Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Falk Liberta, Sarah Loerch, Matthies Rennegarbe, Angelika Schierhorn, Per Westermark, Gunilla T. Westermark, Bouke P. C. Hazenberg, Nikolaus Grigorieff, Marcus Fändrich, Matthias Schmidt

ABSTRACT

Systemic AA amyloidosis is a worldwide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from the acute phase protein serum amyloid A. Here, we report the purification and electron cryo-microscopy analysis of amyloid fibrils from a mouse and a human patient with systemic AA amyloidosis. The obtained resolutions are 3.0 Å and 2.7 Å for the murine and human fibril, respectively. The two fibrils differ in fundamental properties, such as presence of right-hand or left-hand twisted cross-β sheets and overall fold of the fibril proteins. Yet, both proteins adopt highly similar β-arch conformations within the N-terminal ~21 residues. Our data demonstrate the importance of the fibril protein N-terminus for the stability of the analyzed amyloid fibril morphologies and suggest strategies of combating this disease by interfering with specific fibril polymorphs. More... »

PAGES

1104

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-09033-z

DOI

http://dx.doi.org/10.1038/s41467-019-09033-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112603084

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30846696


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1101", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biochemistry and Metabolomics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloidosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cryoelectron Microscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron, Transmission", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation, beta-Strand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Interaction Domains and Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Stability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serum Amyloid A Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Ulm", 
          "id": "https://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Institute of Protein Biochemistry, Ulm University, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liberta", 
        "givenName": "Falk", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "Janelia Research Campus, Howard Hughes Medical Institute, 20147, Ashburn, VA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loerch", 
        "givenName": "Sarah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulm", 
          "id": "https://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Institute of Protein Biochemistry, Ulm University, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rennegarbe", 
        "givenName": "Matthies", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Biochemistry and Biotechnology, Martin-Luther-University, 06120, Halle (Saale), Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schierhorn", 
        "givenName": "Angelika", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Immunology, Genetics, and Pathology, Uppsala University, SE-751 85, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Westermark", 
        "givenName": "Per", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Medical Cell Biology, Uppsala University, SE-75123, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Westermark", 
        "givenName": "Gunilla T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hazenberg", 
        "givenName": "Bouke P. C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "Janelia Research Campus, Howard Hughes Medical Institute, 20147, Ashburn, VA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grigorieff", 
        "givenName": "Nikolaus", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulm", 
          "id": "https://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Institute of Protein Biochemistry, Ulm University, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "F\u00e4ndrich", 
        "givenName": "Marcus", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulm", 
          "id": "https://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Institute of Protein Biochemistry, Ulm University, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidt", 
        "givenName": "Matthias", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1107/s0907444910007493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000235100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444910007493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000235100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000839622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0700848104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003048275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.02.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004054282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.3541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004871597", 
          "https://doi.org/10.1038/nmeth.3541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2560775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005942173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2560775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005942173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13506129409148635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006600987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.20084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008225564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.394155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008589501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1997.1348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008860580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-pathol-020712-163913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012575149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909042073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018458004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909042073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018458004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13506129.2016.1257986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019038589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2006.02.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020106740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904019158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsbi.1996.0013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021707312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2009.04.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022952203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-001-0582-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024244927", 
          "https://doi.org/10.1007/s00428-001-0582-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-001-0582-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024244927", 
          "https://doi.org/10.1007/s00428-001-0582-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkh429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024962691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198006123022403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025208502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13506129908993291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025499621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026706357", 
          "https://doi.org/10.1038/nmeth.2019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4439(94)00076-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029561208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02899027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029746132", 
          "https://doi.org/10.1007/bf02899027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02899027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029746132", 
