Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Rachel J. Perry, Aviva Rabin-Court, Joongyu D. Song, Rebecca L. Cardone, Yongliang Wang, Richard G. Kibbey, Gerald I. Shulman

ABSTRACT

Sodium-glucose transport protein 2 (SGLT2) inhibitors are a class of anti-diabetic agents; however, concerns have been raised about their potential to induce euglycemic ketoacidosis and to increase both glucose production and glucagon secretion. The mechanisms behind these alterations are unknown. Here we show that the SGLT2 inhibitor (SGLT2i) dapagliflozin promotes ketoacidosis in both healthy and type 2 diabetic rats in the setting of insulinopenia through increased plasma catecholamine and corticosterone concentrations secondary to volume depletion. These derangements increase white adipose tissue (WAT) lipolysis and hepatic acetyl-CoA content, rates of hepatic glucose production, and hepatic ketogenesis. Treatment with a loop diuretic, furosemide, under insulinopenic conditions replicates the effect of dapagliflozin and causes ketoacidosis. Furthermore, the effects of SGLT2 inhibition to promote ketoacidosis are independent from hyperglucagonemia. Taken together these data in rats identify the combination of insulinopenia and dehydration as a potential target to prevent euglycemic ketoacidosis associated with SGLT2i. More... »

PAGES

548

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-019-08466-w

DOI

http://dx.doi.org/10.1038/s41467-019-08466-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111837609

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30710078


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzhydryl Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dehydration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucocorticoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucosides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ketosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipolysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Adrenergic, beta-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium-Glucose Transporter 2 Inhibitors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Departments of Internal Medicine, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA", 
            "Departments of Cellular and Molecular Physiology, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perry", 
        "givenName": "Rachel J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Departments of Internal Medicine, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rabin-Court", 
        "givenName": "Aviva", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Departments of Internal Medicine, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Joongyu D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Departments of Internal Medicine, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cardone", 
        "givenName": "Rebecca L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Departments of Internal Medicine, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yongliang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Departments of Internal Medicine, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA", 
            "Departments of Cellular and Molecular Physiology, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kibbey", 
        "givenName": "Richard G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Departments of Internal Medicine, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA", 
            "Departments of Cellular and Molecular Physiology, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shulman", 
        "givenName": "Gerald I.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/dom.12127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001011725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/meta.2000.17721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001505405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2015.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004866748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2169/internalmedicine.56.7501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005064728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci72227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005774065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40268-016-0137-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007120806", 
          "https://doi.org/10.1007/s40268-016-0137-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40268-016-0137-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007120806", 
          "https://doi.org/10.1007/s40268-016-0137-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.01.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008078979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2014.01.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008749214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci70704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009314948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneph.2016.170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009448867", 
          "https://doi.org/10.1038/nrneph.2016.170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00296.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009790781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-015-3845-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010598485", 
          "https://doi.org/10.1007/s00125-015-3845-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-015-3845-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010598485", 
          "https://doi.org/10.1007/s00125-015-3845-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc15-1380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011725783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci109294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012654812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014276972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015376836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci108764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017952828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00210-003-0858-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020698571", 
          "https://doi.org/10.1007/s00210-003-0858-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jphs.2016.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025313857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nutd.2014.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026500443", 
          "https://doi.org/10.1038/nutd.2014.20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4158/ep14489.or", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027605181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jemermed.2016.07.082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028218198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db10-1328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030301468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031444747", 
          "https://doi.org/10.1038/nm.3579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033956920", 
