In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Vanina Dengler Haunreiter, Mathilde Boumasmoud, Nicola Häffner, Dennis Wipfli, Nadja Leimer, Carole Rachmühl, Denise Kühnert, Yvonne Achermann, Reinhard Zbinden, Stefano Benussi, Clement Vulin, Annelies S. Zinkernagel

ABSTRACT

Treatment failure in biofilm-associated bacterial infections is an important healthcare issue. In vitro studies and mouse models suggest that bacteria enter a slow-growing/non-growing state that results in transient tolerance to antibiotics in the absence of a specific resistance mechanism. However, little clinical confirmation of antibiotic tolerant bacteria in patients exists. In this study we investigate a Staphylococcus epidermidis pacemaker-associated endocarditis, in a patient who developed a break-through bacteremia despite taking antibiotics to which the S. epidermidis isolate is fully susceptible in vitro. Characterization of the clinical S. epidermidis isolates reveals in-host evolution over the 16-week infection period, resulting in increased antibiotic tolerance of the entire population due to a prolonged lag time until growth resumption and a reduced growth rate. Furthermore, we observe adaptation towards an increased biofilm formation capacity and genetic diversification of the S. epidermidis isolates within the patient. More... »

PAGES

1149

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-09053-9

    DOI

    http://dx.doi.org/10.1038/s41467-019-09053-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112641436

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30850614


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