          "https://doi.org/10.1007/bf02899027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-94-009-4309-4_14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030058514", 
          "https://doi.org/10.1007/978-94-009-4309-4_14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(73)90022-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030931444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.med.57.121304.131243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031557953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/clin.1996.0152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034616867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.03206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037149355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.09-145979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038126392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(05)80107-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039294411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0800367105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040656828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201511524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040759175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2007.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042204379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2830673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044614982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2830673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044614982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bip.360221211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045206155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2013.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048377060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2013.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048377060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2015.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049504602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.092205999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049764139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.23.13363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050742662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2010.08.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051321764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1322357111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053227181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja800328y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055857769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja800328y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055857769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4414/smw.2012.13580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072527969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082781019", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2017.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083743564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2017.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083743564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.4193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129286", 
          "https://doi.org/10.1038/nmeth.4193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-biochem-061516-045115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085400537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-biochem-061516-045115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085400537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201701761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085562940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201701761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085562940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature23002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090348371", 
          "https://doi.org/10.1038/nature23002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature23002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090348371", 
          "https://doi.org/10.1038/nature23002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-06419-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090754934", 
          "https://doi.org/10.1038/s41598-017-06419-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-06419-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090754934", 
          "https://doi.org/10.1038/s41598-017-06419-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aao2825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091615552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aao2825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091615552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.36402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105294900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.36402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105294900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0454-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106388788", 
          "https://doi.org/10.1038/s41586-018-0454-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0454-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106388788", 
          "https://doi.org/10.1038/s41586-018-0454-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0454-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106388788", 
          "https://doi.org/10.1038/s41586-018-0454-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0454-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106388788", 
          "https://doi.org/10.1038/s41586-018-0454-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0454-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106388788", 
          "https://doi.org/10.1038/s41586-018-0454-y"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Systemic AA amyloidosis is a worldwide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from the acute phase protein serum amyloid A. Here, we report the purification and electron cryo-microscopy analysis of amyloid fibrils from a mouse and a human patient with systemic AA amyloidosis. The obtained resolutions are 3.0\u2009\u00c5 and 2.7\u2009\u00c5 for the murine and human fibril, respectively. The two fibrils differ in fundamental properties, such as presence of right-hand or left-hand twisted cross-\u03b2 sheets and overall fold of the fibril proteins. Yet, both proteins adopt highly similar \u03b2-arch conformations within the N-terminal ~21 residues. Our data demonstrate the importance of the fibril protein N-terminus for the stability of the analyzed amyloid fibril morphologies and suggest strategies of combating this disease by interfering with specific fibril polymorphs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-019-09033-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids", 
    "pagination": "1104", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-019-09033-z"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2e672e29f5326e7c04617dc42a6f9ea010697eea80c3c290413ca3c998ce648f"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112603084"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30846696"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-019-09033-z", 
      "https://app.dimensions.ai/details/publication/pub.1112603084"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91462_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-019-09033-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09033-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09033-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09033-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09033-z'


