Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSHiroyasu Kidoya, Fumitaka Muramatsu, Teppei Shimamura, Weizhen Jia, Takashi Satoh, Yumiko Hayashi, Hisamichi Naito, Yuya Kunisaki, Fumio Arai, Masahide Seki, Yutaka Suzuki, Tsuyoshi Osawa, Shizuo Akira, Nobuyuki Takakura
ABSTRACTThe balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) maintains hematopoietic homeostasis, failure of which can lead to hematopoietic disorder. HSPC fate is controlled by signals from the bone marrow niche resulting in alteration of the stem cell transcription network. Regnase-1, a member of the CCCH zinc finger protein family possessing RNAse activity, mediates post-transcriptional regulatory activity through degradation of target mRNAs. The precise function of Regnase-1 has been explored in inflammation-related cytokine expression but its function in hematopoiesis has not been elucidated. Here, we show that Regnase-1 regulates self-renewal of HSPCs through modulating the stability of Gata2 and Tal1 mRNA. In addition, we found that dysfunction of Regnase-1 leads to the rapid onset of abnormal hematopoiesis. Thus, our data reveal that Regnase-1-mediated post-transcriptional regulation is required for HSPC maintenance and suggest that it represents a leukemia tumor suppressor. More... »
PAGES1072
http://scigraph.springernature.com/pub.10.1038/s41467-019-09028-w
DOIhttp://dx.doi.org/10.1038/s41467-019-09028-w
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112573228
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30842549
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Marrow",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Differentiation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Proliferation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Self Renewal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Datasets as Topic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "GATA2 Transcription Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Neoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Knockdown Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HEK293 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hematopoietic Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hematopoietic Stem Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia, Myeloid, Acute",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred C57BL",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Knockout",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA Processing, Post-Transcriptional",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Messenger",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Small Interfering",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ribonucleases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "T-Cell Acute Lymphocytic Leukemia Protein 1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transcription Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation Chimera",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, 565-0871, Osaka, Suita, Japan"
],
"type": "Organization"
},
"familyName": "Kidoya",
"givenName": "Hiroyasu",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, 565-0871, Osaka, Suita, Japan"
],
"type": "Organization"
},
"familyName": "Muramatsu",
"givenName": "Fumitaka",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University",
"id": "https://www.grid.ac/institutes/grid.27476.30",
"name": [
"Division of Systems Biology, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, 466-8550, Nagoya, Showa-ku, Japan"
],
"type": "Organization"
},
"familyName": "Shimamura",
"givenName": "Teppei",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, 565-0871, Osaka, Suita, Japan"
],
"type": "Organization"
},
"familyName": "Jia",
"givenName": "Weizhen",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, 565-0871, Osaka, Suita, Japan"
],
"type": "Organization"
},
"familyName": "Satoh",
"givenName": "Takashi",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, 565-0871, Osaka, Suita, Japan"
],
"type": "Organization"
},
"familyName": "Hayashi",
"givenName": "Yumiko",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, 565-0871, Osaka, Suita, Japan"
],
"type": "Organization"
},
"familyName": "Naito",
"givenName": "Hisamichi",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyushu University",
"id": "https://www.grid.ac/institutes/grid.177174.3",
"name": [
"Department of Stem Cell Biology and Medicine/Cancer Stem Cell Research, Kyushu University, 3-1-1 Maidashi, 812-8582, Fukuoka, Higashi-ku, Japan"
],
"type": "Organization"
},
"familyName": "Kunisaki",
"givenName": "Yuya",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyushu University",
"id": "https://www.grid.ac/institutes/grid.177174.3",
"name": [
"Department of Stem Cell Biology and Medicine/Cancer Stem Cell Research, Kyushu University, 3-1-1 Maidashi, 812-8582, Fukuoka, Higashi-ku, Japan"
],
"type": "Organization"
},
"familyName": "Arai",
"givenName": "Fumio",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Medical Genome Sciences Graduate School of Frontier Sciences, The University of Tokyo, 277-8561, Chiba, Japan"
],
"type": "Organization"
},
"familyName": "Seki",
"givenName": "Masahide",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Medical Genome Sciences Graduate School of Frontier Sciences, The University of Tokyo, 277-8561, Chiba, Japan"
],
"type": "Organization"
},
"familyName": "Suzuki",
"givenName": "Yutaka",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Division of Integrative Nutriomics and Oncology, Research Center for Advanced Science and Technology, The University of Tokyo, 4\u22126-1 Komaba, 153-8904, Tokyo, Meguro-ku, Japan"
],
"type": "Organization"
},
"familyName": "Osawa",
"givenName": "Tsuyoshi",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, 565-0871, Osaka, Suita, Japan",
"Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center, Osaka University, 565-0871, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Akira",
"givenName": "Shizuo",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, 565-0871, Osaka, Suita, Japan"
],
"type": "Organization"
},
"familyName": "Takakura",
"givenName": "Nobuyuki",
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/371221a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000056814",
"https://doi.org/10.1038/371221a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.913",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001065103",
"https://doi.org/10.1038/ng.913"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.devcel.2015.02.024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001082989"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07924",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002169141",
"https://doi.org/10.1038/nature07924"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07924",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002169141",
"https://doi.org/10.1038/nature07924"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/aid.2015.0343",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002538209"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.coi.2016.01.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003626236"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.brainresbull.2009.01.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004529713"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni.3008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004704971",
"https://doi.org/10.1038/ni.3008"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tcb.2015.10.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006331419"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2015.04.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007354859"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2015.04.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007354859"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.immunol.25.022106.141538",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007716470"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-015-1919-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008293045",
"https://doi.org/10.1007/s12185-015-1919-5"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1493506",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009054338"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cyto.2012.01.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009784151"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2012.11.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009956931"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2012.11.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009956931"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2005-08-3482",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011158755"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2008.10.048",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012237517"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2012.06.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012743909"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2012.06.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012743909"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2016.07.058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014224363"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2016.07.058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014224363"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkv007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016098431"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2009-12-260703",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017080815"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/76211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018120939",