          "https://doi.org/10.1038/nm.3828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(78)90150-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036346143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(78)90150-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036346143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-8587(15)00417-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041327919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci107395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046009247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jdiacomp.2016.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051266499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2015-1884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051974919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep31214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053341804", 
          "https://doi.org/10.1038/srep31214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1439783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062482232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.116.07703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063345153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.116.07703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063345153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db15-1356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070729741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc15-1995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070730129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc15-1995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070730129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc15-2688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070730176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc15-2688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070730176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci88477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074186762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.12881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074226992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1955.184.1.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075606933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11936-017-0522-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084033512", 
          "https://doi.org/10.1007/s11936-017-0522-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11936-017-0522-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084033512", 
          "https://doi.org/10.1007/s11936-017-0522-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc16-2724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084405007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.diabet.2017.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085381383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2324709617710040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085587783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2324709617710040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085587783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1701990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085917007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2324709617712736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085936923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2324709617712736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085936923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.2924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090877724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehx511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091149503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2324709617725351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091333457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2324709617725351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091333457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1708337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091621235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jemermed.2017.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092828997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc17-1096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093166788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100201139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2017.11.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100422265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc17-1721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101029645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000011056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104997788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000011056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104997788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000011056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104997788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajem.2018.08.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106271441"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Sodium-glucose transport protein 2 (SGLT2) inhibitors are a class of anti-diabetic agents; however, concerns have been raised about their potential to induce euglycemic ketoacidosis and to increase both glucose production and glucagon secretion. The mechanisms behind these alterations are unknown. Here we show that the SGLT2 inhibitor (SGLT2i) dapagliflozin promotes ketoacidosis in both healthy and type 2 diabetic rats in the setting of insulinopenia through increased plasma catecholamine and corticosterone concentrations secondary to volume depletion. These derangements increase white adipose tissue (WAT) lipolysis and hepatic acetyl-CoA content, rates of hepatic glucose production, and hepatic ketogenesis. Treatment with a loop diuretic, furosemide, under insulinopenic conditions replicates the effect of dapagliflozin and causes ketoacidosis. Furthermore, the effects of SGLT2 inhibition to promote ketoacidosis are independent from hyperglucagonemia. Taken together these data in rats identify the combination of insulinopenia and dehydration as a potential target to prevent euglycemic ketoacidosis\u00a0associated with SGLT2i.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-019-08466-w", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5475983", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7027891", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3536855", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7725683", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696394", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683100", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705220", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683414", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats", 
    "pagination": "548", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "820565fe87d0f4ff97c9546b1c3d0a7fee5f630f392c39dd4be5047e456c9785"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30710078"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-019-08466-w"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111837609"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-019-08466-w", 
      "https://app.dimensions.ai/details/publication/pub.1111837609"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130817_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-019-08466-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08466-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08466-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08466-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08466-w'


