CreativeWork
295 https://app.dimensions.ai/details/publication/pub.1105953181 schema:CreativeWork
296 https://doi.org/10.1002/anie.200803552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008863993
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/0896-6273(91)90343-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011111707
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/bs.ctm.2017.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084700761
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.bbamem.2016.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049145627
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.cell.2018.02.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101695500
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.celrep.2013.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002514910
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.celrep.2016.10.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004820740
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.celrep.2017.09.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092053091
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.celrep.2017.10.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093048875
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.celrep.2017.11.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099605998
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.celrep.2018.03.094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103396615
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.chemphyslip.2018.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100565168
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.phytochem.2003.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050959105
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.sbi.2018.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101819366
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.semcdb.2017.06.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090324868
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/j.stemcr.2018.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106804187
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/j.tibs.2016.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047351173
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/s0006-3495(00)76295-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001659056
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1021/bi200770q schema:sameAs https://app.dimensions.ai/details/publication/pub.1055204311
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1021/ja046453b schema:sameAs https://app.dimensions.ai/details/publication/pub.1055836934
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1038/emboj.2009.398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019622874
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1053/j.seminhematol.2004.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006469642
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1063/1.1143970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057671893
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1073/pnas.0701015104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003745894
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1073/pnas.1219777110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051394223
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1073/pnas.1302018110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002590966
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1073/pnas.1409233111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042698756
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1073/pnas.1409802111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050781678
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1073/pnas.1412740111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007685387
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1073/pnas.1414298111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051491860
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1085/jgp.113.4.525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018556897
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1085/jgp.201711835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099659377
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1101/377978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105861140
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1111/j.1469-7793.1998.037bz.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008728161
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1113/jp275718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100395604
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1126/sciadv.aao1193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092593312
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1126/science.1193270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039293916
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1126/science.aau6324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107896180
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1126/scisignal.2005667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043888030
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1172/jci87343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022743695
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1182/blood-2012-04-422253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034669221
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1182/blood-2013-02-482489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040406318
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1182/blood-2017-05-786004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090748388
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1182/bloodadvances.2018021444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106152949
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1242/dmm.030841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090862076
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1371/journal.pone.0116195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005456613
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1371/journal.pone.0132117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039945932
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1523/jneurosci.1150-14.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023557133
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1529/biophysj.104.058180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016212527
393 rdf:type schema:CreativeWork
394 https://doi.org/10.3389/fphys.2017.00043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083694711
395 rdf:type schema:CreativeWork
396 https://doi.org/10.3945/ajcn.112.036319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022689941
397 rdf:type schema:CreativeWork
398 https://doi.org/10.7554/elife.07369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042628248
399 rdf:type schema:CreativeWork
400 https://doi.org/10.7554/elife.07370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025250131
401 rdf:type schema:CreativeWork
402 https://doi.org/10.7554/elife.12088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029755198
403 rdf:type schema:CreativeWork
404 https://doi.org/10.7554/elife.21074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074248745
405 rdf:type schema:CreativeWork
406 https://doi.org/10.7554/elife.33149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106293638
407 rdf:type schema:CreativeWork
408 https://doi.org/10.7554/elife.33660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099654859
409 rdf:type schema:CreativeWork
410 https://doi.org/10.7554/elife.34396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100690044
411 rdf:type schema:CreativeWork
412 https://doi.org/10.7554/elife.44003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111330946
413 rdf:type schema:CreativeWork
414 https://www.grid.ac/institutes/grid.267301.1 schema:alternateName University of Tennessee Health Science Center
415 schema:name Department of Pharmaceutical Sciences and Institute of Biomarker and Molecular Therapeutics (IBMT), College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave., 38163, Memphis, TN, USA
416 Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 71S. Manassas St., 38163, Memphis, TN, USA
417 rdf:type schema:Organization
418 https://www.grid.ac/institutes/grid.419886.a schema:alternateName Monterrey Institute of Technology and Higher Education
419 schema:name Centro de Investigación Biomédica, Hospital Zambrano Hellion, TecSalud, Ave. Batallon de San Patricio 112, 66278, San Pedro Garza García, Nuevo León, Mexico
420 Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 71S. Manassas St., 38163, Memphis, TN, USA
421 Tecnólogico de Monterrey, Escuela de Ingeniería y Ciencias, Ave. Eugenio Garza Sada 2501 Sur, 64849, Monterrey, Nuevo León, Mexico
422 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...