Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSBob Fregin, Fabian Czerwinski, Doreen Biedenweg, Salvatore Girardo, Stefan Gross, Konstanze Aurich, Oliver Otto
ABSTRACTIn life sciences, the material properties of suspended cells have attained significance close to that of fluorescent markers but with the advantage of label-free and unbiased sample characterization. Until recently, cell rheological measurements were either limited by acquisition throughput, excessive post processing, or low-throughput real-time analysis. Real-time deformability cytometry expanded the application of mechanical cell assays to fast on-the-fly phenotyping of large sample sizes, but has been restricted to single material parameters as the Young's modulus. Here, we introduce dynamic real-time deformability cytometry for comprehensive cell rheological measurements at up to 100 cells per second. Utilizing Fourier decomposition, our microfluidic method is able to disentangle cell response to complex hydrodynamic stress distributions and to determine viscoelastic parameters independent of cell shape. We demonstrate the application of our technology for peripheral blood cells in whole blood samples including the discrimination of B- and CD4+ T-lymphocytes by cell rheological properties. More... »
PAGES415
http://scigraph.springernature.com/pub.10.1038/s41467-019-08370-3
DOIhttp://dx.doi.org/10.1038/s41467-019-08370-3
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30679420
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08370-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08370-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08370-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-019-08370-3'
This table displays all metadata directly associated to this object as RDF triples.
327 TRIPLES
21 PREDICATES
91 URIs
35 LITERALS
23 BLANK NODES