Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSMathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist, Alexander M. Walter
ABSTRACTNeuronal communication across synapses relies on neurotransmitter release from presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic plasticity homeostatically maintains functionality during perturbations and enables memory formation. Postsynaptic plasticity targets neurotransmitter receptors, but presynaptic mechanisms regulating the neurotransmitter release apparatus remain largely enigmatic. By studying Drosophila neuromuscular junctions (NMJs) we show that AZs consist of nano-modular release sites and identify a molecular sequence that adds modules within minutes of inducing homeostatic plasticity. This requires cognate transport machinery and specific AZ-scaffolding proteins. Structural remodeling is not required for immediate potentiation of neurotransmitter release, but necessary to sustain potentiation over longer timescales. Finally, mutations in Unc13 disrupting homeostatic plasticity at the NMJ also impair short-term memory when central neurons are targeted, suggesting that both plasticity mechanisms utilize Unc13. Together, while immediate synaptic potentiation capitalizes on available material, it triggers the coincident incorporation of modular release sites to consolidate synaptic potentiation. More... »
PAGES1085
http://scigraph.springernature.com/pub.10.1038/s41467-019-08977-6
DOIhttp://dx.doi.org/10.1038/s41467-019-08977-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112581205
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30842428
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals, Genetically Modified",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Behavior, Animal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drosophila Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drosophila melanogaster",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Long-Term Potentiation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Memory, Short-Term",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Animal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mushroom Bodies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nerve Tissue Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neuromuscular Junction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neurotransmitter Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Patch-Clamp Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Presynaptic Terminals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Synaptic Transmission",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Synaptic Vesicles",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Freie Universit\u00e4t Berlin",
"id": "https://www.grid.ac/institutes/grid.14095.39",
"name": [
"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), 13125, Berlin, Germany",
"NeuroCure Cluster of Excellence, Charit\u00e9 Universit\u00e4tsmedizin, 10117, Berlin, Germany",
"Institute for Biology/Genetics, Freie Universit\u00e4t Berlin, 14195, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "B\u00f6hme",
"givenName": "Mathias A.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Molekulare Pharmakologie",
"id": "https://www.grid.ac/institutes/grid.418832.4",
"name": [
"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), 13125, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "McCarthy",
"givenName": "Anthony W.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Charit\u00e9",
"id": "https://www.grid.ac/institutes/grid.6363.0",
"name": [
"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), 13125, Berlin, Germany",
"NeuroCure Cluster of Excellence, Charit\u00e9 Universit\u00e4tsmedizin, 10117, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Grasskamp",
"givenName": "Andreas T.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Freie Universit\u00e4t Berlin",
"id": "https://www.grid.ac/institutes/grid.14095.39",
"name": [
"NeuroCure Cluster of Excellence, Charit\u00e9 Universit\u00e4tsmedizin, 10117, Berlin, Germany",
"Institute for Biology/Genetics, Freie Universit\u00e4t Berlin, 14195, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Beuschel",
"givenName": "Christine B.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Southern California",
"id": "https://www.grid.ac/institutes/grid.42505.36",
"name": [
"Department of Neurobiology, University of Southern California, 90089, Los Angeles, CA, USA"
],
"type": "Organization"
},
"familyName": "Goel",
"givenName": "Pragya",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Molekulare Pharmakologie",
"id": "https://www.grid.ac/institutes/grid.418832.4",
"name": [
"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), 13125, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Jusyte",
"givenName": "Meida",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Charit\u00e9",
"id": "https://www.grid.ac/institutes/grid.6363.0",
"name": [
"Institut f\u00fcr Neurophysiologie, Charit\u00e9 Universit\u00e4tsmedizin, 10117, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Laber",
"givenName": "Desiree",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Freie Universit\u00e4t Berlin",
"id": "https://www.grid.ac/institutes/grid.14095.39",
"name": [
"Institute for Biology/Genetics, Freie Universit\u00e4t Berlin, 14195, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Huang",
"givenName": "Sheng",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Max Planck Institute of Colloids and Interfaces",
"id": "https://www.grid.ac/institutes/grid.419564.b",
"name": [
"Institute for Biology/Genetics, Freie Universit\u00e4t Berlin, 14195, Berlin, Germany",
"Department of Theory and Bio-systems, Max Planck Institute of Colloids and Interfaces, Science Park Golm, 14424, Potsdam, Germany"
],
"type": "Organization"
},
"familyName": "Rey",
"givenName": "Ulises",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Freie Universit\u00e4t Berlin",
"id": "https://www.grid.ac/institutes/grid.14095.39",
"name": [
"Institute for Biology/Genetics, Freie Universit\u00e4t Berlin, 14195, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Petzoldt",
"givenName": "Astrid G.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Molekulare Pharmakologie",
"id": "https://www.grid.ac/institutes/grid.418832.4",
"name": [
"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), 13125, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Lehmann",
"givenName": "Martin",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Max Planck Institute for Biophysical Chemistry",
"id": "https://www.grid.ac/institutes/grid.418140.8",
"name": [
"Department of Nanobiophotonics, Max Planck Institute for Biophysical Chemistry, 37077, G\u00f6ttingen, Germany"
],
"type": "Organization"
},
"familyName": "G\u00f6ttfert",
"givenName": "Fabian",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Buck Institute for Research on Aging",
"id": "https://www.grid.ac/institutes/grid.272799.0",
"name": [
"Buck Institute for Research on Aging, Novato, CA, USA"
],
"type": "Organization"
},
"familyName": "Haghighi",
"givenName": "Pejmun",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Max Planck Institute for Biophysical Chemistry",
"id": "https://www.grid.ac/institutes/grid.418140.8",
"name": [
"Department of Nanobiophotonics, Max Planck Institute for Biophysical Chemistry, 37077, G\u00f6ttingen, Germany"
],
"type": "Organization"
},
"familyName": "Hell",
"givenName": "Stefan W.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Charit\u00e9",
"id": "https://www.grid.ac/institutes/grid.6363.0",
"name": [
"Institut f\u00fcr Neurophysiologie, Charit\u00e9 Universit\u00e4tsmedizin, 10117, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Owald",
"givenName": "David",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Southern California",
"id": "https://www.grid.ac/institutes/grid.42505.36",
"name": [
"Department of Neurobiology, University of Southern California, 90089, Los Angeles, CA, USA"
],
"type": "Organization"
},
"familyName": "Dickman",
"givenName": "Dion",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Freie Universit\u00e4t Berlin",
"id": "https://www.grid.ac/institutes/grid.14095.39",
"name": [
"NeuroCure Cluster of Excellence, Charit\u00e9 Universit\u00e4tsmedizin, 10117, Berlin, Germany",
"Institute for Biology/Genetics, Freie Universit\u00e4t Berlin, 14195, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Sigrist",
"givenName": "Stephan J.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Molekulare Pharmakologie",
"id": "https://www.grid.ac/institutes/grid.418832.4",
"name": [
"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), 13125, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Walter",