 

This table displays all metadata directly associated to this object as RDF triples.

378 TRIPLES      21 PREDICATES      102 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-019-09033-z schema:about N0a435cd9e7b84980b7a904ebc5243f85
2 N0f326417f8d24c39a2e75ed9867e05b3
3 N1da644a7039a495c99573cb2f2030df5
4 N239c333b1e224891be4457e5fa27a0dd
5 N24f18e74c02b4154aa055166b35132d0
6 N3192262a1441463ca27276fdf14bc31c
7 N5d787e11cf6e4b96857ed7dac4da1272
8 N70c14e19b036461f9300b14e822449ec
9 N713778e90c5c489bb6c78aae8035df53
10 N7506ec99ee754df19ac17e7e218526b9
11 N815b3f9ce99a4d57afb22e569df2afff
12 N903bdeba1f3c4a759fb6f8b25a3746db
13 Nbce3446f261745fe89812385799537f3
14 Nbf8ec7616f1146a9b7e00e245219d997
15 Ndd7586f643094bdbb6066f3f23af41a3
16 Ne464c80bd3924521a48c43bfaf06bb5a
17 Ne759dcd5748145e3815136ca04423a37
18 Nfd9698c088254ecba864aa2484a64897
19 anzsrc-for:11
20 anzsrc-for:1101
21 schema:author N84b6ca6dd7794faeb23688355b09ad60
22 schema:citation sg:pub.10.1007/978-94-009-4309-4_14
23 sg:pub.10.1007/bf02899027
24 sg:pub.10.1007/s00428-001-0582-9
25 sg:pub.10.1038/nature23002
26 sg:pub.10.1038/nmeth.2019
27 sg:pub.10.1038/nmeth.3541
28 sg:pub.10.1038/nmeth.4193
29 sg:pub.10.1038/s41586-018-0454-y
30 sg:pub.10.1038/s41598-017-06419-1
31 https://app.dimensions.ai/details/publication/pub.1082781019
32 https://doi.org/10.1002/anie.201511524
33 https://doi.org/10.1002/anie.201701761
34 https://doi.org/10.1002/bip.360221211
35 https://doi.org/10.1002/jcc.20084
36 https://doi.org/10.1006/clin.1996.0152
37 https://doi.org/10.1006/jmbi.1997.1348
38 https://doi.org/10.1006/jsbi.1996.0013
39 https://doi.org/10.1016/0022-2836(73)90022-3
40 https://doi.org/10.1016/0925-4439(94)00076-3
41 https://doi.org/10.1016/j.bbrc.2010.08.101
42 https://doi.org/10.1016/j.cell.2012.02.022
43 https://doi.org/10.1016/j.febslet.2009.04.026
44 https://doi.org/10.1016/j.jmb.2006.02.039
45 https://doi.org/10.1016/j.jmb.2007.05.022
46 https://doi.org/10.1016/j.jsb.2013.07.005
47 https://doi.org/10.1016/j.jsb.2015.11.003
48 https://doi.org/10.1016/j.jsb.2017.02.003
49 https://doi.org/10.1016/s0006-291x(05)80107-x
50 https://doi.org/10.1021/ja800328y
51 https://doi.org/10.1042/bj2560775
52 https://doi.org/10.1042/bj2830673
53 https://doi.org/10.1056/nejm198006123022403
54 https://doi.org/10.1073/pnas.0700848104
55 https://doi.org/10.1073/pnas.0800367105
56 https://doi.org/10.1073/pnas.092205999
57 https://doi.org/10.1073/pnas.1322357111
58 https://doi.org/10.1073/pnas.95.23.13363
59 https://doi.org/10.1074/jbc.m112.394155
60 https://doi.org/10.1080/13506129.2016.1257986
61 https://doi.org/10.1093/nar/gkh429
62 https://doi.org/10.1093/nar/gkn212
63 https://doi.org/10.1096/fj.09-145979
64 https://doi.org/10.1107/s0907444904019158
65 https://doi.org/10.1107/s0907444909042073
66 https://doi.org/10.1107/s0907444909052925
67 https://doi.org/10.1107/s0907444910007493
68 https://doi.org/10.1126/science.aao2825
69 https://doi.org/10.1146/annurev-biochem-061516-045115
70 https://doi.org/10.1146/annurev-pathol-020712-163913
71 https://doi.org/10.1146/annurev.med.57.121304.131243
72 https://doi.org/10.3109/13506129409148635
73 https://doi.org/10.3109/13506129908993291
74 https://doi.org/10.4414/smw.2012.13580
75 https://doi.org/10.7554/elife.03206
76 https://doi.org/10.7554/elife.36402
77 schema:datePublished 2019-12
78 schema:datePublishedReg 2019-12-01
79 schema:description Systemic AA amyloidosis is a worldwide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from the acute phase protein serum amyloid A. Here, we report the purification and electron cryo-microscopy analysis of amyloid fibrils from a mouse and a human patient with systemic AA amyloidosis. The obtained resolutions are 3.0 Å and 2.7 Å for the murine and human fibril, respectively. The two fibrils differ in fundamental properties, such as presence of right-hand or left-hand twisted cross-β sheets and overall fold of the fibril proteins. Yet, both proteins adopt highly similar β-arch conformations within the N-terminal ~21 residues. Our data demonstrate the importance of the fibril protein N-terminus for the stability of the analyzed amyloid fibril morphologies and suggest strategies of combating this disease by interfering with specific fibril polymorphs.
80 schema:genre research_article
81 schema:inLanguage en
82 schema:isAccessibleForFree true
83 schema:isPartOf N3993806fb6814d929eb00955a4c646cb
84 N755625487742488bbc15f9dfcb00b094
85 sg:journal.1043282
86 schema:name Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids
87 schema:pagination 1104
88 schema:productId N240d4abcf8b049cb81e81882329daa2a
89 N97e906641037480f95a4d97252d8fafc
90 N9e99e5ec0f714721b1e8fb7fc5df3061
91 Nb1c0dbc30799438eb536fc2bfa20e81c
92 Nf90ea0b86da94e819e4435d546ef3364
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112603084
94 https://doi.org/10.1038/s41467-019-09033-z
95 schema:sdDatePublished 2019-04-15T09:03
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N6c1e4a4093194f08aae4031fb1959fb8
98 schema:url https://www.nature.com/articles/s41467-019-09033-z
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N0a435cd9e7b84980b7a904ebc5243f85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Amyloidosis