 

This table displays all metadata directly associated to this object as RDF triples.

365 TRIPLES      21 PREDICATES      102 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-019-08466-w schema:about N0d4b1c3e9ba443cabc80e96c71cc123c
2 N29a3b9494e1b421c895a77fb4f3bdaf9
3 N2f7be792db2249ea84fe757e375f4bc6
4 N3106fd12a6e64a14a8a70dffdaee13e9
5 N3445ce64ce9344a79f0b348ba81a0390
6 N3b73f0da3f494e128718064c48c56068
7 N5ff458d8ef1647a59c4bae89ce539f12
8 N79dab8d3cd0d4a8bb15b6ebf2eb4b71e
9 N81ee5a57729449cf89702fca6b5d5c15
10 N8e7a5a8164fa42b2ad5b1e896e498b47
11 N9d361b269c71427eb6800e876cd5bd07
12 Nc9c05b4fd04a4037b8faee0820a6b4f8
13 Ncce11534507944a283c6b8f0d5e892ad
14 Nea8c39b25edd44648a03e5ba2bd3f6f4
15 Ned58e493170f49fea1be6305c0614196
16 Nf86ba986b16b4951b477eed985eae8d5
17 Nfd4040ea171648f58c9be3fc65cd993e
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N33944f1e12cc441d9056156bd7eeee27
21 schema:citation sg:pub.10.1007/s00125-015-3845-8
22 sg:pub.10.1007/s00210-003-0858-5
23 sg:pub.10.1007/s11936-017-0522-x
24 sg:pub.10.1007/s40268-016-0137-9
25 sg:pub.10.1038/nm.3579
26 sg:pub.10.1038/nm.3828
27 sg:pub.10.1038/nrneph.2016.170
28 sg:pub.10.1038/nutd.2014.20
29 sg:pub.10.1038/srep31214
30 https://doi.org/10.1002/dmrr.2924
31 https://doi.org/10.1016/0005-2760(78)90150-9
32 https://doi.org/10.1016/j.ajem.2018.08.054
33 https://doi.org/10.1016/j.cell.2015.01.012
34 https://doi.org/10.1016/j.cell.2017.12.001
35 https://doi.org/10.1016/j.diabet.2017.04.002
36 https://doi.org/10.1016/j.ejphar.2014.01.040
37 https://doi.org/10.1016/j.jacc.2017.11.022
38 https://doi.org/10.1016/j.jdiacomp.2016.02.015
39 https://doi.org/10.1016/j.jemermed.2016.07.082
40 https://doi.org/10.1016/j.jemermed.2017.10.001
41 https://doi.org/10.1016/j.jphs.2016.06.004
42 https://doi.org/10.1016/j.tem.2015.05.011
43 https://doi.org/10.1016/s2213-8587(15)00417-9
44 https://doi.org/10.1053/meta.2000.17721
45 https://doi.org/10.1056/nejmc1701990
46 https://doi.org/10.1056/nejmoa1708337
47 https://doi.org/10.1093/eurheartj/ehx511
48 https://doi.org/10.1097/md.0000000000011056
49 https://doi.org/10.1111/dom.12127
50 https://doi.org/10.1111/dom.12881
51 https://doi.org/10.1126/science.1439783
52 https://doi.org/10.1152/ajpcell.00296.2010
53 https://doi.org/10.1152/ajplegacy.1955.184.1.91
54 https://doi.org/10.1161/hypertensionaha.116.07703
55 https://doi.org/10.1172/jci107395
56 https://doi.org/10.1172/jci108764
57 https://doi.org/10.1172/jci109294
58 https://doi.org/10.1172/jci118846
59 https://doi.org/10.1172/jci119867
60 https://doi.org/10.1172/jci70704
61 https://doi.org/10.1172/jci72227
62 https://doi.org/10.1172/jci88477
63 https://doi.org/10.1177/2324709617710040
64 https://doi.org/10.1177/2324709617712736
65 https://doi.org/10.1177/2324709617725351
66 https://doi.org/10.1210/jc.2015-1884
67 https://doi.org/10.2169/internalmedicine.56.7501
68 https://doi.org/10.2337/db10-1328
69 https://doi.org/10.2337/db15-1356
70 https://doi.org/10.2337/dc15-1380
71 https://doi.org/10.2337/dc15-1995
72 https://doi.org/10.2337/dc15-2688
73 https://doi.org/10.2337/dc16-2724
74 https://doi.org/10.2337/dc17-1096
75 https://doi.org/10.2337/dc17-1721
76 https://doi.org/10.4158/ep14489.or
77 schema:datePublished 2019-12
78 schema:datePublishedReg 2019-12-01
79 schema:description Sodium-glucose transport protein 2 (SGLT2) inhibitors are a class of anti-diabetic agents; however, concerns have been raised about their potential to induce euglycemic ketoacidosis and to increase both glucose production and glucagon secretion. The mechanisms behind these alterations are unknown. Here we show that the SGLT2 inhibitor (SGLT2i) dapagliflozin promotes ketoacidosis in both healthy and type 2 diabetic rats in the setting of insulinopenia through increased plasma catecholamine and corticosterone concentrations secondary to volume depletion. These derangements increase white adipose tissue (WAT) lipolysis and hepatic acetyl-CoA content, rates of hepatic glucose production, and hepatic ketogenesis. Treatment with a loop diuretic, furosemide, under insulinopenic conditions replicates the effect of dapagliflozin and causes ketoacidosis. Furthermore, the effects of SGLT2 inhibition to promote ketoacidosis are independent from hyperglucagonemia. Taken together these data in rats identify the combination of insulinopenia and dehydration as a potential target to prevent euglycemic ketoacidosis associated with SGLT2i.
80 schema:genre research_article
81 schema:inLanguage en
82 schema:isAccessibleForFree true
83 schema:isPartOf N9ef07f73cc0d4b7bb9204f7959b7eb01
84 Nce7b2d4514ea4d1084722aa3954f76e8
85 sg:journal.1043282
86 schema:name Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats
87 schema:pagination 548
88 schema:productId N54bb6f8219284475b463bceb3dd70c78
89 N6c34f2677b884163ab399b0a240ea877
90 Nc2e296a1fdc445bf966df17060f2e510
91 Nce08ba51dcc749899d99abc27782558f
92 Nfd3ac04c844a49ff9c28247b22a37f34
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111837609
94 https://doi.org/10.1038/s41467-019-08466-w