"givenName": "Alexander M.",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1101/pdb.prot5487",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000046988"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2016.02.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000340185"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.2122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000634198",
"https://doi.org/10.1038/nn.2122"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1252884",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002414967"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn959",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002716821",
"https://doi.org/10.1038/nn959"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn959",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002716821",
"https://doi.org/10.1038/nn959"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pgen.1000700",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003617691"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2010.11.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004596045"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2010.11.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004596045"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.288.5466.672",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005433563"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.01180",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005560825"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200812150",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006926355"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.274.5295.2104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007374753"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2008.11.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009689631"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2008.11.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009689631"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1098/rstb.2013.0288",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010013091"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2007.472",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010021075",
"https://doi.org/10.1038/nprot.2007.472"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.5160-12.2013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010216034"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuropharm.2013.06.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010254533"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200908055",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010632210"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2016.07.042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010769665"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2016.07.042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010769665"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn1808",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011202054",
"https://doi.org/10.1038/nn1808"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn1808",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011202054",
"https://doi.org/10.1038/nn1808"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2011.01.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011890003"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0896-6273(94)90022-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012805000"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms9362",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013602582",
"https://doi.org/10.1038/ncomms9362"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0896-6273(00)80415-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014053769"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.3267-12.2012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015830090"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.4364",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016181404",
"https://doi.org/10.1038/nn.4364"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms5650",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016328859",
"https://doi.org/10.1038/ncomms5650"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.04577",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017281005"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/sj.emboj.7600753",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017608892"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms13660",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018067256",
"https://doi.org/10.1038/ncomms13660"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2005.10.047",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020787271"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2012.06.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021739266"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.3848-08.2009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023514674"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2015.03.046",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024159444"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.3137",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024289159",
"https://doi.org/10.1038/nn.3137"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.6698-10.2011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024292845"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2015.01.024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025413292"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2015.01.024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025413292"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.201601098",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025777687"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.3553-03.2004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026023933"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev-physiol-021014-071740",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027308664"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pcbi.1004407",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027910455"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2006.09.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028101649"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2008.09.057",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028380001"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2008.09.057",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028380001"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2015.03.025",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029599773"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.1000193",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029724096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2006.09.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030034191"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(94)90398-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031860215"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/262576a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032905521",
"https://doi.org/10.1038/262576a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/262576a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032905521",
"https://doi.org/10.1038/262576a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuropharm.2013.02.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033189919"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3791/3625",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038111375"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.00967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040278547"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0896-6273(02)00643-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042851996"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.06935",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043200262"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2014.03.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044117530"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0896-6273(02)00589-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044357733"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2012.04.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045763528"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2012.04.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045763528"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.0040192",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046549769"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1126308",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047488338"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2006.11.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047607576"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.0981-12.2012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047738035"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bpj.2013.05.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048113354"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bpj.2013.05.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048113354"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.npp.1301559",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049375841",
