Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Huabin Zhu, Brinda Bhatt, Sathish Sivaprakasam, Yafei Cai, Siyang Liu, Sai Karthik Kodeboyina, Nikhil Patel, Natasha M. Savage, Ashok Sharma, Randal J. Kaufman, Honglin Li, Nagendra Singh

ABSTRACT

The IRE1α/XBP1 branch of unfolded protein response (UPR) pathway has a critical function in endoplasmic reticulum (ER) expansion in plasma cells via unknown mechanisms; interestingly, another UPR branch, PERK, is suppressed during plasma cell development. Here we show that Ufbp1, a target and cofactor of the ufmylation pathway, promotes plasma cell development by suppressing the activation of PERK. By contrast, the IRE1α/XBP1 axis upregulates the expression of Ufbp1 and ufmylation pathway genes in plasma cells, while Ufbp1 deficiency impairs ER expansion in plasma cells and retards immunoglobulin production. Structure and function analysis suggests that lysine 267 of Ufbp1, the main lysine in Ufbp1 that undergoes ufmylation, is dispensable for the development of plasmablasts, but is required for immunoglobulin production and stimulation of ER expansion in IRE1α-deficient plasmablasts. Thus, Ufbp1 distinctly regulates different branches of UPR pathway to promote plasma cell development and function. More... »

PAGES

1084

References to SciGraph publications

  • 2011-03. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress in NATURE CELL BIOLOGY
  • 2001-07. Plasma cell differentiation requires the transcription factor XBP-1 in NATURE
  • 2006-07. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination in NATURE IMMUNOLOGY
  • 2015-12. RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis in CELL DEATH & DIFFERENTIATION
  • 2015-03. The generation of antibody-secreting plasma cells in NATURE REVIEWS IMMUNOLOGY
  • 2004-06. The transcriptional programme of antibody class switching involves the repressor Bach2 in NATURE
  • 2010-05. Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response in CELL STRESS AND CHAPERONES
  • 2015-12. Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8 in NATURE IMMUNOLOGY
  • 2016-03. Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response in NATURE IMMUNOLOGY
  • 2011-09. The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice in NATURE COMMUNICATIONS
  • 2014-09. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease in NATURE GENETICS
  • 2012-05. The translational landscape of mTOR signalling steers cancer initiation and metastasis in NATURE
  • 2014-06. The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress in NATURE
  • 2017-01-27. A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability in NATURE COMMUNICATIONS
  • 2015-06. Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells in NATURE IMMUNOLOGY
  • 2000-12. BLIMP-1 mediates extinction of major histocompatibility class II transactivator expression in plasma cells in NATURE IMMUNOLOGY
  • 2005-12. Isolation and Characterization of Ubiquitin-activating Enzyme E1-domain Containing 1, UBE1DC1 in MOLECULAR BIOLOGY REPORTS
  • 2016-07. Genome-wide association studies identify genetic loci for low von Willebrand factor levels in EUROPEAN JOURNAL OF HUMAN GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-08908-5

    DOI

    http://dx.doi.org/10.1038/s41467-019-08908-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112582204

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30842412


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