Dietary fatty acids fine-tune Piezo1 mechanical response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Luis O. Romero, Andrew E. Massey, Alejandro D. Mata-Daboin, Francisco J. Sierra-Valdez, Subhash C. Chauhan, Julio F. Cordero-Morales, Valeria Vásquez

ABSTRACT

Mechanosensitive ion channels rely on membrane composition to transduce physical stimuli into electrical signals. The Piezo1 channel mediates mechanoelectrical transduction and regulates crucial physiological processes, including vascular architecture and remodeling, cell migration, and erythrocyte volume. The identity of the membrane components that modulate Piezo1 function remain largely unknown. Using lipid profiling analyses, we here identify dietary fatty acids that tune Piezo1 mechanical response. We find that margaric acid, a saturated fatty acid present in dairy products and fish, inhibits Piezo1 activation and polyunsaturated fatty acids (PUFAs), present in fish oils, modulate channel inactivation. Force measurements reveal that margaric acid increases membrane bending stiffness, whereas PUFAs decrease it. We use fatty acid supplementation to abrogate the phenotype of gain-of-function Piezo1 mutations causing human dehydrated hereditary stomatocytosis. Beyond Piezo1, our findings demonstrate that cell-intrinsic lipid profile and changes in the fatty acid metabolism can dictate the cell's response to mechanical cues. More... »

PAGES

1200

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-09055-7

    DOI

    http://dx.doi.org/10.1038/s41467-019-09055-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112734575

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30867417


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    415 schema:name Department of Pharmaceutical Sciences and Institute of Biomarker and Molecular Therapeutics (IBMT), College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave., 38163, Memphis, TN, USA
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    419 schema:name Centro de Investigación Biomédica, Hospital Zambrano Hellion, TecSalud, Ave. Batallon de San Patricio 112, 66278, San Pedro Garza García, Nuevo León, Mexico
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    421 Tecnólogico de Monterrey, Escuela de Ingeniería y Ciencias, Ave. Eugenio Garza Sada 2501 Sur, 64849, Monterrey, Nuevo León, Mexico
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