95 schema:sdDatePublished 2019-04-11T13:57
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N1fdec672a7bf4eb69b88a782110c5028
98 schema:url https://www.nature.com/articles/s41467-019-08466-w
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N0a890486f84d4890ab39c137aff314b0 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
103 schema:familyName Cardone
104 schema:givenName Rebecca L.
105 rdf:type schema:Person
106 N0c94b6e865bd46ee9bb0146486a9abcc rdf:first N1df02a547c424e9ab6d48e5060706213
107 rdf:rest N908529b2cece43d197c7b45289231be4
108 N0d4b1c3e9ba443cabc80e96c71cc123c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Glucosides
110 rdf:type schema:DefinedTerm
111 N1df02a547c424e9ab6d48e5060706213 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
112 schema:familyName Kibbey
113 schema:givenName Richard G.
114 rdf:type schema:Person
115 N1fdec672a7bf4eb69b88a782110c5028 schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 N29a3b9494e1b421c895a77fb4f3bdaf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Disease Models, Animal
119 rdf:type schema:DefinedTerm
120 N2f7be792db2249ea84fe757e375f4bc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Insulin
122 rdf:type schema:DefinedTerm
123 N3106fd12a6e64a14a8a70dffdaee13e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Animals
125 rdf:type schema:DefinedTerm
126 N33944f1e12cc441d9056156bd7eeee27 rdf:first Nfc7d9b0cd8ba4969820cbcb0aff23a20
127 rdf:rest Nc91f9c82facb4966aeaecf2fdac42df8
128 N3445ce64ce9344a79f0b348ba81a0390 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Dehydration
130 rdf:type schema:DefinedTerm
131 N344fdb8142a749d6ab533781afa4c86a rdf:first Ncd25a0fb96ab4e85b1feac000bdf058b
132 rdf:rest N0c94b6e865bd46ee9bb0146486a9abcc
133 N3b73f0da3f494e128718064c48c56068 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Liver
135 rdf:type schema:DefinedTerm
136 N54bb6f8219284475b463bceb3dd70c78 schema:name dimensions_id
137 schema:value pub.1111837609
138 rdf:type schema:PropertyValue
139 N5ff458d8ef1647a59c4bae89ce539f12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Glucose
141 rdf:type schema:DefinedTerm
142 N6bc1a7b04948480186337fb9c11c3a0d schema:affiliation https://www.grid.ac/institutes/grid.47100.32
143 schema:familyName Shulman
144 schema:givenName Gerald I.
145 rdf:type schema:Person
146 N6c34f2677b884163ab399b0a240ea877 schema:name nlm_unique_id
147 schema:value 101528555
148 rdf:type schema:PropertyValue
149 N79dab8d3cd0d4a8bb15b6ebf2eb4b71e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 N81ee5a57729449cf89702fca6b5d5c15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Glucocorticoids
154 rdf:type schema:DefinedTerm
155 N8c45f78f9abc4630b51508ff783abc52 rdf:first Nceaa7ca6562045169c7d050fa7e16a50
156 rdf:rest Nab8cf210d2684654b2907f22c7966d76
157 N8e7a5a8164fa42b2ad5b1e896e498b47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Lipolysis
159 rdf:type schema:DefinedTerm
160 N908529b2cece43d197c7b45289231be4 rdf:first N6bc1a7b04948480186337fb9c11c3a0d
161 rdf:rest rdf:nil
162 N9d361b269c71427eb6800e876cd5bd07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Receptors, Adrenergic, beta-1
164 rdf:type schema:DefinedTerm
165 N9ef07f73cc0d4b7bb9204f7959b7eb01 schema:issueNumber 1
166 rdf:type schema:PublicationIssue
167 Nab8cf210d2684654b2907f22c7966d76 rdf:first N0a890486f84d4890ab39c137aff314b0
168 rdf:rest N344fdb8142a749d6ab533781afa4c86a
169 Nc2e296a1fdc445bf966df17060f2e510 schema:name readcube_id
170 schema:value 820565fe87d0f4ff97c9546b1c3d0a7fee5f630f392c39dd4be5047e456c9785
171 rdf:type schema:PropertyValue
172 Nc91f9c82facb4966aeaecf2fdac42df8 rdf:first Nca48978f0fc9492ea18ee23ce25d11d7
173 rdf:rest N8c45f78f9abc4630b51508ff783abc52
174 Nc9c05b4fd04a4037b8faee0820a6b4f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Ketosis
176 rdf:type schema:DefinedTerm
177 Nca48978f0fc9492ea18ee23ce25d11d7 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
178 schema:familyName Rabin-Court
179 schema:givenName Aviva
180 rdf:type schema:Person
181 Ncce11534507944a283c6b8f0d5e892ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Diabetes Mellitus, Type 2
183 rdf:type schema:DefinedTerm
184 Ncd25a0fb96ab4e85b1feac000bdf058b schema:affiliation https://www.grid.ac/institutes/grid.47100.32
185 schema:familyName Wang
186 schema:givenName Yongliang
187 rdf:type schema:Person
188 Nce08ba51dcc749899d99abc27782558f schema:name doi
189 schema:value 10.1038/s41467-019-08466-w
190 rdf:type schema:PropertyValue
191 Nce7b2d4514ea4d1084722aa3954f76e8 schema:volumeNumber 10
192 rdf:type schema:PublicationVolume
193 Nceaa7ca6562045169c7d050fa7e16a50 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
194 schema:familyName Song
195 schema:givenName Joongyu D.
196 rdf:type schema:Person
197 Nea8c39b25edd44648a03e5ba2bd3f6f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Sodium-Glucose Transporter 2 Inhibitors
199 rdf:type schema:DefinedTerm
200 Ned58e493170f49fea1be6305c0614196 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Benzhydryl Compounds