104 rdf:type schema:DefinedTerm
105 N0f326417f8d24c39a2e75ed9867e05b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 N1da644a7039a495c99573cb2f2030df5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Amyloid
110 rdf:type schema:DefinedTerm
111 N239c333b1e224891be4457e5fa27a0dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Female
113 rdf:type schema:DefinedTerm
114 N240d4abcf8b049cb81e81882329daa2a schema:name pubmed_id
115 schema:value 30846696
116 rdf:type schema:PropertyValue
117 N24f18e74c02b4154aa055166b35132d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Mice
119 rdf:type schema:DefinedTerm
120 N3192262a1441463ca27276fdf14bc31c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Protein Conformation
122 rdf:type schema:DefinedTerm
123 N3993806fb6814d929eb00955a4c646cb schema:volumeNumber 10
124 rdf:type schema:PublicationVolume
125 N3b576fc0e181442095c0b502a0c2b874 rdf:first N478cb610d80b40d989985d974e39b5ee
126 rdf:rest N435c811c5ee3441793333aaced04425e
127 N435c811c5ee3441793333aaced04425e rdf:first N7eef72b4d5254d878c21f4dc32953e74
128 rdf:rest N99831bc5acca4d35815ad00b45078e27
129 N478cb610d80b40d989985d974e39b5ee schema:affiliation https://www.grid.ac/institutes/grid.413575.1
130 schema:familyName Loerch
131 schema:givenName Sarah
132 rdf:type schema:Person
133 N5cc8fcd3cc6c49ae82559a4e6bb44b5f schema:affiliation https://www.grid.ac/institutes/grid.8993.b
134 schema:familyName Westermark
135 schema:givenName Gunilla T.
136 rdf:type schema:Person
137 N5d787e11cf6e4b96857ed7dac4da1272 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Serum Amyloid A Protein
139 rdf:type schema:DefinedTerm
140 N65659e90ac2444a3966f6af10cdf5296 rdf:first N5cc8fcd3cc6c49ae82559a4e6bb44b5f
141 rdf:rest N7452cda6ae5347d5a23381ecc81aebaa
142 N6c1e4a4093194f08aae4031fb1959fb8 schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 N70c14e19b036461f9300b14e822449ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Sequence Homology, Amino Acid
146 rdf:type schema:DefinedTerm
147 N713778e90c5c489bb6c78aae8035df53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Species Specificity
149 rdf:type schema:DefinedTerm
150 N7452cda6ae5347d5a23381ecc81aebaa rdf:first N9f61f9a768864eaeaa351db6892dd617
151 rdf:rest Nd50549a744714d4eadd02d71380c3802
152 N7506ec99ee754df19ac17e7e218526b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Microscopy, Electron, Transmission
154 rdf:type schema:DefinedTerm
155 N755625487742488bbc15f9dfcb00b094 schema:issueNumber 1
156 rdf:type schema:PublicationIssue
157 N7c3be653f5844c95aaeae8f5ea79479c schema:affiliation https://www.grid.ac/institutes/grid.413575.1
158 schema:familyName Grigorieff
159 schema:givenName Nikolaus
160 rdf:type schema:Person
161 N7eef72b4d5254d878c21f4dc32953e74 schema:affiliation https://www.grid.ac/institutes/grid.6582.9
162 schema:familyName Rennegarbe
163 schema:givenName Matthies
164 rdf:type schema:Person
165 N815b3f9ce99a4d57afb22e569df2afff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Protein Conformation, beta-Strand
167 rdf:type schema:DefinedTerm
168 N84b6ca6dd7794faeb23688355b09ad60 rdf:first Nf0c325dded514a7597fe184250f4ede6
169 rdf:rest N3b576fc0e181442095c0b502a0c2b874
170 N903bdeba1f3c4a759fb6f8b25a3746db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Amino Acid Sequence
172 rdf:type schema:DefinedTerm
173 N97e906641037480f95a4d97252d8fafc schema:name nlm_unique_id
174 schema:value 101528555
175 rdf:type schema:PropertyValue
176 N99831bc5acca4d35815ad00b45078e27 rdf:first Nbdb6be6205174000b6bdc32a41d681ce
177 rdf:rest Ne088c945ecc64a7b99d52802202c05b8
178 N9e99e5ec0f714721b1e8fb7fc5df3061 schema:name readcube_id
179 schema:value 2e672e29f5326e7c04617dc42a6f9ea010697eea80c3c290413ca3c998ce648f
180 rdf:type schema:PropertyValue
181 N9f61f9a768864eaeaa351db6892dd617 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
182 schema:familyName Hazenberg
183 schema:givenName Bouke P. C.
184 rdf:type schema:Person
185 Na037e628d5394fd2807c93821d1e7482 schema:affiliation https://www.grid.ac/institutes/grid.6582.9
186 schema:familyName Fändrich
187 schema:givenName Marcus
188 rdf:type schema:Person
189 Nb1c0dbc30799438eb536fc2bfa20e81c schema:name doi
190 schema:value 10.1038/s41467-019-09033-z
191 rdf:type schema:PropertyValue
192 Nbce3446f261745fe89812385799537f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Models, Molecular
194 rdf:type schema:DefinedTerm
195 Nbdb6be6205174000b6bdc32a41d681ce schema:affiliation Ncb83ac3a1a564dcc92b99eb76b7661b2
196 schema:familyName Schierhorn
197 schema:givenName Angelika
198 rdf:type schema:Person
199 Nbf8ec7616f1146a9b7e00e245219d997 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Middle Aged
201 rdf:type schema:DefinedTerm
202 Nc1302896dc2f4fb5bb71d8f79db25927 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
203 schema:familyName Westermark
204 schema:givenName Per
205 rdf:type schema:Person
206 Ncb83ac3a1a564dcc92b99eb76b7661b2 schema:name Institute of Biochemistry and Biotechnology, Martin-Luther-University, 06120, Halle (Saale), Germany
207 rdf:type schema:Organization
