ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

M. Teresa Bertran, Stéphane Mouilleron, Yanxiang Zhou, Rakhi Bajaj, Federico Uliana, Ganesan Senthil Kumar, Audrey van Drogen, Rebecca Lee, Jennifer J. Banerjee, Simon Hauri, Nicola O’Reilly, Matthias Gstaiger, Rebecca Page, Wolfgang Peti, Nicolas Tapon

ABSTRACT

Serine/threonine phosphatases such as PP1 lack substrate specificity and associate with a large array of targeting subunits to achieve the requisite selectivity. The tumour suppressor ASPP (apoptosis-stimulating protein of p53) proteins associate with PP1 catalytic subunits and are implicated in multiple functions from transcriptional regulation to cell junction remodelling. Here we show that Drosophila ASPP is part of a multiprotein PP1 complex and that PP1 association is necessary for several in vivo functions of Drosophila ASPP. We solve the crystal structure of the human ASPP2/PP1 complex and show that ASPP2 recruits PP1 using both its canonical RVxF motif, which binds the PP1 catalytic domain, and its SH3 domain, which engages the PP1 C-terminal tail. The ASPP2 SH3 domain can discriminate between PP1 isoforms using an acidic specificity pocket in the n-Src domain, providing an exquisite mechanism where multiple motifs are used combinatorially to tune binding affinity to PP1. More... »

PAGES

771

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-08686-0

DOI

http://dx.doi.org/10.1038/s41467-019-08686-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112165478