202 rdf:type schema:DefinedTerm
203 Nf86ba986b16b4951b477eed985eae8d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Male
205 rdf:type schema:DefinedTerm
206 Nfc7d9b0cd8ba4969820cbcb0aff23a20 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
207 schema:familyName Perry
208 schema:givenName Rachel J.
209 rdf:type schema:Person
210 Nfd3ac04c844a49ff9c28247b22a37f34 schema:name pubmed_id
211 schema:value 30710078
212 rdf:type schema:PropertyValue
213 Nfd4040ea171648f58c9be3fc65cd993e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Rats, Sprague-Dawley
215 rdf:type schema:DefinedTerm
216 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
217 schema:name Medical and Health Sciences
218 rdf:type schema:DefinedTerm
219 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
220 schema:name Clinical Sciences
221 rdf:type schema:DefinedTerm
222 sg:grant.2683100 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08466-w
223 rdf:type schema:MonetaryGrant
224 sg:grant.2683414 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08466-w
225 rdf:type schema:MonetaryGrant
226 sg:grant.2696394 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08466-w
227 rdf:type schema:MonetaryGrant
228 sg:grant.2705220 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08466-w
229 rdf:type schema:MonetaryGrant
230 sg:grant.3536855 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08466-w
231 rdf:type schema:MonetaryGrant
232 sg:grant.5475983 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08466-w
233 rdf:type schema:MonetaryGrant
234 sg:grant.7027891 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08466-w
235 rdf:type schema:MonetaryGrant
236 sg:grant.7725683 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-019-08466-w
237 rdf:type schema:MonetaryGrant
238 sg:journal.1043282 schema:issn 2041-1723
239 schema:name Nature Communications
240 rdf:type schema:Periodical
241 sg:pub.10.1007/s00125-015-3845-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010598485
242 https://doi.org/10.1007/s00125-015-3845-8
243 rdf:type schema:CreativeWork
244 sg:pub.10.1007/s00210-003-0858-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020698571
245 https://doi.org/10.1007/s00210-003-0858-5
246 rdf:type schema:CreativeWork
247 sg:pub.10.1007/s11936-017-0522-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1084033512
248 https://doi.org/10.1007/s11936-017-0522-x
249 rdf:type schema:CreativeWork
250 sg:pub.10.1007/s40268-016-0137-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007120806
251 https://doi.org/10.1007/s40268-016-0137-9
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nm.3579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031444747
254 https://doi.org/10.1038/nm.3579
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nm.3828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033956920
257 https://doi.org/10.1038/nm.3828
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nrneph.2016.170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009448867
260 https://doi.org/10.1038/nrneph.2016.170
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nutd.2014.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026500443
263 https://doi.org/10.1038/nutd.2014.20
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/srep31214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053341804
266 https://doi.org/10.1038/srep31214
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1002/dmrr.2924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090877724
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/0005-2760(78)90150-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036346143
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.ajem.2018.08.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106271441
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.cell.2015.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008078979
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.cell.2017.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100201139
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.diabet.2017.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085381383
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.ejphar.2014.01.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008749214
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.jacc.2017.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100422265
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.jdiacomp.2016.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051266499
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.jemermed.2016.07.082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028218198
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.jemermed.2017.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092828997
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.jphs.2016.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025313857