208 Nd2601deab4584dbdb1321265c0be48df rdf:first Ne9ed8fcfaa00440dbd7739cb77baf87f
209 rdf:rest rdf:nil
210 Nd50549a744714d4eadd02d71380c3802 rdf:first N7c3be653f5844c95aaeae8f5ea79479c
211 rdf:rest Nda3ba75499064e86b1ae6551ebd81c5c
212 Nda3ba75499064e86b1ae6551ebd81c5c rdf:first Na037e628d5394fd2807c93821d1e7482
213 rdf:rest Nd2601deab4584dbdb1321265c0be48df
214 Ndd7586f643094bdbb6066f3f23af41a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Animals
216 rdf:type schema:DefinedTerm
217 Ne088c945ecc64a7b99d52802202c05b8 rdf:first Nc1302896dc2f4fb5bb71d8f79db25927
218 rdf:rest N65659e90ac2444a3966f6af10cdf5296
219 Ne464c80bd3924521a48c43bfaf06bb5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Protein Stability
221 rdf:type schema:DefinedTerm
222 Ne759dcd5748145e3815136ca04423a37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Cryoelectron Microscopy
224 rdf:type schema:DefinedTerm
225 Ne9ed8fcfaa00440dbd7739cb77baf87f schema:affiliation https://www.grid.ac/institutes/grid.6582.9
226 schema:familyName Schmidt
227 schema:givenName Matthias
228 rdf:type schema:Person
229 Nf0c325dded514a7597fe184250f4ede6 schema:affiliation https://www.grid.ac/institutes/grid.6582.9
230 schema:familyName Liberta
231 schema:givenName Falk
232 rdf:type schema:Person
233 Nf90ea0b86da94e819e4435d546ef3364 schema:name dimensions_id
234 schema:value pub.1112603084
235 rdf:type schema:PropertyValue
236 Nfd9698c088254ecba864aa2484a64897 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Protein Interaction Domains and Motifs
238 rdf:type schema:DefinedTerm
239 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
240 schema:name Medical and Health Sciences
241 rdf:type schema:DefinedTerm
242 anzsrc-for:1101 schema:inDefinedTermSet anzsrc-for:
243 schema:name Medical Biochemistry and Metabolomics
244 rdf:type schema:DefinedTerm
245 sg:journal.1043282 schema:issn 2041-1723
246 schema:name Nature Communications
247 rdf:type schema:Periodical
248 sg:pub.10.1007/978-94-009-4309-4_14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030058514
249 https://doi.org/10.1007/978-94-009-4309-4_14
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/bf02899027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029746132
252 https://doi.org/10.1007/bf02899027
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/s00428-001-0582-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024244927
255 https://doi.org/10.1007/s00428-001-0582-9
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/nature23002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090348371
258 https://doi.org/10.1038/nature23002
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/nmeth.2019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026706357
261 https://doi.org/10.1038/nmeth.2019
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/nmeth.3541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004871597
264 https://doi.org/10.1038/nmeth.3541
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nmeth.4193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129286
267 https://doi.org/10.1038/nmeth.4193
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/s41586-018-0454-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1106388788
270 https://doi.org/10.1038/s41586-018-0454-y
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/s41598-017-06419-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090754934
273 https://doi.org/10.1038/s41598-017-06419-1
274 rdf:type schema:CreativeWork
275 https://app.dimensions.ai/details/publication/pub.1082781019 schema:CreativeWork
276 https://doi.org/10.1002/anie.201511524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040759175
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1002/anie.201701761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085562940
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/bip.360221211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045206155
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1006/clin.1996.0152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034616867
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1006/jmbi.1997.1348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008860580
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1006/jsbi.1996.0013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021707312
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/0022-2836(73)90022-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030931444
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/0925-4439(94)00076-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029561208
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.bbrc.2010.08.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051321764
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.cell.2012.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004054282
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.febslet.2009.04.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022952203
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.jmb.2006.02.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020106740