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30770806


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis Regulatory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catalytic Domain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Phosphatase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substrate Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "src Homology Domains", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bertran", 
        "givenName": "M. Teresa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Structural Biology - Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mouilleron", 
        "givenName": "St\u00e9phane", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Yanxiang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Chemistry and Biochemistry Department, University of Arizona, 1041 E. Lowell Street, Biosciences West, 517, 85721, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bajaj", 
        "givenName": "Rakhi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swiss Federal Institute of Technology in Zurich", 
          "id": "https://www.grid.ac/institutes/grid.5801.c", 
          "name": [
            "Department of Biology, Institute of Molecular Systems Biology, ETH Z\u00fcrich, 8093, Z\u00fcrich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uliana", 
        "givenName": "Federico", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Chemistry and Biochemistry Department, University of Arizona, 1041 E. Lowell Street, Biosciences West, 517, 85721, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumar", 
        "givenName": "Ganesan Senthil", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swiss Federal Institute of Technology in Zurich", 
          "id": "https://www.grid.ac/institutes/grid.5801.c", 
          "name": [
            "Department of Biology, Institute of Molecular Systems Biology, ETH Z\u00fcrich, 8093, Z\u00fcrich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Drogen", 
        "givenName": "Audrey", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Structural Biology - Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Rebecca", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Banerjee", 
        "givenName": "Jennifer J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swiss Federal Institute of Technology in Zurich", 
          "id": "https://www.grid.ac/institutes/grid.5801.c", 
          "name": [
            "Department of Biology, Institute of Molecular Systems Biology, ETH Z\u00fcrich, 8093, Z\u00fcrich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hauri", 
        "givenName": "Simon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Peptide Chemistry Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Reilly", 
        "givenName": "Nicola", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swiss Federal Institute of Technology in Zurich", 
          "id": "https://www.grid.ac/institutes/grid.5801.c", 
          "name": [
            "Department of Biology, Institute of Molecular Systems Biology, ETH Z\u00fcrich, 8093, Z\u00fcrich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gstaiger", 
        "givenName": "Matthias", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Chemistry and Biochemistry Department, University of Arizona, 1041 E. Lowell Street, Biosciences West, 517, 85721, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Page", 
        "givenName": "Rebecca", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Chemistry and Biochemistry Department, University of Arizona, 1041 E. Lowell Street, Biosciences West, 517, 85721, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peti", 
        "givenName": "Wolfgang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tapon", 
        "givenName": "Nicolas", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1107/s0907444910007493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000235100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444910007493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000235100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.074773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000365948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444913015308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000406951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2012.08547.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002649733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m703472200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002916962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2006.08.094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004073653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.07-092841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004840735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(95)01347-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006004209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2012.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009027493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2006.02.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009244931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trsl.2014.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009296502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/msb.201304750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010123291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/msb.201304750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010123291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2012.08535.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010635936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011233561", 
          "https://doi.org/10.1038/sj.bjc.6603525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011233561", 
          "https://doi.org/10.1038/sj.bjc.6603525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m203365200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011541075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2010.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012403844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2010.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012403844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889807021206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012753217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.15.12.6829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013829606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2012.04.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013913259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1317395111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014288137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2010.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015628916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2010.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015628916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coph.2016.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016241096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.01641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016708031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1022836027055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017323120", 
          "https://doi.org/10.1023/a:1022836027055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.6355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017678840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.106.069914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017966370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.106.069914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017966370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019225036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m701272200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019630386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.088757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020133420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0111384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021647197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.04871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022027735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.04871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022027735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.111310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024432136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024504943", 
          "https://doi.org/10.1038/nature02582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024504943", 
          "https://doi.org/10.1038/nature02582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1001492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027355513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.270751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028005353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20100883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028530778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20100883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028530778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2012.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028830161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2012.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028830161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/msb.2008.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029551850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/msb.2008.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029551850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2015.02.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031418035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20120506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031749944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20120506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031749944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.116277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032989644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb1101-998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033216784", 
          "https://doi.org/10.1038/nsb1101-998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m300175200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033568892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035046377", 
          "https://doi.org/10.1038/nsmb.1786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035046377", 
          "https://doi.org/10.1038/nsmb.1786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/376745a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035124605", 
          "https://doi.org/10.1038/376745a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035389711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035540766", 
          "https://doi.org/10.1038/ng1312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035540766", 
          "https://doi.org/10.1038/ng1312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cb300597g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036016014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2009.10.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036389554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2009.10.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036389554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.111054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036665745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037529414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2009.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037843913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.05.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038120899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.05.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038120899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1110/ps.051563605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038321450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1110/ps.051563605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038321450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2012.08509.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038532043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2010.06.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038807508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200508154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038877781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2007.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039595242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2007.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039595242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2015.01.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040765389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2015.01.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040765389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.8.1876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041722677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998006684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044366173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2013.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045222064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.16539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046322915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047379825", 
          "https://doi.org/10.1038/nmeth.1322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047379825", 
          "https://doi.org/10.1038/nmeth.1322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.12.7870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047685612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049469421", 
          "https://doi.org/10.1038/nbt.1511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.194019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050584184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.12068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051574564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.21.13217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052395623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m115.703108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058214351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.274.5289.1001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062554681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/stke.2003.179.re8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062691482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074785694", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20160154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083841742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20160154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083841742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2018.06.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106061457"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Serine/threonine phosphatases such as PP1 lack substrate specificity and associate with a large array of targeting subunits to achieve the requisite selectivity. The tumour suppressor ASPP (apoptosis-stimulating protein of p53) proteins associate with PP1 catalytic subunits and are implicated in multiple functions from transcriptional regulation to cell junction remodelling. Here we show that Drosophila ASPP is part of a multiprotein PP1 complex and that PP1 association is necessary for several in vivo functions of Drosophila ASPP. We solve the crystal structure of the human ASPP2/PP1 complex and show that ASPP2 recruits PP1 using both its canonical RVxF motif, which binds the PP1 catalytic domain, and its SH3 domain, which engages the PP1 C-terminal tail. The ASPP2 SH3 domain can discriminate between PP1 isoforms using an acidic specificity pocket in the n-Src domain, providing an exquisite mechanism where multiple motifs are used combinatorially to tune binding affinity to PP1.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-019-08686-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2521344", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6798142", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4579955", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5493182", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3867214", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail", 
    "pagination": "771", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-019-08686-0"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6cd4007089b8194ac1b3df6f348495cc9e76bc254252c8e4439493bc8dbd2a39"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112165478"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30770806"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-019-08686-0", 
      "https://app.dimensions.ai/details/publication/pub.1112165478"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119741_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-019-08686-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08686-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08686-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08686-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08686-0'


 

This table displays all metadata directly associated to this object as RDF triples.