"https://doi.org/10.1038/sj.npp.1301559"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2016.07.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051647316"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01350033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051837300",
"https://doi.org/10.1007/bf01350033"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/cshperspect.a005728",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052164485"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.2767",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052866081",
"https://doi.org/10.1038/nn.2767"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/neuro.04.017.2009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053282232"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature19058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053337007",
"https://doi.org/10.1038/nature19058"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/pdb.prot068601",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060409368"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1212991",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062465594"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.19-08-03023.1999",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074353886"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.23-16-06546.2003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1075320689"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/eneuro.0335-16.2017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083789413"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1621495114",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083808986"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2017.02.028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084098870"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2017.02.028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084098870"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms15293",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085378079",
"https://doi.org/10.1038/ncomms15293"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2017.07.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090943410"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2017.07.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090943410"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2017.08.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091395810"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/550s109a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092261927",
"https://doi.org/10.1038/550s109a"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/550s109a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092261927",
"https://doi.org/10.1038/550s109a"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2017.10.116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1093051055"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neures.2017.09.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099604354"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41593-017-0041-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099725402",
"https://doi.org/10.1038/s41593-017-0041-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neures.2017.12.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099909492"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neures.2017.12.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099909492"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41467-017-02494-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100351815",
"https://doi.org/10.1038/s41467-017-02494-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.34338",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103173621"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.34338",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103173621"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.34338",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103173621"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.34338",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103173621"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41593-018-0138-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103549274",
"https://doi.org/10.1038/s41593-018-0138-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41593-018-0138-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103549274",
"https://doi.org/10.1038/s41593-018-0138-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.38268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1105457254"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.38268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1105457254"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.38183",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1107825664"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.40385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1109831971"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.40385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1109831971"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.40385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1109831971"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.40385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1109831971"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.3068-18.2019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1111748760"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.3068-18.2019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1111748760"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.3068-18.2019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1111748760"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "Neuronal communication across synapses relies on neurotransmitter release from presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic plasticity homeostatically maintains functionality during perturbations and enables memory formation. Postsynaptic plasticity targets neurotransmitter receptors, but presynaptic mechanisms regulating the neurotransmitter release apparatus remain largely enigmatic. By studying Drosophila neuromuscular junctions (NMJs) we show that AZs consist of nano-modular release sites and identify a molecular sequence that adds modules within minutes of inducing homeostatic plasticity. This requires cognate transport machinery and specific AZ-scaffolding proteins. Structural remodeling is not required for immediate potentiation of neurotransmitter release, but necessary to sustain potentiation over longer timescales. Finally, mutations in Unc13 disrupting homeostatic plasticity at the NMJ also impair short-term memory when central neurons are targeted, suggesting that both plasticity mechanisms utilize Unc13. Together, while immediate synaptic potentiation capitalizes on available material, it triggers the coincident incorporation of modular release sites to consolidate synaptic potentiation.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41467-019-08977-6",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.3867213",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1043282",
"issn": [
"2041-1723"
],
"name": "Nature Communications",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "10"
}
],
"name": "Rapid active zone remodeling consolidates presynaptic potentiation",
"pagination": "1085",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41467-019-08977-6"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"d909e4c073716ed4bed7e2374225768ad22ff5592e3f16199f86840b9cbb042f"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112581205"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101528555"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30842428"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41467-019-08977-6",
"https://app.dimensions.ai/details/publication/pub.1112581205"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-15T09:00",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91438_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41467-019-08977-6"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08977-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08977-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08977-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08977-6'
This table displays all metadata directly associated to this object as RDF triples.
556 TRIPLES
21 PREDICATES
137 URIs
40 LITERALS
28 BLANK NODES