"https://doi.org/10.1038/76211"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/76211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018120939",
"https://doi.org/10.1038/76211"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1074-7613(01)00220-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018440325"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.res.0000220106.64661.71",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018783866"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.res.0000220106.64661.71",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018783866"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2014-08-570226",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021056218"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2011-12-397083",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022835371"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.stem.2013.05.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022976822"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.stem.2013.05.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022976822"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2004.05.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023684149"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2004.05.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023684149"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11930",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025252627",
"https://doi.org/10.1038/nature11930"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.stem.2014.02.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025977869"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)00025-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026253134"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg2269",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027616254",
"https://doi.org/10.1038/nrg2269"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.stem.2012.07.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029383404"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.stem.2012.07.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029383404"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1535-6108(02)00018-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030156052"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1535-6108(02)00018-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030156052"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.15252/embj.201490804",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030258416"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2015.11.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030292768"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2015.11.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030292768"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2015.11.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030292768"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2005-06-2527",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030582841"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni.2137",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030704067",
"https://doi.org/10.1038/ni.2137"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.0020301",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031585777"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0133746",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033374424"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2013.04.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035498060"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1679/aohc.66.123",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036924360"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0049841",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037084286"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2011.09.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037297965"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0506580102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037705714"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0506580102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037705714"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.96.26.14943",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039097335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/moh.0000000000000111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039188710"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/moh.0000000000000111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039188710"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-011-0905-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041091518",
"https://doi.org/10.1007/s12185-011-0905-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-011-0905-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041091518",
"https://doi.org/10.1007/s12185-011-0905-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3390/cells5010004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041689776"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12984",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045199334",
"https://doi.org/10.1038/nature12984"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri.2016.129",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046329564",
"https://doi.org/10.1038/nri.2016.129"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.cellbio.042308.113248",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047941470"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.annepidem.2011.10.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048540466"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1742-4658.2009.07452.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049209949"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000339066",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049404691"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/emboj.2011.465",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049551508"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/sqb.2013.78.019877",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049715855"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.261562798",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051244772"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1196/annals.1392.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051459184"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.1500756",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052822289"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bioinformatics/bts635",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053365587"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.273.5272.242",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062553596"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.4197",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084129290",
"https://doi.org/10.1038/nmeth.4197"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gky106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100953548"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "The balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) maintains hematopoietic homeostasis, failure of which can lead to hematopoietic disorder. HSPC fate is controlled by signals from the bone marrow niche resulting in alteration of the stem cell transcription network. Regnase-1, a member of the CCCH zinc finger protein family possessing RNAse activity, mediates post-transcriptional regulatory activity through degradation of target mRNAs. The precise function of Regnase-1 has been explored in inflammation-related cytokine expression but its function in hematopoiesis has not been elucidated. Here, we show that Regnase-1 regulates self-renewal of HSPCs through modulating the stability of Gata2 and Tal1 mRNA. In addition, we found that dysfunction of Regnase-1 leads to the rapid onset of abnormal hematopoiesis. Thus, our data reveal that Regnase-1-mediated post-transcriptional regulation is required for HSPC maintenance and suggest that it represents a leukemia tumor suppressor.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41467-019-09028-w",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.5899099",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5868258",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5914447",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1043282",
"issn": [
"2041-1723"
],
"name": "Nature Communications",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "10"
}
],
"name": "Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis",
"pagination": "1072",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41467-019-09028-w"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"5c3e6c4c9b7675b090d524e3d233656b8ddce41cd224f4ed7437f02c62cb60c6"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112573228"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101528555"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30842549"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41467-019-09028-w",
"https://app.dimensions.ai/details/publication/pub.1112573228"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-15T09:04",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91466_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41467-019-09028-w"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09028-w'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09028-w'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09028-w'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-09028-w'
This table displays all metadata directly associated to this object as RDF triples.
468 TRIPLES
21 PREDICATES
118 URIs
46 LITERALS
34 BLANK NODES