453 TRIPLES      21 PREDICATES      117 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-019-08686-0 schema:about N5d271f10da0e4a8da4e30edfd60912c0
2 N6a646f7d98f746a6ad59615db89b7068
3 N912921e3ca0045ee84e0b5aaa268c117
4 N95dfb2d6aed34288bdfdd3abca31d6bf
5 N9be0484b73df43bc851907a8042f69ff
6 Na33ddca687bc4dfdb97d8762d2bc8d30
7 Nba7b2d7b5a0d4496b61960bb9de673bb
8 Nc71a1b3ea11d4a299c5709b07f24dfdf
9 Nde0dff98997a42f3bc8fc07d63dc7d89
10 Nde1555ce55c64e2488fe829a9b9fbcea
11 Nf1449cf1898d425ab32ca756c3a9d576
12 Nf6b71d582f4e473aa5d7ae5a7b4a8338
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author N4ee341bb458545e0a68ba8b3f53834d0
16 schema:citation sg:pub.10.1023/a:1022836027055
17 sg:pub.10.1038/376745a0
18 sg:pub.10.1038/nature02582
19 sg:pub.10.1038/nbt.1511
20 sg:pub.10.1038/ng1312
21 sg:pub.10.1038/nmeth.1322
22 sg:pub.10.1038/nsb1101-998
23 sg:pub.10.1038/nsmb.1786
24 sg:pub.10.1038/sj.bjc.6603525
25 https://app.dimensions.ai/details/publication/pub.1074785694
26 https://doi.org/10.1002/msb.201304750
27 https://doi.org/10.1016/0014-5793(95)01347-4
28 https://doi.org/10.1016/j.bbrc.2015.01.136
29 https://doi.org/10.1016/j.bmc.2015.02.040
30 https://doi.org/10.1016/j.celrep.2015.05.043
31 https://doi.org/10.1016/j.chembiol.2009.02.012
32 https://doi.org/10.1016/j.coph.2016.05.002
33 https://doi.org/10.1016/j.cub.2009.10.027
34 https://doi.org/10.1016/j.cub.2010.06.024
35 https://doi.org/10.1016/j.devcel.2007.11.005
36 https://doi.org/10.1016/j.devcel.2010.06.003
37 https://doi.org/10.1016/j.febslet.2012.04.042
38 https://doi.org/10.1016/j.jmb.2006.02.027
39 https://doi.org/10.1016/j.jmb.2006.08.094
40 https://doi.org/10.1016/j.jmb.2012.08.005
41 https://doi.org/10.1016/j.jmb.2013.03.018
42 https://doi.org/10.1016/j.molcel.2009.02.015
43 https://doi.org/10.1016/j.str.2012.08.003
44 https://doi.org/10.1016/j.str.2018.06.013
45 https://doi.org/10.1016/j.tibs.2010.03.002
46 https://doi.org/10.1016/j.trsl.2014.07.001
47 https://doi.org/10.1021/cb300597g
48 https://doi.org/10.1038/msb.2008.75
49 https://doi.org/10.1042/bj20100883
50 https://doi.org/10.1042/bj20120506
51 https://doi.org/10.1042/bst20160154
52 https://doi.org/10.1073/pnas.1317395111
53 https://doi.org/10.1074/jbc.273.21.13217
54 https://doi.org/10.1074/jbc.274.12.7870
55 https://doi.org/10.1074/jbc.m109.074773
56 https://doi.org/10.1074/jbc.m110.194019
57 https://doi.org/10.1074/jbc.m111.270751
58 https://doi.org/10.1074/jbc.m115.703108
59 https://doi.org/10.1074/jbc.m203365200
60 https://doi.org/10.1074/jbc.m300175200
61 https://doi.org/10.1074/jbc.m701272200
62 https://doi.org/10.1074/jbc.m703472200
63 https://doi.org/10.1083/jcb.200508154
64 https://doi.org/10.1093/emboj/16.8.1876
65 https://doi.org/10.1093/emboj/cdf428
66 https://doi.org/10.1093/nar/gkv500
67 https://doi.org/10.1096/fj.07-092841
68 https://doi.org/10.1107/s0021889807021206
69 https://doi.org/10.1107/s0907444909052925
70 https://doi.org/10.1107/s0907444910007493
71 https://doi.org/10.1107/s0907444913015308
72 https://doi.org/10.1107/s0907444998006684
73 https://doi.org/10.1110/ps.051563605
74 https://doi.org/10.1111/j.1742-4658.2012.08509.x
75 https://doi.org/10.1111/j.1742-4658.2012.08535.x
76 https://doi.org/10.1111/j.1742-4658.2012.08547.x
77 https://doi.org/10.1126/science.274.5289.1001
78 https://doi.org/10.1126/stke.2003.179.re8
79 https://doi.org/10.1128/mcb.15.12.6829
80 https://doi.org/10.1242/dev.088757
81 https://doi.org/10.1242/dev.111054
82 https://doi.org/10.1242/dev.111310
83 https://doi.org/10.1242/dev.116277
84 https://doi.org/10.1371/journal.pbio.1001492
85 https://doi.org/10.1371/journal.pone.0111384
86 https://doi.org/10.1534/genetics.106.069914
87 https://doi.org/10.18632/oncotarget.6355
88 https://doi.org/10.7554/elife.01641
89 https://doi.org/10.7554/elife.04871
90 https://doi.org/10.7554/elife.12068
91 https://doi.org/10.7554/elife.16539
92 schema:datePublished 2019-12
93 schema:datePublishedReg 2019-12-01
94 schema:description Serine/threonine phosphatases such as PP1 lack substrate specificity and associate with a large array of targeting subunits to achieve the requisite selectivity. The tumour suppressor ASPP (apoptosis-stimulating protein of p53) proteins associate with PP1 catalytic subunits and are implicated in multiple functions from transcriptional regulation to cell junction remodelling. Here we show that Drosophila ASPP is part of a multiprotein PP1 complex and that PP1 association is necessary for several in vivo functions of Drosophila ASPP. We solve the crystal structure of the human ASPP2/PP1 complex and show that ASPP2 recruits PP1 using both its canonical RVxF motif, which binds the PP1 catalytic domain, and its SH3 domain, which engages the PP1 C-terminal tail. The ASPP2 SH3 domain can discriminate between PP1 isoforms using an acidic specificity pocket in the n-Src domain, providing an exquisite mechanism where multiple motifs are used combinatorially to tune binding affinity to PP1.
95 schema:genre research_article
96 schema:inLanguage en
97 schema:isAccessibleForFree true
