The Cep57-pericentrin module organizes PCM expansion and centriole engagement View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02-25

AUTHORS

Koki Watanabe, Daisuke Takao, Kei K Ito, Mikiko Takahashi, Daiju Kitagawa

ABSTRACT

Centriole duplication occurs once per cell cycle to ensure robust formation of bipolar spindles and chromosome segregation. Each newly-formed daughter centriole remains connected to its mother centriole until late mitosis. The disengagement of the centriole pair is required for centriole duplication. However, the mechanisms underlying centriole engagement remain poorly understood. Here, we show that Cep57 is required for pericentriolar material (PCM) organization that regulates centriole engagement. Depletion of Cep57 causes PCM disorganization and precocious centriole disengagement during mitosis. The disengaged daughter centrioles acquire ectopic microtubule-organizing-center activity, which results in chromosome mis-segregation. Similar defects are observed in mosaic variegated aneuploidy syndrome patient cells with cep57 mutations. We also find that Cep57 binds to the well-conserved PACT domain of pericentrin. Microcephaly osteodysplastic primordial dwarfism disease pericentrin mutations impair the Cep57-pericentrin interaction and lead to PCM disorganization. Together, our work demonstrates that Cep57 provides a critical interface between the centriole core and PCM. More... »

PAGES

931

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-08862-2

DOI

http://dx.doi.org/10.1038/s41467-019-08862-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112364087

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30804344


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