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.jmb.2007.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042204379
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.jsb.2013.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048377060
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.jsb.2015.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049504602
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.jsb.2017.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083743564
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s0006-291x(05)80107-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039294411
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1021/ja800328y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055857769
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1042/bj2560775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005942173
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1042/bj2830673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044614982
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1056/nejm198006123022403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025208502
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1073/pnas.0700848104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003048275
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1073/pnas.0800367105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040656828
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1073/pnas.092205999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049764139
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1073/pnas.1322357111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053227181
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1073/pnas.95.23.13363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050742662
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1074/jbc.m112.394155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008589501
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1080/13506129.2016.1257986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019038589
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/nar/gkh429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024962691
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/nar/gkn212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000839622
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1096/fj.09-145979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038126392
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1107/s0907444909042073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018458004
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1107/s0907444909052925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777046
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1107/s0907444910007493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000235100
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1126/science.aao2825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091615552
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1146/annurev-biochem-061516-045115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085400537
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1146/annurev-pathol-020712-163913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012575149
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1146/annurev.med.57.121304.131243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031557953
355 rdf:type schema:CreativeWork
356 https://doi.org/10.3109/13506129409148635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006600987
357 rdf:type schema:CreativeWork
358 https://doi.org/10.3109/13506129908993291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025499621
359 rdf:type schema:CreativeWork
360 https://doi.org/10.4414/smw.2012.13580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072527969
361 rdf:type schema:CreativeWork
362 https://doi.org/10.7554/elife.03206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037149355
363 rdf:type schema:CreativeWork
364 https://doi.org/10.7554/elife.36402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105294900
365 rdf:type schema:CreativeWork
366 https://www.grid.ac/institutes/grid.413575.1 schema:alternateName Howard Hughes Medical Institute
367 schema:name Janelia Research Campus, Howard Hughes Medical Institute, 20147, Ashburn, VA, USA
368 rdf:type schema:Organization
369 https://www.grid.ac/institutes/grid.4494.d schema:alternateName University Medical Center Groningen
370 schema:name Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands
371 rdf:type schema:Organization
372 https://www.grid.ac/institutes/grid.6582.9 schema:alternateName University of Ulm
373 schema:name Institute of Protein Biochemistry, Ulm University, 89081, Ulm, Germany
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.8993.b schema:alternateName Uppsala University
376 schema:name Department of Immunology, Genetics, and Pathology, Uppsala University, SE-751 85, Uppsala, Sweden
377 Department of Medical Cell Biology, Uppsala University, SE-75123, Uppsala, Sweden
378 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...