98 schema:isPartOf N20aabe37f91844138255b809a712d806
99 N84a0dceb575c4b4c87507a37dc43681d
100 sg:journal.1043282
101 schema:name ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail
102 schema:pagination 771
103 schema:productId N1dbd13a369844db09fcdd2694e07d872
104 N92288a6732ca4eddb8ef15da82447a9f
105 Ne3cbff4b7ca94ca18876fa4344d98efd
106 Nefe009c63ab9438aabe30cfe8cc0f231
107 Nf0b0cde1af564addbf1749439ff13c41
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112165478
109 https://doi.org/10.1038/s41467-019-08686-0
110 schema:sdDatePublished 2019-04-15T08:52
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher Nd324c53974e642c4949e1092af05e0c9
113 schema:url https://www.nature.com/articles/s41467-019-08686-0
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N08d639b7dfd44cdfa46dceec2050ee53 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
118 schema:familyName Kumar
119 schema:givenName Ganesan Senthil
120 rdf:type schema:Person
121 N0a2ef3d16f2c40aab329a9144321f2dd rdf:first N5bff2123d39343779e4509ccbd2d8f3d
122 rdf:rest N762b8736ae4544048b8459e97ad6e13d
123 N0f38965e2c214848b2e32e826a0feade rdf:first Nd23a0a009e1e4bed9cb3c7bb98253ce2
124 rdf:rest Nc566bd9e20c44babb799af1e184d2024
125 N1dbd13a369844db09fcdd2694e07d872 schema:name readcube_id
126 schema:value 6cd4007089b8194ac1b3df6f348495cc9e76bc254252c8e4439493bc8dbd2a39
127 rdf:type schema:PropertyValue
128 N20aabe37f91844138255b809a712d806 schema:volumeNumber 10
129 rdf:type schema:PublicationVolume
130 N24852093e23940108e288760be0dda39 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
131 schema:familyName O’Reilly
132 schema:givenName Nicola
133 rdf:type schema:Person
134 N2ee600a455894019b68c5ab0be7a19f7 rdf:first N24852093e23940108e288760be0dda39
135 rdf:rest N0f38965e2c214848b2e32e826a0feade
136 N30441081f8e8430889eb52c09854917a rdf:first Nfdece15fca754f5b91cedad98b68cf59
137 rdf:rest Ndf1849e45f1e44a8a151fd513c4d530a
138 N47e271a711ce4fe582a43b24ff01056e schema:affiliation https://www.grid.ac/institutes/grid.5801.c
139 schema:familyName van Drogen
140 schema:givenName Audrey
141 rdf:type schema:Person
142 N4ee341bb458545e0a68ba8b3f53834d0 rdf:first Ncfc52dbcad1f4849bf4dfa557ee01d33
143 rdf:rest N71996f21a4c44d0a8bfbf30aa3e5857c
144 N5bff2123d39343779e4509ccbd2d8f3d schema:affiliation https://www.grid.ac/institutes/grid.451388.3
145 schema:familyName Banerjee
146 schema:givenName Jennifer J.
147 rdf:type schema:Person
148 N5d271f10da0e4a8da4e30edfd60912c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Protein Phosphatase 1
150 rdf:type schema:DefinedTerm
151 N63e7c3a4be7a454d97a0d0c7168d6efa rdf:first N9453f1b3fadf4318a39680c0caa39072
152 rdf:rest Ncb6708e10801428ba5789c2671177051
153 N6a646f7d98f746a6ad59615db89b7068 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Binding Sites
155 rdf:type schema:DefinedTerm
156 N711c3565134741178248df3f6a2c35ba schema:affiliation https://www.grid.ac/institutes/grid.451388.3
157 schema:familyName Mouilleron
158 schema:givenName Stéphane
159 rdf:type schema:Person
160 N71996f21a4c44d0a8bfbf30aa3e5857c rdf:first N711c3565134741178248df3f6a2c35ba
161 rdf:rest Nf91eb5d8c2664add8bd04f2553b1425f
162 N71f2717bcda1401c9f32d2befda48746 rdf:first N08d639b7dfd44cdfa46dceec2050ee53
163 rdf:rest Nd794d95502d145abbbf5837f4c9f176a
164 N762b8736ae4544048b8459e97ad6e13d rdf:first Ne3e268cff1554bb3b99714774885439d
165 rdf:rest N2ee600a455894019b68c5ab0be7a19f7
166 N84a0dceb575c4b4c87507a37dc43681d schema:issueNumber 1
167 rdf:type schema:PublicationIssue
168 N912921e3ca0045ee84e0b5aaa268c117 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name src Homology Domains
170 rdf:type schema:DefinedTerm
171 N92288a6732ca4eddb8ef15da82447a9f schema:name doi
172 schema:value 10.1038/s41467-019-08686-0
173 rdf:type schema:PropertyValue
174 N9453f1b3fadf4318a39680c0caa39072 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
175 schema:familyName Bajaj
176 schema:givenName Rakhi
177 rdf:type schema:Person
178 N95dfb2d6aed34288bdfdd3abca31d6bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 N9be0484b73df43bc851907a8042f69ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Apoptosis Regulatory Proteins
183 rdf:type schema:DefinedTerm
184 Na33ddca687bc4dfdb97d8762d2bc8d30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Protein Binding
186 rdf:type schema:DefinedTerm
187 Nae0c933e90e04647bc4d277989bdf88c schema:affiliation https://www.grid.ac/institutes/grid.134563.6
188 schema:familyName Page
189 schema:givenName Rebecca
190 rdf:type schema:Person
191 Naeff071e41d74733ae07158a10d2e429 rdf:first Nbff21fea32544f07b9a9adaf99d2f6f4
192 rdf:rest N0a2ef3d16f2c40aab329a9144321f2dd
193 Nba7b2d7b5a0d4496b61960bb9de673bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Amino Acid Sequence
195 rdf:type schema:DefinedTerm
196 Nbff21fea32544f07b9a9adaf99d2f6f4 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
197 schema:familyName Lee
198 schema:givenName Rebecca
199 rdf:type schema:Person
200 Nc566bd9e20c44babb799af1e184d2024 rdf:first Nae0c933e90e04647bc4d277989bdf88c
201 rdf:rest N30441081f8e8430889eb52c09854917a
