Programming chain-growth copolymerization of DNA hairpin tiles for in-vitro hierarchical supramolecular organization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Honglu Zhang, Yu Wang, Huan Zhang, Xiaoguo Liu, Antony Lee, Qiuling Huang, Fei Wang, Jie Chao, Huajie Liu, Jiang Li, Jiye Shi, Xiaolei Zuo, Lihua Wang, Lianhui Wang, Xiaoyu Cao, Carlos Bustamante, Zhongqun Tian, Chunhai Fan

ABSTRACT

Formation of biological filaments via intracellular supramolecular polymerization of proteins or protein/nucleic acid complexes is under programmable and spatiotemporal control to maintain cellular and genomic integrity. Here we devise a bioinspired, catassembly-like isothermal chain-growth approach to copolymerize DNA hairpin tiles (DHTs) into nanofilaments with desirable composition, chain length and function. By designing metastable DNA hairpins with shape-defining intramolecular hydrogen bonds, we generate two types of DHT monomers for copolymerization with high cooperativity and low dispersity indexes. Quantitative single-molecule dissection methods reveal that catalytic opening of a DHT motif harbouring a toehold triggers successive branch migration, which autonomously propagates to form copolymers with alternate tile units. We find that these shape-defined supramolecular nanostructures become substrates for efficient endocytosis by living mammalian cells in a stiffness-dependent manner. Hence, this catassembly-like in-vitro reconstruction approach provides clues for understanding structure-function relationship of biological filaments under physiological and pathological conditions. More... »

PAGES

1006

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-09004-4

    DOI

    http://dx.doi.org/10.1038/s41467-019-09004-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112473372

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30824698


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