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.tem.2015.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004866748
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/s2213-8587(15)00417-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041327919
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1053/meta.2000.17721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001505405
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1056/nejmc1701990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085917007
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1056/nejmoa1708337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091621235
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1093/eurheartj/ehx511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091149503
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1097/md.0000000000011056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104997788
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1111/dom.12127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001011725
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/dom.12881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074226992
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1126/science.1439783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062482232
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1152/ajpcell.00296.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009790781
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1152/ajplegacy.1955.184.1.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075606933
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1161/hypertensionaha.116.07703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063345153
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1172/jci107395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046009247
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1172/jci108764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017952828
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1172/jci109294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012654812
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1172/jci118846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015376836
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1172/jci119867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014276972
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1172/jci70704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009314948
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1172/jci72227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005774065
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1172/jci88477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074186762
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1177/2324709617710040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085587783
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1177/2324709617712736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085936923
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1177/2324709617725351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091333457
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1210/jc.2015-1884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051974919
341 rdf:type schema:CreativeWork
342 https://doi.org/10.2169/internalmedicine.56.7501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005064728
343 rdf:type schema:CreativeWork
344 https://doi.org/10.2337/db10-1328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030301468
345 rdf:type schema:CreativeWork
346 https://doi.org/10.2337/db15-1356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070729741
347 rdf:type schema:CreativeWork
348 https://doi.org/10.2337/dc15-1380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011725783
349 rdf:type schema:CreativeWork
350 https://doi.org/10.2337/dc15-1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070730129
351 rdf:type schema:CreativeWork
352 https://doi.org/10.2337/dc15-2688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070730176
353 rdf:type schema:CreativeWork
354 https://doi.org/10.2337/dc16-2724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084405007
355 rdf:type schema:CreativeWork
356 https://doi.org/10.2337/dc17-1096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093166788
357 rdf:type schema:CreativeWork
358 https://doi.org/10.2337/dc17-1721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101029645
359 rdf:type schema:CreativeWork
360 https://doi.org/10.4158/ep14489.or schema:sameAs https://app.dimensions.ai/details/publication/pub.1027605181
361 rdf:type schema:CreativeWork
362 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
363 schema:name Departments of Cellular and Molecular Physiology, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA
364 Departments of Internal Medicine, Yale University School of Medicine, P.O. Box 208020, TAC S269, 06519, New Haven, CT, USA
365 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...