202 Nc71a1b3ea11d4a299c5709b07f24dfdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Drosophila Proteins
204 rdf:type schema:DefinedTerm
205 Ncb6708e10801428ba5789c2671177051 rdf:first Nfb5db2ce3a334cab93b2c294313fa3c7
206 rdf:rest N71f2717bcda1401c9f32d2befda48746
207 Ncd00c59d89a044babca70b3e6c0088b0 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
208 schema:familyName Tapon
209 schema:givenName Nicolas
210 rdf:type schema:Person
211 Ncfc52dbcad1f4849bf4dfa557ee01d33 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
212 schema:familyName Bertran
213 schema:givenName M. Teresa
214 rdf:type schema:Person
215 Nd23a0a009e1e4bed9cb3c7bb98253ce2 schema:affiliation https://www.grid.ac/institutes/grid.5801.c
216 schema:familyName Gstaiger
217 schema:givenName Matthias
218 rdf:type schema:Person
219 Nd324c53974e642c4949e1092af05e0c9 schema:name Springer Nature - SN SciGraph project
220 rdf:type schema:Organization
221 Nd794d95502d145abbbf5837f4c9f176a rdf:first N47e271a711ce4fe582a43b24ff01056e
222 rdf:rest Naeff071e41d74733ae07158a10d2e429
223 Nde0dff98997a42f3bc8fc07d63dc7d89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Substrate Specificity
225 rdf:type schema:DefinedTerm
226 Nde1555ce55c64e2488fe829a9b9fbcea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Animals
228 rdf:type schema:DefinedTerm
229 Ndf1849e45f1e44a8a151fd513c4d530a rdf:first Ncd00c59d89a044babca70b3e6c0088b0
230 rdf:rest rdf:nil
231 Ne3cbff4b7ca94ca18876fa4344d98efd schema:name pubmed_id
232 schema:value 30770806
233 rdf:type schema:PropertyValue
234 Ne3e268cff1554bb3b99714774885439d schema:affiliation https://www.grid.ac/institutes/grid.5801.c
235 schema:familyName Hauri
236 schema:givenName Simon
237 rdf:type schema:Person
238 Nefe009c63ab9438aabe30cfe8cc0f231 schema:name dimensions_id
239 schema:value pub.1112165478
240 rdf:type schema:PropertyValue
241 Nf0b0cde1af564addbf1749439ff13c41 schema:name nlm_unique_id
242 schema:value 101528555
243 rdf:type schema:PropertyValue
244 Nf1449cf1898d425ab32ca756c3a9d576 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
245 schema:name Drosophila
246 rdf:type schema:DefinedTerm
247 Nf6b71d582f4e473aa5d7ae5a7b4a8338 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
248 schema:name Catalytic Domain
249 rdf:type schema:DefinedTerm
250 Nf91eb5d8c2664add8bd04f2553b1425f rdf:first Nfadfc0c5cfec4a15a0f96ba05802e140
251 rdf:rest N63e7c3a4be7a454d97a0d0c7168d6efa
252 Nfadfc0c5cfec4a15a0f96ba05802e140 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
253 schema:familyName Zhou
254 schema:givenName Yanxiang
255 rdf:type schema:Person
256 Nfb5db2ce3a334cab93b2c294313fa3c7 schema:affiliation https://www.grid.ac/institutes/grid.5801.c
257 schema:familyName Uliana
258 schema:givenName Federico
259 rdf:type schema:Person
260 Nfdece15fca754f5b91cedad98b68cf59 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
261 schema:familyName Peti
262 schema:givenName Wolfgang
263 rdf:type schema:Person
264 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
265 schema:name Biological Sciences
266 rdf:type schema:DefinedTerm
267 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
268 schema:name Biochemistry and Cell Biology
269 rdf:type schema:DefinedTerm
270 sg:grant.2521344 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08686-0
271 rdf:type schema:MonetaryGrant
272 sg:grant.3867214 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08686-0
273 rdf:type schema:MonetaryGrant
274 sg:grant.4579955 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08686-0
275 rdf:type schema:MonetaryGrant
276 sg:grant.5493182 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08686-0
277 rdf:type schema:MonetaryGrant
278 sg:grant.6798142 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08686-0
279 rdf:type schema:MonetaryGrant
280 sg:journal.1043282 schema:issn 2041-1723
281 schema:name Nature Communications
282 rdf:type schema:Periodical
283 sg:pub.10.1023/a:1022836027055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017323120
284 https://doi.org/10.1023/a:1022836027055
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/376745a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035124605
287 https://doi.org/10.1038/376745a0
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/nature02582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024504943
290 https://doi.org/10.1038/nature02582
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/nbt.1511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049469421
293 https://doi.org/10.1038/nbt.1511
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/ng1312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035540766
296 https://doi.org/10.1038/ng1312
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/nmeth.1322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047379825
299 https://doi.org/10.1038/nmeth.1322
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/nsb1101-998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033216784
302 https://doi.org/10.1038/nsb1101-998
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/nsmb.1786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035046377
305 https://doi.org/10.1038/nsmb.1786
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/sj.bjc.6603525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011233561
308 https://doi.org/10.1038/sj.bjc.6603525
309 rdf:type schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1074785694 schema:CreativeWork
311 https://doi.org/10.1002/msb.201304750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010123291
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/0014-5793(95)01347-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006004209
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.bbrc.2015.01.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040765389
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.bmc.2015.02.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031418035
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.celrep.2015.05.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038120899
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.chembiol.2009.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037843913
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.coph.2016.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016241096
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.cub.2009.10.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036389554
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.cub.2010.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038807508
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.devcel.2007.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039595242
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.devcel.2010.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015628916
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.febslet.2012.04.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013913259
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.jmb.2006.02.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009244931
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.jmb.2006.08.094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004073653
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.jmb.2012.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009027493
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.jmb.2013.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045222064
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/j.molcel.2009.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037529414
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/j.str.2012.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028830161
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/j.str.2018.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106061457
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/j.tibs.2010.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012403844
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/j.trsl.2014.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009296502
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1021/cb300597g schema:sameAs https://app.dimensions.ai/details/publication/pub.1036016014
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1038/msb.2008.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029551850
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1042/bj20100883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028530778
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1042/bj20120506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031749944
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1042/bst20160154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083841742
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1073/pnas.1317395111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014288137
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1074/jbc.273.21.13217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052395623
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1074/jbc.274.12.7870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047685612
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1074/jbc.m109.074773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000365948
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1074/jbc.m110.194019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050584184
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1074/jbc.m111.270751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028005353
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1074/jbc.m115.703108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058214351
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1074/jbc.m203365200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011541075
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1074/jbc.m300175200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033568892
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1074/jbc.m701272200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019630386
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1074/jbc.m703472200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002916962
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1083/jcb.200508154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038877781
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1093/emboj/16.8.1876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041722677
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1093/emboj/cdf428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019225036
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1093/nar/gkv500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035389711
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1096/fj.07-092841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004840735
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1107/s0021889807021206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012753217
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1107/s0907444909052925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777046
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1107/s0907444910007493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000235100
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1107/s0907444913015308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000406951
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1107/s0907444998006684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044366173
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1110/ps.051563605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038321450
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1111/j.1742-4658.2012.08509.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038532043
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1111/j.1742-4658.2012.08535.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010635936
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1111/j.1742-4658.2012.08547.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002649733
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1126/science.274.5289.1001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554681
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1126/stke.2003.179.re8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062691482
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1128/mcb.15.12.6829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013829606
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1242/dev.088757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020133420
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1242/dev.111054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036665745
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1242/dev.111310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024432136
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1242/dev.116277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032989644
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1371/journal.pbio.1001492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027355513
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1371/journal.pone.0111384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021647197
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1534/genetics.106.069914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017966370
432 rdf:type schema:CreativeWork
433 https://doi.org/10.18632/oncotarget.6355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017678840
434 rdf:type schema:CreativeWork
435 https://doi.org/10.7554/elife.01641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016708031
436 rdf:type schema:CreativeWork
437 https://doi.org/10.7554/elife.04871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022027735
438 rdf:type schema:CreativeWork
439 https://doi.org/10.7554/elife.12068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051574564
440 rdf:type schema:CreativeWork
441 https://doi.org/10.7554/elife.16539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046322915
442 rdf:type schema:CreativeWork
443 https://www.grid.ac/institutes/grid.134563.6 schema:alternateName University of Arizona
444 schema:name Chemistry and Biochemistry Department, University of Arizona, 1041 E. Lowell Street, Biosciences West, 517, 85721, Tucson, AZ, USA
445 rdf:type schema:Organization
446 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
447 schema:name Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK
448 Peptide Chemistry Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK
449 Structural Biology - Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK
450 rdf:type schema:Organization
451 https://www.grid.ac/institutes/grid.5801.c schema:alternateName Swiss Federal Institute of Technology in Zurich
452 schema:name Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, 8093, Zürich, Switzerland
453 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...